Browsing Bergen Open Research Archive by Author "Li, Xingang"
Now showing items 21-27 of 27
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Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma
Han, Mingzhi; Wang, Shuai; Yang, Ning; Wang, Xu; Zhao, Wenbo; Sdik Saed, Halala; Daubon, Thomas; Huang, Bin; Chen, Anjing; Li, Gang; Miletic, Hrvoje; Thorsen, Frits; Bjerkvig, Rolf; Li, Xingang; Wang, Jian (Peer reviewed; Journal article, 2019-11-28)Dysregulated cholesterol metabolism is a hallmark of many cancers, including glioblastoma (GBM), but its role in disease progression is not well understood. Here, we identified cholesterol 24‐hydroxylase (CYP46A1), a ... -
Trifluoperazine prolongs the survival of experimental brain metastases by STAT3-dependent lysosome membrane permeabilization
Zhang, Xin; Ding, Kaikai; Ji, Jianxiong; Parajuli, Himalaya; Aasen, Synnøve Nymark; Espedal, Heidi; Huang, Bin; Chen, Anjing; Wang, Jian; Li, Xingang; Thorsen, Frits (Journal article; Peer reviewed, 2020)Brain metastasis is a major cause of mortality in melanoma patients. The blood-brain barrier (BBB) prevents most anti-tumor compounds from entering the brain, which significantly limits their use in the treatment of brain ... -
Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination
Zhang, Xin; Xu, Ran; Zhang, Chao; Xu, Yangyang; Han, Mingzhi; Huang, Bin; Chen, Anjing; Qiu, Chen; Thorsen, Frits; Prestegarden, Lars; Bjerkvig, Rolf; Wang, Jian; Li, Xingang (Peer reviewed; Journal article, 2017-09-05)Background: Resistance to adjuvant radiotherapy is a major cause of treatment failure in patients with glioblastoma (GBM). Autophagy inhibitors have been shown to enhance the efficacy of radiotherapy for certain solid ... -
TRIM22 activates NF-κB signaling in glioblastoma by accelerating the degradation of IκBα
Ji, Jianxiong; Ding, Kaikai; Luo, Tao; Zhang, Xin; Chen, Anjing; Zhang, Di; Li, Gang; Thorsen, Frits; Huang, Bin; Li, Xingang; Wang, Jian (Journal article; Peer reviewed, 2021)NF-κB signaling plays a critical role in tumor growth and treatment resistance in GBM as in many other cancers. However, the molecular mechanisms underlying high, constitutive NF-κB activity in GBM remains to be elucidated. ... -
TRIM56 promotes malignant progression of glioblastoma by stabilizing cIAP1 protein
Yang, Xu; Zhang, Yan; Xue, Zhiwei; Hu, Yaotian; Zhou, Wenjing; Xue, Zhiyi; Liu, Xuemeng; Liu, Guowei; Li, Wenjie; Liu, Xiaofei; Li, Xingang; Han, Mingzhi; Wang, Jian (Journal article; Peer reviewed, 2022)Background The tripartite motif (TRIM) family of proteins plays a key role in the developmental growth and therapeutic resistance of many tumors. However, the regulatory mechanisms and biological functions of TRIM proteins ... -
Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts
Leiss, Lina Wik; Mutlu, Ercan; Øyan, Anne Margrete; Yan, Tao; Tsinkalovsky, Oleg; Sleire, Linda; Petersen, Kjell; Rahman, Mohummad Aminur; Johannessen, Mireille Kayitesi; Mitra, Siddharta S.; Jacobsen, Hege; Talasila, Krishna Mukharji; Miletic, Hrvoje; Jonassen, Inge; Li, Xingang; Brons, Nicolas H.C.; Kalland, Karl-Henning; Wang, Jian; Enger, Per Øyvind (Peer reviewed; Journal article, 2017-02-07)Background: Little is known about the role of glial host cells in brain tumours. However, supporting stromal cells have been shown to foster tumour growth in other cancers. Methods: We isolated stromal cells from patient-derived ... -
Ursodeoxycholic Acid Inhibits Glioblastoma Progression via Endoplasmic Reticulum Stress Related Apoptosis and Synergizes with the Proteasome Inhibitor Bortezomib
Yao, Zhong; Zhang, Xun; Zhao, Feihu; Wang, Shuai; Chen, Anjing; Huang, Bin; Wang, Jian; Li, Xingang (Journal article; Peer reviewed, 2020)Ursodeoxycholic acid (UDCA) has demonstrated cancer suppressive potential in several tumors. Here, we investigated the antitumor potential and biochemical mechanism of UDCA on glioblastoma multiforme (GBM), the deadliest ...