Blar i Bergen Open Research Archive på forfatter "Jugessur, Astanand"
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Haplin power analysis: a software module for power and sample size calculations in genetic association analyses of family triads and unrelated controls
Gjerdevik, Miriam; Jugessur, Astanand; Haaland, Øystein Ariansen; Romanowska, Julia; Lie, Rolv T.; Cordell, Heather J.; Gjessing, Håkon K. (Peer reviewed; Journal article, 2019-04-02)Background: Log-linear and multinomial modeling offer a flexible framework for genetic association analyses of offspring (child), parent-of-origin and maternal effects, based on genotype data from a variety of child-parent ... -
Levels of per- and polyfluoroalkyl substances (PFAS) in Norwegian children stratified by age and sex - Data from the Bergen Growth Study 2
Forthun, Ingvild Halsør; Roelants, Mathieu; Haug, Line Småstuen; Knutsen, Helle Katrine; Schell, Lawrence M.; Jugessur, Astanand; Bjerknes, Robert; Sabaredzovic, Azemira; Bruserud, Ingvild S.; Juliusson, Petur Benedikt (Journal article; Peer reviewed, 2023)Background and aim Due to the persistence, bioaccumulation and potential adverse health effects, there have been restrictions and phase out in the production of certain per- and polyfluoroalkyl substances (PFAS) since the ... -
Maternal angiotensinogen (AGT) haplotypes, fetal renin (REN) haplotypes and risk of preeclampsia; estimation of gene-gene interaction from family-triad data
Vefring, Hege K.; Wee, Line; Jugessur, Astanand; Gjessing, Håkon K.; Nilsen, Stein Tore; Lie, Rolv Terje (Peer reviewed; Journal article, 2010-06-10)Background Preeclampsia is a debilitating disorder affecting approximately 3% of pregnant women in the Western world. Although inconclusive, current evidence suggests that the renin-angiotensin system may be involved in ... -
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia
Jugessur, Astanand; Shi, Min; Gjessing, Håkon K.; Lie, Rolv Terje; Wilcox, Allen James; Weinberg, Clarice Ring; Christensen, Kaare; Boyles, Abee Lowman; Daack-Hirsch, Sandra; Nguyen, Truc Trung; Christiansen, Lene; Lidral, Andrew Carl; Murray, Jeffrey Clark (Peer reviewed; Journal article, 2010-07-09)Background Fetal conditions can in principle be affected by the mother's genotype working through the prenatal environment. Methodology/Principal Findings Genotypes for 1536 SNPs in 357 cleft candidate genes were available ... -
Matrilineal diversity and population history of Norwegians
Kristjansson, Dana; Bohlin, Jon; Jugessur, Astanand; Schurr, Theodore G. (Journal article; Peer reviewed, 2021)Background: While well known for its Viking past, Norway's population history and the influences that have shaped its genetic diversity are less well understood. This is particularly true with respect to its demography, ... -
A new approach to chromosome-wide analysis of X-linked markers identifies new associations in Asian and European case-parent triads of orofacial clefts
Skare, Øivind; Gjessing, Håkon K.; Gjerdevik, Miriam; Haaland, Øystein Ariansen; Romanowska, Julia; Lie, Rolv T.; Jugessur, Astanand (Peer reviewed; Journal article, 2017-09-06)Background: GWAS discoveries on the X-chromosome are underrepresented in the literature primarily because the analytical tools that have been applied were originally designed for autosomal markers. Our objective here is ... -
Nucleated red blood cells explain most of the association between DNA methylation and gestational age
Haftorn, Kristine Løkås; Denault, William Robert Paul; Lee, Yunsung; Page, Christian Magnus; Romanowska, Julia; Lyle, Robert; Næss, Øyvind Erik; Kristjansson, Dana; Magnus, Per Minor; Håberg, Siri Eldevik; Bohlin, Jon; Jugessur, Astanand (Journal article; Peer reviewed, 2023)Determining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the biological mechanisms underlying the association. Our EWAS of ... -
Parent-of-origin-environment interactions in case-parent triads with or without independent controls
Gjerdevik, Miriam; Haaland, Øystein Ariansen; Romanowska, Julia; Lie, Rolv T.; Jugessur, Astanand; Gjessing, Håkon K. (Peer reviewed; Journal article, 2018-03)With case–parent triad data, one can frequently deduce parent of origin of the child's alleles. This allows a parent‐of‐origin (PoO) effect to be estimated as the ratio of relative risks associated with the alleles inherited ... -
Phylogeographic history of mitochondrial haplogroup J in Scandinavia
Kristjansson, Dana; Schurr, Theodore; Bohlin, Jon; Jugessur, Astanand (Journal article, 2023)Background: Mitochondrial DNA haplogroup J is the third most frequent haplogroup in modern-day Scandinavia, although it did not originate there. To infer the genetic history of haplogroup J in Scandinavia, we examined ... -
