• Association Between Amygdala Volume and Trajectories of Neuropsychiatric Symptoms in Alzheimer’s Disease and Dementia With Lewy Bodies 

      Jaramillo-Jiménez, Alberto; Melvær, Giil Lasse; Tovar-Rios, Diego Alejandro; Borda, Miguel Germán; Ferreira, Daniel; Brønnick, Kolbjørn Kallesten; Oppedal, Ketil; Aarsland, Dag (Journal article; Peer reviewed, 2021)
      Introduction: The amygdala is implicated in psychiatric illness. Even as the amygdala undergoes significant atrophy in mild dementia, amygdala volume is underexplored as a risk factor for neuropsychiatric symptoms ...
    • The association between aspects of carer distress and time until nursing home admission in persons with Alzheimer’s disease and dementia with Lewy bodies 

      Terum, Toril Marie; Rongve, Arvid; Testad, Ingelin; Aarsland, Dag; Svendsboe, Ellen J; Andersen, John Roger (Journal article; Peer reviewed, 2020)
      Objective: The aim of this study was to explore the association between specific aspects of carer distress and time until nursing home admission (NHA) in people with mild dementia. Design: Prospective cohort ...
    • The association between specific neuropsychiatric disturbances in people with Alzheimer's disease and dementia with Lewy bodies and carer distress 

      Terum, Toril Marie; Testad, Ingelin; Rongve, Arvid; Aarsland, Dag; Svendsboe, Ellen J; Andersen, John Roger (Peer reviewed; Journal article, 2019)
      Objective: Neuropsychiatric symptoms (NPSs) are identified as important care‐recipient variables in terms of the impact on carer distress. The aim of this study was to determine whether specific neuropsychiatric disturbances ...
    • Augmented reality versus standard tests to assess cognition and function in early Alzheimer’s disease 

      Muurling, Marijn; de Boer, Casper; Vairavan, Srinivasan; Harms, Robbert L.; Chadha, Antonella Santuccione; Tarnanas, Ioannis; Luis, Estefania Vilarino; Religa, Dorota; Gjestsen, Martha Therese; Galluzzi, Samantha; Ibarria Sala, Marta; Koychev, Ivan; Hausner, Lucrezia; Gkioka, Mara; Aarsland, Dag; Visser, Pieter Jelle; Brem, Anna-Katharine (Journal article; Peer reviewed, 2023)
      Augmented reality (AR) apps, in which the virtual and real world are combined, can recreate instrumental activities of daily living (IADL) and are therefore promising to measure cognition needed for IADL in early Alzheimer’s ...
    • Benzodiazepines and antidepressants: Effects on cognitive and functional decline in Alzheimer's disease and Lewy body dementia 

      Borda, Miguel Germán; Jaramillo-Jiménez, Alberto; Oesterhus, Ragnhild; Santacruz, José Manuel; Tovar-Rios, Diego Alejandro; Sønnesyn, Hogne; Cano-Gutierrez, Carlos Alberto; Vik‐Mo, Audun Osland; Aarsland, Dag (Journal article; Peer reviewed, 2021-12-31)
      Objectives We aim to study the effects of the prescription of benzodiazepines and antidepressants on cognitive and functional decline in older adults living with Alzheimer's disease (AD) and Lewy body dementia (LBD) over ...
    • Brain amyloid and vascular risk are related to distinct white matter hyperintensity patterns 

      Pålhaugen, Lene; Sudre, Carole H; Teceläo, Sandra Raquel Ramos; Nakling, Arne; Almdahl, Ina Selseth; Kalheim, Lisa Flem; Cardoso, M Jorge; Johnsen, Stein Harald; Rongve, Arvid; Aarsland, Dag; Bjørnerud, Atle; Selnes, Per; Fladby, Tormod (Journal article; Peer reviewed, 2020)
      White matter hyperintensities (WMHs) are associated with vascular risk and Alzheimer’s disease. In this study, we examined relations between WMH load and distribution, amyloid pathology and vascular risk in 339 controls ...
    • Clinical outcome measures in dementia with Lewy bodies trials: critique and recommendations 

