Browsing Bergen Open Research Archive by Author "Lysne, Vegard"
Now showing items 1-20 of 31
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Adherence to the Healthy Nordic Food Index and the incidence of acute myocardial infarction and mortality among patients with stable angina pectoris
Puaschitz, Nathalie Genevieve; Assmus, Jörg; Strand, Elin; Karlsson, Therese; Vinknes, Kathrine; Lysne, Vegard; Drevon, Christian A; Tell, Grethe S.; Dierkes, Jutta; Nygård, Ottar (Peer reviewed; Journal article, 2018-08-08)Background: The Healthy Nordic Food Index (HNFI) has been associated with beneficial effects on markers of cardiovascular disease (CVD). Whether such effects are present among patients with established coronary heart disease ... -
Assessment of Dietary Choline Intake, Contributing Food Items, and Associations with One-Carbon and Lipid Metabolites in Middle-Aged and Elderly Adults: The Hordaland Health Study
Van Parys, Anthea; Lysne, Vegard; Dierkes, Jutta; Nygård, Ottar Kjell; Øyen, Jannike; Vinknes, Kathrine Jørgensen; Karlsson, Therese; Haugsgjerd, Teresa Risan; Tell, Grethe S.; Ueland, Per Magne; Brække, Maria Sandvik (Journal article; Peer reviewed, 2022)Background: Choline is an essential nutrient for humans and is involved in various physiologic functions. Through its metabolite betaine, it is closely connected to the one-carbon metabolism, and the fat-soluble choline ... -
The association between dairy intake and risk of cardiovascular disease and mortality in patients with stable angina pectoris
Parys, Anthea van; Sæle, Jostein; Puaschitz, Nathalie; Anfinsen, Åslaug Matre; Karlsson, Therese; Olsen, Thomas; Haugsgjerd, Teresa Risan; Vinknes, Kathrine Jørgensen; Holven, Kirsten Bjørklund; Dierkes, Jutta; Nygård, Ottar Kjell; Lysne, Vegard (Journal article; Peer reviewed, 2022)Aims The association of dairy products with cardiovascular disease and mortality risk remains heavily debated. We aimed to investigate the association between intake of total dairy and dairy products and the risk of acute ... -
Association between dietary macronutrient composition and plasma one-carbon metabolites and B-vitamin cofactors in patients with stable angina pectoris
Bråtveit, Marianne; Parys, Anthea van; Olsen, Thomas; Strand, Elin; Marienborg, Ingvild; Laupsa-Borge, Johnny; Haugsgjerd, Teresa Risan; McCann, Adrian; Dhar, Indu; Ueland, Per Magne; Dierkes, Jutta; Dankel, Simon Erling Nitter; Nygård, Ottar Kjell; Lysne, Vegard (Journal article; Peer reviewed, 2024)Elevated plasma concentrations of several one-carbon metabolites are associated with increased CVD risk. Both diet-induced regulation and dietary content of one-carbon metabolites can influence circulating concentrations ... -
Association of dietary vitamin K and risk of coronary heart disease in middle-age adults: the Hordaland Health Study Cohort
Haugsgjerd, Teresa Risan; Egeland, Grace M.; Nygård, Ottar; Vinknes, Kathrine; Sulo, Gerhard; Lysne, Vegard; Igland, Jannicke; Tell, Grethe S. (Journal article; Peer reviewed, 2020)Objective: The role of vitamin K in the regulation of vascular calcification is established. However, the association of dietary vitamins K1 and K2 with risk of coronary heart disease (CHD) is inconclusive. Design: ... -
The Association of Meat Intake With All-Cause Mortality and Acute Myocardial Infarction Is Age-Dependent in Patients With Stable Angina Pectoris
Matre, Åslaug Oddsdatter; Van Parys, Anthea; Olsen, Thomas; Haugsgjerd, Teresa Risan; Baravelli, Carl Michael; Nygård, Ottar; Dierkes, Jutta; Lysne, Vegard (Journal article; Peer reviewed, 2021)Background: Red and processed meat intake have been associated with increased risk of morbidity and mortality, and a restricted intake is encouraged in patients with cardiovascular disease. However, evidence on the association ... -
