Department of Clinical Science
Recent Submissions
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Time-Resolved Concentrations of Serum Amino Acids, One-carbon Metabolites, and B-vitamin Biomarkers during the Postprandial and Fasting State: The Postprandial Metabolism in Healthy Young Adults (PoMet) study
(Journal article; Peer reviewed, 2023)Metabolomics has been utilised in epidemiological studies to investigate biomarkers of nutritional status and metabolism in relation to non-communicable diseases. However, little is known about the effect of prandial status ... -
The dynamics of nutritional-related blood biomarker and metabolite concentrations during the postprandial and fasting states : And the implications when using nutritional-related biomarkers and metabolites in clinical care and research settings
(Doctoral thesis, 2024-04-05)BAKGRUNN: Vi vet lite om hvordan ernæringsrelaterte biomarkører og metabolitter endrer seg i blodet i postprandiell og fastende tilstand. MÅL: Å undersøke hvordan konsentrasjonen av aminosyrer, en-karbon metabolitter, ... -
Peripheral and central macrophages in obesity
(Journal article; Peer reviewed, 2023)Obesity is associated with chronic, low-grade inflammation. Excessive nutrient intake causes adipose tissue expansion, which may in turn cause cellular stress that triggers infiltration of pro-inflammatory immune cells ... -
Association of Myocardial Changes and Gene Expression of the NFATC1 and NFATC4—Calcineurin Signaling Pathway in Children with Bicuspid Aortic Valve
(Journal article; Peer reviewed, 2023)Background: The role of NFATC gene expression in bicuspid aortic valve (BAV) progression is not fully understood. The aim of this study is to determine the significance of NFATC1 and NFATC4 gene expression for myocardial ... -
Casein Kinase 2 (CK2): A Possible Therapeutic Target in Acute Myeloid Leukemia
(Journal article; Peer reviewed, 2023)The protein kinase CK2 (also known as casein kinase 2) is one of the main contributors to the human phosphoproteome. It is regarded as a possible therapeutic strategy in several malignant diseases, including acute myeloid ... -
Indoor Airborne Microbiome and Endotoxin: Meteorological Events and Occupant Characteristics Are Important Determinants
(Journal article; Peer reviewed, 2023)Airborne bacteria and endotoxin may affect asthma and allergies. However, there is limited understanding of the environmental determinants that influence them. This study investigated the airborne microbiomes in the homes ... -
Clinical features and risk factors for death in acute undifferentiated fever: A prospective observational study in rural community hospitals in six states of India
(Journal article; Peer reviewed, 2023)Background Acute undifferentiated fever (AUF) ranges from self-limiting illness to life-threatening infections, such as sepsis, malaria, dengue, leptospirosis and rickettsioses. Similar clinical presentation challenges ... -
Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders
(Journal article; Peer reviewed, 2023)C-reactive protein (CRP) tends to be elevated in individuals with psychiatric disorders. Recent findings have suggested a protective effect of the genetic liability to elevated CRP on schizophrenia risk and a causative ... -
Reduced Plasma Guanylin Levels Following Enterotoxigenic Escherichia coli-Induced Diarrhea
(Journal article; Peer reviewed, 2023)The intestinal peptide hormones guanylin (GN) and uroguanylin (UGN) interact with the epithelial cell receptor guanylate cyclase C to regulate fluid homeostasis. Some enterotoxigenic Escherichia coli (ETEC) produce heat-stable ... -
Vitamin B12 Deficiency (Un-)Detected Using Newborn Screening in Norway
(Journal article; Peer reviewed, 2023)Untreated vitamin B12 (B12) deficiency may cause delayed development in infants. Several newborn screening (NBS) programs have reported an increased detection rate of B12 deficiency when second-tier dried blood spot (DBS) ... -
Pleural Empyema Caused by Streptococcus intermedius and Fusobacterium nucleatum: A Distinct Entity of Pleural Infections
(Journal article; Peer reviewed, 2023)Background Many community-acquired pleural infections are caused by facultative and anaerobic bacteria from the human oral microbiota. The epidemiology, clinical characteristics, pathogenesis, and etiology of such ... -
Safety of hypoxic red blood cell administration in patients with transfusion-dependent hematological malignancies: An interim analysis
(Journal article; Peer reviewed, 2023)Anemia is a common symptom of hematological malignancies and red blood cell (RBC) transfusion is the primary supportive treatment, with many patients becoming transfusion dependent. Hemanext Inc. (Lexington, MA, United ... -
Operator radiation exposure in cardiac catheterization
(Doctoral thesis, 2024-03-22)Introduksjon Røntgenveiledete hjerteprosedyrer utsetter både pasient og operatør for ioniserende stråling. Selv om operatørdosen er en brøkdel av pasientdosen, kan en operatør utføre tusenvis av prosedyrer i løpet av en ... -
What determines who gets cardiac resynchronization therapy in Europe? A comparison between ESC-HF-LT registry, SwedeHF registry, and ESC-CRT Survey II
(Journal article; Peer reviewed, 2023)Aims Cardiac resynchronization therapy (CRT) is effective in heart failure with reduced ejection fraction (HFrEF) and dyssynchrony but is underutilized. In a cohort study, we identified clinical, organizational, and ... -
Expression of ANK3 moderates the association between childhood trauma and affective traits in severe mental disorders
(Journal article; Peer reviewed, 2023)Exposure to early life trauma increases the risk of psychopathology later in life. Here we investigated if ANK3 mRNA levels influence the relationship between childhood trauma experiences and clinical characteristics in ... -
Safety and efficacy of pegunigalsidase alfa in patients with Fabry disease who were previously treated with agalsidase alfa: results from BRIDGE, a phase 3 open-label study
(Journal article; Peer reviewed, 2023)Background Pegunigalsidase alfa is a novel, PEGylated α-galactosidase-A enzyme-replacement therapy approved in the EU and US to treat patients with Fabry disease (FD). Objective/methods BRIDGE is a phase 3 open-label, ... -
Long-term impact of gastropexy on use of acid-reducing medication, second operations for gastroesophageal reflux and subjective reflux symptoms after sleeve gastrectomy
(Journal article; Peer reviewed, 2023)We investigated whether adding gastropexy to sleeve gastrectomy (SG) reduced gastroesophageal reflux disease (GERD) in patients operated for severe obesity, assessed mainly by use of anti-reflux medication (ARM) and second ... -
Multimodality imaging in the immediate and long-term evaluation of bioresorbable vascular scaffolds : In patients with ST-elevation myocardial infarction
(Doctoral thesis, 2024-03-15)Introduksjon Akutt revaskularisering med primær perkutan koronar revaskularisering (PCI) er foretrukne strategi for pasienter med ST-elevasjons myokardielt infarkt (STEMI). Nåværende teknikk er å implantere stenter laget ... -
Cardiac troponin measurement at the point of care: educational recommendations on analytical and clinical aspects by the IFCC Committee on Clinical Applications of Cardiac Bio-Markers (IFCC C-CB)
(Journal article; Peer reviewed, 2023)The International Federation of Clinical Chemistry and Laboarator Medicine (IFCC) Committee on Clinical Applications of Cardiac Bio-Markers (C-CB) has provided evidence-based educational resources to aid and improve the ...