      Rodriguez-Porcel, Federico; Wyman-Chick, Kathryn A.; Abdelnour Ruiz, Carla; Toledo, Jon B.; Ferreira, Daniel; Urwyler, Prabitha; Weil, Rimona S.; Kane, Joseph; Pilotto, Andrea; Rongve, Arvid; Boeve, Bradley; Taylor, John-Paul; McKeith, Ian; Aarsland, Dag; Lewis, Simon J. G. (Journal article; Peer reviewed, 2022)
      The selection of appropriate outcome measures is fundamental to the design of any successful clinical trial. Although dementia with Lewy bodies (DLB) is one of the most common neurodegenerative conditions, assessment of ...
    • Combinatory microRNA serum signatures as classifiers of Parkinson's disease 

      Patil, Ketan S.; Basak, Indranil; Dalen, Ingvild; Hoedt, Esthelle; Lange, Johannes; Lunde, Kristin Aaser; Liu, Ying; Tysnes, Ole-Bjørn; Forsgren, Lars; Aarsland, Dag; Neubert, Thomas A.; Larsen, Jan Petter; Alves, Guido Werner; Møller, Simon Geir (Peer reviewed; Journal article, 2019)
      Introduction: As current clinical diagnostic protocols for Parkinson's disease (PD) may be prone to inaccuracies there is a need to identify and validate molecular biomarkers, such as circulating microRNAs, which will ...
    • Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores 

      de Rojas, Itziar; Moreno-Grau, Sonia; Tesi, Niccolo; Grenier-Boley, Benjamin; Andrade, Victor; Jansen, Iris E.; Rongve, Arvid; Aarsland, Dag; Selbæk, Geir; Saltvedt, Ingvild; Sando, Sigrid Botne; Djurovic, Srdjan; Andreassen, Ole; Pedersen, Nancy L.; Stringa, Najada; Zettergren, Anna; Hernández, Isabel; Montrreal, Laura; Antunez, Carmen; Antonell, Anna; Tankard, Rick; Bis, Joshua C.; Sims, Rebecca; Bellenguez, Celine; Quintela, Inés; González-Pérez, Antonio; Calero, Miguel; Franco-Macias, Emilio; Macias, Juan; Blesa, Rafael; Cervera-Carles, Laura; Menendez-Gonzalez, Manuel; Frank-Garcia, Ana; Royo, José Luis; Moreno, Fermin; Vilas, Raquel Huerto; Baquero, Miquel; Diez-Fairen, Monica; Lage, Carmen; García-Madrona, Sebastian; Garcia-Gonzalez, Pablo; Alarcón-Martín, Emilio; Valero, Sergi; Sotolongo-Grau, Oscar; Ullgren, Abbe; Naj, Adam C.; Lemstra, Afina W.; Benaque, Alba; Perez-Cordon, Alba; Benussi, Alberto; Rabano, Alberto (Journal article; Peer reviewed, 2021)
      Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical ...
    • COSMOS-improving the quality of life in nursing home patients: Protocol for an effectiveness-implementation cluster randomized clinical hybrid trial 

      Husebø, Bettina; Flo, Elisabeth; Aarsland, Dag; Selbæk, Geir; Testad, Ingelin; Gulla, Christine; Aasmul, Irene; Ballard, Clive (Peer reviewed; Journal article, 2015-09-15)
      Background: Nursing home patients have complex mental and physical health problems, disabilities and social needs, combined with widespread prescription of psychotropic drugs. Preservation of their quality of life is an ...
    • Differentiating traits and states identifies the importance of chronic neuropsychiatric symptoms for cognitive prognosis in mild dementia 

