Blar i Bergen Open Research Archive på forfatter "Cox, Rebecca Jane"
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Haemagglutination inhibition and virus microneutralisation serology assays: use of harmonised protocols and biological standards in seasonal influenza serology testing and their impact on inter-laboratory variation and assay correlation: A FLUCOP collaborative study
Waldock, Joanna; Remarque, Edmond J.; Zheng, Lingyi; Ho, Sammy; Hoschler, Katja; Neumann, Britta; Sediri-Schön, Hanna; Trombetta, Claudia M.; Montomoli, Emanuele; Marchi, Serena; Lapini, Giulia; Zhou, Fan; Jalloh, Sarah Larteley Lartey; Cox, Rebecca Jane; Facchini, Marzia; Castrucci, Maria Rita; Friel, Damien; Ollinger, Thierry; Caillet, Catherine; Music, Nedzad; Palladino, Giuseppe; Engelhardt, Othmar G. (Journal article; Peer reviewed, 2023)Introduction: The haemagglutination inhibition assay (HAI) and the virus microneutralisation assay (MN) are long-established methods for quantifying antibodies against influenza viruses. Despite their widespread use, both ... -
Harmonization and qualification of an IFN-γ Enzyme-Linked ImmunoSpot assay (ELISPOT) to measure influenza-specific cell-mediated immunity within the FLUCOP consortium
Waerlop, Gwenn; Leroux-Roels, Geert; Lambe, Teresa; Bellamy, Duncan; Medaglini, Donata; Pettini, Elena; Cox, Rebecca Jane; Trieu, Mai Chi; Davies, Richard Allan; Bredholt, Geir; Montomoli, Emanuele; Gianchecchi, Elena; Clement, Frédéric (Journal article; Peer reviewed, 2022-09-08)Influenza continues to be the most important cause of viral respiratory disease, despite the availability of vaccines. Today’s evaluation of influenza vaccines mainly focuses on the quantitative and functional analyses of ... -
Harmonization and qualification of intracellular cytokine staining to measure influenza-specific CD4+ T cell immunity within the FLUCOP consortium
Begue, Sarah; Waerlop, Gwenn; Salaun, Bruno; Janssens, Michel; Bellamy, Duncan; Cox, Rebecca Jane; Davies, Richard Allan; Gianchecchi, Elena; Medaglini, Donata; Montomoli, Emanuele; Pettini, Elena; Leroux-Roels, Geert; Clement, Frédéric; Pagnon, Anke (Journal article; Peer reviewed, 2022-10-20)Despite the knowledge that cell-mediated immunity (CMI) contributes to the reduction of severe influenza infection, transmission, and disease outcome, the correlates of protection for cell-mediated immunity remain still ... -
High prevalence of humoral and cellular immunity to influenza viruses in pre-school children living in Addis Ababa, Ethiopia
Dembinski, Jennifer Lynn; Mihret, Adane; Yimer, Solomon Abebe; Tessema, Bamlak; Trieu, Mai Chi; Tarekegn, Azeb; Getachew, Nahom; Cox, Rebecca Jane; Oftung, Fredrik; Haneberg, Bjørn; Aseffa, Abraham; Mjaaland, Siri (Peer reviewed; Journal article, 2017-01)Background. Influenza in children who reside in tropical and subtropical regions has until recently been regarded as insignificant. However, new evidence suggests that it significantly impacts hospitalization and promotes ... -
Immune Responses in Acute and Convalescent Patients with Mild, Moderate and Severe Disease during the 2009 Influenza Pandemic in Norway
Mohn, Kristin Greve-Isdahl; Cox, Rebecca Jane; Tunheim, Gro; Berdal, Jan Erik; Hauge, Anna G; Jul-Larsen, Åsne; Peters, Bjørn; Oftung, Fredrik; Jonassen, Christine M; Mjaaland, Siri (Peer reviewed; Journal article, 2015-11-25)Increased understanding of immune responses influencing clinical severity during pandemic influenza infection is important for improved treatment and vaccine development. In this study we recruited 46 adult patients during ... -
Influenza Vaccination Strategies: Comparing Inactivated and Live Attenuated Influenza Vaccines
Sridhar, Saranya; Brokstad, Karl Albert; Cox, Rebecca Jane (Peer reviewed; Journal article, 2015-04-24)Influenza is a major respiratory pathogen causing annual outbreaks and occasional pandemics. Influenza vaccination is the major method of prophylaxis. Currently annual influenza vaccination is recommended for groups at ... -
