Browsing Bergen Open Research Archive by Author "Berge, Rolf Kristian"
Now showing items 21-40 of 61
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Increased Plasma Levels of Triglyceride-Enriched Lipoproteins Associate with Systemic Inflammation, Lipopolysaccharides, and Gut Dysbiosis in Common Variable Immunodeficiency
Macpherson, Magnhild Eide; Skarpengland, Tonje; Hov, Johannes Espolin Roksund; Ranheim, Trine; Vestad, Beate; Dahl, Tuva Børresdatter; Fraz, Mai Sasaki Aanensen; Michelsen, Annika Elisabet; Holven, Kirsten Bjørklund; Fevang, Børre; Berge, Rolf Kristian; Aukrust, Pål; Halvorsen, Bente; Jørgensen, Silje Fjellgård (Journal article; Peer reviewed, 2023)Purpose: Triglycerides (TG) and their major transport lipoprotein in the circulation (VLDL) appear to be related to inflammation. Patients with common variable immunodeficiency (CVID) have inflammatory complications ... -
Induction of mitochondrial biogenesis and respiration is associated with mTOR regulation in hepatocytes of rats treated with the pan-PPAR activator tetradecylthioacetic acid (TTA)
Hagland, Hanne; Hodneland, Linn I.; Burri, Lena; Nikolaisen, Julie; Berge, Rolf Kristian; Tronstad, Karl Johan (Peer reviewed; Journal article, 2013-01)The hypolipidemic effect of peroxisome proliferator-activated receptor (PPAR) activators has been explained by increasing mitochondrial fatty acid oxidation, as observed in livers of rats treated with the pan-PPAR activator ... -
Krill oil attenuates left ventricular dilatation after myocardial infarction in rats
Fosshaug, Linn Elisabeth; Berge, Rolf Kristian; Beitnes, Jan Otto; Berge, Kjetil; Vik, Hogne; Aukrust, Pål; Gullestad, Lars; Vinge, Leif Erik; Øie, Erik (Peer reviewed; Journal article, 2011-12-29)Background: In the western world, heart failure (HF) is one of the most important causes of cardiovascular mortality. Supplement with n-3 polyunsaturated fatty acids (PUFA) has been shown to improve cardiac function in HF ... -
Krill oil reduces plasma triacylglycerol level and improves related lipoprotein particle concentration, fatty acid composition and redox status in healthy young adults - a pilot study
Berge, Rolf Kristian; Ramsvik, Marie Sannes; Bohov, Pavol; Svardal, Asbjørn; Nordrehaug, Jan Erik; Rostrup, Espen; Bruheim, Inge; Bjørndal, Bodil (Peer reviewed; Journal article, 2015-12-15)Background: Lipid abnormalities, enhanced inflammation and oxidative stress seem to represent a vicious circle in atherogenesis, and therapeutic options directed against these processes seems like a reasonable approach in ... -
Lipid-Lowering Effects of Tetradecylthioacetic Acid in Antipsychotic-Exposed, Female Rats: Challenges with Long-Term Treatment
Skrede, Silje; Fernø, Johan; Bjørndal, Bodil; Brede, Wenche Rødseth; Bohov, Pavol; Berge, Rolf Kristian; Steen, Vidar Martin (Peer reviewed; Journal article, 2012-11-30)Background: Psychiatric patients often require chronic treatment with antipsychotic drugs, and while rats are frequently used to study antipsychotic-induced metabolic adverse effects, long-term exposure has only partially ... -
Long-term treatment with the pan-PPAR agonist tetradecylthioacetic acid or fish oil is associated with increased cardiac content of n-3 fatty acids in rat
Strand, Elin; Bjørndal, Bodil; Nygård, Ottar; Burri, Lena; Berge, Christ; Bohov, Pavol; Christensen, Bjørn Jostein; Berge, Kjetil; Wergedahl, Hege; Viste, Asgaut; Berge, Rolf Kristian (Peer reviewed; Journal article, 2012-06-27)Background: Excess peroxisome proliferator-activated receptor (PPAR) stimulation has been associated with detrimental health effects including impaired myocardial function. Recently, supplementation with n-3 polyunsaturated ... -
Low fibre intake is associated with gut microbiota alterations in chronic heart failure
