Blar i Bergen Open Research Archive på forfatter "Langeland, Nina"
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Highly contiguous genomes of human clinical isolates of Giardia duodenalis reveal assemblage-and sub-assemblage-specific presence–absence variation in protein-coding genes
Klotz, Christian; Schmid, Marc William; Winter, Katja; Ignatius, Ralf; Weisz, Filip; Saghaug, Christina Skår; Langeland, Nina; Dawson, Scott; Lalle, Marco; Hanevik, Kurt; Cacciò, Simone M.; Aebischer, Toni (Journal article; Peer reviewed, 2023)Giardia duodenalis (syn. G. intestinalis, G. lamblia) is a widespread gastrointestinal protozoan parasite with debated taxonomic status. Currently, eight distinct genetic sub-groups, termed assemblages A–H, are defined ... -
Horizontal plasmid transfer among klebsiella pneumoniae isolates is the key factor for dissemination of extended-spectrum β-lactamases among children in Tanzania
Pedersen, Torunn Annie; Tellevik, Marit Gjerde; Kommedal, Øyvind; Lindemann, Paul Christoffer; Moyo, Sabrina John; James Peter, Jessin Janice; Blomberg, Bjørn; Samuelsen, Ørjan; Langeland, Nina (Journal article; Peer reviewed, 2020)Increased knowledge about the role of horizontal gene transfer is key to improve our understanding of the spread of antimicrobial resistance (AMR) in human populations. We therefore studied the dissemination of the blaCTX-M-15 ... -
Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 respiratory virus
Ekanger, Camilla Tvedt; Zhou, Fan; Bohan, Dana; Lotsberg, Maria Lie; Ramnefjell, Maria; Hoareau, Laurence; Røsland, Gro Vatne; Lu, Ning; Aanerud, Marianne; Gärtner, Fabian; Salminen, Pirjo-Riitta; Bentsen, Mariann; Halvorsen, Thomas; Ræder, Helge; Akslen, Lars Andreas; Langeland, Nina; Brokstad, Rebecca Jane Cox; Maury, Wendy; Stuhr, Linda Elin Birkhaug; Lorens, James; Engelsen, Agnete Svendsen Tenfjord (Journal article; Peer reviewed, 2022)The ongoing coronavirus disease 2019 (COVID-19) pandemic has led to the initiation of unprecedented research efforts to understand the pathogenesis mediated by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). ... -
Identification of diarrheagenic Escherichia coli isolated from infants and children in Dar es Salaam, Tanzania
Moyo, Sabrina John; Maselle, Samwel Y.; Matee, Mecky I.; Langeland, Nina; Mylvaganam, Haima (Peer reviewed; Journal article, 2007-08-09)Background: Relatively few studies have been done in Tanzania to detect and classify diarrheagenic Escherichia coli (DEC) strains among children with diarrhea. This study aimed at investigating DEC among children in Dar ... -
IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria
Otterdal, Kari; Berg, Åse; Michelsen, Annika Elisabet; Yndestad, Arne; Patel, Sam; Gregersen, Ida; Halvorsen, Bente; Ueland, Thor; Langeland, Nina; Aukrust, Pål (Journal article; Peer reviewed, 2021)Background: Several inflammatory molecules participate in the immune response to malaria. Interleukin (IL)-18 is an inflammatory cytokine activated by NLRP3 inflammasomes. In clinical falciparum malaria, with and without ... -
Immunophenotyping in post-giardiasis functional gastrointestinal disease and chronic fatigue syndrome
Hanevik, Kurt; Kristoffersen, Einar K.; Sørnes, Steinar; Mørch, Kristine; Næss, Halvor; Rivenes, Ann Christin; Bødtker, Jørn; Hausken, Trygve; Langeland, Nina (Peer reviewed; Journal article, 2012-10-14)Background: A Giardia outbreak was associated with development of post-infectious functional gastrointestinal disorders (PI-FGID) and chronic fatigue syndrome (PI-CFS). Markers of immune dysfunction have given conflicting ... -
Impact of IL28B-Related Single Nucleotide Polymorphisms on Liver Histopathology in Chronic Hepatitis C Genotype 2 and 3