Intranasal H5N1 vaccines, adjuvanted with chitosan derivatives, protect ferrets against highly pathogenic influenza intranasal and intratracheal challenge
Mann, Alex; Noulin, Nicolas; Catchpole, Andrew; Stittelaar, Koert J.; De Waal, Leon; Veldhuis Kroeze, Edwin J.B.; Hinchcliffe, Michael; Smith, Alan; Montomoli, Emanuele; Piccirella, Simona; Osterhaus, Albert D.M. E.; Knight, Alastair; Oxford, John S.; Lapini, Giulia; Cox, Rebecca Jane; Lambkin-Williams, Rob (Peer reviewed; Journal article, 2014-05-21)We investigated the protective efficacy of two intranasal chitosan (CSN and TM-CSN) adjuvanted H5N1 Influenza vaccines against highly pathogenic avian Influenza (HPAI) intratracheal and intranasal challenge in a ferret ... -
Intranasal vaccination with a plant-derived H5 HA vaccine protects mice and ferrets against highly pathogenic avian influenza virus challenge
Major, Diane; Chichester, Jessica A.; Pathirana, Rishi; Guilfoyle, Kate; Shoji, Yoko; Guzman, Carlos A.; Yusibov, Vidadi; Cox, Rebecca Jane (Peer reviewed; Journal article, 2015-05)Highly pathogenic avian influenza H5N1 infection remains a public health threat and vaccination is the best measure of limiting the impact of a potential pandemic. Mucosal vaccines have the advantage of eliciting immune ... -
Learning from the COVID-19 pandemic among migrants: An innovative, system-level, interdisciplinary approach is needed to improve public health
Diaz Perez, Esperanza; Mamelund, Svenn-Erik; Eid, Jarle; Aasen, Henriette Sinding; Kaarbøe, Oddvar Martin; Cox, Rebecca Jane; Gloppen, Siri; Beyer, Anders; Kumar, Bernadette. N (Journal article; Peer reviewed, 2021)The effects of the COVID-19 pandemic are amplified among socially vulnerable groups, including international migrants, in terms of both disease transmission and outcomes and the consequences of mitigation measures. Migrants ... -
Live attenuated influenza vaccine in children induces b-cell responses in tonsils
Mohn, Kristin Greve-Isdahl; Brokstad, Karl Albert; Pathirana, Rishi; Bredholt, Geir; Jul-Larsen, Åsne; Trieu, Mai Chi; Jalloh, Sarah Larteley Lartey; Montemoli, Emanuele; Tøndel, Camilla; Aarstad, Hans Jørgen; Cox, Rebecca Jane (Peer reviewed; Journal article, 2016)Background. Tonsils play a key role in eliciting immune responses against respiratory pathogens. Little is known about how tonsils contribute to the local immune response after intranasal vaccination. Here, we uniquely ... -
Live-attenuated influenza vaccine induces tonsillar follicular T helper cell responses that correlate with antibody induction
Jalloh, Sarah Larteley Lartey; Zhou, Fan; Brokstad, Karl Albert; Mohn, Kristin Greve-Isdahl; Slettevoll, Steffen Aleksander; Pathirana, Rishi; Cox, Rebecca Jane (Journal article; Peer reviewed, 2020)Background: Influenza remains a major threat to public health. Live-attenuated influenza vaccines (LAIV) have been shown to be effective, particularly in children. Follicular T helper (TFH) cells provide B-cell help and ... -
Long COVID in a prospective cohort of home-isolated patients
Blomberg, Bjørn; Mohn, Kristin Greve-Isdahl; Brokstad, Karl Albert; Zhou, Fan; Linchausen, Dagrunn Waag; Hansen, Bernt-Are; Jalloh, Sarah Larteley Lartey; Onyango, Therese Bredholt; Kuwelker, Kanika; Sævik, Marianne; Bartsch, Hauke; Tøndel, Camilla; Kittang, Bård Reiakvam; Cox, Rebecca Jane; Langeland, Nina (Journal article; Peer reviewed, 2021)Long-term complications after coronavirus disease 2019 (COVID-19) are common in hospitalized patients, but the spectrum of symptoms in milder cases needs further investigation. We conducted a long-term follow-up in a ... -
Longevity of B-cell and T-cell responses after live attenuated influenza vaccination in children
Mohn, Kristin Greve-Isdahl; Bredholt, Geir; Brokstad, Karl Albert; Pathirana, Rishi; Aarstad, Hans Jørgen; Tøndel, Camilla; Cox, Rebecca Jane (Peer reviewed; Journal article, 2015-05-15)Background. The live attenuated influenza vaccine (LAIV) is the preferred vaccine for children, but the mechanisms behind protective immune responses are unclear, and the duration of immunity remains to be elucidated. This ... -
