Department of Clinical Medicine: Recent submissions
Now showing items 1-20 of 2061
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Molecular mechanisms of mitochondrial dysfunction in neurodegenerative diseases
(Doctoral thesis, 2024-06-05)Bakgrunn Nevrodegenerative lidelser er komplekse lidelser i sentralnervesystemet som er typisk preget av akkumulering av feilfoldede proteiner og progressiv degenerasjon og død av sårbare cellepopulasjoner i de berørte ... -
Impact of birth weight on kidney health in middle-aged adults : Results from the Haugesund Low Birth Weight Study
(Doctoral thesis, 2024-06-07)Bakgrunn: Tidligere studier, inkludert flere studier basert på medisinsk fødselsregister i Norge, har vist en sammenheng mellom lav fødselsvekt og redusert nyrefunksjon hos voksne. Studier som bruker målt glomerulær ... -
Trajectories of response in schizophrenia-spectrum disorders: A one-year prospective cohort study of antipsychotic effectiveness
(Journal article; Peer reviewed, 2022)Background: Antipsychotic drugs remain the mainstay of schizophrenia treatment; however, their effectiveness has been questioned, and it is not possible to predict the response to a specific antipsychotic drug in an ... -
Improving Outcomes of Antipsychotic Treatment in Schizophrenia
(Doctoral thesis, 2024-05-31)Bakgrunn/Formål: Den farmakologiske behandlingen av schizofreni gir langt fra optimale resultater, i forhold til både positive og negative symptomer. Denne avhandlingen hadde som hensikt å undersøke utfall i form av respons ... -
An interdisciplinary intervention for children and adolescents with multiple referrals and complex health complaints: a feasibility study
(Journal article; Peer reviewed, 2023-11-11)Background: Children and adolescents with complex health complaints are often referred to several different healthcare specialists for assessments and treatment. This may result in fragmented care, higher risks of medical ... -
Allogenous Bone Grafting Technique for Staged Revision Anterior Cruciate Ligament Surgery
(Journal article, 2023)Background: Tunnel widening, slightly malplaced former tunnels or bone loss due to hardware removal might prevent a 1-stage anterior cruciate ligament (ACL) revision procedure due to tunnel convergence or challenging graft ... -
High-Dose Folic Acid Use during Pregnancy and Cancer Risk in Mothers and Children With Focus on Maternal Epilepsy
(Doctoral thesis, 2024-05-23)Norsk sammendrag: Bakgrunn: Gravide kvinner som tar antianfallsmedikasjon (ASM) anbefales høyere daglige doser av folsyre (>1 mg) enn den generelle befolkningen (0.4–0.8 mg) for å beskytte fosteret. Folsyre, den syntetiske ... -
Transitioning from transrectal to transperineal prostate biopsy using a freehand cognitive approach
(Journal article; Peer reviewed, 2024)Objectives To report a single-centre experience of a complete transition from transrectal (TR) to transperineal (TP) prostate biopsy under local anaesthesia using a freehand cognitive coaxial approach and without use ... -
Comparative Risk of Major Congenital Malformations With Antiseizure Medication Combinations vs Valproate Monotherapy in Pregnancy
(Journal article; Peer reviewed, 2023)Background and Objectives Valproate should be avoided in pregnancy, but it is the most effective drug for generalized epilepsies. Alternative treatment may require combinations of other drugs. Our objectives were to ... -
Norwegian paediatric habilitation centres judge their own competence on cerebral visual impairment as limited
(Journal article; Peer reviewed, 2023)Aim: Cerebral visual impairment (CVI), a frequently occurring functional impairment in children with neurodevelopmental disorders, leads to communicative, social and academic challenges. In Norway, children with ... -
Prescribing patterns for higher dose folic acid in pregnant women with epilepsy treated with antiseizure medication
(Journal article; Peer reviewed, 2024)Objective: This study was undertaken to characterize the use of higher doses of folic acid (≥1 mg daily) in relation to pregnancy in Denmark, Norway, and Sweden in women with epilepsy treated with antiseizure medication ... -
Call for better response evaluation after neoadjuvant therapy in pancreatic cancer
(Journal article; Peer reviewed, 2023) -
The Association of Isocaloric Subtitution of Dietary Protein in Middle Age with Muscle Mass and Strength in Old Age: The Hordaland Health Study
(Journal article; Peer reviewed, 2024)Background Age-associated loss of muscle mass and strength is an important predictor of disability in older persons. Although several mechanisms contribute to the decline in muscle mass and function seen with aging, the ... -
Self-assessment of range of motion in patients undergoing surgery for a unilateral shoulder condition
(Journal article; Peer reviewed, 2023)Objective: This study aimed to investigate the agreement of patient-assessed and researcher/physician-assessed measurements of the difference in range of motion between the unaffected and affected shoulders in 55 patients ... -
Verified Parental Cardiovascular Events for Young and Middle-Aged Ischaemic Stroke Patients and Controls
(Journal article; Peer reviewed, 2023)Introduction: Nonmodifiable cardiovascular risk factors, like age and sex, are easily quantifiable. Due to immense technical progress in diagnostics and medical data storage, the aim of this study was to quantify, verify, ... -
Neurobiological mechanisms of ECT and TMS treatment in depression: study protocol of a multimodal magnetic resonance investigation
(Journal article; Peer reviewed, 2023)Background: Noninvasive neurostimulation treatments are increasingly being used to treat major depression, which is a common cause of disability worldwide. While electroconvulsive therapy (ECT) and transcranial magnetic ... -
Transcriptomic analysis reveals partial epithelial–mesenchymal transition and inflammation as common pathogenic mechanisms in hypertensive nephrosclerosis and Type 2 diabetic nephropathy
(Journal article; Peer reviewed, 2023)Hypertensive nephrosclerosis (HN) and Type 2 diabetic nephropathy (T2DN) are the leading causes of chronic kidney disease (CKD). To explore shared pathogenetic mechanisms, we analyzed transcriptomes of kidney biopsies from ... -
Quantitative analogues to visual spike interpretation in EEG
(Doctoral thesis, 2024-05-03)Bakgrunn: Noen skarpe transienter i EEG er interiktale epileptiforme utladninger (IEU) og representerer en biomarkør for epilepsi. Visuell analyse er den gjeldende gullstandarden for å detektere IEUer. En slik analyse ... -
Cementing techniques for total knee arthroplasty in Norwegian hospitals; a questionnaire-based study
(Journal article; Peer reviewed, 2023-11-18)Background: Cementing technique in total knee arthroplasty (TKA) may influence implant survival. There is limited knowledge about the results with clinically used techniques. The aim of this study was to investigate ... -
Case report: Seropositive myasthenia gravis complicated by limbic encephalitis positive for antibodies to AMPAR and Lgi1
(Journal article; Peer reviewed, 2023-10-12)Objectives: Autoantibodies to the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) and leucine-rich glioma-inactivated 1 (Lgi1) are associated with autoimmune encephalitis. We described an acetylcholine ...