Rembeck, Karolina; Alsiö, Åsa; Christensen, Peer Brehm; Färkkilä, Martti; Langeland, Nina; Buhl, Mads Rauning; Pedersen, Court; Mørch, Kristine; Westin, Johan; Lindh, Magnus; Hellstrand, Kristoffer; Norkrans, Gunnar; Lagging, Martin (Peer reviewed; Journal article, 2012-01-13)Background and Aims: Recently, several genome-wide association studies have revealed that single nucleotide polymorphisms (SNPs) in proximity to IL28B predict spontaneous clearance of HCV infection as well as outcome ... -
Impact of Obesity on the Bioavailability of Peginterferon-α2a and Ribavirin and Treatment Outcome for Chronic Hepatitis C Genotype 2 or 3
Alsiö, Åsa; Rembeck, Karolina; Askarieh, Galia; Christensen, Peer Brehm; Färkkilä, Martti; Langeland, Nina; Mørch, Kristine (Peer reviewed; Journal article, 2012-05-24)Background and Aims: Having a body mass index above or equal to 30 kg/m2 in conjunction with chronic hepatitis C virus infection is associated with non-responsiveness to treatment with interferon and ribavirin, but details ... -
Increased severity and mortality in adults co-infected with malaria and HIV in Maputo, Mozambique: a prospective cross-sectional study
Berg, Åse; Patel, Sam; Aukrust, Pål; David, Catarina; Gonca, Miguel; Berg, Einar Sverre; Dalen, Ingvild; Langeland, Nina (Peer reviewed; Journal article, 2014-02-05)Background: Co-infection with falciparum malaria and HIV-1 increases the severity and mortality of both infections in unstable malaria-transmission areas. In contrast, in stable transmission areas, HIV co-infection increases ... -
Irritable Bowel Syndrome and Chronic Fatigue 6 Years After Giardia Infection: A Controlled Prospective Cohort Study
Hanevik, Kurt; Wensaas, Knut-Arne; Rørtveit, Guri; Eide, Geir Egil; Mørch, Kristine; Langeland, Nina (Peer reviewed; Journal article, 2014-08-12)Background. Functional gastrointestinal disorders and fatigue may follow acute infections. This study aimed to estimate the persistence, prevalence, and risk of irritable bowel syndrome and chronic fatigue 6 years after ... -
A large community outbreak of waterborne giardiasis- delayed detection in a non-endemic urban area
Nygård, Karin; Schimmer, Barbara; Søbstad, Øystein; Walde, Anna; Tveit, Ingvar; Langeland, Nina; Hausken, Trygve; Aavitsland, Preben (BMC Public Health 6(141), Peer reviewed; Journal article, 2006-05-25)Background: Giardia is not endemic in Norway, and more than 90% of reported cases acquire the infection abroad. In late October 2004, an increase in laboratory confirmed cases of giardiasis was reported in the city of ... -
Leishmaniasis i Norge
Muller, Karl Erik; Blomberg, Bjørn; Tellevik, Marit Gjerde; Jensenius, Mogens; Fladeby, Cathrine; Lier, Tore; Sand, Geir; Hannula, Raisa; Langeland, Nina; Mørch, Kristine (Journal article; Peer reviewed, 2021)Bakgrunn: Leishmaniasis er en sjelden, men potensielt alvorlig tropisk infeksjonssykdom. Norske klinikere er lite kjent med diagnostikk og behandling av denne sykdommen. Formålet med studien var å undersøke forekomst, ... -
Long COVID in a prospective cohort of home-isolated patients
Blomberg, Bjørn; Mohn, Kristin Greve-Isdahl; Brokstad, Karl Albert; Zhou, Fan; Linchausen, Dagrunn Waag; Hansen, Bernt-Are; Jalloh, Sarah Larteley Lartey; Onyango, Therese Bredholt; Kuwelker, Kanika; Sævik, Marianne; Bartsch, Hauke; Tøndel, Camilla; Kittang, Bård Reiakvam; Cox, Rebecca Jane; Langeland, Nina (Journal article; Peer reviewed, 2021)Long-term complications after coronavirus disease 2019 (COVID-19) are common in hospitalized patients, but the spectrum of symptoms in milder cases needs further investigation. We conducted a long-term follow-up in a ... -
Lower antibiotic prescription rates in hospitalized COVID-19 patients than influenza patients, a prospective study
