Department of Clinical Science: Recent submissions

Now showing items 1-20 of 2319

    • European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation 

      Budu-Aggrey, Ashley; Kilanowski, Anna; Sobczyk, Maria K.; Shringarpure, Suyash S.; Mitchell, Ruth; Reis, Kadri; Reigo, Anu; Mägi, Reedik; Nelis, Mari; Tanaka, Nao; Brumpton, Ben Michael; Thomas, Laurent Francois; Sole-Navais, Pol; Flatley, Christopher; Espuela-Ortiz, Antonio; Herrera-Luis, Esther; Lominchar, Jesus V. T.; Bork-Jensen, Jette; Marenholz, Ingo; Arnau-Soler, Aleix; Jeong, Ayoung; Fawcett, Katherine A.; Baurecht, Hansjorg; Rodriguez, Elke; Alves, Alexessander Couto; Kumar, Ashish; Sleiman, Patrick M.; Chang, Xiao; Medina-Gomez, Carolina; Hu, Chen; Xu, Cheng-jian; Qi, Cancan; El-Heis, Sarah; Titcombe, Philip; Antoun, Elie; Fadista, João; Wang, Carol A.; Thiering, Elisabeth; Wu, Baojun; Kress, Sara; Kothalawala, Dilini M.; Kadalayil, Latha; Duan, Jiasong; Zhang, Hongmei; Hadebe, Sabelo; Hoffmann, Thomas; Jorgenson, Eric; Choquet, Hélène; Risch, Neil; Njølstad, Pål Rasmus; Andreassen, Ole; Johansson, Stefan; Almqvist, Catarina; Gong, Tong; Ullemar, Vilhelmina; Karlsson, Robert; Magnusson, Patrik K. E.; Szwajda, Agnieszka; Burchard, Esteban G.; Thyssen, Jacob P.; Hansen, Torben; Kårhus, Line L.; Dantoft, Thomas M.; Jeanrenaud, Alexander C.S.N.; Ghauri, Ahla; Arnold, Andreas; Homuth, Georg; Lau, Susanne; Nöthen, Markus M.; Hübner, Norbert; Imboden, Medea; Visconti, Alessia; Falchi, Mario; Bataille, Veronique; Hysi, Pirro; Ballardini, Natalia; Boomsma, Dorret I.; Hottenga, Jouke J.; Müller-Nurasyid, Martina; Ahluwalia, Tarunveer S.; Stokholm, Jakob; Chawes, Bo; Schoos, Ann-Marie M.; Esplugues, Ana; Bustamante, Mariona; Raby, Benjamin; Arshad, Syed; German, Chris; Esko, Tõnu; Milani, Lili A.; Metspalu, Andres; Terao, Chikashi; Abuabara, Katrina; Løset, Mari; Hveem, Kristian; Jacobsson, Bo; Pino-Yanes, Maria; Strachan, David P.; Grarup, Niels; Linneberg, Allan; Lee, Young-Ae; Probst-Hensch, Nicole; Weidinger, Stephan; Jarvelin, Marjo-Riitta; Melén, Erik; Hakonarson, Hakon; Irvine, Alan D.; Jarvis, Deborah; Nijsten, Tamar; Duijts, Liesbeth; Vonk, Judith M.; Koppelmann, Gerard H.; Godfrey, Keith M.; Barton, Sheila J.; Feenstra, Bjarke; Pennell, Craig E.; Sly, Peter D.; Holt, Patrick G.; Williams, L. Keoki; Bisgaard, Hans; Bønnelykke, Klaus; Curtin, John; Simpson, Angela; Murray, Clare; Schikowski, Tamara; Bunyavanich, Supinda; Weiss, Scott T.; Holloway, John W.; Min, Josine L.; Brown, Sara J.; Standl, Marie; Paternoster, Lavinia (Journal article; Peer reviewed, 2023)
      Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery ...

