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Agonistic and potentiating effects of perfluoroalkyl substances (PFAS) on the Atlantic cod (Gadus morhua) peroxisome proliferator-activated receptors (Ppars)
Söderström, Sofie Karin; Lille-Langøy, Roger; Yadetie, Fekadu; Rauch, Mateusz; Milinski, Ana; Dejaegere, Annick; Stote, Roland H.; Goksøyr, Anders; Karlsen, Odd André (Journal article; Peer reviewed, 2022)Toxicity mediated by per- and polyfluoroalkyl substances (PFAS), and especially perfluoroalkyl acids (PFAAs), has been linked to activation of peroxisome proliferator-activated receptors (Ppar) in many vertebrates. Here, ... -
Application of quantitative transcriptomics in evaluating the ex vivo effects of per- and polyfluoroalkyl substances on Atlantic cod (Gadus morhua) ovarian physiology
Khan, Essa Ahsan; Zhang, Xiaokang; Hanna, Eileen Marie; Yadetie, Fekadu; Jonassen, Inge; Goksøyr, Anders; Arukwe, Augustine (Journal article; Peer reviewed, 2021)Because of their global consumption and persistence, per- and polyfluoroalkyl substances (PFASs), are ubiquitously distributed in the environment, as well as in wildlife and humans. In the present study, we have employed ... -
Attuning to a changing ocean
Stenseth, Nils Christian; Payne, Mark R.; Bonsdorff, Erik; Dankel, Dorothy Jane; Durant, Joel Marcel; Anderson, Leif G.; Armstrong, Claire W.; Blenckner, Thorsten; Brakstad, Ailin; Dupont, Sam; Eikeset, Anne Maria; Goksøyr, Anders; Jónsson, Steingrímur; Kuparinen, Anna; Våge, Kjetil; Österblom, Henrik; Paasche, Øyvind (Journal article; Peer reviewed, 2020)The ocean is a lifeline for human existence, but current practices risk severely undermining ocean sustainability. Present and future social−ecological challenges necessitate the maintenance and development of knowledge ... -
The chemical defensome of five model teleost fish
Eide, Marta; Zhang, Xiaokang; Karlsen, Odd André; Goldstone, Jared V.; Stegeman, John; Jonassen, Inge; Goksøyr, Anders (Journal article; Peer reviewed, 2021)How an organism copes with chemicals is largely determined by the genes and proteins that collectively function to defend against, detoxify and eliminate chemical stressors. This integrative network includes receptors and ... -
Co-Exposure of Phenanthrene and the cyp-Inducer 3-Methylchrysene Leads to Altered Biotransformation and Increased Toxicity in Fish Egg and Larvae
Donald, Carey; Sørhus, Elin; Perrichon, Prescilla; Nakken, Charlotte L.; Goksøyr, Anders; Jørgensen, Kåre Bredeli; Mayer, Philipp; da Silva, Denis A.M.; Meier, Sonnich (Journal article; Peer reviewed, 2023)Polycyclic aromatic hydrocarbons (PAHs) have frequently been suspected of governing crude oil toxicity because of similar morphological defects in fish. However, PAH concentrations are often not high enough to explain the ... -
Concentrations and endocrine disruptive potential of phthalates in marine mammals from the Norwegian Arctic
Routti, Heli Anna Irmeli; Harju, Mikael; Lühmann, Katharina; Aars, Jon; Ask, Amalie; Goksøyr, Anders; Kovacs, Kit M.; Lydersen, Christian (Journal article; Peer reviewed, 2021)This study investigated concentrations of phthalates (diesters of phthalic acids) in blubber/adipose tissue of blue whales (Balaenoptera musculus), fin whales (Balaenoptera physalus), bowhead whales (Balaena mysticetus) ... -
Conservation and divergence of chemical defense system in the tunicate Oikopleura dioica revealed by genome wide response to two xenobiotics