Mayerhofer, Cristiane C.K.; Kummen, Martin; Holm, Kristian; Broch, Kaspar; Awoyemi, Ayodeji Olawale; Vestad, Beate; Larsen, Christopher Storm; Seljeflot, Ingebjørg; Ueland, Thor; Bohov, Pavol; Berge, Rolf Kristian; Svardal, Asbjørn M.; Gullestad, Lars; Yndestad, Arne; Aukrust, Pål; Hov, Johannes Espolin Roksund; Trøseid, Marius (Journal article; Peer reviewed, 2020)Aims Recent reports have suggested that patients with heart failure (HF) have an altered gut microbiota composition; however, associations with diet remain largely uninvestigated. We aimed to explore differences in the ... -
Major increase in microbiota-dependent proatherogenic metabolite TMAO one year after bariatric surgery
Trøseid, Marius; Hov, Johannes Espolin Roksund; Nestvold, Torunn Kristin; Thoresen, Hanne; Berge, Rolf Kristian; Svardal, Asbjørn M.; Lappegård, Knut Tore (Journal article; Peer reviewed, 2016)Background: Trimethylamine-N-oxide (TMAO) is formed in the liver from trimethylamine (TMA), a product exclusively generated by the gut microbiota from dietary phosphatidylcholine and carnitine. An alternative pathway of ... -
Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy
Åsrud, Kathrine Sivertsen; Pedersen, Line; Æsøy, Reidun; Muwonge, Haruna; Aasebø, Elise; Pettersen, Ina Katrine Nitschke; Herfindal, Lars; Dobie, Ross; Jenkins, Stephen; Berge, Rolf Kristian; Henderson, Neil Cowan; Selheim, Frode; Doskeland, Stein Ove; Bakke, Marit (Peer reviewed; Journal article, 2019-09-24)The exchange proteins directly activated by cAMP 1 and 2 (Epac1 and Epac2) are expressed in a cell specific manner in the liver, but their biological functions in this tissue are poorly understood. The current study was ... -
A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats
Lindquist, Carine; Bjørndal, Bodil; Bakke, Hege Gilbø; Slettom, Grete; Karoliussen, Marie; Rustan, Arild; Thoresen, G. Hege; Skorve, Jon; Nygård, Ottar; Berge, Rolf Kristian (Peer reviewed; Journal article, 2019-09-24)A fatty acid analogue, 2-(tridec-12-yn-1-ylthio)acetic acid (1-triple TTA), was previously shown to have hypolipidemic effects in rats by targeting mitochondrial activity predominantly in liver. This study aimed to determine ... -
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice
Skarpengland, Tonje; Holm, Sverre; Scheffler, Katja; Gregersen, Ida; Dahl, Tuva Børresdatter; Suganthan, Rajikala; Segers, Filip; Østlie, Ingunn; Otten, Jeroen J.T.; Gomez, Luisa Fernanda Luna; Ketelhuth, Daniel F.J.; Lundberg, Anna M.; Neurauter, Christine Gran; Hildrestrand, Gunn Annette; Skjelland, Mona; Bjørndal, Bodil; Svardal, Asbjørn M.; Iversen, Per Ole; Hedin, Ulf; Nygård, Ståle; Olstad, Ole Kristoffer; Krohg-Sørensen, Kirsten; Slupphaug, Geir; Eide, Lars; Kusnierczyk, Anna; Folkersen, Lasse; Ueland, Thor; Berge, Rolf Kristian; Hansson, Göran K.; Biessen, Erik A.L.; Halvorsen, Bente; Bjørås, Magnar; Aukrust, Pål (Journal article; Peer reviewed, 2016)Increasing evidence suggests that oxidative DNA damage accumulates in atherosclerosis. Recently, we showed that a genetic variant in the human DNA repair enzyme NEIL3 was associated with increased risk of myocardial ... -
NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet
Sokolova, Marina; Yang, Kuan; Hansen, Simen Hyll; Louwe, Mieke C.; Kummen, Martin; Hov, Johannes Espolin Roksund; Sjaastad, Ivar; Berge, Rolf Kristian; Halvorsen, Bente; Aukrust, Pål; Yndestad, Arne; Ranheim, Trine (Journal article; Peer reviewed, 2020)Obesity-related diseases (e.g. type 2 diabetes mellitus and cardiovascular disorders) represent an increasing health problem worldwide. NLRP3 inflammasome activation may underlie obesity-induced inflammation and insulin ... -
NLRP3 inflammasome promotes myocardial remodeling during diet-induced obesity
Sokolova, Marina; Sjaastad, Ivar; Louwe, Maria Cornelia; Alfsnes, Katrine; Aronsen, Jan Magnus; Zhang, Lili; Haugstad, Solveig Bjærum; Bendiksen, Bård Andre; Øgaard, Jonas; Bliksøen, Marte; Lien, Egil; Berge, Rolf Kristian; Aukrust, Pål; Ranheim, Trine; Yndestad, Arne (Peer reviewed; Journal article, 2019-07-16)Background: Obesity is an increasingly prevalent metabolic disorder in the modern world and is associated with structural and functional changes in the heart. The NLRP3 inflammasome is an innate immune sensor that can be ... -
