• Interferon gamma (IFN-γ)-mediated inflammation and the kynurenine pathway in relation to risk of hip fractures: The Hordaland Health Study 

      Apalset, Ellen M.; Gjesdal, Clara Gram; Ueland, Per Magne; Øyen, Jannike; Meyer, Klaus; Midttun, Øivind; Eide, Geir Egil; Tell, Grethe Seppola (Peer reviewed; Journal article, 2014-05-10)
      Summary The cytokine interferon gamma (IFN-γ) stimulates neopterin release and tryptophan degradation into kynurenines through the kynurenine pathway. High levels of neopterin were associated with increased hip fracture ...
    • Interferon-γ–induced inflammatory markers and the risk of cancer: The Hordaland Health Study 

      Zuo, Hui; Tell, Grethe Seppola; Vollset, Stein Emil; Ueland, Per Magne; Nygård, Ottar; Midttun, Øivind; Meyer, Klaus; Ulvik, Arve; Eussen, Simone (Peer reviewed; Journal article, 2014-06-19)
      Background It has been reported that interferon-γ (IFN-γ)–induced inflammatory markers, such as circulating neopterin and kynurenine-to-tryptophan ratio (KTR), are increased in patients with cancer and are also a predictor ...
    • Kynurenines, Neuropsychiatric Symptoms, and Cognitive Prognosis in Patients with Mild Dementia 

      Solvang, Stein-Erik Hafstad; Nordrehaug, Jan Erik; Aarsland, Dag; Lange, Johannes; Ueland, Per Magne; McCann, Adrian; Midttun, Øivind; Tell, Grethe S.; Melvær, Giil Lasse (Journal article; Peer reviewed, 2019)
      Introduction: Circulating tryptophan (Trp) and its downstream metabolites, the kynurenines, are potentially neuroactive. Consequently, they could be associated with neuropsychiatric symptoms and cognitive prognosis in ...
    • Lipid parameters and vitamin A modify cardiovascular risk prediction by plasma neopterin 

      Dhar, Indu; Siddique, Sumia; Pedersen, Eva Kristine Ringdal; Svingen, Gard FT; Lysne, Vegard; Olsen, Thomas; Nilsen, Dennis W.T.; Nordrehaug, Jan Erik; Midttun, Øivind; Ueland, Per Magne; Tell, Grethe S; Nygård, Ottar (Journal article; Peer reviewed, 2020)
      Objectives Oxidised cholesterol metabolites are linked to increased production of the active vitamin A (Vit-A) form and monocyte/macrophage activation, which may be reflected by neopterin, a marker of both interferon-γ–mediated ...
    • Markers of vitamin B6 status and metabolism as predictors of incident cancer: The Hordaland Health Study. 

      Zuo, Hui; Ueland, Per Magne; Eussen, Simone; Tell, Grethe Seppola; Vollset, Stein Emil; Nygård, Ottar; Midttun, Øivind; Meyer, Klaus; Ulvik, Arve (Peer reviewed; Journal article, 2014-11-26)
      Dietary intake and/or circulating concentrations of vitamin B6 have been associated with risk of cancer, but results are inconsistent and mechanisms uncertain. Pyridoxal 5'-phosphate (PLP) is the most commonly used marker ...
    • Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns 

      Joubert, Bonnie R; Den Dekker, Herman T; Felix, Janine F; Bohlin, Jon; Ligthart, Symen; Beckett, Emma; Tiemeier, Henning; van Meurs, Joyce B; Uitterlinden, Andre G; Hofman, Albert; Håberg, Siri Eldevik; Reese, Sarah E; Peters, Marjolein J; Kulle Andreassen, Bettina; Steegers, Eric A P; Nilsen, Roy Miodini; Vollset, Stein Emil; Midttun, Øivind; Ueland, Per Magne; Franco, Oscar H; Dehghan, Abbas; De Jongste, Johan C; Wu, Michael C; Wang, Tianyuan; Peddada, Shyamal D; Jaddoe, Vincent W V; Nystad, Wenche; Duijts, Liesbeth; London, Stephanie J (Peer reviewed; Journal article, 2016-02-10)
      Folate is vital for fetal development. Periconceptional folic acid supplementation and food fortification are recommended to prevent neural tube defects. Mechanisms whereby periconceptional folate influences normal development ...
    • Motor development related to duration of exclusive breastfeeding, B vitamin status and B12 supplementation in infants with a birth weight between 2000-3000 g, results from a randomized intervention trial 