Placental epigenetic clocks: estimating gestational age using placental DNA methylation levels
Lee, Yunsung; Choufani, Sanaa; Weksberg, Rosanna; Wilson, Samantha L.; Yuan, Victor; Burt, Amber; Marsit, Carmen; Lu, Ake T.; Ritz, Beate; Bohlin, Jon; Gjessing, Håkon K.; Harris, Jennifer Ruth; Magnus, Per; Binder, Alexandra M.; Robinson, Wendy P.; Jugessur, Astanand; Horvath, Steve (Peer reviewed; Journal article, 2019)The human pan-tissue epigenetic clock is widely used for estimating age across the entire lifespan, but it does not lend itself well to estimating gestational age (GA) based on placental DNAm methylation (DNAm) data. We ... -
Rapid genotyping of the human renin (REN) gene by the LightCycler® instrument: Identification of unexpected nucleotide substitutions within the selected hybridization probe area
Wee, Line L.; Vefring, Hege; Jonsson, Grete; Jugessur, Astanand; Lie, Rolv Terje (Peer reviewed; Journal article, 2010)Preeclampsia is a serious disorder affecting nearly 3% of all in the Western world. It is associated with hypertension and proteinuria, and several lines of evidence suggest that the renin-angiotensin system (RAS) may be ... -
Retirement age and disability status as pathways to later-life cognitive impairment: Evidence from the Norwegian HUNT Study linked with Norwegian population registers
Zotcheva, Ekaterina; Strand, Bjørn Heine; Bowen, Catherine E; Bratsberg, Bernt Magne; Jugessur, Astanand; Engdahl, Bo Lars; Selbæk, Geir; Kohler, Hans-Peter; Harris, Jennifer Ruth; Weiss, Jordan; Grøtting, Maja Weemes; Tom, Sarah E.; Krokstad, Steinar; Stern, Yaakov; Håberg, Asta; Skirbekk, Vegard Fykse (Journal article; Peer reviewed, 2023)Background Research shows that retirement age is associated with later-life cognition but has not sufficiently distinguished between retirement pathways. We examined how retirement age was associated with later-life ... -
Statistical methods to detect mother-father genetic interaction effects on risk of infertility: A genome-wide approach
Skodvin, Siri Nærland; Gjessing, Håkon Kristian; Jugessur, Astanand; Romanowska, Julia; Page, Christian Magnus; Corfield, Elizabeth Claire; Lee, Yunsung; Håberg, Siri Eldevik; Gjerdevik, Miriam (Journal article; Peer reviewed, 2023)Infertility is a heterogeneous phenotype, and for many couples, the causes of fertility problems remain unknown. One understudied hypothesis is that allelic interactions between the genotypes of the two parents may influence ... -
Wavelet Screening identifies regions highly enriched for differentially methylated loci for orofacial clefts
Denault, William Robert Paul; Romanowska, Julia; Haaland, Øystein Ariansen; Lyle, Robert; Taylor, Jack A.; Xu, Zongli; Lie, Rolv T.; Gjessing, Håkon K.; Jugessur, Astanand (Journal article; Peer reviewed, 2021)DNA methylation is the most widely studied epigenetic mark in humans and plays an essential role in normal biological processes as well as in disease development. More focus has recently been placed on understanding ... -
Wavelet Screening: a novel approach to analyzing GWAS data
Denault, William Robert Paul; Gjessing, Håkon K.; Juodakis, Julius; Jacobsson, Bo; Jugessur, Astanand (Journal article; Peer reviewed, 2021)Background Traditional methods for single-variant genome-wide association study (GWAS) incur a substantial multiple-testing burden because of the need to test for associations with a vast number of single-nucleotide ... -
The X-factor in ART: does the use of assisted reproductive technologies influence DNA methylation on the X chromosome?
Romanowska, Julia; Nustad, Haakon Egdetveit; Page, Christian Magnus; Denault, William Robert Paul; Lee, Yunsung; Magnus, Maria Christine; Haftorn, Kristine Løkås; Gjerdevik, Miriam; Novakovic, Boris; Saffery, Richard; Gjessing, Håkon K.; lyle, robert; Magnus, Per Minor; Håberg, Siri Eldevik; Jugessur, Astanand (Journal article; Peer reviewed, 2023)Background Assisted reproductive technologies (ART) may perturb DNA methylation (DNAm) in early embryonic development. Although a handful of epigenome-wide association studies of ART have been published, none have investigated ... -
X-Linked Genes and Risk of Orofacial Clefts: Evidence from Two Population-Based Studies in Scandinavia
Jugessur, Astanand; Skare, Øivind; Lie, Rolv Terje; Wilcox, Allen James; Christensen, Kaare; Christiansen, Lene; Nguyen, Truc Trung; Murray, Jeffrey Clark; Gjessing, Håkon K. (Peer reviewed; Journal article, 2012-06-19)Background: Orofacial clefts are common birth defects of complex etiology, with an excess of males among babies with cleft lip and palate, and an excess of females among those with cleft palate only. Although genes on the ...