• Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III 

      Nerpin, Elisabet; Olivieri, Mario; Gislason, Thorainn; Olin, Anna C.; Nielsen, Rune; Johannessen, Ane; Ferreira, Diogenes S.; Marcon, Alessandro; Cazzoletti, Lucia; Accordini, Simone; Pin, Isabelle; Corsico, Angelo; Demoly, Pascal; Weyler, Joost; Nowak, Dennis; Jõgi, Rain; Forsberg, Bertil; Zock, Jan P.; Sigsgaard, Torben; Heinric, Joachim; Bono, Roberto; Leynaert, Bénédicte; Jarvis, Deborah; Janson, Christer; Malinovschi, Anderi (Peer reviewed; Journal article, 2019)
      Introduction: The fractional exhaled nitric oxide (FENO ) is a marker for type 2 inflammation used in diagnostics and management of asthma. In order to use FENO as a reliable biomarker, it is important to investigate factors ...
    • Early life environment and snoring in adulthood 

      Franklin, Karl A.; Janson, Christer; Gíslason, Thórarinn; Gulsvik, Amund; Gunnbjörnsdottir, Maria; Lærum, Birger Norderud; Lindberg, Eva; Norrman, Eva; Nyström, Lennarth; Omenaas, Ernst; Torén, Kjell; Svanes, Cecilie (Peer reviewed; Journal article, 2008-08-22)
      Background: To our knowledge, no studies of the possible association of early life environment with snoring in adulthood have been published. We aimed to investigate whether early life environment is associated with snoring ...
    • Early life exposures contributing to accelerated lung function decline in adulthood – a follow-up study of 11,000 adults from the general population 

      Kirkeleit, Jorunn; Riise, Trond; Wielscher, Mathias; Accordini, Simone; Carsin, Anne-Elie; Dratva, Julie; Franklin, Karl A.; Garcia-Aymerich, Judith; Jarvis, Deborah; Leynaert, Benedicte; Lodge, Caroline J.; Gomez Real, Francisco; Schlünssen, Vivi; Corsico, Angelo Guido; Heinrich, Joachim; Holm, Matthias; Janson, Christer; Benediktsdóttir, Bryndís; Jogi, Rain; Dharmage, Shyamali C.; Jarvelin, Marjo-Riitta; Svanes, Cecilie (Journal article; Peer reviewed, 2023)
      Background We aimed to assess whether exposure to risk factors in early life from conception to puberty continue to contribute to lung function decline later in life by using a pooled cohort comprising approx. 11,000 adults ...
    • Eosinophilic airway diseases: basic science, clinical manifestations and future challenges 

      Janson, Christer; Bjermer, Leif; Lehtimäki, Lauri; Kankaanranta, Hannu; Karjalainen, Jussi; Altraja, Alan; Yasinska, Valentyna; Aarli, Bernt Bøgvald; Rådinger, Madeleine; Hellgren, Johan; Lofdahl, Magnus; Howarth, Peter H; Porsbjerg, Celeste (Journal article; Peer reviewed, 2022)
      Eosinophils have a broad range of functions, both homeostatic and pathological, mediated through an array of cell surface receptors and specific secretory granules that promote interactions with their microenvironment. ...
    • Food hypersensitivity: an examination of factors influencing symptoms and temporal changes in the prevalence of sensitization in an adult sample 

      Lam, Holly C. Y.; Neukirch, Catherine; Janson, Christer; Garcia-Aymerich, Judith; Clausen, Michael; Idrose, N. Sabrina; Demoly, Pascal; Bertelsen, Randi Jacobsen; Ruiz, Lidia C.; Raherison, Chantal; Jarvis, Deborah L. (Journal article; Peer reviewed, 2023)
      Background/Objectives: Food hypersensitivity (FHS) is common, but little is known about the factors associated with severe reactions, age of onset and whether sensitization persists. This study examines the factors associated ...
    • Greenness exposure: beneficial but multidimensional 

