Blar i Bergen Open Research Archive på forfatter "Bruserud, Øystein"
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Interleukin-6 in allogeneic stem cell transplantation: Its possible importance for immunoregulation and as a therapeutic target
Tvedt, Tor Henrik Anderson; Ersvær, Elisabeth; Tveita, Anders; Bruserud, Øystein (Peer reviewed; Journal article, 2017-06-08)Allogeneic stem cell transplantation is associated with a high risk of treatment-related mortality mainly caused by infections and graft-versus-host disease (GVHD). GVHD is characterized by severe immune dysregulation and ... -
Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from Streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells
Myhren, Lene Elisabeth; Nygård, Gyrid; Gausdal, Gro; Sletta, Håvard; Teigen, Knut; Degnes, Kristin Fløgstad; Zahlsen, Kolbjørn; Brunsvik, Anders; Bruserud, Øystein; Døskeland, Stein Ove; Selheim, Frode; Herfindal, Lars (Peer reviewed; Journal article, 2013-01-30)Despite recent improvement in therapy, acute myeloid leukemia (AML) is still associated with high lethality. In the presented study, we analyzed the bioactive compound iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from a ... -
Kronisk transplantat-mot-vertsykdom
Rørvik, Synne Dragesund; Abrahamsen, Ingerid Weum; Myhre, Anders Eivind; Vo, Camilla Dao; Meling, Eva Ødegaard; Bruserud, Øystein; Gedde-Dahl, Tobias; Tvedt, Tor Henrik Anderson (Journal article; Peer reviewed, 2023)Kronisk transplantat-mot-vert-sykdom er en senkomplikasjon etter allogen stamcelletransplantasjon, og medfører kronisk inflammasjon og fibrose i forskjellige organer på grunn av feil regulering av donors immunceller. ... -
Mesenchymal stem cells support survival and proliferation of primary human acute myeloid leukemia cells through heterogeneous molecular mechanisms
Brenner, Annette; Nepstad, Ina; Bruserud, Øystein (Peer reviewed; Journal article, 2017-02-09)Acute myeloid leukemia (AML) is a bone marrow malignancy, and various bone marrow stromal cells seem to support leukemogenesis, including osteoblasts and endothelial cells. We have investigated how normal bone marrow ... -
Metabolic serum profiles for patients receiving allogeneic stem cell transplantation: the pretransplant profile differs for patients with and without posttransplant capillary leak syndrome
Reikvam, Håkon; Grønningsæter, Ida-Sofie; Ahmed, Aymen B; Hatfield, Kimberley Joanne; Bruserud, Øystein (Peer reviewed; Journal article, 2015-12)Allogeneic stem cell transplantation is commonly used in the treatment of younger patients with severe hematological diseases, and endothelial cells seem to be important for the development of several posttransplant ... -
Modulation of phospho-proteins by interferon-alpha and valproic acid in acute myeloid leukemia
Forthun, Rakel Brendsdal; Hellesøy, Monica; Sulen, Andre; Kopperud, Reidun Kristin; Sjøholt, Gry; Bruserud, Øystein; McCormack, Emmet; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2019)Purpose. Valproic acid (VPA) is suggested to be therapeutically beneficial in combination with interferon-alpha (IFNα) in various cancers. Therefore, we examined IFNα and VPA alone and in combinations in selected AML models, ... -
Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia
Haaland, Ingvild; Opsahl, Jill Anette; Berven, Frode S.; Reikvam, Håkon; Fredly, Hanne Kristin; Haugse, Ragnhild; Thiede, Bernd; McCormack, Emmet; Lain, Sonia; Bruserud, Øystein; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2014-05-21)Background: The small-molecule MDM2 antagonist nutlin-3 has proved to be an effective p53 activating therapeutic compound in several preclinical cancer models, including acute myeloid leukemia (AML). We and others have ... -
NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival
Gras Navarro, Andrea; Kmiecik, Justyna; Leiss, Lina Wik; Zelkowski, Mateusz; Engelsen, Agnete; Bruserud, Øystein; Zimmer, Jacques; Enger, Per Øyvind; Chekenya, Martha (Peer reviewed; Journal article, 2014-12)Glioblastomas (GBMs) are lethal brain cancers that are resistant to current therapies. We investigated the cytotoxicity of human allogeneic NK cells against patient-derived GBM in vitro and in vivo, as well as mechanisms ... -
p53 Protein Isoform Profiles in AML: Correlation with Distinct Differentiation Stages and Response to Epigenetic Differentiation Therapy
Haaland, Ingvild; Hjelle, Sigrun Margrethe; Reikvam, Håkon; Sulen, André; Ryningen, Anita; McCormack, Emmet; Bruserud, Øystein; Gjertsen, Bjørn Tore (Journal article; Peer reviewed, 2021)p53 protein isoform expression has been found to correlate with prognosis and chemotherapy response in acute myeloid leukemia (AML). We aimed to investigate how p53 protein isoforms are modulated during epigenetic ... -
Patient Heterogeneity in Acute Myeloid Leukemia: Leukemic Cell Communication by Release of Soluble Mediators and Its Effects on Mesenchymal Stem Cells