Yadetie, Fekadu; Butcher, Stephen; Førde, Hilde E.; Campsteijn, Coen; Bouquet, Jean-Marie; Karlsen, Odd André; Denoeud, France; Metpally, Raghu; Thompson, Eric M.; Manak, J. Robert; Goksøyr, Anders; Chourrout, Daniel (Peer reviewed; Journal article, 2012-02-02)Background Animals have developed extensive mechanisms of response to xenobiotic chemical attacks. Although recent genome surveys have suggested a broad conservation of the chemical defensome across metazoans, global gene ... -
Contaminant accumulation and biological responses in Atlantic cod (Gadus morhua) caged at a capped waste disposal site in Kollevåg, Western Norway
Dale, Karina; Müller, Mette Bjørge; Tairova, Zhanna; Khan, Essa Ahsan; Hatlen, Kristin; Grung, Merete; Yadetie, Fekadu; Lille-Langøy, Roger; Blaser, Nello; Skaug, Hans J; Lyche, Jan Ludvig; Arukwe, Augustine; Hylland, Ketil; Karlsen, Odd André; Goksøyr, Anders (Peer reviewed; Journal article, 2019)The aim of this study was to assess whether fish in Kollevåg, a sheltered bay on the western coast of Norway, previously utilized as a waste disposal site, could be affected by environmental contaminants leaking from the ... -
Effects of Agricultural Pesticides in Aquafeeds on Wild Fish Feeding on Leftover Pellets Near Fish Farms
Olsvik, Pål Asgeir; Larsen, Anett Kristin; Berntssen, Marc; Goksøyr, Anders; Karlsen, Odd Andre; Yadetie, Fekadu; Sanden, Monica; Kristensen, Torstein (Peer reviewed; Journal article, 2019-09-26)Screening has revealed that modern-day feeds used in Atlantic salmon aquaculture might contain trace amounts of agricultural pesticides. To reach slaughter size, salmon are produced in open net pens in the sea. Uneaten ... -
Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently
Lille-Langøy, Roger; Goldstone, Jared; Rusten, Marte; Milnes, Matthew R.; Male, Rune; Stegeman, John J.; Blumberg, Bruce; Goksøyr, Anders (Peer reviewed; Journal article, 2015-04-01)Background Many persistent organic pollutants (POPs) accumulate readily in polar bears because of their position as apex predators in Arctic food webs. The pregnane X receptor (PXR, formally NR1I2, here proposed to be named ... -
Environmental contaminants modulate the transcriptional activity of polar bear (Ursus maritimus) and human peroxisome proliferator-activated receptor alpha (PPARA)
Routti, Heli Anna Irmeli; Berg, Mari Katrine; Lille-Langøy, Roger; Øygarden, Lene Eidsvik; Harju, Mikael; Dietz, Rune; Sonne, Christian; Goksøyr, Anders (Peer reviewed; Journal article, 2019-05-06)Peroxisome proliferator-activated receptor alfa (PPARA/NR1C1) is a ligand activated nuclear receptor that is a key regulator of lipid metabolism in tissues with high fatty acid catabolism such as the liver. Here, we cloned ... -
Environmental effects of offshore produced water discharges: A review focused on the Norwegian continental shelf
Beyer, Jonny; Goksøyr, Anders; Hjermann, Dag Øystein; Klungsøyr, Jarle (Journal article; Peer reviewed, 2020)Produced water (PW), a large byproduct of offshore oil and gas extraction, is reinjected to formations or discharged to the sea after treatment. The discharges contain dispersed crude oil, polycyclic aromatic hydrocarbons ... -
Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua)
Olsvik, Pål Asgeir; Meier, Sonnich; Zhang, Xiaokang; Goksøyr, Anders; Karlsen, Odd André; Yadetie, Fekadu (Journal article; Peer reviewed, 2023)In the North Sea and North Atlantic coastal areas, fish experience relatively high background levels of persistent organic pollutants. This study aimed to compare the mode of action of environmentally relevant concentrations ... -
Establishment of killer whale (Orcinus orca) primary fibroblast cell cultures and their transcriptomic responses to pollutant exposure
