Browsing Bergen Open Research Archive by Author "Høivik, Erling Andre"

Now showing items 21-23 of 23

    • Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth 

      Holst, Frederik; Høivik, Erling Andre; Gibson, William J.; Taylor-Weiner, Amaro; Schumacher, Steven E.; Asmann, Yan W.; Grossmann, Patrick; Trovik, Jone; Necela, Brian M.; Thompson, E. Aubrey; Meyerson, Matthew; Beroukhim, Rameen; Salvesen, Helga Birgitte; Cherniack, Andrew D. (Peer reviewed; Journal article, 2016-05-10)
      The estrogen receptor alpha (ERα) is highly expressed in both endometrial and breast cancers, and represents the most prevalent therapeutic target in breast cancer. However, anti-estrogen therapy has not been shown to be ...

    • Regulation of CDKN2B expression by interaction of Arnt with Miz-1 - a basis for functional integration between the HIF and Myc gene regulatory pathways 

      Æsøy, Reidun; Gradin, Katarina; Åsrud, Kathrine Sivertsen; Høivik, Erling Andre; Ruas, Jorge L.; Poellinger, Lorenz; Bakke, Marit (Peer reviewed; Journal article, 2014-03-11)
      Background: Hypoxia- and Myc-dependent transcriptional regulatory pathways are frequently deregulated in cancer cells. These pathways converge in many cellular responses, but the underlying molecular mechanisms are unclear. ...

    • Tissue and imaging biomarkers for hypoxia predict poor outcome in endometrial cancer 

      Berg, Anna; Fasmer, Kristine Eldevik; Mauland, Karen Klepsland; Ytre-Hauge, Sigmund; Høivik, Erling Andre; Husby, Jenny Hild Aase; Tangen, Ingvild Løberg; Trovik, Jone; Halle, Mari Kyllesø; Woie, Kathrine; Bjørge, Line; Bjørnerud, Atle; Salvesen, Helga; Werner, Henrica Maria Johanna; Krakstad, Camilla; Haldorsen, Ingfrid S. (Peer reviewed; Journal article, 2016-09-13)
      Hypoxia is frequent in solid tumors and linked to aggressive phenotypes and therapy resistance. We explored expression patterns of the proposed hypoxia marker HIF-1α in endometrial cancer (EC) and investigate whether ...