      Melvær, Giil Lasse; Aarsland, Dag; Vik-Mo, Audun Osland (Journal article; Peer reviewed, 2021)
      Introduction Neuropsychiatric symptoms (NPS) in dementia are associated with poor cognitive outcomes in longitudinal studies. Whether this is due to differences in symptom burden between persons (BP) or changes within ...
    • Effects of anthocyanin supplementation on serum lipids, glucose, markers of inflammation and cognition in adults with increased risk of dementia - A pilot study 

      Bergland, Anne Katrine; Sønnesyn, Hogne; Dalen, Ingvild; Rodriguez-Mateos, Ana; Berge, Rolf Kristian; Melvær, Giil Lasse; Rajendran, Lawrence; Siow, Richard; Tassotti, Michele; Larsen, Alf Inge; Aarsland, Dag (Peer reviewed; Journal article, 2019-06-11)
      Background: Anthocyanins may protect against cardiovascular related cognitive decline and dementia. Objective: Open-label study to measure changes in serum lipids, glucose, glycosylated hemoglobin (HbA1c), and markers of ...
    • Effects of purified anthocyanins in people at risk for dementia: Study protocol for a phase II randomized controlled trial 

      Khalifa, Khadija; Bergland, Anne Katrine; Sønnesyn, Hogne; Oppedal, Ketil; Oesterhus, Ragnhild; Dalen, Ingvild; Larsen, Alf Inge; Fladby, Tormod; Brooker, Helen; Wesnes, Keith A.; Ballard, Clive; Aarsland, Dag (Journal article; Peer reviewed, 2020)
      Background: The number of people with dementia is increasing, with huge challenges for society and health-care systems. There are no disease-modifying therapies available. There is, therefore, an urgent need to identify ...
    • Efficacy and Safety of Analgesic Treatment for Depression in People with Advanced Dementia: Randomised, Multicentre, Double-Blind, Placebo-Controlled Trial (DEP.PAIN.DEM) 

      Erdal, Ane; Flo, Elisabeth; Aarsland, Dag; Ballard, Clive; Slettebø, Dagrun Daltveit; Husebø, Bettina (Peer reviewed; Journal article, 2018-06)
      Background Chronic pain and depression often co-occur, and pain may exacerbate depression in people with dementia. Objective The objective of this study was to assess the efficacy and safety of analgesic treatment for ...
    • Efficacy of pain treatment on mood syndrome in patients with dementia: a randomized clinical trial 

      Husebø, Bettina Sandgathe; Ballard, Clive; Fritze, Friederike; Sandvik, Reidun Karin; Aarsland, Dag (Peer reviewed; Journal article, 2014-08)
      Background: Depression is common in nursing home (NH) patients with dementia, and often clustered with anxiety and other mood symptoms. An association between pain and depressive symptoms has been reported, but the impact ...
    • Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease 

      Creese, Byron; Vassos, Evangelos; Bergh, Sverre; Athanasiu, Lavinia; Johar, Iskandar; Rongve, Arvid; Medbøen, Ingrid Tøndel; Da Silva, Miguel Vasconcelos; Aakhus, Eivind; Andersen, Fred; Bettella, Francesco; Brækhus, Anne; Djurovic, Srdjan; Paroni, Giulia; Proitsi, Petroula; Saltvedt, Ingvild; Seripa, Davide; Stordal, Eystein; Fladby, Tormod; Aarsland, Dag; Andreassen, Ole Andreas; Ballard, Clive; Selbæk, Geir (Peer reviewed; Journal article, 2019-10-22)
      Psychosis (delusions or hallucinations) in Alzheimer’s disease (AD + P) occurs in up to 50% of individuals and is associated with significantly worse clinical outcomes. Atypical antipsychotics, first developed for ...
    • Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations 

