Browsing Bergen Open Research Archive by Author "Jonsson, Roland"

Now showing items 21-35 of 35

    • Microbiological and bioinformatics analysis of primary Sjogren's syndrome patients with normal salivation 

      Siddiqui, Huma; Chen, Tsute; Aliko, Ardita; Mydel, Piotr Mateusz; Jonsson, Roland; Olsen, Ingar (Peer reviewed; Journal article, 2016-10-20)
      Background: Reduced salivation is considered a major clinical feature of most but not all cases of primary Sjögren’s syndrome (pSS). Reduced saliva flow may lead to changes in the salivary microbiota. These changes have ...

    • Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing 

      Sandling, Johanna K.; Pucholt, Pascal; Hultin Rosenberg, Lina; Farias, Fabiana H.G.; Kozyrev, Sergey V.; Eloranta, Maija-Leena; Alexsson, Andrei; Bianchi, Matteo; Padyukov, Leonid; Bengtsson, Christine; Jonsson, Roland; Omdal, Roald; Lie, Benedicte Alexandra; Massarenti, Laura; Steffensen, Rudi; Jakobsen, Marianne A.; Lillevang, Søren T.; Lerang, Karoline; Molberg, Øyvind; Voss, Anne; Troldborg, Anne; Jacobsen, Søren; Syvänen, Ann-Christine; Jönsen, Andreas; Gunnarsson, Iva; Svenungsson, Elisabet; Rantapää-Dahlqvist, Solbritt; Bengtsson, Anders A.; Sjöwall, Christopher; Leonard, Dag; Lindblad-Toh, Kerstin; Rönnblom, Lars (Journal article, 2021)
      Objectives Systemic lupus erythematosus (SLE) is an autoimmune disease with extensive heterogeneity in disease presentation between patients, which is likely due to an underlying molecular diversity. Here, we aimed at ...

    • A Mouse Model for Slowly Progressive Primary Tuberculosis 

      Mustafa, Tehmina; Phyu, S.; Nilsen, Rune; Jonsson, Roland; Bjune, Gunnar Aksel (Journal article, 1999-08)
      The progression from primary Mycobacterium tuberculosis infection to disease is usually slow in humans. The aim of this study was to develop and characterize a mouse model for slowly progressive primary tuberculosis, using ...

    • The neutrophil protein S100A12 is associated with a comprehensive ultrasonographic synovitis score in a longitudinal study of patients with rheumatoid arthritis treated with adalimumab 

      Nordal, Hilde Haugedal; Brun, Johan Gorgas; Halse, Anne-Kristine; Jonsson, Roland; Fagerhol, Magne Kristoffer; Hammer, Hilde Berner (Peer reviewed; Journal article, 2014-10-04)
      Background: The calcium-binding protein S100A12 correlates with measures of disease activity in patients with rheumatoid arthritis (RA). The protein reflects neutrophil activation and the present objective was to explore ...

    • The neutrophil protein S100A12 is associated with a comprehensive ultrasonographic synovitis score in a longitudinal study of patients with rheumatoid arthritis treated with adalimumab 

      Nordal, Hilde Haugedal; Brun, Johan G; Halse, Anne-Kristine; Jonsson, Roland; Fagerhol, Magne Kristoffer; Hammer, Hilde Berner (Peer reviewed; Journal article, 2014-10-04)
      Background. The calcium-binding protein S100A12 correlates with measures of disease activity in patients with rheumatoid arthritis (RA). The protein reflects neutrophil activation and the present objective was to explore ...

    • An optimized multiplex flow cytometry protocol for the analysis of intracellular signaling in peripheral blood mononuclear cells 

      Davies, Richard Allan; Vogelsang, Petra; Jonsson, Roland; Appel, Silke (Peer reviewed; Journal article, 2016-09)
      Phosphoflow cytometry is increasingly being used as a tool for the discovery of biomarkers used in the treatment and monitoring of disease and therapy. The ability to measure numerous phospho-protein targets simultaneously ...

    • Oral microbiota in autoimmune polyendocrine syndrome type 1 

      Bruserud, Øyvind; Siddiqui, Huma; Marthinussen, Michaela Cuida; Chen, Tsute; Jonsson, Roland; Oftedal, Bergithe Eikeland; Olsen, Ingar; Husebye, Eystein Sverre; Wolff, Anette Bøe (Peer reviewed; Journal article, 2018)
      Background: Autoimmune polyendocrine syndrome type-1 (APS-1) is a rare, childhood onset disease caused by mutations in the Autoimmune Regulator gene. The phenotypic expression is highly variable and includes disease ...

    • Parenteral Vaccination against Influenza Does Not Induce a Local Antigen-Specific Immune Response in the Nasal Mucosa 

      Brokstad, Karl Albert; Eriksson, Jens-Christian Haug; Cox, Rebecca Jane; Tynning, Turid Liv; Olofsson, Jan; Jonsson, Roland; Davidsson, Åke (Peer reviewed; Journal article, 2002-03-19)
      The immune response in the nasal mucosa to influenza vaccination in 23 patients scheduled for tonsillectomy was studied. A statistically significant increase in influenza virus–specific serum and oral fluid antibodies was ...

    • Salivary glands of primary Sjögren’s syndrome patients express factors vital for plasma cell survival 

      Szyszko, Ewa A.; Brokstad, Karl Albert; Øijordsbakken, Gunnvor; Jonsson, Malin Viktoria; Jonsson, Roland; Skarstein, Kathrine (Peer reviewed; Journal article, 2011-01-07)
      Introduction: The presence of circulating Ro/SSA and La/SSB autoantibodies has become an important marker in the classification criteria for primary Sjögren’s syndrome (pSS). Plasma cells producing these autoantibodies are ...

