Now showing items 21-40 of 48

    • Generating a Precision Endoxifen Prediction Algorithm to Advance Personalized Tamoxifen Treatment in Patients with Breast Cancer 

      Helland, Thomas; Alsomairy, Sarah; Lin, Chenchia; Søiland, Håvard; Mellgren, Gunnar; Hertz, Daniel Louis (Journal article; Peer reviewed, 2021)
      Tamoxifen is an endocrine treatment for hormone receptor positive breast cancer. The effectiveness of tamoxifen may be compromised in patients with metabolic resistance, who have insufficient metabolic generation of the ...
    • Gruppeveiledning av doktorgradstipendiater i en forskningsgruppe 

      Mellgren, Gunnar (UPED-skrift nr. ?/2006, Working paper, 2006)
      Formålet med denne studien var å stimulere den vitenskapelige kommunikasjonen mellom forskningsgruppens medlemmer, samt å forbedre og effektivisere forskningsveiledningen. En sentral problemstilling var om det er mulig å ...
    • High visceral fat percentage is associated with poor outcome in endometrial cancer 

      Mauland, Karen Klepsland; Eng, Øyvin Andre Solberg; Ytre-Hauge, Sigmund; Tangen, Ingvild Løberg; Berg, Anna; Salvesen, Helga; Salvesen, Øyvind; Krakstad, Camilla; Trovik, Jone; Høivik, Erling Andre; Werner, Henrica Maria Johanna; Mellgren, Gunnar; Haldorsen, Ingfrid S. (Peer reviewed; Journal article, 2017-10-19)
      Despite evidence of increased endometrial cancer (EC) risk in obese women, the impact of obesity on clinical and histological phenotype is poorly understood. This study explored abdominal fat volumes and fat distribution ...
    • Hormone references for ultrasound breast staging and endocrine profiling to detect female onset of puberty 

      Madsen, Andre; Bruserud, Ingvild Særvold; Bertelsen, Bjørn-Erik; Roelants, Mathieu; Oehme, Ninnie; Viste, Kristin; Bjerknes, Robert; Almås, Bjørg; Rosendahl, Karen; Mellgren, Gunnar; Sagen, Jørn V.; Juliusson, Petur Benedikt (Journal article; Peer reviewed, 2020)
      Context Application of ultrasound (US) to evaluate attainment and morphology of glandular tissue provides a new rationale for evaluating onset and progression of female puberty, but currently no hormone references complement ...
    • Inflammatory markers, the tryptophan-kynurenine pathway, and Vitamin B status after bariatric surgery 

      Christensen, Monika; Fadnes, Dag Jone Stokke; Røst, Therese Halvorsen; Pedersen, Eva Ringdal; Andersen, John Roger; Våge, Villy; Ulvik, Arve; Midttun, Øivind; Ueland, Per Magne; Nygård, Ottar; Mellgren, Gunnar (Peer reviewed; Journal article, 2018-02-05)
      Objective: Obesity is associated with increased inflammation and insulin resistance. In conditions with chronic immune activation, low plasma vitamin B6-levels are described, as well as an increased kynurenine:tryptophan-ratio ...
    • Intake of baked cod fillet resulted in lower serum cholesterol and higher long chain n-3 PUFA concentrations in serum and tissues in hypercholesterolemic obese Zucker fa/fa rats 

      Vikøren, Linn Anja Slåke; Drotningsvik, Aslaug; Bergseth, Marthe Tønder; Mjøs, Svein Are; Austgulen, Maren Hoff; Mellgren, Gunnar; Gudbrandsen, Oddrun Anita (Peer reviewed; Journal article, 2018-06-28)
      Increasing evidence indicates that lean fish consumption may benefit cardiovascular health. High cholesterol and low n-3 PUFA concentrations in serum are associated with an increased risk of coronary heart disease; therefore, ...
    • Low Z-4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen 

      Helland, Thomas; Naume, Bjørn; Hustad, Steinar; Bifulco, Ersilia; Kvaløy, Jan Terje; Sætersdal, Anna Barbro; Synnestvedt, Marit; Lende, Tone Hoel; Gilje, Bjørnar; Mjaaland, Ingvil; Weyde, Kjetil; Blix, Egil Støre; Wiedswang, Gro; Borgen, Elin; Hertz, Daniel Louis; Janssen, Emiel; Mellgren, Gunnar; Søiland, Håvard (Journal article; Peer reviewed, 2021)
      Low steady‐state levels of active tamoxifen metabolites have been associated with inferior treatment outcomes. In this retrospective analysis of 406 estrogen receptor‐positive breast cancer (BC) patients receiving adjuvant ...
    • Low β2-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism 