Bjørneset, Juni; Blévin, Pierre; Bjørnstad, Pål Marius; Dalmo, Roy Ambli; Goksøyr, Anders; Harju, Mikael; Yadetie, Fekadu; Routti, Heli Anna Irmeli (Journal article; Peer reviewed, 2023)Populations of killer whale (Orcinus orca) contain some of the most polluted animals on Earth. Yet, the knowledge on effects of chemical pollutants is limited in this species. Cell cultures and in vitro exposure experiments ... -
Expression and localization of the aryl hydrocarbon receptors and cytochrome P450 1A during early development of Atlantic cod (Gadus morhua)
Aranguren Abadía, Libe; Donald, Carey; Eilertsen, Mariann; Gharbi, Naouel; Tronci, Valentina; Sørhus, Elin; Mayer, Philipp; Nilsen, Tom Ole; Meier, Sonnich; Goksøyr, Anders; Karlsen, Odd Andre (Journal article; Peer reviewed, 2020)The aryl hydrocarbon receptor (Ahr) is a ligand-activated transcription factor that mediates the toxicity of dioxins and dioxin-like compounds (DLCs) in vertebrates. Two clades of the Ahr family exist in teleosts (Ahr1 and ... -
Fish zona radiata (eggshell) protein: A sensitive biomarker for environmental estrogens
Arukve, Augustine; Knudsen, F.R; Goksøyr, Anders (Peer reviewed; Journal article, 1997-04)Environmental estrogens have recently caused great concern because of their ability to mimic natural hormones and influence vital endocrine functions in humans and wildlife. The induction of vitellogenin (Vtg) synthesis ... -
Independent losses of a xenobiotic receptor across teleost evolution
Eide, Marta; Rydbeck, Halfdan; Tørresen, Ole K.; Lille-Langøy, Roger; Puntervoll, Pål; Goldstone, Jared V.; Jakobsen, Kjetill Sigurd; Stegeman, John; Goksøyr, Anders; Karlsen, Odd Andre (Peer reviewed; Journal article, 2018-07-10)Sensitivity to environmental stressors largely depend on the genetic complement of the organism. Recent sequencing and assembly of teleost fish genomes enable us to trace the evolution of defense genes in the largest and ... -
Integrative omics-analysis of lipid metabolism regulation by peroxisome proliferator-activated receptor a and b agonists in male Atlantic cod
Eide, Marta; Goksøyr, Anders; Yadetie, Fekadu; Gilabert, Alejandra; Bartosova, Zdenka; Frøysa, Håvard Guldbrandsen; Fallahi, Shirin; Zhang, Xiaokang; Blaser, Nello; Jonassen, Inge; Bruheim, Per; Alendal, Guttorm; Brun, Morten; Porte, Cinta; Karlsen, Odd André (Journal article; Peer reviewed, 2023-03-22)Lipid metabolism is essential in maintaining energy homeostasis in multicellular organisms. In vertebrates, the peroxisome proliferator-activated receptors (PPARs, NR1C) regulate the expression of many genes involved in ... -
Interactions between xenoestrogens and ketoconazole on hepatic CYP1A and CYP3A, in juvenile Atlantic cod (Gadus morhua)
Hasselberg, Linda; Grøsvik, Bjørn Einar; Goksøyr, Anders; Celander, Malin C. (Peer reviewed; Journal article, 2005-02-08)Background: Xenoestrogens and antifungal azoles probably share a common route of metabolism, through hepatic cytochrome P450 (CYP) enzymes. Chemical interactions with metabolic pathways may affect clearance of both xenobiotics ... -
Intestinal permeability and gene expression after polyethylene and polyamide microplastic ingestion in Wistar rats
Toto, Benuarda; Refosco, Alice; O'Keeffe, Maria; Barkhald, Øyvind Halås; Brønstad, Aurora Margrethe; Lied, Gülen Arslan; Yadetie, Fekadu; Goksøyr, Anders; Kögel, Tanja; Dierkes, Jutta (Journal article; Peer reviewed, 2022)Microplastic particles are ubiquitous in the environment. However, little is known about their uptake and effects in humans or mammalian model organisms. Here, we studied the effects of pristine polyamide (15–20 µm) and ...