dc.contributor.author | Haldorsen, Ingfrid S. | en_US |
dc.contributor.author | Stefansson, Ingunn | en_US |
dc.contributor.author | Grüner, Renate | en_US |
dc.contributor.author | Husby, Jenny Hild Aase | en_US |
dc.contributor.author | Magnussen, Inger Johanne | en_US |
dc.contributor.author | Werner, Henrica Maria Johanna | en_US |
dc.contributor.author | Salvesen, Øyvind | en_US |
dc.contributor.author | Bjørge, Line | en_US |
dc.contributor.author | Trovik, Jone | en_US |
dc.contributor.author | Taxt, Torfinn | en_US |
dc.contributor.author | Akslen, Lars A. | en_US |
dc.contributor.author | Salvesen, Helga Birgitte | en_US |
dc.date.accessioned | 2015-05-15T07:10:14Z | |
dc.date.available | 2015-05-15T07:10:14Z | |
dc.date.issued | 2014 | eng |
dc.identifier.issn | 0007-0920 | |
dc.identifier.uri | https://hdl.handle.net/1956/9874 | |
dc.description.abstract | Background: We aimed to study the angiogenic profile based on histomorphological markers in endometrial carcinomas in relation to imaging parameters obtained from preoperative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI) and to explore the potential value of these markers to identify patients with poor outcome. Methods: In fifty-four surgically staged endometrial carcinoma patients, immunohistochemical staining with factor VIII and Ki67 allowed assessment of microvessel density (MVD) and microvascular proliferation reflecting tumour angiogenesis. In the same patients, preoperative pelvic DCE-MRI and DWI allowed the calculation of parameters describing tumour microvasculature and microstructure in vivo. Results: Microvascular proliferation was negatively correlated to tumour blood flow (Fb) (r=−0.36, P=0.008), capillary permeability surface area product (PS) (r=−0.39, P=0.004) and transfer from the blood to extravascular extracellular space (EES) (Ktrans) (r=−0.40, P=0.003), and was positively correlated to tumour volume (r=0.34; P=0.004). High-tumour microvascular proliferation, low Fb and low Ktrans were all significantly associated with reduced progression/recurrence-free survival (P<0.05). Conclusion: Disorganised angiogenesis with coexisting microvascular proliferation and low tumour blood flow is a poor prognostic factor supporting that hypoxia is associated with progression and metastatic spread in endometrial carcinomas. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Nature Publishing Group | eng |
dc.rights | Attribution-NonCommercial-ShareAlike CC BY-NC-SA | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/ | eng |
dc.subject | endometrial carcinoma | eng |
dc.subject | histomorphological marker | eng |
dc.subject | dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) | eng |
dc.subject | diffusion-weighted imaging (DWI) | eng |
dc.subject | Biomarker | eng |
dc.subject | Angiogenesis | eng |
dc.title | Increased microvascular proliferation is negatively correlated to tumour blood flow and is associated with unfavourable outcome in endometrial carcinomas | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2015-04-08T09:47:25Z | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2014 Cancer Research UK | |
dc.identifier.doi | https://doi.org/10.1038/bjc.2013.694 | |
dc.identifier.cristin | 1112321 | |
dc.source.journal | British Journal of Cancer | |
dc.source.40 | 110 | |
dc.source.14 | 1 | |
dc.source.pagenumber | 107-114 | |
dc.relation.project | Norges forskningsråd: 223250 | |
dc.relation.project | Norges forskningsråd: 191778 | |
dc.relation.project | Norges forskningsråd: 205404 | |
dc.subject.nsi | VDP::Medical sciences: 700::Clinical medical sciences: 750::Gynaecology and obstetrics: 756 | eng |
dc.subject.nsi | VDP::Medical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical microbiology: 715 | eng |
dc.subject.nsi | VDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756 | nob |
dc.subject.nsi | VDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi : 715 | nob |