Browsing Bergen Open Research Archive by Author "Delaleu, Nicolas"
Now showing items 1-5 of 5
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Altered immune activation and IL-23 signaling in response to Candida albicans in autoimmune polyendocrine syndrome type 1
Bruserud, Øyvind; Bratland, Eirik; Hellesen, Alexander; Delaleu, Nicolas; Reikvam, Håkon; Oftedal, Bergithe Eikeland; Wolff, Anette Susanne Bøe (Peer reviewed; Journal article, 2017-09-01)Objective: Autoimmune polyendocrine syndrome type 1 (APS-1) is a rare, childhood onset disease caused by mutations in the autoimmune regulator (AIRE) gene. Chronic mucocutaneous candidiasis (CMC) is one of the three major ... -
Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis
Hellvard, Annelie; Zeitlmann, Lutz; Heiser, Ulrich; Kehlen, Astrid; Niestroj, André; Demuth, Hans-Ulrich; Koziel, Joanna; Delaleu, Nicolas; Potempa, Jan; Mydel, Piotr Mateusz (Peer reviewed; Journal article, 2016-08-11)Rheumatoid arthritis is characterised by synovial inflammation and proliferation of fibroblast-like synoviocytes. The induction of apoptosis has long been proposed as a target for proliferative autoimmune diseases, and has ... -
Network-Based Assessment of Minimal Change Disease Identifies Glomerular Response to IL-7 and IL-12 Pathways Activation as Innovative Treatment Target
Eikrem, Øystein Solberg; Lillefosse, Bjørnar; Delaleu, Nicolas; Strauss, Philipp; Osman, Tarig Al-Hadi; Vikse, Bjørn Egil; Debiec, Hanna; Ronco, Pierre; Sekulic, Miroslav; Koch, Even Evjen; Furriol, Jessica; Leh, Sabine; Marti, Hans Peter (Journal article; Peer reviewed, 2023)Background: Minimal change disease (MCD), a major cause of nephrotic syndrome, is usually treated by corticosteroid administration. MCD unresponsiveness to therapy and recurrences are nonetheless frequently observed, ... -
Systemic interferon type I and B cell responses are impaired in autoimmune polyendocrine syndrome type 1
Oftedal, Bergithe Eikeland; Delaleu, Nicolas; Dolan, David William Peter; Meager, Anthony; Husebye, Eystein Sverre; Wolff, Anette Susanne Bøe (Journal article; Peer reviewed, 2023)Autoimmune polyendocrine syndrome type I (APS-1) is caused by mutations in the autoimmune regulator (AIRE) gene and characterised clinically by multiple autoimmune manifestations and serologically by autoantibodies against ... -
Systems analyses of the Fabry kidney transcriptome and its response to enzyme replacement therapy identified and cross-validated enzyme replacement therapy-resistant targets amenable to drug repurposing
Delaleu, Nicolas; Marti, Hans Peter; Strauss, Philipp; Sekulic, Miroslav; Osman, Tarig Al-Hadi; Tøndel, Camilla; Skrunes, Rannveig; Leh, Sabine; Svarstad, Einar; Nowak, Albina; Gaspert, Ariana; Rusu, Elena; Kwee, Ivo; Rinaldi, Andrea; Flatberg, Arnar; Eikrem, Øystein Solberg (Journal article; Peer reviewed, 2023)Fabry disease is a rare disorder caused by variations in the alpha-galactosidase gene. To a degree, Fabry disease is manageable via enzyme replacement therapy (ERT). By understanding the molecular basis of Fabry nephropathy ...