      Braadland, Peder; Grytli, Helene Hartvedt; Ramberg, Håkon Andre; Katz, Betina; Kellmann, Ralf; Gauthier-Landry, louis; Fazli, Ladan; Krobert, Kurt Allen; Wang, Wanzhong; Levy, Finn Olav; Bjartell, Anders; Berge, Viktor; Rennie, Paul S.; Mellgren, Gunnar; Mælandsmo, Gunhild; Svindland, Aud; Barbier, Olivier; Tasken, Kristin Austlid (Peer reviewed; Journal article, 2016-12-04)
      The underlying mechanisms responsible for the development of castration-resistant prostate cancer (CRPC) in patients who have undergone androgen deprivation therapy are not fully understood. This is the first study to ...
    • Maternal PCOS status and metformin in pregnancy: Steroid hormones in 5–10 years old children from the PregMet randomized controlled study 

      Hanem, Liv Guro Engen; Salvesen, Øyvind; Madsen, Andre; Sagen, Jørn Vegard; Mellgren, Gunnar; Juliusson, Petur Benedikt; Carlsen, Sven Magnus; Vanky, Eszter; Ødegård, Rønnaug (Journal article; Peer reviewed, 2021)
      Objective: Polycystic ovary syndrome (PCOS) is a common endocrine disorder, with potential effects on offspring both genetically and through altered intrauterine environment. Metformin, which ameliorate hormonal disturbances ...
    • Meal patterns associated with energy intake in people with obesity 

      Horn, Cathrine; Laupsa-Borge, Johnny; Andersen, Amanda; Dyer, Laurence; Revheim, Ingrid; Leikanger, Trine; Næsheim, Nicole Tandrevold; Storås, Inghild; Johannessen, Kristine Kjerpeseth; Mellgren, Gunnar; Dierkes, Jutta; Dankel, Simon Erling Nitter (Journal article; Peer reviewed, 2021)
      It is widely assumed that people with obesity have several common eating patterns, including breakfast-skipping (1), eating during the night (2) and high fast-food consumption (3). However, differences in individual meal ...
    • Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2) 

      Madsen, Andre; Bozickovic, Olivera; Bjune, Jan Inge; Mellgren, Gunnar; Sagen, Jørn V. (Peer reviewed; Journal article, 2015-11-09)
      The ability of the anti-diabetic drug metformin to inhibit anabolic processes including gluconeogenesis and lipogenesis is partly attributable to activation of the AMP-activated protein kinase (AMPK) pathway. The p160 ...
    • A MicroRNA Linking Human Positive Selection and Metabolic Disorders 

      Wang, Lifeng; Sinnott-Armstrong, Nicholas A; Wagschal, Alexandre; Wark, Abigail R.; Camporez, Joao-Paulo; Perry, Rachel J.; Ji, Fei; Sohn, Yoojin; Oh, Justin; Wu, Su; Chery, Jessica; Moud, Bahareh Nemati; Saadat, Alham; Dankel, Simon N; Mellgren, Gunnar; Tallapragada, Divya Sri Priyanka; Strobel, Sophie Madlen; Lee, Mi-Jeong; Tewhey, Ryan; Sabeti, Pardis C.; Schaefer, Anne; Petri, Andreas; Kauppinen, Sakari; Chung, Raymond T.; Soukas, Alexander; Avruch, Joseph; Fried, Susan K.; Hauner, Hans; Sadreyev, Ruslan I.; Shulman, Gerald I.; Claussnitzer, Melina; Näär, Anders M. (Journal article; Peer reviewed, 2020)
      Positive selection in Europeans at the 2q21.3 locus harboring the lactase gene has been attributed to selection for the ability of adults to digest milk to survive famine in ancient times. However, the 2q21.3 locus is also ...
    • Primary Hyperparathyroidism Influences the Expression of Inflammatory and Metabolic Genes in Adipose Tissue 

      Christensen, Monika H. E.; Dankel, Simon N; Nordbø, Yngve; Varhaug, Jan Erik; Almås, Bjørg; Lien, Ernst Asbjørn; Mellgren, Gunnar (Peer reviewed; Journal article, 2011-06-17)
      Background: Primary hyperparathyroidism (PHPT) is characterised by increased production of parathyroid hormone (PTH) resulting in elevated serum calcium levels. The influence on bone metabolism with altered bone resorption ...
    • Reference curves for pediatric endocrinology: leveraging biomarker z-scores for clinical classifications 

      Madsen, Andre; Almås, Bjørg; Bruserud, Ingvild Særvold; Oehme, Ninnie Helen Bakken; Nielsen, Christopher Sivert; Roelants, Mathieu; Hundhausen, Thomas Eckhard; Ljubicic, Marie Lindhardt; Bjerknes, Robert; Mellgren, Gunnar; Sagen, Jørn V.; Juliusson, Pétur Benedikt; Viste, Kristin (Journal article; Peer reviewed, 2022)
      Context Hormone reference intervals in pediatric endocrinology are traditionally partitioned by age and lack the framework for benchmarking individual blood test results as normalized z-scores and plotting sequential ...
    • A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density 