Low temperature and low UV indexes correlated with peaks of influenza virus activity in Northern Europe during 2010-2018
Ianevski, Aleksandr; Zusinaite, Eva; Shtaida, Nastassia; Kallio-Kokko, Hannimari; Valkonen, Mia; Kantele, Anu; Telling, Kaidi; Lutsar, Irja; Letjuka, Pille; Metelitsa, Natalja; Oksenych, Valentyn; Dumpis, Uga; Vitkauskiene, Astra; Stašaitis, Kestutis; Öhrmalm, Christina; Bondeson, Kåre; Bergqvist, Anders; Cox, Rebecca Jane; Tenson, Tanel; Merits, Andres; Kainov, Denis (Peer reviewed; Journal article, 2019-03-01)With the increasing pace of global warming, it is important to understand the role of meteorological factors in influenza virus (IV) epidemics. In this study, we investigated the impact of temperature, UV index, humidity, ... -
Lower antibiotic prescription rates in hospitalized COVID-19 patients than influenza patients, a prospective study
Fjelltveit, Elisabeth Berg; Cox, Rebecca Jane; Kittang, Bård Reiakvam; Blomberg, Bjørn; Buanes, Eirik A.; Langeland, Nina; Mohn, Kristin Greve-Isdahl (Journal article; Peer reviewed, 2022)Background COVID-19 patients are extensively treated with antibiotics despite few bacterial complications. We aimed to study antibiotic use in hospitalized COVID-19 patients compared to influenza patients in two consecutive ... -
Matrix M Adjuvanted H5N1 Vaccine Elicits Broadly Neutralizing Antibodies and Neuraminidase Inhibiting Antibodies in Humans That Correlate With In Vivo Protection
Zhou, Fan; Hansen, Lena; Pedersen, Gabriel Kristian; Grødeland, Gunnveig; Cox, Rebecca Jane (Journal article; Peer reviewed, 2021)The highly pathogenic avian influenza H5N1 viruses constantly evolve and give rise to novel variants that have caused widespread zoonotic outbreaks and sporadic human infections. Therefore, vaccines capable of eliciting ... -
Matrix M H5N1 vaccine induces cross-H5 clade humoral immune responses in a randomized clinical trial and provides protection from highly pathogenic influenza challenge in ferrets
Cox, Rebecca Jane; Major, Diane; Pedersen, Gabriel Kristian; Pathirana, Rishi; Höschler, Katja; Guilfoyle, Kate; Roseby, Sarah; Bredholt, Geir; Assmus, Jörg; Breakwell, Lucy; Campitelli, Laura; Sjursen, Haakon (Peer reviewed; Journal article, 2015-07-06)Background and Methods: Highly pathogenic avian influenza (HPAI) viruses constitute a pandemic threat and the development of effective vaccines is a global priority. Sixty adults were recruited into a randomized clinical ... -
Mortality related to hospital-associated infections in a tertiary hospital; repeated cross-sectional studies between 2004-2011
Koch, Anne Mette; Nilsen, Roy Miodini; Eriksen, Hanne-Merete; Cox, Rebecca Jane; Harthug, Stig (Peer reviewed; Journal article, 2015-12-29)Background: Hospital-associated infections (HAIs) are reported to increase patient mortality and incur longer hospital stays. Most studies to date have focused on specific groups of hospitalised patients with a rather short ... -
A Novel Prophylaxis Strategy Using Liposomal Vaccine Adjuvant CAF09b Protects against Influenza Virus Disease
Zimmermann, Julie; Schmidt, Signe Tandrup; Trebbien, Ramona; Cox, Rebecca Jane; Zhou, Fan; Follmann, Frank; Pedersen, Gabriel Kristian; Christensen, Dennis (Journal article; Peer reviewed, 2022-02-06)The SARS-CoV-2 pandemic caused a massive health and societal crisis, although the fast development of effective vaccines reduced some of the impact. To prepare for future respiratory virus pandemics, a pan-viral prophylaxis ... -
Pandemic influenza vaccines - the challenges
Haaheim, Lars Reinhardt; Madhun, Abdullah Sami; Cox, Rebecca Jane (Peer reviewed; Journal article, 2009-12-03)Recent years’ enzootic spread of highly pathogenic H5N1 virus among poultry and the many lethal zoonoses in its wake has stimulated basic and applied pandemic vaccine research. The quest for an efficacious, affordable and ...