Biomarkers and Algorithms for the Diagnosis of Vitamin B12 Deficiency
Hannibal, Luciana; Lysne, Vegard; Bjørke-Monsen, Anne-Lise; Behringer, Sidney; Grünert, Sarah C.; Spiekerkoetter, Ute; Jacobsen, Donald W.; Blom, Henk J. (Peer reviewed; Journal article, 2016-06-27)Vitamin B12 (cobalamin, Cbl, B12) is an indispensable water-soluble micronutrient that serves as a coenzyme for cytosolic methionine synthase (MS) and mitochondrial methylmalonyl-CoA mutase (MCM). Deficiency of Cbl, whether ... -
Biomarkers of one-carbon metabolism and B-vitamin status : Targeted metabolomics in rats and humans exploring the effects of PPARα-activation and dietary composition
Lysne, Vegard (Doctoral thesis, 2019-10-04)BACKGROUND: One-carbon metabolism is an overarching term describing central metabolic pathways involved in the transfer of one-carbon units. These include the methionine-homocysteine and folate cycles, as well as the choline ... -
Creatinine, total cysteine and uric acid are associated with serum retinol in patients with cardiovascular disease
Olsen, Thomas; Vinknes, Kathrine; Blomhoff, Rune; Lysne, Vegard; Midttun, Øivind; Dhar, Indu; Ueland, Per Magne; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Drevon, Christian A; Refsum, Helga; Nygård, Ottar (Peer reviewed; Journal article, 2019-09-09)Purpose: We hypothesized that biomarkers and dietary factors related to cardiovascular disease risk were associated with serum retinol and evaluated these potential associations in patients with suspected coronary artery ... -
Cystatin C proteoforms in chronic kidney disease
Dahl, Helene; Meyer, Klaus; Sandnes, Kristina; Welland, Natasha Lervaag; Arnesen, Iselin; Marti, Hans Peter; Dierkes, Jutta; Lysne, Vegard (Journal article; Peer reviewed, 2023)Cystatin C, a cysteine protease inhibitor, is used as a biomarker of renal function. It offers several advantages compared to creatinine, and formulas for the estimation of the glomerular filtration rate based on cystatin ... -
Elevated plasma cystathionine is associated with increased risk of mortality among patients with suspected or established coronary heart disease
Dhar, Indu; Lysne, Vegard; Svingen, Gard Frodahl Tveitevåg; Ueland, Per Magne; Gregory, Jesse F.; Bønaa, Kaare Harald; Nygård, Ottar (Journal article; Peer reviewed, 2019)Background Elevated circulating cystathionine levels are related to atherosclerotic cardiovascular disease, a leading cause of death globally. Objective We investigated whether plasma cystathionine was associated with ... -
Expanding the utilization of formalin-fixed, paraffin-embedded archives: Feasibility of miR-Seq for disease exploration and biomarker development from biopsies with clear cell renal cell Carcinoma
Strauss, Philipp; Marti, Hans-Peter; Beisland, Christian; Scherer, Andreas; Lysne, Vegard; Leh, Sabine Maria; Flatberg, Arnar; Koch, Even Evjen; Beisvag, Vidar; Landolt, Lea Zoe; Skogstrand, Trude; Eikrem, Øystein Solberg (Peer reviewed; Journal article, 2018-03-10)Novel predictive tools for clear cell renal cell carcinoma (ccRCC) are urgently needed. MicroRNAs (miRNAs) have been increasingly investigated for their predictive value, and formalin-fixed paraffin-embedded biopsy archives ... -
Exploratory analyses on the effect of time since last meal on concentrations of amino acids, lipids, one-carbon metabolites, and vitamins in the Hordaland Health Study
Anfinsen, Åslaug Matre; Rosendahl-Riise, Hanne; Nygård, Ottar Kjell; Tell, Grethe S.; Ueland, Per Magne; Ulvik, Arve; McCann, Adrian; Dierkes, Jutta; Lysne, Vegard (Journal article; Peer reviewed, 2023)Purpose Dietary intake may have pronounced effects on circulating biomarker concentrations. Therefore, the aim was to provide a descriptive overview of serum metabolite concentrations in relation to time since last meal, ... -