    • Cardiac rehabilitation participation within 6 months of discharge in 37 136 myocardial infarction survivors: a nationwide registry study 

      Norekvål, Tone Merete; Bale, Marte; Bedane, Haji Kedir; Hole, Torstein Laurits; Ingul, Charlotte Ingeborg Björk; Munkhaugen, John (Journal article; Peer reviewed, 2023)

    • Real-world data on niraparib maintenance treatment in patients with non-gBRCA mutated platinum-sensitive recurrent ovarian cancer 

      Elgaaen, Bente Vilming; Dahl, Jørgen Fallås; Bentzen, Anne Gry; Ingebrigtsen, Vibeke Anett; Nilsen, Elisabeth Berge; Vistad, Ingvild; Dørum, Anne; Popova, Olesya; Bjørge, Line; Zucknick, Manuela; Aune, Guro; Lindemann, Kristina Yvonne Kathe (Journal article; Peer reviewed, 2023)
      Objectives The aim of this study was to provide real-world efficacy and safety data on niraparib maintenance treatment in patients with non-germline (gBRCA)1/2 mutated platinum-sensitive recurrent ovarian cancer. Methods ...

    • Unveiling sex bias and adverse neonatal outcomes in ultrasound estimation of gestational age: A population-based cohort study 

      Einum, Anders; Sørbye, Linn Marie; Nilsen, Roy Miodini; Ebbing, Cathrine; Morken, Nils-Halvdan (Journal article; Peer reviewed, 2024)
      Background Gestational age estimation by second-trimester ultrasound biometry introduces systematic errors due to sex differences in early foetal growth, consequently increasing the risk of adverse neonatal outcomes. ...

    • The impact of placental genomic risk for schizophrenia and birth asphyxia on brain development 

      Wortinger, Laura Anne; Shadrin, Alexey; Szabo, Attila; Nerland, Stener; Smelror, Runar; Jørgensen, Kjetil Nordbø; Barth, Claudia; Andreou, Dimitrios; Thoresen, Marianne; Andreassen, Ole; Djurovic, Srdjan; Ursini, Gianluca; Agartz, Ingrid (Journal article; Peer reviewed, 2023)
      The placenta plays a role in fetal brain development, and pregnancy and birth complications can be signs of placental dysfunction. Birth asphyxia is associated with smaller head size and higher risk of developing schizophrenia ...

    • SARS-CoV-2 specific immune responses in overweight and obese COVID-19 patients 

      Onyango, Therese Bredholt; Zhou, Fan; Bredholt, Geir; Brokstad, Karl Albert; Jalloh, Sarah Larteley Lartey; Mohn, Kristin Greve-Isdahl; Özgümüs, Türküler; Kittang, Bård Reiakvam; Linchausen, Dagrun Waag; Shafiani, Shahin; Elyanow, Rebecca; Blomberg, Bjørn; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2023)
      Obesity is a known risk factor for severe respiratory tract infections. In this prospective study, we assessed the impact of being obese or overweight on longitudinal SARS-CoV-2 humoral and cellular responses up to 18 ...

    • Point-of-care high-sensitivity troponin assays: Advancements, clinical applications, and implementation considerations 

      Thulin, Ingrid Viola Lavesson; Myrmel, Gard Mikael Saele; Jordalen, Silje; Collinson, Paul; Aakre, Kristin Moberg (Journal article; Peer reviewed, 2023)
      High-sensitivity cardiac troponin (hs-cTn) assays have changed the workflow in emergency departments allowing for rapid allocation of patients with high or low risk of non-ST elevation myocardial infarction. Recently, ...

    • Genetic Predictors of Comorbid Course of COVID-19 and MAFLD: A Comprehensive Analysis 

      Buchynskyi, Mykhailo; Oksenych, Valentyn; Kamyshna, Iryna; Vari, Sandor G.; Kamyshnyi, Aleksandr (Journal article; Peer reviewed, 2023)
      Metabolic-associated fatty liver disease (MAFLD) and its potential impact on the severity of COVID-19 have gained significant attention during the pandemic. This review aimed to explore the genetic determinants associated ...

