Blar i Bergen Open Research Archive på forfatter "Gilja, Odd Helge"
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Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study
de Vries, Elisabeth M.G.; Färkkilä, Martti; Milkiewicz, Piotr; Hov, Johannes Espolin Roksund; Eksteen, Bertus; Thorburn, Douglas; Chazouillères, Olivier; Pares, Albert; Nygård, Ståle; Gilja, Odd Helge; Wunsch, Ewa; Invernizzi, Pietro; Carbone, Marco; Bernuzzi, Francesca; Boberg, Kirsten Muri; Røsjø, Helge; Rosenberg, William; Beuers, Ulrich H.; Ponsioen, Cyriel Y.; Karlsen, Tom Hemming; Vesterhus, Mette (Peer reviewed; Journal article, 2017-10)Background & Aims: Biomarkers reflecting disease activity and prognosis in primary sclerosing cholangitis (PSC) have not been firmly established. Enhanced liver fibrosis (ELF) test was previously reported to predict outcome ... -
Factors affecting the outcome of fecal microbiota transplantation for patients with irritable bowel syndrome
El-Salhy, Magdhy; Gilja, Odd Helge; Hatlebakk, Jan Gunnar (Journal article; Peer reviewed, 2023)Background A previous study that introduced a Fecal microbiota transplantation (FMT) protocol with a high efficacy applied a combination of favorable factors. Aims The present study aimed to evaluate some of these ... -
Fecal fat analyses in chronic pancreatitis importance of fat ingestion before stool collection
Erchinger, Friedemann Georg; Engjom, Trond; Jurmy, Palwasha; Tjora, Erling; Gilja, Odd Helge; Dimcevski, Georg Gjorgji (Peer reviewed; Journal article, 2017-01-17)Objective: Quantitative determination of fecal fat still is the gold standard for measuring malabsorption. We evaluated the importance of standardized food intake before and under the collection of feces. Material and ... -
Fluctuating biomarkers in primary sclerosing cholangitis: A longitudinal comparison of alkaline phosphatase, liver stiffness, and ELF
Fossdal, Guri; Mjelle, Anders Batman; Wiencke, Kristine; Bjørk, Ida Torunn; Gilja, Odd Helge; Folseraas, Trine; Karlsen, Tom Hemming; Rosenberg, William; Melvær, Giil Lasse; Vesterhus, Mette Nåmdal (Journal article; Peer reviewed, 2021)Background & Aims Primary sclerosing cholangitis (PSC) is a progressive liver disease characterised by fluctuating liver biochemistries and highly variable disease progression. The Enhanced Liver Fibrosis (ELF®) test and ... -
Formulation and characterisation of drug-loaded antibubbles for image-guided and ultrasound-triggered drug delivery
Kotopoulis, Spiros; Lam, Christina; Haugse, Ragnhild; Snipstad, Sofie; Murvold, Elsa Thodesen; Jouleh, Tæraneh; Berg, Sigrid; Hansen, Rune; Popa, Mihaela-Lucia; Mccormack, Emmet Matin; Gilja, Odd Helge; Poortinga, Albert (Journal article; Peer reviewed, 2022)The aim of this study was to develop high load-capacity antibubbles that can be visualized using diagnostic ultrasound and the encapsulated drug can be released and delivered using clinically translatable ultrasound. The ... -
Gastric function in diabetic gastroparesis assessed by ultrasound and scintigraphy
Steinsvik, Elisabeth Kjelsvik; Sangnes, Dag A.; Søfteland, Eirik; Biermann, Martin; Assmus, Jörg; Dimcevski, Georg Gjorgji; Gilja, Odd Helge; Hausken, Trygve (Journal article; Peer reviewed, 2021)Background: Gastroparesis is a severe diabetes complication characterized by delayed gastric emptying. We examined patients with symptoms of diabetic gastroparesis using gastric emptying scintigraphy and ultrasound drink ... -
Gastrointestinal transit and contractility in diabetic constipation: A wireless motility capsule study on diabetes patients and healthy controls
Sangnes, Dag A.; Lundervold, Katarina; Bekkelund, Mattis; Volkmann, Hilde Løland Von; Berentsen, Birgitte; Gilja, Odd Helge; Dimcevski, Georg; Søfteland, Eirik (Journal article; Peer reviewed, 2021)Background: Diabetic constipation is traditionally attributed to slow colonic transit, despite limited evidence. More than half of patients find treatment unsatisfactory. To improve treatment, there is a need for better ... -
Gastrointestinal Ultrasound Can Predict Endoscopic Activity in Crohn’s Disease
Sævik, Fredrik; Gilja, Odd Helge; Nylund, Kim (Journal article; Peer reviewed, 2020-04-24)Purpose To explore the ability of gastrointestinal ultrasound (GIUS) to separate patients in endoscopic remission from patients with active disease in a heterogeneous hospital cohort with Crohn’s disease (CD). Materials ... -
Gastrointestinal Ultrasound in Functional Disorders of the Gastrointestinal Tract - EFSUMB Consensus Statement
Maconi, Giovanni; Hausken, Trygve; Dietrich, Christoph F.; Pallotta, Nadia; Sporea, Ioan; Nürnberg, Dieter; Dirks, Klaus; Romanini, Laura; Serra, Carla; Braden, Barbara; Spârchez, Zeno; Gilja, Odd Helge (Journal article; Peer reviewed, 2021)Abdominal ultrasonography and intestinal ultrasonography are widely used as first diagnostic tools for investigating patients with abdominal symptoms, mainly for excluding organic diseases. However, gastrointestinal ... -
A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer
Dimcevski, Georg Gjorgji; Kotopoulis, Spiros; Bjånes, Tormod Karlsen; Hoem, Dag; Schjøtt, Jan; Gjertsen, Bjørn Tore; Biermann, Martin; Molven, Anders; Sorbye, Halfdan; McCormack, Emmet; Postema, Michiel; Gilja, Odd Helge (Peer reviewed; Journal article, 2016-12)Background: The primary aim of our study was to evaluate the safety and potential toxicity of gemcitabine combined with microbubbles under sonication in inoperable pancreatic cancer patients. The secondary aim was to ... -
Increasing the transplant dose and repeating faecal microbiota transplantation results in the responses of male patients with IBS reaching those of females
El-Salhy, Magdhy; Gilja, Odd Helge; Hatlebakk, Jan Gunnar (Journal article; Peer reviewed, 2023)Background Faecal microbiota transplantation (FMT) performed with a proper protocol is a safe treatment for IBS that has high efficacy and durable effects. Females have been reported to respond better than males to FMT. ... -
Interaction between ingested nutrients and gut endocrine cells in patients with irritable bowel syndrome (Review)
El-Salhy, Magdy; Gilja, Odd Helge; Gundersen, Doris Irene; Hatlebakk, Jan G; Hausken, Trygve (Peer reviewed; Journal article, 2014-08)Several endocrine cell abnormalities have been reported in different segments of the gastrointestinal tract of patients with irritable bowel syndrome (IBS). These cells have specialized microvilli that project into the ... -
Intestinal ultrasound early on in treatment follow-up predicts endoscopic response to anti-TNFα treatment in Crohn's disease
de Voogd, Floris; Bots, Steven; Gecse, Krisztina B.; Gilja, Odd Helge; D'Haens, Geert; Nylund, Kim (Journal article; Peer reviewed, 2022)Background To assess treatment response, objective measures are superior to clinical improvement in Crohn’s disease [CD]. Intestinal ultrasound [IUS] is an attractive, non-invasive alternative to endoscopy, demonstrating ... -
Is irritable bowel syndrome an organic disorder?
El-Salhy, Magdy; Gundersen, Doris Irene; Gilja, Odd Helge; Hatlebakk, Jan G; Hausken, Trygve (Peer reviewed; Journal article, 2014-01-14)Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that is generally considered to be functional because there appears to be no associated anatomical defect. Stress and psychological factors are thought ... -
The kinetics of gut microbial community composition in patients with irritable bowel syndrome following fecal microbiota transplantation
Mazzawi, Tarek; Lied, Gülen Arslan; Sangnes, Dag André; El-Salhy, Magdy; Hov, Johannes Espolin Roksund; Gilja, Odd Helge; Hatlebakk, Jan Gunnar; Hausken, Trygve (Peer reviewed; Journal article, 2018-11-14)Background: Gut microbiota alterations are important in irritable bowel syndrome (IBS). The aim was to investigate the effect of fecal microbiota transplantation (FMT) on gut microbiota and the symptoms in patients with ... -
Liver elastography in healthy children using three different systems - how many measurements are necessary?
Mjelle, Anders Batman; Mulabecirovic, Anesa; Havre, Roald Flesland; Olafsdottir, Edda Jonina; Gilja, Odd Helge; Vesterhus, Mette (Journal article; Peer reviewed, 2020-12-21)Purpose Liver elastography is increasingly being applied in screening for and follow-up of pediatric liver disease, and has been shown to correlate well with fibrosis staging through liver biopsy. Because time is of the ... -
Liver Elastography in Primary Sclerosing Cholangitis Patients Using Three Different Scanner Systems
Mjelle, Anders Batman; Fossdal, Guri; Gilja, Odd Helge; Vesterhus, Mette (Journal article; Peer reviewed, 2020)The aim of the study described here was to characterize three different liver elastography methods in primary sclerosing cholangitis (PSC) patients, for the first time exploring 2-D shear wave elastography (2-D-SWE) in PSC ... -
Long-term effects of fecal microbiota transplantation (FMT) in patients with irritable bowel syndrome
El-Salhy, Magdy; Bråthen Kristoffersen, Anja; Valeur, Jørgen; Casén, Christina; Hatlebakk, Jan Gunnar; Gilja, Odd Helge; Hausken, Trygve (Journal article; Peer reviewed, 2021)Background We recently found fecal microbiota transplantation (FMT) in irritable bowel syndrome (IBS) patients to be an effective and safe treatment after 3 months. The present follow-up study investigated the efficacy ... -
Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells
Haugse, Ragnhild; Langer, Anika; Murvold, Elsa Thodesen; Costea, Daniela Elena; Gjertsen, Bjørn Tore; Gilja, Odd Helge; Kotopoulis, Spiros; Ruiz de Garibay, Gorka; McCormack, Emmet (Journal article; Peer reviewed, 2020)The use of ultrasound (US) and microbubbles (MB), usually referred to as sonoporation, has great potential to increase the efficacy of chemotherapy. However, the molecular mechanisms that mediate sonoporation response are ... -
Navigated retrograde endoscopic myotomy (REM) for the treatment of therapy-resistant achalasia
Pham, Khanh Do-Cong; Havre, Roald Flesland; Langø, Thomas; Hofstad, Erlend Fagertun; Tangen, Geir Arne; Mårvik, Ronald; Pham, T.; Gilja, Odd Helge; Hatlebakk, Jan Gunnar; Viste, Asgaut (Peer reviewed; Journal article, 2018-04)Background In achalasia, muscle spasm may involve the proximal esophagus. When the muscle spasm is located in the proximal esophagus, conventional per oral endoscopic myotomy (POEM) may not be sufficient to relieve symptoms. ...