    • Single cell based phosphorylation profiling identifies alterations in toll-like receptor 7 and 9 signaling in patients with primary Sjögren's syndrome 

      Davies, Richard Allan; Sarkar, Irene; Hammenfors, Daniel; Bergum, Brith; Vogelsang, Petra; Solberg, Silje Michelsen; Gavasso, Sonia; Brun, Johan G; Jonsson, Roland; Appel, Silke (Peer reviewed; Journal article, 2019-02-21)
      Primary Sjögren's syndrome (pSS) is associated with polymorphisms and mRNA expression profiles that are indicative of an exaggerated innate and type I IFN immune response. Excessive activation potential of signaling pathways ...

    • Sjögren’s syndrome: studying the disease in mice 

      Delaleu, Nicolas Hervé; Nguyen, Cuong Q.; Peck, Ammon B.; Jonsson, Roland (Peer reviewed; Journal article, 2011-06-13)
      Sjögren’s syndrome (SS), a systemic autoimmune disease, is characterized by infl ammation of exocrine tissues accompanied by a signifi cant loss of their secretory function. Clinical symptoms develop late and there are no ...

    • Stratified genetic analysis reveals sex differences in MPO-ANCA-associated vasculitis 

      Ekman, Diana; Sennblad, Bengt; Knight, Ann; Karlsson, Åsa; Rantapää-Dahlqvist, Solbritt; Berglin, Ewa; Stegmayr, Bernd; Baslund, Bo; Palm, Øyvind; Haukeland, Hilde; Gunnarsson, Iva; Bruchfeld, Annette; Segelmark, Mårten; Ohlsson, Sophie; Mohammad, Aladdin J; Svärd, Anna; Pullerits, Rille; Herlitz, Hans; Söderbergh, Annika; Omdal, Roald; Jonsson, Roland; Rönnblom, Lars; Eriksson, Per; Lindblad-Toh, Kerstin; Dahlqvist, Johanna (Journal article; Peer reviewed, 2023)
      Objective To identify and genetically characterize subgroups of patients with ANCA-associated vasculitides (AAV) based on sex and ANCA subtype. Methods A previously established SNP dataset derived from DNA sequencing ...

    • Strong association of combined genetic deficiencies in the classical complement pathway with risk of systemic lupus erythematosus and primary Sjögren's syndrome 

      Lundtoft, Christian; Sjöwall, Christopher; Rantapää-Dahlqvist, Solbritt; Bengtsson, Anders A.; Jönsen, Andreas; Pucholt, Pascal; Wu, Yee Ling; Lundström, Emeli; Eloranta, Maija-Leena; Gunnarsson, Iva; Baecklund, Eva; Jonsson, Roland; Hammenfors, Daniel; Forsblad-d'Elia, Helena; Eriksson, Per; Mandl, Thomas; Bucher, Sara; Norheim, Katrine Brække; Johnsen, Svein Joar Auglæn; Omdal, Roald; Kvarnström, Marika; Wahren Herlenius, Marie Elisabeth; Truedsson, Lennart; Nilsson, Bo; Kozyrev, Sergey V.; Bianchi, Matteo; Lindblad-Toh, Kerstin; Yu, Chack-Yung; Nordmark, Gunnel; Sandling, Johanna K.; Svenungsson, Elisabet; Leonard, Dag; Rönnblom, Lars (Journal article; Peer reviewed, 2022)
      Objective Complete genetic deficiency of the complement component C2 is a strong risk factor for monogenic systemic lupus erythematosus (SLE), but whether heterozygous C2 deficiency adds to the risk of SLE or primary ...

    • Transcriptional landscapes of emerging autoimmunity: transient aberrations in the targeted tissue's extracellular milieu precede immune responses in Sjögren's syndrome 

      Delaleu, Nicolas Hervé; Nguyen, Cuong Q.; Tekle, Kidane Mebrahtu; Jonsson, Roland; Peck, Ammon B. (Peer reviewed; Journal article, 2013-10-31)
      Introduction: Our understanding of autoimmunity is skewed considerably towards the late stages of overt disease and chronic inflammation. Defining the targeted organ’s role during emergence of autoimmune diseases is, ...

    • Variability of Primary Sjögren’s Syndrome Is Driven by Interferon-α and Interferon-α Blood Levels Are Associated With the Class II HLA–DQ Locus 

      Trutschel, Diana; Bost, Pierre; Mariette, Xavier; Bondet, Vincent; Llibre, Alba; Posseme, Celine; Charbit, Bruno; Thorball, Christian W.; Jonsson, Roland; Lessard, Christopher J.; Felten, Renaud; Ng, Wan Fai; Chatenoud, Lucienne; Dumortier, Hélène; Sibilia, Jean; Fellay, Jacques; Brokstad, Karl Albert; Appel, Silke; Tarn, Jessica R; Quintana-Murci, Lluis; Mingueneau, Michael; Meyer, Nicolas; Duffy, Darragh; Schwikowski, Benno; Gottenberg, Jacques Eric (Journal article; Peer reviewed, 2022)
      Objective Primary Sjögren's syndrome (SS) is the second most frequent systemic autoimmune disease, affecting 0.1% of the general population. To characterize the molecular and clinical variabilities among patients with ...