      Johannessen, Ane; Xu, Shanshan; Abbah, Achenyo Peace; Janson, Christer (Journal article; Peer reviewed, 2023)
      Many studies have shown that greenness has beneficial health effects, particularly on psychological and cardiovascular outcomes. In this narrative review, we provide a synthesis of knowledge regarding greenness exposure ...
    • Health-related quality of life as associated with asthma control, psychological status and insomnia 

      Rask-Andersen, Anna; Leander, Mai; Sundbom, Fredrik; Lampa, Erik; Oudin, Anna; Leynaert, Bénédicte; Svanes, Cecilie; Gislason, Thorarinn; Torén, Kjell; Janson, Christer (Journal article; Peer reviewed, 2022)
      Background: Asthma is associated not only with lower health-related quality of life (HRQL) but also with psychological health and insomnia. The aim of this study was to investigate associations between HRQL, asthma symptoms, ...
    • Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study 

      Accordini, Simone; Calciano, Lucia; Marcon, Alessandro; Pesce, Giancarlo; Antó, Josep M.; Beckmeyer-Borowko, Anna B.; Carsin, Anne-Elie; Corsico, Angelo G.; Imboden, Medea; Janson, Christer; Keidel, Dirk; Locatelli, Francesca; Svanes, Cecilie; Burney, Peter G.J.; Jarvis, Deborah L.; Probst-Hensch, Nicole M.; Minelli, Cosetta (Journal article; Peer reviewed, 2020)
      Investigating COPD trends may help healthcare providers to forecast future disease burden. We estimated sex- and smoking-specific incidence trends of pre-bronchodilator airflow obstruction (AO) among adults without asthma ...
    • Indoor Airborne Microbiome and Endotoxin: Meteorological Events and Occupant Characteristics Are Important Determinants 

      Abouelhana, Hesham Amin Mohamed; Šantl-Temkiv, Tina; Cramer, Christine; Finster, Kai; Gomez Real, Francisco; Gislason, Thorarinn; Holm, Mathias; Janson, Christer; Jögi, Nils Oskar; Jogi, Rain; Malinovschi, Andrei; Marshall, Ian P. G.; Modig, Lars; Norbäck, Dan; Shigdel, Rajesh; Sigsgaard, Torben; Svanes, Cecilie; Thorarinsdottir, Hulda; Wouters, Inge M.; Schlünssen, Vivi; Bertelsen, Randi Jacobsen (Journal article; Peer reviewed, 2023)
      Airborne bacteria and endotoxin may affect asthma and allergies. However, there is limited understanding of the environmental determinants that influence them. This study investigated the airborne microbiomes in the homes ...
    • Inflammatory bowel disease and asthma. Results from the RHINE study 

      Kisiel, Marta A.; Sedvall, Martin; Malinovschi, Andrei; Franklin, Karl A.; Gislason, Thorarinn; Shlunssen, Vivi; Johansson, Ane; Modig, Lars; Jogi, Rain; Holm, Mathias; Svanes, Cecilie; Lindholdt, Louise; Carlson, Marie; Janson, Christer (Journal article; Peer reviewed, 2023)
      Background Asthma and inflammatory bowel disease (IBD) are common inflammatory diseases. The aim of this study was to investigate the associations of IBD with asthma and respiratory symptoms. Methods This study is ...
    • Interaction between gas cooking and GSTM1 null genotype in bronchial responsiveness: Results from the European Community Respiratory Health Survey 

      Amaral, André F.S.; Ramasamy, Adaikalavan; Castro-Giner, Francesc; Minelli, Cosetta; Accordini, Simone; Sørheim, Inga Cecilie; Pin, Isabelle; Kogevinas, Manolis; Jõgi, Rain; Balding, David J.; Norbäck, Dan; Verlato, Guiseppe; Olivieri, Mario; Probst-Hensch, Nicole; Janson, Christer; Zock, Jan-Paul; Heinrich, Joachim; Jarvis, Deborah L. (Peer reviewed; Journal article, 2014)
      Background: Increased bronchial responsiveness is characteristic of asthma. Gas cooking, which is a major indoor source of the highly oxidant nitrogen dioxide, has been associated with respiratory symptoms and reduced lung ...
    • Lifelong exposure to air pollution and greenness in relation to asthma, rhinitis and lung function in adulthood 

