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The genetic architecture of sporadic and multiple consecutive miscarriage
(Journal article; Peer reviewed, 2020)Miscarriage is a common, complex trait affecting ~15% of clinically confirmed pregnancies. Here we present the results of large-scale genetic association analyses with 69,054 cases from five different ancestries for sporadic ... -
The genetic architecture of the human cerebral cortex
(Journal article; Peer reviewed, 2020)INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be ... -
Genetic aspects of preeclampsia and the HELLP syndrome
(Peer reviewed; Journal article, 2014-06-02)Both preeclampsia and the HELLP syndrome have their origin in the placenta. The aim of this study is to review genetic factors involved in development of preeclampsia and the HELLP syndrome using literature search in PubMed. ... -
Genetic association study of childhood aggression across raters, instruments, and age
(Journal article; Peer reviewed, 2021)Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from ... -
Genetic associations in myasthenia gravis. Implications for pathogenesis
(Doctoral thesis, 2010-11-11) -
The genetic basis for ecological adaptation of the Atlantic herring revealed by genome sequencing
(Peer reviewed; Journal article, 2016-05-03)Ecological adaptation is of major relevance to speciation and sustainable population management, but the underlying genetic factors are typically hard to study in natural populations due to genetic differentiation caused ... -
The genetic basis for PRC1 complex diversity emerged early in animal evolution
(Journal article; Peer reviewed, 2020)Polycomb group proteins are essential regulators of developmental processes across animals. Despite their importance, studies on Polycomb are often restricted to classical model systems and, as such, little is known about ... -
Genetic biomarkers as prognostic and predictive factors in metastatic malignant melanoma
(Doctoral thesis, 2010-10-26)Malignant melanoma is one of the most chemoresistant malignancies in man. Although effort is put into developing new drugs to treat metastatic melanoma, still dacarbazine, an alkylating agent approved in 1975 for therapeutic ... -
Genetic connectivity from the Arctic to the Antarctic: Sclerolinum contortum and Nicomache lokii (Annelida) are both widespread in reducing environments
(Peer reviewed; Journal article, 2018-03-19)The paradigm of large geographic ranges in the deep sea has been challenged by genetic studies, which often reveal putatively widespread species to be several taxa with more restricted ranges. Recently, a phylogeographic ... -
Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)
(Peer reviewed; Journal article, 2015)General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait ... -
Genetic control of variability in subcortical and intracranial volumes
(Journal article; Peer reviewed, 2020)Sensitivity to external demands is essential for adaptation to dynamic environments, but comes at the cost of increased risk of adverse outcomes when facing poor environmental conditions. Here, we apply a novel methodology ... -
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
(Journal article; Peer reviewed, 2020)Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these ... -
Genetic determinants of macrolide and tetracycline resistance in penicillin non-susceptible Streptococcus pneumoniae isolates from people living with HIV in Dar es Salaam, Tanzania
(Journal article; Peer reviewed, 2023-02-20)Background: Over one million yearly deaths are attributable to Streptococcus pneumoniae and people living with HIV are particularly vulnerable. Emerging penicillin non-susceptible Streptococcus pneumoniae (PNSP) challenges ... -
Genetic differentiation and plasticity interact along temperature and precipitation gradients to determine plant performance under climate change
(Journal article, 2017-09)1. Understanding species' abilities to cope with changing climate is a key prerequisite for predicting the future fates of species and ecosystems. Despite considerable research on species responses to changing climate, ... -
Genetic diversification in the Tropical Western Atlantic Ocean: Phylogeography of the gastropod Bulla occidentalis
(Master thesis, 2011-06-01)The region under study is the Tropical Western Atlantic (TWA) which includes the Caribbean Sea with adjacent coastlines, the Gulf of Mexico, Bermuda and the coast of South America down to the tropical/temperate transitional ... -
Genetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical samples of Giardia lamblia
(Journal article; Peer reviewed, 2023)The effectiveness of metronidazole against the tetraploid intestinal parasite Giardia lamblia is dependent on its activation/inactivation within the cytoplasm. There are several activating enzymes, including pyruvate ... -
Genetic diversity of astrovirus in children from a birth cohort in Nepal
(Journal article; Peer reviewed, 2021)Objective: This study describes the types of Human astroviruses detected in stool samples collected from a birth cohort of children in Nepal. Methods: Using a commercial kit (ProSpecT), a total of 5,224 diarrheal and ... -
Genetic diversity of circulating rotavirus strains in Tanzania prior to the introduction of vaccination
(Peer reviewed; Journal article, 2014-05-20)Background: Tanzania currently rolls out vaccination against rotavirus-diarrhea, a major cause of child illness and death. As the vaccine covers a limited number of rotavirus variants, this study describes the molecular ... -
Genetic diversity of Newcastle disease virus in Pakistan: a countrywide perspective
(Peer reviewed; Journal article, 2013-05-30)Background: Newcastle disease (ND) is one of the most deadly diseases of poultry around the globe. The disease is endemic in Pakistan and recurrent outbreaks are being reported regularly in wild captive, rural and commercial ... -
Genetic diversity of the flavohemoprotein gene of Giardia lamblia: Evidence for high allelic heterozygosity and copy number variation
(Journal article; Peer reviewed, 2020)Purpose: The flavohemoprotein (gFlHb) in Giardia plays an important role in managing nitrosative and oxidative stress, and potentially also in virulence and nitroimidazole drug tolerance. The aim of this study was to analyze ...