Food Sources Contributing to Intake of Choline and Individual Choline Forms in a Norwegian Cohort of Patients With Stable Angina Pectoris
Van Parys, Anthea; Karlsson, Therese; Vinknes, Kathrine; Olsen, Thomas; Øyen, Jannike; Dierkes, Jutta; Nygård, Ottar Kjell; Lysne, Vegard (Journal article; Peer reviewed, 2021)Background: Choline is an essential nutrient involved in a wide range of physiological functions. It occurs in water- and lipid-soluble forms in the body and diet. Foods with a known high choline content are eggs, beef, ... -
Intake of carbohydrates and SFA and risk of CHD in middle-age adults: The Hordaland Health Study (HUSK)
Haugsgjerd, Teresa Risan; Egeland, Grace M.; Nygård, Ottar; Igland, Jannicke; Sulo, Gerhard; Lysne, Vegard; Vinknes, Kathrine; Bjørnevik, Kjetil Lauvland; Tell, Grethe S. (Journal article; Peer reviewed, 2020)Objective: Limiting SFA intake may minimise the risk of CHD. However, such reduction often leads to increased intake of carbohydrates. We aimed to evaluate associations and the interplay of carbohydrate and SFA intake on ... -
Lipid parameters and vitamin A modify cardiovascular risk prediction by plasma neopterin
Dhar, Indu; Siddique, Sumia; Pedersen, Eva Kristine Ringdal; Svingen, Gard FT; Lysne, Vegard; Olsen, Thomas; Nilsen, Dennis W.T.; Nordrehaug, Jan Erik; Midttun, Øivind; Ueland, Per Magne; Tell, Grethe S; Nygård, Ottar (Journal article; Peer reviewed, 2020)Objectives Oxidised cholesterol metabolites are linked to increased production of the active vitamin A (Vit-A) form and monocyte/macrophage activation, which may be reflected by neopterin, a marker of both interferon-γ–mediated ... -
MRI adipose tissue segmentation and quantification in R (RAdipoSeg)
Haugen, Christine; Lysne, Vegard; Haldorsen, Ingfrid S.; Tjora, Erling; Gudbrandsen, Oddrun Anita; Sagen, Jørn Vegard; Dankel, Simon N; Mellgren, Gunnar (Journal article; Peer reviewed, 2022-10-08)Background: Excess adipose tissue is associated with increased cardiovascular and metabolic risk, but the volume of visceral and subcutaneous adipose tissue poses different metabolic risks. MRI with fat suppression can be ... -
No effect of plasma trimethylamine N-Oxide (TMAO) and plasma trimethyllysine (TML) on the association between choline intake and acute myocardial infarction risk in patients with stable angina pectoris
Van Parys, Anthea; Lysne, Vegard; Øyen, Jannike; Dierkes, Jutta; Nygård, Ottar Kjell (Journal article, 2020)Plasma concentrations of trimethylamine N-oxide (TMAO) have been linked to cardiovascular disease (CVD) risk and mortality. TMAO is formed through the bacterial conversion of trimethylamine which is obtained either directly ... -
Peroxisome Proliferator-Activated Receptor Activation is Associated with Altered Plasma One-Carbon Metabolites and B-Vitamin Status in Rats
Lysne, Vegard; Strand, Elin; Svingen, Gard Frodahl Tveitevåg; Bjørndal, Bodil; Pedersen, Eva Ringdal; Midttun, Øivind; Olsen, Thomas; Ueland, Per Magne; Berge, Rolf Kristian; Nygård, Ottar (Peer reviewed; Journal article, 2016-01-05)Plasma concentrations of metabolites along the choline oxidation pathway have been linked to increased risk of major lifestyle diseases, and peroxisome proliferator-activated receptors (PPARs) have been suggested to be ... -
Plasma cystathionine and risk of incident stroke in patients with suspected stable angina pectoris
Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Ueland, Per Magne; Lysne, Vegard; Svenningsson, Mads Malm; Tell, Grethe S.; Nygård, Ottar (Peer reviewed; Journal article, 2018)Background: Cystathionine is an intermediate product in the transsulfuration pathway and formed during the B6‐dependent conversion of methionine to cysteine. Elevated plasma cystathionine has been related to atherosclerosis, ...