      Kuiper, Ingrid Nordeide; Svanes, Cecilie; Markevych, Iana; Accordini, Simone; Bertelsen, Randi Jacobsen; Bråbäck, Lennart; Christensen, Jesper Heile; Forsberg, Bertil; Halvorsen, Thomas; Heinrich, Joachim; Hertel, Ole; Hoek, Gerard; Holm, Mathias; De Hoogh, Kees; Janson, Christer; Malinovschi, Andrei; Marcon, Alessandro; Nilsen, Roy Miodini; Sigsgaard, Torben; Johannessen, Ane (Journal article; Peer reviewed, 2021)
      Objectives To investigate if air pollution and greenness exposure from birth till adulthood affects adult asthma, rhinitis and lung function. Methods: We analysed data from 3428 participants (mean age 28) in the RHINESSA ...
    • Long-term exposure to low-level air pollution and greenness and mortality in Northern Europe. The Life-GAP project 

      Xu, Shanshan; Marcon, Alessandro; Bertelsen, Randi Jacobsen; Benediktsdottir, Bryndis; Brandt, Jørgen; Engemann, Kristine; Frohn, Lise Marie; Geels, Camilla; Gislason, Thorarinn; Heinrich, Joachim; Holm, Mathias; Janson, Christer; Markevych, Iana; Modig, Lars; Orru, Hans; Schlunssen, Vivi; Sigsgaard, Torben; Johannessen, Ane (Journal article; Peer reviewed, 2023)
      Background Air pollution has been linked to mortality, but there are few studies examining the association with different exposure time windows spanning across several decades. The evidence for the effects of green space ...
    • Longterm follow-up in European respiratory health studies - patterns and implications 

      Johannessen, Ane; Verlato, Guiseppe; Benediktsdottir, Bryndis; Forsberg, Bertil; Franklin, Karl; Gíslason, Thorainn; Holm, Mathias; Janson, Christer; Jögi, Rain; Lindberg, Eva; Macsali, Ferenc; Omenaas, Ernst; Gomez Real, Francisco; Saure, Eirunn Waatevik; Schlünssen, Vivi; Sigsgaard, Torben; Skorge, Trude Duelien; Svanes, Cecilie; Torén, Kjell; Waatevik, Marie Johanne; Nilsen, Roy Miodini; de Marco, Roberto (Peer reviewed; Journal article, 2014-04-16)
      Background: Selection bias is a systematic error in epidemiologic studies that may seriously distort true measures of associations between exposure and disease. Observational studies are highly susceptible to selection ...
    • Maternal and paternal tuberculosis is associated with increased asthma and respiratory symptoms in their offspring: a study from Northern Europe 

      Gyawali, Sanjay; Lopez Cervantes, Juan Pablo; Johannessen, Ane; Gislason, Thorarinn; Holm, Mathias; Janson, Christer; Jögi, Rain; Modig, Lars; Schlünssen, Vivi; Mustafa, Tehmina; Svanes, Cecilie (Journal article; Peer reviewed, 2023)
      Background: Given the profound impact of tuberculosis (TB) on immunity and given murine studies suggesting that infections may influence immunity across generations, we hypothesize that parental TB might impact health and ...
    • Maternal preconception occupational exposure to cleaning products and disinfectants and offspring asthma 