Fjelltveit, Elisabeth Berg; Cox, Rebecca Jane; Kittang, Bård Reiakvam; Blomberg, Bjørn; Buanes, Eirik A.; Langeland, Nina; Mohn, Kristin Greve-Isdahl (Journal article; Peer reviewed, 2022)Background COVID-19 patients are extensively treated with antibiotics despite few bacterial complications. We aimed to study antibiotic use in hospitalized COVID-19 patients compared to influenza patients in two consecutive ... -
Malaria prevalence among patients with acute undifferentiated fever in secondary hospitals in India
Haanshuus, Christel Gill; Vivek, Rosario; Xena, Deepika; Chandy, Sara; Mathai, Dilip; Manoharan, Anand; Langeland, Nina; Blomberg, Bjørn; Mørch, Kristine (Conference poster, 2014-09-22) -
Malaria prevalence and performance of diagnostic tests among patients hospitalized with acute undifferentiated fever in Zanzibar
Onken, Annette; Haanshuus, Christel Gill; Miraji, Mohammed Khamis; Marijani, Msafiri; Kibwana, Kibwana Omar; Abeid, Khamis Ali; Mørch, Kristine; Reimers, Marianne; Langeland, Nina; Müller, Fredrik; Jenum, Pål; Blomberg, Bjørn (Journal article; Peer reviewed, 2022-02-19)Background: Control efforts in Zanzibar reduced the burden of malaria substantially from 2000 to 2015, but re-emergence of falciparum malaria has been observed lately. This study evaluated the prevalence of malaria and ... -
Molecular characterisation of the first New Delhi metallo-β-lactamase 1-producing Acinetobacter baumannii from Tanzania
Moyo, Sabrina John; Manyahi, Joel; Hubbard, Alasdair T. M; Byrne, Rachel L; Masoud, Nahya Salim; Aboud, Said; Manji, Karim; Blomberg, Bjørn; Langeland, Nina; Roberts, Adam P. (Journal article; Peer reviewed, 2021)Background We aimed to characterise the genetic determinants and context of two meropenem-resistant clinical isolates of Acinetobacter baumannii isolated from children hospitalised with bloodstream infections in Dar es ... -
A New Human Challenge Model for Testing Heat-Stable Toxin-Based Vaccine Candidates for Enterotoxigenic Escherichia Coli Diarrhea - Dose Optimization, Clinical Outcomes, and CD4+ T Cell Responses
Sakkestad, Sunniva Todnem; Steinsland, Hans; Skrede, Steinar; Lillebø, Kristine; Skutlaberg, Dag Harald; Guttormsen, Anne Berit; Zavialov, Anton; Paavilainen, Sari; Søyland, Hanne; Sævik, Marianne; Rykkje Heien, Astrid; Gjerde Tellevik, Marit; Barry, Eileen; Langeland, Nina; Sommerfelt, Halvor; Hanevik, Kurt (Peer reviewed; Journal article, 2019-10-30)Enterotoxigenic Escherichia coli (ETEC) are a common cause of diarrheal illness in young children and travelers. There is yet no licensed broadly protective vaccine against ETEC. One promising vaccine development strategy ... -
No asymptomatic malaria parasitaemia found among 108 young children at one health facility in Dar es Salaam, Tanzania
Strøm, Gro Elizabeth Ann; Tellevik, Marit Gjerde; Fataki, Maulidi; Langeland, Nina; Blomberg, Bjørn (Peer reviewed; Journal article, 2013-11-14)Background: Asymptomatic malaria parasitaemia has been reported in areas with high malaria transmission. It may serve as a reservoir for continued transmission, and furthermore complicates diagnostics, as not all individuals ... -
No difference in serum levels of B-cell activating receptor and antibodies against cytolethal distending toxin B and flagellin in post-infectious irritable bowel syndrome and chronic fatigue syndrome after Giardia infection
Hanevik, Kurt; Saghaug, Christina Skår; Aaland, Maren; Mørch, Kristine; Langeland, Nina (Journal article; Peer reviewed, 2022)Background and Aim Functional gastrointestinal disorders (FGIDs) and chronic fatigue syndrome (CFS) frequently occur as comorbid conditions to each other. A shared etiology of these syndromes has been proposed because of ...