Blar i Bergen Open Research Archive på forfatter "Herfindal, Lars"
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A liposomal formulation of simvastatin and doxorubicin for improved cardioprotective and anti-cancer effect
Bjørnstad, Ronja; Reiten, Ingeborg Nerbø; Knudsen, Kaja Skålnes; Schjøtt, Jan Didrik; Herfindal, Lars (Journal article; Peer reviewed, 2022)Anthracyclines such as doxorubicin (Dox) are the preferred chemotherapeutics for several cancers. However, Dox-induced cardiotoxicity limits its therapeutic potential. Liposomal encapsulation of Dox has been used for ... -
Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes
Oftedal, Linn Silje Wathne; Selheim, Frode; Wahlsten, Matti; Sivonen, Kaarina; Døskeland, Stein Ove; Herfindal, Lars (Peer reviewed; Journal article, 2010-10-14)The potential of marine benthic cyanobacteria as a source of anticancer drug candidates was assessed in a screen for induction of cell death (apoptosis) in acute myeloid leukemia (AML) cells. Of the 41 marine cyanobacterial ... -
Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity
Prestegard, Siv Kristin; Oftedal, Linn Silje Wathne; Coyne, Rosie Theresa; Nygård, Gyrid; Skjærven, Kaja Helvik; Knutsen, Gjert; Døskeland, Stein Ove; Herfindal, Lars (Peer reviewed; Journal article, 2009-11-18)In spite of the high abundance and species diversity of diatoms, only a few bioactive compounds from them have been described. The present study reveals a high number of mammalian cell death inducing substances in ... -
Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy
Åsrud, Kathrine Sivertsen; Pedersen, Line; Æsøy, Reidun; Muwonge, Haruna; Aasebø, Elise; Pettersen, Ina Katrine Nitschke; Herfindal, Lars; Dobie, Ross; Jenkins, Stephen; Berge, Rolf Kristian; Henderson, Neil Cowan; Selheim, Frode; Doskeland, Stein Ove; Bakke, Marit (Peer reviewed; Journal article, 2019-09-24)The exchange proteins directly activated by cAMP 1 and 2 (Epac1 and Epac2) are expressed in a cell specific manner in the liver, but their biological functions in this tissue are poorly understood. The current study was ... -
New CDK8 inhibitors as potential anti-leukemic agents – Design, synthesis and biological evaluation
Solum, Eirik Johansson; Hansen, Trond Vidar; Æsøy, Reidun; Herfindal, Lars (Journal article; Peer reviewed, 2020)Cyclin-dependent kinase 8 (CDK8) plays a vital role in regulating cell transcription either through its association with the mediator complex or by the phosphorylation of transcription factors. CDK8-mediated activation of ... -
New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells
Viktorsson, Elvar Örn; Aesoy, Reidun; Støa, Sindre; Lekve, Viola; Doskeland, Stein Ove; Herfindal, Lars; Rongved, Pål (Journal article, 2021)Novel chemotherapeutic strategies for acute myeloid leukemia (AML) treatment are called for. We have recently demonstrated that the phenazine 5,10-dioxide natural products iodinin (3) and myxin (4) exhibit potent and ... -
A new software tool for computer assisted in vivo high-content analysis of transplanted fluorescent cells in intact zebrafish larvae
Førde, Jan-Lukas; Reiten, Ingeborg Nerbø; Fladmark, Kari Espolin; Kittang, Astrid Marta Olsnes; Herfindal, Lars (Journal article; Peer reviewed, 2022)Acute myeloid leukemia and myelodysplastic syndromes are cancers of the bone marrow with poor prognosis in frail and older patients. To investigate cancer pathophysiology and therapies, confocal imaging of fluorescent ... -
NordAqua, a Nordic Center of Excellence to develop an algae-based photosynthetic production platform
Allahverdiyeva, Yagut; Aro, Eva-Mari; Bavel, Bert van; Escudero, Carlos; Funk, Christiane; Heinonen, Jarna; Herfindal, Lars; Lindblad, Peter; Makinen, Sari; Penttilä, Merja; Sivonen, Kaarina; Chauton, Matilde Skogen; Skomedal, Hanne; Skjermo, Jorunn (Journal article; Peer reviewed, 2021)NordAqua is a multidisciplinary Nordic Center of Excellence funded by NordForsk Bioeconomy program (2017–2022). The research center promotes Blue Bioeconomy and endeavours to reform the use of natural resources in a ... -
A novel bicyclic lactone and other polyphenols from the commercially important vegetable Anthriscus cerefolium
Slimestad, Rune; Rathe, Bendik Auran; Aesoy, Reidun; Diaz, Andrea Estefania Carpinteyro; Herfindal, Lars; Fossen, Torgils (Journal article; Peer reviewed, 2022)Garden chervil, Anthriscus cerefolium (L.) Hoffm. is an important herb commonly applied in Norwegian large-scale commercial kitchens. This species is a highly enriched source of phenolics, containing 1260 mg gallic acid ... -
A novel poly-oxygenated flavone glucoside from aerial parts of the Brazilian plant Neoglaziovia variegata (Bromeliaceae)
Ibrahim, Ayaan Hamdi Haji; Herfindal, Lars; Rathe, Bendik Auran; Andersen, Heidi Lie; Almeida, Jackson R. G. S.; Fossen, Torgils (Peer reviewed; Journal article, 2019)Neoglaziovia variegata is endemic to northeastern Brazil. The drought resistant plant produces edible fruits and is used as a fibre plant by rural communities in the Caatinga region where a variety of products are made ... -
Ocrelizumab and ofatumumab, but not rituximab, trigger complement induction in vitro
Førde, Jan-Lukas; Herfindal, Lars; Myhr, Kjell-Morten; Torkildsen, Øivind; Mollnes, Tom Eirik; Skrede, Silje (Journal article; Peer reviewed, 2023)The clinical and adverse effects of the therapeutic monoclonal antibodies (mAb) ocrelizumab, ofatumumab and rituximab in multiple sclerosis (MS) are presently subject to extensive study. While the two former are approved ... -
Repurposing chlorpromazine for anti-leukaemic therapy by nanoparticle encapsulation
Gundersen, Edvin Tang; Førde, Jan-Lukas; Tislevoll, Benedicte Sjo; Leitch, Calum; Barratt, Gillian; Gjertsen, Bjørn Tore; Herfindal, Lars (Journal article; Peer reviewed, 2022)Treatment of acute myeloid leukaemia (AML) relies on decades-old drugs, and while recent years have seen some breakthroughs, AML is still characterised by poor prognosis and survival rate. Drug repurposing can expedite the ... -
Sequential bortezomib and temozolomide treatment promotes immunological responses in glioblastoma patients with positive clinical outcomes: A phase 1B study
Rahman, Mohummad Aminur; Brekke, Jorunn; Arnesen, Victoria Smith; Hannisdal, Marianne; Navarro, Andrea Gras; Waha, Andreas; Herfindal, Lars; Rygh, Cecilie Brekke; Bratland, Eirik; Brandal, Petter; Haász, Judit; Oltedal, Leif; Miletic, Hrvoje; Lundervold, Arvid; Lie, Stein Atle; Goplen, Dorota; Chekenya, Martha (Journal article; Peer reviewed, 2020)Background Glioblastoma (GBM) is an aggressive malignant brain tumor where median survival is approximately 15 months after best available multimodal treatment. Recurrence is inevitable, largely due to O6 methylguanine ...