Blar i Bergen Open Research Archive på forfatter "Sinturel, Flore"
-
Circadian organization of lipid landscape is perturbed in type 2 diabetic patients
Sinturel, Flore; Chera, Simona; Brulhart-Meynet, Marie-Claude; Montoya, Jonathan Paz; Stenvers, Dirk Jan; Bisschop, Peter H.; Kalsbeek, Andries; Guessous, Idris; Jornayvaz, François R.; Philippe, Jacques; Brown, Steven A.; D'Angelo, Giovanni; Riezman, Howard; Dibner, Charna (Journal article; Peer reviewed, 2023)Lipid homeostasis in humans follows a diurnal pattern in muscle and pancreatic islets, altered upon metabolic dysregulation. We employ tandem and liquid-chromatography mass spectrometry to investigate daily regulation of ... -
Type 2 diabetes disrupts circadian orchestration of lipid metabolism and membrane fluidity in human pancreatic islets
Petrenko, Volodymyr; Sinturel, Flore; Loizides-Mangold, Ursula; Montoya, Jonathan Paz; Chera, Simona; Riezman, Howard; Dibner, Charna (Journal article; Peer reviewed, 2022-08-03)Recent evidence suggests that circadian clocks ensure temporal orchestration of lipid homeostasis and play a role in pathophysiology of metabolic diseases in humans, including type 2 diabetes (T2D). Nevertheless, circadian ...