Blar i Bergen Open Research Archive på forfatter "Alves, Guido Werner"
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Lack of Association Between GBA Mutations and Motor Complications in European and American Parkinson’s Disease Cohorts
Grødem, Jodi Maple; Paul, Kimberly C.; Dalen, Ingvild; Ngo, Kathie J.; Wong, Darice; Macleod, Angus D.; Counsell, Carl E.; Bäckström, David; Forsgren, Lars; Tysnes, Ole-Bjørn; Kusters, Cynthia D.J.; Fogel, Brent L.; Bronstein, Jeff M.; Ritz, Beate; Alves, Guido Werner (Journal article; Peer reviewed, 2021)Background: Motor complications are a consequence of the chronic dopaminergic treatment of Parkinson’s disease (PD) and include levodopa-induced dyskinesia (LIDs) and motor fluctuations (MF). Currently, evidence is on ... -
Meta-analysis of whole-exome sequencing data from two independent cohorts finds no evidence for rare variant enrichment in Parkinson disease associated loci
Gaare, Johannes Jernqvist; Sanchez Nido, Gonzalo; Dölle, Christian; Sztromwasser, Pawel Szymon; Alves, Guido Werner; Tysnes, Ole-Bjørn; Haugarvoll, Kristoffer; Tzoulis, Charalampos (Journal article; Peer reviewed, 2020-10-01)Parkinson disease (PD) is a complex neurodegenerative disorder influenced by both environmental and genetic factors. While genome wide association studies have identified several susceptibility loci, many causal variants ... -
Neurofilament and Brain Atrophy and Their Association with Cognition in Multiple Sclerosis: A 10-Year Follow-Up Study
Bhan, Alok; Jacobsen, Cecilie; Dalen, Ingvild; Alves, Guido Werner; Bergsland, Niels; Myhr, Kjell-Morten; Zetterberg, Henrik; Zivadinov, Robert; Farbu, Elisabeth (Journal article; Peer reviewed, 2023)Introduction. Cognitive impairment is an important contributor to disability in multiple sclerosis (MS). Disconnection of neuronal circuits due to axonal injury is probably an important underlying mechanism for this ... -
Neurofilament light is a biomarker of brain involvement in lupus and primary Sjögren’s syndrome
Tjensvoll, Anne Bolette; Lauvsnes, Maria Boge; Zetterberg, Henrik; Kvaløy, Jan Terje; Kvivik, Ingeborg; Maroni, Stian; Greve, Ole Jacob; Beyer, Mona K.; Hirohata, Shunsei; Putterman, Chaim; Alves, Guido Werner; Harboe, Erna; Blennow, Kaj; Gøransson, Lasse; Omdal, Roald (Journal article; Peer reviewed, 2020)Background To test the hypothesis that neurofilament light (NfL) in CSF is a biomarker of CNS involvement in patients with systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS), we measured NfL in CSF ... -
Seed Amplification Assay as a Diagnostic Tool in Newly-Diagnosed Parkinson's Disease
Oftedal, Linn Silje Wathne; Maple-Gørdem, Jodi; Tysnes, Ole-Bjørn; Alves, Guido Werner; Lange, Johannes (Journal article; Peer reviewed, 2023)Seed amplification assays (SAA) are the first credible molecular assay for Parkinson’s disease (PD). However, the value of SAA to support the clinicians’ initial diagnosis of PD is not clear. In our study, we analyzed ... -
Ultra-deep whole genome bisulfite sequencing reveals a single methylation hotspot in human brain mitochondrial DNA
Guitton, Romain Guillaume Bernard; Dölle, Christian; Alves, Guido Werner; Tysnes, Ole-Bjørn; Nido, Gonzalo Sanchez; Tzoulis, Charalampos (Journal article; Peer reviewed, 2022)While DNA methylation is established as a major regulator of gene expression in the nucleus, the existence of mitochondrial DNA (mtDNA) methylation remains controversial. Here, we characterized the mtDNA methylation landscape ... -
The value of cerebrospinal fluid α‐synuclein and the tau/α‐synuclein ratio for diagnosis of neurodegenerative disorders with Lewy pathology
Førland, Marthe Gurine; Tysnes, Ole-Bjørn; Aarsland, Dag; Maple-Grødem, Jodi; Pedersen, Kenn Freddy; Alves, Guido Werner; Lange, Johannes (Peer reviewed; Journal article, 2019-07-10)Background and purpose: Parkinson's disease (PD), dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are three of the most common neurodegenerative disorders. Up to 20% of these patients have the wrong diagnosis, ...