One-Year Treatment with Olanzapine Depot in Female Rats: Metabolic Effects
Ersland, Kari Merete; Myrmel, Lene Secher; Fjære, Even; Berge, Rolf Kristian; Madsen, Lise; Steen, Vidar Martin; Skrede, Silje (Peer reviewed; Journal article, 2019-05)Background: Antipsychotic drugs can negatively affect the metabolic status of patients, with olanzapine as one of the most potent drugs. While patients are often medicated for long time periods, experiments in rats typically ... -
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation
Yang, Mingyi; Lin, Xiaolin; Segers, Filip; Suganthan, Rajikala; Hildrestrand, Gunn Annette; Rinholm, Johanne Egge; Aas, Per Arne; Sousa, Mirta; Holm, Sverre; Bolstad, Nils; Warren, David; Berge, Rolf Kristian; Johansen, Rune Forstrøm; Yndestad, Arne; Kristiansen, Elise; Klungland, Arne; Gomez, Luisa Fernanda Luna; Eide, Lars; Halvorsen, Bente; Aukrust, Pål; Bjørås, Magnar (Journal article; Peer reviewed, 2020)Oxidation resistance gene 1 (OXR1) protects cells against oxidative stress. We find that male mice with brain-specific isoform A knockout (Oxr1A−/−) develop fatty liver. RNA sequencing of male Oxr1A−/− liver indicates ... -
Peroxisome Proliferator-Activated Receptor Activation is Associated with Altered Plasma One-Carbon Metabolites and B-Vitamin Status in Rats
Lysne, Vegard; Strand, Elin; Svingen, Gard Frodahl Tveitevåg; Bjørndal, Bodil; Pedersen, Eva Ringdal; Midttun, Øivind; Olsen, Thomas; Ueland, Per Magne; Berge, Rolf Kristian; Nygård, Ottar (Peer reviewed; Journal article, 2016-01-05)Plasma concentrations of metabolites along the choline oxidation pathway have been linked to increased risk of major lifestyle diseases, and peroxisome proliferator-activated receptors (PPARs) have been suggested to be ... -
A Phospholipid-Protein Complex from Antarctic Krill Reduced Plasma Homocysteine Levels and Increased Plasma Trimethylamine-N-Oxide (TMAO) and Carnitine Levels in Male Wistar Rats
Bjørndal, Bodil; Ramsvik, Marie Sannes; Lindquist, Carine; Nordrehaug, Jan Erik; Bruheim, Inge; Svardal, Asbjørn M.; Nygård, Ottar; Berge, Rolf Kristian (Peer reviewed; Journal article, 2015-09-08)Seafood is assumed to be beneficial for cardiovascular health, mainly based on plasma lipid lowering and anti-inflammatory effects of n-3 polyunsaturated fatty acids. However, other plasma risk factors linked to cardiovascular ... -
A phospholipid-protein complex from krill with antioxidative and immunomodulating properties reduced plasma triacylglycerol and hepatic lipogenesis in rats
Ramsvik, Marie Sannes; Bjørndal, Bodil; Bruheim, Inge; Bohov, Pavol; Berge, Rolf Kristian (Peer reviewed; Journal article, 2015-07-16)Dietary intake of marine omega-3 polyunsaturated fatty acids (n-3 PUFAs) can change the plasma profile from atherogenic to cardioprotective. In addition, there is growing evidence that proteins of marine origin may have ... -
Phospholipids from herring roe improve plasma lipids and glucose tolerance in healthy, young adults
Bjørndal, Bodil; Strand, Elin; Gjerde, Jennifer; Bohov, Pavol; Svardal, Asbjørn; Diehl, Bernd W. K.; Innis, Sheila M.; Berger, Alvin; Berge, Rolf Kristian (Peer reviewed; Journal article, 2014-05-17)Background: Herring roe is an underutilized source of n-3 polyunsaturated fatty acids (PUFAs) for human consumption with high phospholipid (PL) content. Studies have shown that PL may improve bioavailability of n-3 PUFAs. ... -
Plasma 3-hydroxyisobutyrate (3-HIB) and methylmalonic acid (MMA) are markers of hepatic mitochondrial fatty acid oxidation in male Wistar rats
Bjune, Mona Synnøve; Lindquist, Carine; Stafsnes, Marit Hallvardsdotter; Bjørndal, Bodil; Bruheim, Per; Aloysius, Thomas Aquinas; Nygård, Ottar; Skorve, Jon; Madsen, Lise; Dankel, Simon N; Berge, Rolf Kristian (Journal article; Peer reviewed, 2021)Objective: Discovery of specific markers that reflect altered hepatic fatty acid oxidation could help to detect an individual's risk of fatty liver, type 2 diabetes and cardiovascular disease at an early stage. Lipid and ...