      Olafsson, S.; Stridh, P.; Bos, Steffan Daniel; Ingason, Andrés; Euesden, J; Sulem, Patrick; Thorleifsson, Gudmar; Gustafsson, O; Geirsson, AJ; Jóhannesson, Ari J.; Thorsson, AV; Ludviksson, BR; Sigurgeirsson, Bardur; Jonasson, JG; Olafsson, E; Kristjansdottir, H; Olafsson, JH; Orvar, KB; Benediktsson, Rafn; Bjarnason, Ragnar; Kristjansdottir, Sjofn; Gislason, Thorarin; Valdimarsson, T; Mikaelsdottir, E; Sigurdsson, S; Jonsson, S; Rafnar, Thorunn; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Knudsen, Gun Peggy S.; Celius, Elisabeth Gulowsen; Myhr, Kjell-Morten; Gröndal, Gerdur; Steinsson, K; Valdimarsson, Helgi; Bjornsson, Sigurdur; Bjornsdottir, US; Bjornsson, Einar S.; Nilsson, B; Andreassen, Ole Andreas; Alfredsson, Lars; Hillert, Jan; Kockum, Ingrid; Másson, Gísli; Thorsteinssdottir, U; Gudbjartsson, Daniel F.; Stefansson, H; Hjaltason, H; Harbo, Hanne Flinstad; Olsson, T; Jonsdottir, I; Stefansson, K (Peer reviewed; Journal article, 2017)
      A meta-analysis of publicly available summary statistics on multiple sclerosis combined with three Nordic multiple sclerosis cohorts (21,079 cases, 371,198 controls) revealed seven sequence variants associating with multiple ...
    • GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study 

      Rongve, Arvid; Witoelar, Aree; Ruiz, Agustín; Athanasiu, Lavinia; Abdelnour, Carla; Clarimon, Jordi; Heilmann-Heimbach, Stefanie; Hernández, Isabel; Moreno-Grau, Sonia; de Rojas, Itziar; Morenas-Rodríguez, Estrella; Fladby, Tormod; Sando, Sigrid Botne; Bråthen, Geir; Blanc, Frédéric; Bousiges, Olivier; Lemstra, Afina W.; van Steenoven, Inger; Londos, Elisabet; Almdahl, Ina Selseth; Pålhaugen, Lene; Eriksen, Jon Alm; Djurovic, Srdjan; Stordal, Eystein; Saltvedt, Ingvild; Ulstein, Ingun; Bettella, Francesco; Desikan, Rahul S.; Idland, Ane-Victoria; Toft, Mathias; Pihlstrøm, Lasse; Snaedal, Jon; Tárraga, Lluís; Boada, Mercè; Lleó, Alberto; Stefánsson, Hreinn; Stefánsson, Kári; Ramírez, Alfredo; Aarsland, Dag; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2019-05-07)
      Dementia with Lewy Bodies (DLB) is a common neurodegenerative disorder with poor prognosis and mainly unknown pathophysiology. Heritability estimates exceed 30% but few genetic risk variants have been identified. Here we ...
    • High prevalence of orthostatic hypotension in mild dementia 

      Sønnesyn, Hogne; Nilsen, Dennis W. T.; Rongve, Arvid; Nore, Sabine; Ballard, Clive; Tysnes, Ole-Bjørn; Aarsland, Dag (Peer reviewed; Journal article, 2009-11)
      Background/Aims: Orthostatic hypotension (OH) and QTc prolongation have potentially important prognostic and therapeutic consequences but have rarely been studied in patients with mild dementia. Methods: Patients with mild ...
    • Impact of a stepwise protocol for treating pain on pain intensity in nursing home patients with dementia: A cluster randomized trial 

      Sandvik, Reidun Karin; Selbæk, Geir; Seifert, Reinhard; Aarsland, Dag; Ballard, Clive; Corbett, Anne; Husebø, Bettina Sandgathe (Peer reviewed; Journal article, 2014-05-13)
      Background: Pain is frequent and distressing in people with dementia, but no randomized controlled trials have evaluated the effect of analgesic treatment on pain intensity as a key outcome. Methods: Three hundred fifty-two ...