      Sinnott-Armstrong, Nicholas A; Sousa, Isabel S.; Laber, Samantha; Rendina-Ruedy, Elizabeth; Dankel, Simon N; Ferreira, Teresa; Mellgren, Gunnar; Karasik, David; Rivas, Manuel A.; Pritchard, Jonathan; Guntur, Anyonya R.; Cox, Roger D.; Lindgren, Cecilia M.; Hauner, Hans; Sallari, Richard C; Rosen, Clifford J.; Hsu, Yi-Hsiang; Lander, Eric S.; Kiel, Douglas P.; Claussnitzer, Melina (Journal article; Peer reviewed, 2021)
      Skeletal and glycemic traits have shared etiology, but the underlying genetic factors remain largely unknown. To identify genetic loci that may have pleiotropic effects, we studied Genome-wide association studies (GWASs) ...
    • Retained NK cell phenotype and functionality in non-alcoholic fatty liver disease 

      Stiglund, Natalie; Strand, Kristina; Cornillet, Martin; Stål, Per; Thorell, Anders; Zimmer, Christine L.; Näslund, Erik; Karlgren, Silja; Nilsson, Henrik; Mellgren, Gunnar; Fernø, Johan; Hagström, Hannes; Björkström, Niklas K. (Peer reviewed; Journal article, 2019-06-04)
      Non-alcoholic fatty liver disease (NAFLD), and the progressive stage non-alcoholic steatohepatitis (NASH), is the predominant cause of chronic liver disease globally. As part of the complex pathogenesis, natural killer ...
    • The Rho GTPase RND3 regulates adipocyte lipolysis 

      Dankel, Simon N; Røst, Therese Halvorsen; Kulyté, Agné; Fandalyuk, Zinayida; Skurk, Thomas; Hauner, Hans; Sagen, Jørn V.; Rydén, Mikael; Arner, Peter; Mellgren, Gunnar (Peer reviewed; Journal article, 2019)
      Background: Adipose tissue plays a crucial role in diet- and obesity-related insulin resistance, with implications for several metabolic diseases. Identification of novel target genes and mechanisms that regulate adipocyte ...
    • Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance 

      Jersin, Regine Åsen; Tallapragada, Divya Sri Priyanka; Madsen, André; Skartveit, Linn; Fjære, Even; McCann, Adrian; Dyer, Laurence; Willems, Aron; Bjune, Jan-Inge; Bjune, Mona S.; Våge, Villy; Nielsen, Hans Jørgen; Thorsen, Håvard Luong; Nedrebø, Bjørn Gunnar; Busch, Christian; Steen, Vidar M.; Blüher, Matthias; Jacobson, Peter; Svensson, Per-Arne; Fernø, Johan; Rydén, Mikael; Arner, Peter; Nygård, Ottar; Claussnitzer, Melina; Ellingsen, Ståle; Madsen, Lise; Sagen, Jørn V.; Mellgren, Gunnar; Dankel, Simon N (Journal article; Peer reviewed, 2021)
      Elucidation of mechanisms that govern lipid storage, oxidative stress, and insulin resistance may lead to improved therapeutic options for type 2 diabetes and other obesity-related diseases. Here, we find that adipose ...
    • Salmon fillet intake led to higher serum triacylglycerol in obese zucker Fa/Fa rats but not in normolipidemic Long-Evans rats 

      Vikøren, Linn Anja Slåke; Drotningsvik, Aslaug; Mjøs, Svein Are; Mellgren, Gunnar; Gudbrandsen, Oddrun Anita (Peer reviewed; Journal article, 2018-10-08)
      The triacylglycerol lowering effect of fatty fish and fish oils is well recognized, however we recently showed that salmon intake resulted in higher serum triacylglycerol concentration in obese Zucker fa/fa rats. Since ...
    • Serum Acylcarnitines and Risk of Cardiovascular Death and Acute Myocardial Infarction in Patients With Stable Angina Pectoris 

      Strand, Elin; Pedersen, Eva Ringdal; Svingen, Gard Frodahl Tveitevåg; Olsen, Thomas; Bjørndal, Bodil; Karlsson, Therese; Dierkes, Jutta; Njølstad, Pål Rasmus; Mellgren, Gunnar; Tell, Grethe S.; Berge, Rolf Kristian; Svardal, Asbjørn M.; Nygård, Ottar (Peer reviewed; Journal article, 2017-02)
      Background: Excess levels of serum acylcarnitines, which are intermediate products in metabolism, have been observed in metabolic diseases such as type 2 diabetes mellitus. However, it is not known whether acylcarnitines ...