Aasebø, Elise; Brenner, Annette; Hernandez-Valladares, Maria; Birkeland, Even; Mjaavatten, Olav; Reikvam, Håkon; Selheim, Frode; Berven, Frode Steingrimsen; Bruserud, Øystein (Journal article; Peer reviewed, 2021)Acute myeloid leukemia (AML) is an aggressive bone marrow malignancy, and non-leukemic stromal cells (including mesenchymal stem cells, MSCs) are involved in leukemogenesis and show AML-supporting effects. We investigated ... -
Patients with Bacterial Sepsis Are Heterogeneous with Regard to Their Systemic Lipidomic Profiles
Mosevoll, Knut Anders; Hansen, Bent-Are; Gundersen, Ingunn Margareetta; Reikvam, Håkon; Bruserud, Øyvind; Bruserud, Øystein; Wendelbo, Øystein (Journal article; Peer reviewed, 2023)Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. In the present study, we investigated the systemic/serum lipidomic profile at the time of hospital admission for ... -
Patients with treatment-requiring chronic graft versus host disease after allogeneic stem cell transplantation have altered metabolic profiles due to the disease and immunosuppressive therapy: Potential implication for biomarkers
Reikvam, Håkon; Grønningsæter, Ida Sofie; Mosevoll, Knut Anders; Lindås, Roald; Hatfield, Kimberley Joanne; Bruserud, Øystein (Journal article; Peer reviewed, 2018)Chronic graft versus host disease (cGVHD) is a common long-term complication after allogeneic hematopoietic stem cell transplantation. The objective of our study was to compare the metabolic profiles for allotransplant ... -
Peripheral blood stem cell mobilization in healthy Donors by granulocyte colony-stimulating factor causes preferential mobilization of lymphocyte subsets
Melve, Guro Kristin; Ersvær, Elisabeth; Eide, Geir Egil; Kristoffersen, Einar Klæboe; Bruserud, Øystein (Peer reviewed; Journal article, 2018-05-02)Background: Allogeneic hematopoietic stem cell transplantation is associated with a high risk of immune-mediated post-transplant complications. Graft depletion of immunocompetent cell subsets is regarded as a possible ... -
A Pilot Study of Circulating Monocyte Subsets in Patients Treated with Stem Cell Transplantation for High-Risk Hematological Malignancies.
Rundgren, Ida Marie; Ersvær, Elisabeth; Ahmed, Aymen B; Bruserud, Øystein; Ryningen, Anita (Journal article; Peer reviewed, 2020)Background and Objectives: Autologous and allogeneic stem cell transplantation is used in the treatment of high-risk hematological malignancies, and monocytes are probably involved in hematological reconstitution as well ... -
Pneumomediastinum etter sternalpunksjon
Tvedt, Tor Henrik Anderson; Vetti, Nils; Bruserud, Øystein (Journal article; Peer reviewed, 2021) -
The possible importance of β3 integrins for leukemogenesis and chemoresistance in acute myeloid leukemia
Johansen, Silje; Brenner, Annette; Bartaula-Brevik, Sushma; Reikvam, Håkon; Bruserud, Øystein (Peer reviewed; Journal article, 2018-01-15)Acute myeloid leukemia (AML) is an aggressive bone marrow malignancy where the immature leukemia cells communicate with neighboring cells through constitutive cytokine release and through their cell surface adhesion ... -
Pre-apoptotic response to therapeutic DNA damage involves protein modulation of Mcl-1, Hdm2 and Flt3 in acute myeloid leukemia cells
Wergeland, Line; Sjøholt, Gry; Haaland, Ingvild; Hovland, Randi; Bruserud, Øystein; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2007)Background: Acute myeloid leukemia (AML) cells are characterized by non-mutated TP53, high levels of Hdm2, and frequent mutation of the Flt3 receptor tyrosine kinase. The juxtamembrane mutation of FLT3 is the strongest ... -
Preconditioning serum levels of endothelial cell-derived molecules and the risk of posttransplant complications in patients treated with allogeneic stem cell transplantation.
Lindås, Roald; Tvedt, Tor Henrik Anderson; Hatfield, Kimberley Joanne; Reikvam, Håkon; Bruserud, Øystein (Peer reviewed; Journal article, 2014-10-08)Endothelial cells are involved in the pathogenesis of acute graft-versus-host disease (GVHD) after allogeneic stem cell transplantation. These cells express several molecules that can be detected as biologically active ... -
Pretransplant Systemic Lipidomic Profiles in Allogeneic Stem Cell Transplant Recipients
Hatfield, Kimberley Joanne; Bruserud, Øystein; Reikvam, Håkon (Journal article; Peer reviewed, 2022-06-13)Allogeneic stem cell transplantation is used in the treatment of high-risk hematological malignancies. However, this treatment is associated with severe treatment-related morbidity and mortality. The metabolic status of ... -
Pretransplant systemic metabolic profiles in allogeneic hematopoietic stem cell transplant recipients - identification of patient subsets with increased transplant-related mortality
Reikvam, Håkon; Bruserud, Øystein; Hatfield, Kimberley Joanne (Journal article; Peer reviewed, 2023)Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is used in the treatment of high-risk acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS); however, the treatment has high risk of severe ...