    • Insights into Sex and Gender Differences in Brain and Psychopathologies Using Big Data 

      Zelco, Aura; Wapeesittipan, Pattama; Joshi, Anagha (Journal article; Peer reviewed, 2023)
      The societal implication of sex and gender (SG) differences in brain are profound, as they influence brain development, behavior, and importantly, the presentation, prevalence, and therapeutic response to diseases. ...

    • Atypical (non-V600E) BRAF mutations in metastatic colorectal cancer in population and real-world cohorts 

      Osterlund, Emerik; Ristimäki, Ari; Mäkinen, Markus J.; Kytölä, Soili; Kononen, Juha; Pfeiffer, Per; Soveri, Leena-Maija; Keinänen, Mauri; Sorbye, Halfdan; Nunes, Luís; Salminen, Tapio; Nieminen, Lasse; Uutela, Aki; Halonen, Päivi; Ålgars, Annika; Sundström, Jari; Kallio, Raija; Ristamäki, Raija; Lamminmäki, Annamarja; Stedt, Hanna; Heervä, Eetu; Kuopio, Teijo; Sjöblom, Tobias; Isoniemi, Helena; Glimelius, Bengt; Osterlund, Pia (Journal article; Peer reviewed, 2023)
      BRAF-V600E mutation (mt) is a strong negative prognostic and predictive biomarker in metastatic colorectal cancer (mCRC). Non-V600Emt, designated atypical BRAFmt (aBRAFmt) are rare, and little is known about their frequency, ...

    • The Composite Autonomic Symptom Score 31 Questionnaire: A Sensitive Test to Detect Risk for Autonomic Neuropathy 

      Meling, Sondre V.; Tjora, Erling; Eichele, Heike; Ejskjaer, Niels; Carlsen, Siri; Njølstad, Pål Rasmus; Brock, Christina; Søfteland, Eirik (Journal article; Peer reviewed, 2023)
      Background and Aims. Autonomic neuropathy is a common but often neglected complication of diabetes, prediabetes, and even in individuals with an elevated risk of diabetes. The Composite Autonomic Symptom Score (COMPASS) ...

    • Stratified genetic analysis reveals sex differences in MPO-ANCA-associated vasculitis 

      Ekman, Diana; Sennblad, Bengt; Knight, Ann; Karlsson, Åsa; Rantapää-Dahlqvist, Solbritt; Berglin, Ewa; Stegmayr, Bernd; Baslund, Bo; Palm, Øyvind; Haukeland, Hilde; Gunnarsson, Iva; Bruchfeld, Annette; Segelmark, Mårten; Ohlsson, Sophie; Mohammad, Aladdin J; Svärd, Anna; Pullerits, Rille; Herlitz, Hans; Söderbergh, Annika; Omdal, Roald; Jonsson, Roland; Rönnblom, Lars; Eriksson, Per; Lindblad-Toh, Kerstin; Dahlqvist, Johanna (Journal article; Peer reviewed, 2023)
      Objective To identify and genetically characterize subgroups of patients with ANCA-associated vasculitides (AAV) based on sex and ANCA subtype. Methods A previously established SNP dataset derived from DNA sequencing ...

    • Factors predicting death and cancer in patients with giant cell arteritis in Western Norway 1972–2012: a retrospective observational cohort study 

      Brekke, Lene Kristin; Assmus, Jörg; Fevang, Bjørg Tilde Svanes (Journal article; Peer reviewed, 2023)
      Objectives: Evidence as to whether or not giant cell arteritis (GCA) confers added risk of cancer or death is conflicting. Our aim was to identify factors predicting death or cancer in a large Norwegian GCA-cohort. Methods: ...

    • Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci 

      Jaholkowski, Piotr Pawel; Hindley, Guy; Shadrin, Alexey; Tesfaye, Markos; Bahrami, Shahram; Nerhus, Mari; Rahman, Zillur; O'Connell, Kevin Sean; Holen, Børge; Parker, Nadine; Cheng, Weiqiu; Lin, Aihua; Rødevand, Linn; Karadag, Naz; Frei, Oleksandr; Djurovic, Srdjan; Dale, Anders M.; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article; Peer reviewed, 2023)
      Low vitamin D (vitD) levels have been consistently reported in schizophrenia (SCZ) suggesting a role in the etiopathology. However, little is known about the role of underlying shared genetic mechanisms. We applied a ...

    • The dynamics of nutritional-related blood biomarker and metabolite concentrations during the postprandial and fasting states : And the implications when using nutritional-related biomarkers and metabolites in clinical care and research settings 

      Anfinsen, Åslaug Matre (Doctoral thesis, 2024-04-05)
      BAKGRUNN: Vi vet lite om hvordan ernæringsrelaterte biomarkører og metabolitter endrer seg i blodet i postprandiell og fastende tilstand. MÅL: Å undersøke hvordan konsentrasjonen av aminosyrer, en-karbon metabolitter, ...

    • Time-Resolved Concentrations of Serum Amino Acids, One-carbon Metabolites, and B-vitamin Biomarkers during the Postprandial and Fasting State: The Postprandial Metabolism in Healthy Young Adults (PoMet) study 

      Anfinsen, Åslaug Matre; Johannesen, Christina Osland; Myklebust, Vilde H.; Rosendahl-Riise, Hanne; McCann, Adrian; Nygård, Ottar Kjell; Dierkes, Jutta; Lysne, Vegard (Journal article; Peer reviewed, 2023)
      Metabolomics has been utilised in epidemiological studies to investigate biomarkers of nutritional status and metabolism in relation to non-communicable diseases. However, little is known about the effect of prandial status ...

    • Peripheral and central macrophages in obesity 

      Mukherjee, Sayani; Skrede, Silje; Haugstøyl, Martha; López, Miguel; Fernø, Johan (Journal article; Peer reviewed, 2023)
      Obesity is associated with chronic, low-grade inflammation. Excessive nutrient intake causes adipose tissue expansion, which may in turn cause cellular stress that triggers infiltration of pro-inflammatory immune cells ...

    • Association of Myocardial Changes and Gene Expression of the NFATC1 and NFATC4—Calcineurin Signaling Pathway in Children with Bicuspid Aortic Valve 

      Kamenshchyk, Andrii; Gonchar, Margaryta; Oksenych, Valentyn; Kamyshnyi, Aleksandr (Journal article; Peer reviewed, 2023)
      Background: The role of NFATC gene expression in bicuspid aortic valve (BAV) progression is not fully understood. The aim of this study is to determine the significance of NFATC1 and NFATC4 gene expression for myocardial ...

    • Casein Kinase 2 (CK2): A Possible Therapeutic Target in Acute Myeloid Leukemia 

      Bruserud, Øystein; Reikvam, Håkon (Journal article; Peer reviewed, 2023)
      The protein kinase CK2 (also known as casein kinase 2) is one of the main contributors to the human phosphoproteome. It is regarded as a possible therapeutic strategy in several malignant diseases, including acute myeloid ...

    • Indoor Airborne Microbiome and Endotoxin: Meteorological Events and Occupant Characteristics Are Important Determinants 

      Abouelhana, Hesham Amin Mohamed; Šantl-Temkiv, Tina; Cramer, Christine; Finster, Kai; Gomez Real, Francisco; Gislason, Thorarinn; Holm, Mathias; Janson, Christer; Jögi, Nils Oskar; Jogi, Rain; Malinovschi, Andrei; Marshall, Ian P. G.; Modig, Lars; Norbäck, Dan; Shigdel, Rajesh; Sigsgaard, Torben; Svanes, Cecilie; Thorarinsdottir, Hulda; Wouters, Inge M.; Schlünssen, Vivi; Bertelsen, Randi Jacobsen (Journal article; Peer reviewed, 2023)
      Airborne bacteria and endotoxin may affect asthma and allergies. However, there is limited understanding of the environmental determinants that influence them. This study investigated the airborne microbiomes in the homes ...