      Tjalvin, Gro; Svanes, Øistein; Igland, Jannicke; Bertelsen, Randi Jacobsen; Benediktsdóttir, Bryndís; Dharmage, Shyamali; Forsberg, Bertil; Holm, Mathias; Janson, Christer; Jögi, Nils Oskar; Johannessen, Ane; Malinovschi, Andrei; Pape, Kathrine; Real, Francisco Gomez; Sigsgaard, Torben; Torén, Kjell; Vindenes, Hilde Kristin; Zock, Jan-Paul; Schlünssen, Vivi; Svanes, Cecilie (Journal article; Peer reviewed, 2021)
      Background Emerging research suggests health effects in offspring after parental chemical exposures before conception. Many future mothers are exposed to potent chemicals at work, but potential offspring health effects ...
    • Nasal symptoms increase the risk of snoring and snoring increases the risk of nasal symptoms. A longitudinal population study 

      Värendh, Maria; Janson, Christer; Bengtsson, Caroline; Hellgren, Johan; Holm, Mathias; Schlünssen, Vivi; Johannessen, Ane; Franklin, Karl A.; Storaas, Torgeir; Jõgi, Rain; Gislason, Thorarinn; Lindberg, Eva (Journal article; Peer reviewed, 2021)
      Purpose Humans have a preference for nasal breathing during sleep. This 10-year prospective study aimed to determine if nasal symptoms can predict snoring and also if snoring can predict development of nasal symptoms. The ...
    • Parental Prepuberty Overweight and Offspring Lung Function 

      Lønnebotn, Marianne; Calciano, Lucia; Johannessen, Ane; Jarvis, Deborah L; Abramson, Michael J.; Benediktsdottir, Bryndis; Bråbäck, Lennart; Franklin, Karl A.; Godoy, Raúl; Holm, Mathias; Janson, Christer; Jögi, Nils Oskar; Kirkeleit, Jorunn; Malinovschi, Andrei; Pereira-Vega, Antonio; Schlunssen, Vivi; Dharmage, Shyamali C.; Accordini, Simone; Real, Francisco Gomez; Svanes, Cecilie (Journal article; Peer reviewed, 2022)
      In a recent study we found that fathers’ but not mothers’ onset of overweight in puberty was associated with asthma in adult offspring. The potential impact on offspring’s adult lung function, a key marker of general and ...
    • Parents’ smoking onset before conception as related to body mass index and fat mass in adult offspring: Findings from the RHINESSA generation study 

      Knudsen, Gerd Toril Mørkve; Dharmage, Shyamali C.; Janson, Christer; Abramson, Michael J.; Benediktsdóttir, Bryndís; Malinovschi, Andrei; Skulstad, Svein Magne; Bertelsen, Randi Jacobsen; Real, Francisco Gomez; Schlünssen, Vivi; Jögi, Nils Oskar; Sánchez-Ramos, José Luis; Holm, Mathias; Garcia-Aymerich, Judith; Forsberg, Bertil; Svanes, Cecilie; Johannessen, Ane (Journal article; Peer reviewed, 2020)
      Emerging evidence suggests that parents’ preconception exposures may influence offspring health. We aimed to investigate maternal and paternal smoking onset in specific time windows in relation to offspring body mass index ...
    • Pharmacological treatment of asthma in a cohort of adults during a 20-year period: results from the European Community Respiratory Health Survey I, II and III 

      Janson, Christer; Accordini, Simone; Cazzoletti, Lucia; Cerveri, Isa; Chanoine, S; Corsico, Angelo; Ferreira, D.S.; Garcia-Aymerich, Judith; Gislason, Thorarinn; Nielsen, Rune; Johannessen, Ane; Jõgi, Rain; Malinovschi, Andrei; Moratalla, Jesús Martínez; Marcon, Alessandro; Pin, Isabelle; Quint, JK; Siroux, Valerie; Almar, Enrique; Bellisario, Valeria; Franklin, Karl A.; Gullon, JA; Holm, Mathias; Heinrich, Joachim; Nowak, Dennis; Sánchez-Ramos, José Luis; Weyler, Joost; Jarvis, Deborah (Peer reviewed; Journal article, 2019)
      Asthma often remains uncontrolled, despite the fact that the pharmacological treatment has undergone large changes. We studied changes in the treatment of asthma over a 20-year period and identified factors associated with ...