dc.contributor.author | Kleppe, Rune | en_US |
dc.contributor.author | Martinez, Aurora | en_US |
dc.contributor.author | Døskeland, Stein Ove | en_US |
dc.contributor.author | Haavik, Jan | en_US |
dc.date.accessioned | 2015-04-16T12:04:01Z | |
dc.date.available | 2015-04-16T12:04:01Z | |
dc.date.issued | 2011-09 | eng |
dc.identifier.issn | 1084-9521 | |
dc.identifier.uri | https://hdl.handle.net/1956/9815 | |
dc.description.abstract | Thirty years ago, it was discovered that 14-3-3 proteins could activate enzymes involved in amino acid metabolism. In the following decades, 14-3-3s have been shown to be involved in many different signaling pathways that modulate cellular and whole body energy and nutrient homeostasis. Large scale screening for cellular binding partners of 14-3-3 has identified numerous proteins that participate in regulation of metabolic pathways, although only a minority of these targets have yet been subject to detailed studies. Because of the wide distribution of potential 14-3-3 targets and the resurging interest in metabolic pathway control in diseases like cancer, diabetes, obesity and cardiovascular disease, we review the role of 14-3-3 proteins in the regulation of core and specialized cellular metabolic functions. We cite illustrative examples of 14-3-3 action through their direct modulation of individual enzymes and through regulation of master switches in cellular pathways, such as insulin signaling, mTOR- and AMP dependent kinase signaling pathways, as well as regulation of autophagy. We further illustrate the quantitative impact of 14-3-3 association on signal response at the target protein level and we discuss implications of recent findings showing 14-3-3 protein membrane binding of target proteins. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Elsevier | eng |
dc.rights | Attribution-NonCommercial-NoDerivs CC BY-NC-ND | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | eng |
dc.subject | 14-3-3 Proteins | eng |
dc.subject | Metabolism | eng |
dc.subject | Tyrosine hydroxylase | eng |
dc.subject | Membrane association | eng |
dc.subject | Cell signaling | eng |
dc.title | The 14-3-3 proteins in regulation of cellular metabolism | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2015-04-01T07:05:44Z | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2011 Elsevier Ltd. | |
dc.identifier.doi | https://doi.org/10.1016/j.semcdb.2011.08.008 | |
dc.identifier.cristin | 879273 | |
dc.source.journal | Seminars in Cell and Developmental Biology | |
dc.source.40 | 22 | |
dc.source.14 | 7 | |
dc.source.pagenumber | 713-719 | |
dc.subject.nsi | VDP::Medical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical microbiology: 715 | eng |
dc.subject.nsi | VDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi : 715 | nob |