Browsing Bergen Open Research Archive by Author "Ruiz de Garibay, Gorka"
Now showing items 1-3 of 3
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CytoCy5S™, a compound of many structures. in vitro and in vivo evaluation of four near-infrared fluorescent substrates of nitroreductase (NTR)
García de Jalón, Elvira; Ruiz de Garibay, Gorka; Haug, Bengt Erik; Mccormack, Emmet Matin (Journal article; Peer reviewed, 2021)CytoCy5S™, a quenched, red-shifted fluorescent probe, has been used to exploit the imaging potential of the nitroreductase (NTR) reporter gene platform. Its use has been reported in a number of publications, however there ... -
Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells
Haugse, Ragnhild; Langer, Anika; Murvold, Elsa Thodesen; Costea, Daniela Elena; Gjertsen, Bjørn Tore; Gilja, Odd Helge; Kotopoulis, Spiros; Ruiz de Garibay, Gorka; McCormack, Emmet (Journal article; Peer reviewed, 2020)The use of ultrasound (US) and microbubbles (MB), usually referred to as sonoporation, has great potential to increase the efficacy of chemotherapy. However, the molecular mechanisms that mediate sonoporation response are ... -
Repurposing 18F-FMISO as a PET tracer for translational imaging of nitroreductase-based gene directed enzyme prodrug therapy
Ruiz de Garibay, Gorka; García de Jalón, Elvira; Stigen, Endre; Lund, Kjetil B.; Popa, Mihaela-Lucia; Davidson, Ben; Mayoral Safont, Mireia; Rygh, Cecilie Brekke; Espedal, Heidi; Barrett, Torill; Haug, Bengt Erik; McCormack, Emmet (Journal article; Peer reviewed, 2021)Nitroreductases (NTR) are a family of bacterial enzymes used in gene directed enzyme prodrug therapy (GDEPT) that selectively activate prodrugs containing aromatic nitro groups to exert cytotoxic effects following gene ...