Department of Clinical Science: Nye registreringer
Viser treff 1-20 av 2309
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Variation in antibiotic consumption in very preterm infants-a 10 year population-based study
(Journal article; Peer reviewed, 2023)Objectives Wide variations in antibiotic use in very preterm infants have been reported across centres despite similar rates of infection. We describe 10 year trends in use of antibiotics and regional variations among ... -
Machine learning approaches in microbiome research: challenges and best practices
(Journal article; Peer reviewed, 2023)Microbiome data predictive analysis within a machine learning (ML) workflow presents numerous domain-specific challenges involving preprocessing, feature selection, predictive modeling, performance estimation, model ... -
Phase II study of everolimus and temozolomide as first-line treatment in metastatic high-grade gastroenteropancreatic neuroendocrine neoplasms
(Journal article; Peer reviewed, 2023)Background The optimal treatment for metastatic high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms when Ki-67 ≤55% is unknown. A prospective multi-centre phase 2 study was performed to evaluate the efficacy ... -
Distinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathies
(Journal article; Peer reviewed, 2023)Background In patients with idiopathic inflammatory myopathies (IIM), autoantibodies are associated with specific clinical phenotypes suggesting a pathogenic role of adaptive immunity. We explored if autoantibody profiles ... -
Is the fetus fit for labor? Introducing fast-and-frugal trees (FFTrees) to simplify triage of women for STAN monitoring: An interobserver agreement comparison with traditional classification
(Journal article; Peer reviewed, 2023)Introduction It is a shortcoming of traditional cardiotocography (CTG) classification table formats that CTG traces are frequently classified differently by different users, resulting in poor interobserver agreements. ... -
Prolonging the delivery of influenza virus vaccine improves the quantity and quality of the induced immune responses in mice
(Journal article; Peer reviewed, 2023)Introduction: Influenza vaccines play a vital role in protecting individuals from influenza virus infection and severe illness. However, current influenza vaccines have suboptimal efficacy, which is further reduced in cases ... -
Impaired glucose tolerance and cardiovascular risk factors in relation to infertility: a Mendelian randomization analysis in the Norwegian Mother, Father, and Child Cohort Study
(Journal article; Peer reviewed, 2024)Study question: Are impaired glucose tolerance (as measured by fasting glucose, glycated hemoglobin, and fasting insulin) and cardiovascular disease risk (as measured by low-density lipoprotein cholesterol, high-density ... -
Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease - a cross-sectional study
(Journal article; Peer reviewed, 2023)Objective: Increased prevalence of cardiovascular disease has been reported in autoimmune Addison's disease (AAD), but pathomechanisms are poorly understood. Design: Cross-sectional study. Methods: We compared serum ... -
Do differences in diagnostic criteria for late fetal growth restriction matter?
(Journal article; Peer reviewed, 2023)BACKGROUND Criteria for diagnosis of fetal growth restriction differ widely according to national and international guidelines, and further heterogeneity arises from the use of different biometric and Doppler reference ... -
Reduced lung function and cause-specific mortality: A population-based study of Norwegian men followed for 26 years
(Journal article; Peer reviewed, 2023)Background and aim Reduced lung function is associated with increased mortality, but it is unclear how different spirometric patterns are related to specific deaths. Aim of this study was to investigate these associations ... -
Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids
(Journal article; Peer reviewed, 2023)Rationale Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) ... -
Relation between HLA and copy number variation of steroid 21-hydroxylase in a Swedish cohort of patients with autoimmune Addison’s disease
(Journal article; Peer reviewed, 2023)Objective Autoantibodies against the adrenal enzyme 21-hydroxylase is a hallmark manifestation in autoimmune Addison's disease (AAD). Steroid 21-hydroxylase is encoded by CYP21A2, which is located in the human leucocyte ... -
Aiming toWards Evidence baSed inTerpretation of Cardiac biOmarkers in patients pResenting with chest pain using Point of Care Testing (WESTCOR-POC): study design
(Journal article; Peer reviewed, 2023)Objectives: Patients presenting with symptoms suggestive of acute coronary syndrome (ACS) contribute to a high workload and overcrowding in the Emergency Department (ED). Accelerated diagnostic protocols for non-ST-elevation ... -
The diagnostic utility of microscopic quality assessment of sputum samples in the era of rapid syndromic PCR testing
(Journal article; Peer reviewed, 2023)This prospective study assessed the value of initial microscopy evaluation of sputum samples submitted for rapid syndromic PCR-based testing. Bacterial detections by the BioFire FilmArray Pneumonia Panel plus in 126 high- ... -
Human Embryonic Development : Effects of Physical Activity and Sleep in Physiological Pregnancies
(Doctoral thesis, 2024-05-03)Bakgrunn: Forskningsfeltet "Developmental Origin of Health and Disease" (DOHaD) har vist hvor betydningsfull fosterutviklingen er for individets fremtidige helse og sykdomsrisiko. I senere år har den tidligste perioden av ... -
Maternal physical activity affects yolk sac size and growth in early pregnancy, but girls and boys use different strategies
(Journal article; Peer reviewed, 2023)This longitudinal study investigated the impact of actigraphy-measured maternal physical activity on yolk sac size during early development. The yolk sac, a transient extraembryonic organ, plays a crucial role in embryonic ... -
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Clinical trials, medical treatment and pathomechanisms
(Doctoral thesis, 2024-05-02)Myalgisk encefalomyelitt/kronisk utmattelsessyndrom (ME/CFS) er en underprioritert sykdom som rammer 0,2-0,8 % av befolkningen, med ukjent etiologi, høy symptombelastning, ingen biomarkør, og ingen godkjent effektiv ... -
Longitudinal Transcriptomic Analysis of Human Cortical Spheroids Identifies Axonal Dysregulation in the Prenatal Brain as a Mediator of Genetic Risk for Schizophrenia
(Journal article; Peer reviewed, 2024)Background Schizophrenia (SCZ) has a known neurodevelopmental etiology, but limited access to human prenatal brain tissue hampers the investigation of basic disease mechanisms in early brain development. Here, we elucidate ... -
The influence of socio-demographic and clinical factors on sick leave and return to work after open-heart surgery: a nationwide registry-based cohort study
(Journal article; Peer reviewed, 2023)Aims: To estimate sick leave (SL) duration after first-time elective open-heart surgery and identify factors contributing to increased SL. Methods and results: A retrospective nationwide cohort study combined data from ... -
Combining Mass Cytometry Data by CyTOFmerge Reveals Additional Cell Phenotypes in the Heterogeneous Ovarian Cancer Tumor Microenvironment: A Pilot Study
(Journal article; Peer reviewed, 2023-10-23)The prognosis of high-grade serous ovarian carcinoma (HGSOC) is poor, and treatment selection is challenging. A heterogeneous tumor microenvironment (TME) characterizes HGSOC and influences tumor growth, progression, and ...