Blar i Bergen Open Research Archive på forfatter "McCormack, Emmet"
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Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia
Haaland, Ingvild; Opsahl, Jill Anette; Berven, Frode S.; Reikvam, Håkon; Fredly, Hanne Kristin; Haugse, Ragnhild; Thiede, Bernd; McCormack, Emmet; Lain, Sonia; Bruserud, Øystein; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2014-05-21)Background: The small-molecule MDM2 antagonist nutlin-3 has proved to be an effective p53 activating therapeutic compound in several preclinical cancer models, including acute myeloid leukemia (AML). We and others have ... -
Multimodal Imaging of Orthotopic Mouse Model of Endometrial Carcinoma
Haldorsen, Ingfrid S.; Popa, Mihaela Lucia; Fonnes, Tina; Brekke, Njål; Kopperud, Reidun Kristin; Visser, Nicole C.; Rygh, Cecilie Brekke; Pavlin, Tina; Salvesen, Helga Birgitte; McCormack, Emmet; Krakstad, Camilla (Peer reviewed; Journal article, 2015-08-07)Background: Orthotopic endometrial cancer models provide a unique tool for studies of tumour growth and metastatic spread. Novel preclinical imaging methods also have the potential to quantify functional tumour characteristics ... -
Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes
Suliman, Salwa; Mustafa, Kamal Babikeir Eln; Krueger, Anke; Steinmüller-Nethl, Doris; Finne-Wistrand, Anna; Osdal, Tereza; Osman, Amani Hamza Ali; Sun, Yang; Parajuli, Himalaya; Waag, Thilo; Nickel, Joachim; Johannessen, Anne Christine; McCormack, Emmet; Costea, Daniela Elena (Peer reviewed; Journal article, 2016-07)This study aimed to evaluate the tumorigenic potential of functionalising poly(LLA-co-CL) scaffolds. The copolymer scaffolds were functionalised with nanodiamonds (nDP) or with nDP and physisorbed BMP-2 (nDP-PHY) to enhance ... -
p53 Protein Isoform Profiles in AML: Correlation with Distinct Differentiation Stages and Response to Epigenetic Differentiation Therapy
Haaland, Ingvild; Hjelle, Sigrun Margrethe; Reikvam, Håkon; Sulen, André; Ryningen, Anita; McCormack, Emmet; Bruserud, Øystein; Gjertsen, Bjørn Tore (Journal article; Peer reviewed, 2021)p53 protein isoform expression has been found to correlate with prognosis and chemotherapy response in acute myeloid leukemia (AML). We aimed to investigate how p53 protein isoforms are modulated during epigenetic ... -
Repurposing 18F-FMISO as a PET tracer for translational imaging of nitroreductase-based gene directed enzyme prodrug therapy
Ruiz de Garibay, Gorka; García de Jalón, Elvira; Stigen, Endre; Lund, Kjetil B.; Popa, Mihaela-Lucia; Davidson, Ben; Mayoral Safont, Mireia; Rygh, Cecilie Brekke; Espedal, Heidi; Barrett, Torill; Haug, Bengt Erik; McCormack, Emmet (Journal article; Peer reviewed, 2021)Nitroreductases (NTR) are a family of bacterial enzymes used in gene directed enzyme prodrug therapy (GDEPT) that selectively activate prodrugs containing aromatic nitro groups to exert cytotoxic effects following gene ... -
Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival
Poli, Aurélie; Wang, Jian; Domingues, Olivia; Planagumà, Jesús; Yan, Tao; Rygh, Cecilie Brekke; Skaftnesmo, Kai Ove; Thorsen, Frits Alan; McCormack, Emmet; Hentges, François; Pedersen, Paal-Henning; Zimmer, Jacques; Enger, Per Øyvind; Chekenya, Martha (Peer reviewed; Journal article, 2013-09-09)Glioblastoma (GBM) is the most malignant brain tumor where patients’ survival is only 14.6 months, despite multimodal therapy with debulking surgery, concurrent chemotherapy and radiotherapy. There is an urgent, unmet need ... -
Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys
Eikrem, Øystein Solberg; Kotopoulis, Spiros; Popa, Mihaela-Lucia; Safont, Mireia Mayoral; Fossan, Kjell Ove; Leh, Sabine; Landolt, Lea; Babickova, Janka; Gudbrandsen, Oddrun Anita; Gilja, Odd Helge; Riedel, Bettina Maria Ingeborg; Schjøtt, Jan Didrik; McCormack, Emmet; Marti, Hans-Peter (Journal article; Peer reviewed, 2021-11-29)The use of ultrasound and microbubble-enhanced drug delivery, commonly referred to as sonoporation, has reached numerous clinical trials and has shown favourable results. Nevertheless, the microbubbles and acoustic path ... -
Ultrasound- and Microbubble-Assisted Gemcitabine Delivery to Pancreatic Cancer Cells
Bjånes, Tormod Karlsen; Kotopoulis, Spiros; Murvold, Elsa Thodesen; Kamceva, Tina; Gjertsen, Bjørn Tore; Gilja, Odd Helge; Schjøtt, Jan; Riedel, Bettina; McCormack, Emmet (Journal article; Peer reviewed, 2020)Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death worldwide. Poor drug delivery to tumours is thought to limit chemotherapeutic treatment efficacy. Sonoporation combines ultrasound (US) and microbubbles ...