      Torsvik, Ingrid Kristin; Ueland, Per Magne; Markestad, Trond; Midttun, Øivind; Monsen, Anne-Lise Bjørke (Peer reviewed; Journal article, 2015-12-18)
      Background: Exclusive breastfeeding for 6 months is assumed to ensure adequate micronutrients for term infants. Our objective was to investigate the effects of prolonged breastfeeding on B vitamin status and neurodevelopment ...
    • Neopterin as an effect modifier of the cardiovascular risk predicted by total homocysteine: A prospective 2-cohort study 

      Bjørnestad, Espen Øglænd; Borsholm, Robert Andre; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Seifert, Reinhard; Midttun, Øivind; Ueland, Per Magne; Tell, Grethe S.; Bønaa, Kaare Harald; Nygård, Ottar (Peer reviewed; Journal article, 2017-10)
      Background: Plasma total homocysteine (tHcy) is related to plasma neopterin, an indicator of interferon‐γ‐mediated immune activation, and both biomarkers positively predict cardiovascular risk. We examined whether the ...
    • The PAr index, an indicator reflecting altered vitamin B-6 homeostasis, is associated with long-term risk of stroke in the general population: the Hordaland Health Study (HUSK) 

      Zuo, Hui; Tell, Grethe S.; Ueland, Per Magne; Nygård, Ottar; Vollset, Stein Emil; Midttun, Øivind; Meyer, Klaus; Ulvik, Arve (Peer reviewed; Journal article, 2018-01)
      Background: Vitamin B-6 homeostasis is altered during inflammation and immune activation. It is unknown whether altered vitamin B-6 homeostasis is associated with the risk of stroke. Objective: We investigated the relation ...
    • Parental smoking and risk of childhood-onset type 1 diabetes 

      Magnus, Maria Christine; Tapia, German; Olsen, Sjurdur Frodi; Granström, Charlotta; Mårild, Karl Staffan; Ueland, Per Magne; Midttun, Øivind; Svensson, Jannet; Johannesen, Jesper; Skrivarhaug, Torild; Joner, Geir; Njølstad, Pål Rasmus; Størdal, Ketil; Stene, Lars Christian Mørch (Peer reviewed; Journal article, 2018-11)
      Background: A few prospective studies suggest an association between maternal smoking during pregnancy and lower risk of type 1 diabetes. However, the role of unmeasured confounding and misclassification remains unclear. ...
    • Peroxisome Proliferator-Activated Receptor Activation is Associated with Altered Plasma One-Carbon Metabolites and B-Vitamin Status in Rats 

      Lysne, Vegard; Strand, Elin; Svingen, Gard Frodahl Tveitevåg; Bjørndal, Bodil; Pedersen, Eva Ringdal; Midttun, Øivind; Olsen, Thomas; Ueland, Per Magne; Berge, Rolf Kristian; Nygård, Ottar (Peer reviewed; Journal article, 2016-01-05)
      Plasma concentrations of metabolites along the choline oxidation pathway have been linked to increased risk of major lifestyle diseases, and peroxisome proliferator-activated receptors (PPARs) have been suggested to be ...
    • Plasma 25-hydroxyvitamin D and mortality in patients with suspected stable angina pectoris 

      Degerud, Eirik; Nygård, Ottar; De Vogel, Stefan; Hoff, Rune; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Nilsen, Dennis W.T.; Nordrehaug, Jan Erik; Midttun, Øivind; Ueland, Per Magne; Dierkes, Jutta (Peer reviewed; Journal article, 2018-03)
      Context and Objective: Vitamin D status may affect cardiovascular disease (CVD) development and survival. We studied the relationship between concentrations of the circulating biomarker 25-hydroxyvitamin D (25OHD) and ...
    • Plasma Biomarkers of Inflammation, the Kynurenine Pathway, and Risks of All-Cause, Cancer, and Cardiovascular Disease Mortality. The Hordaland Health Study 

      Zuo, Hui; Ueland, Per Magne; Ulvik, Arve; Eussen, Simone; Vollset, Stein Emil; Nygård, Ottar; Midttun, Øivind; Theofylaktopoulou, Despoina; Meyer, Klaus; Tell, Grethe Seppola (Peer reviewed; Journal article, 2016)
      We aimed to evaluate 10 biomarkers related to inflammation and the kynurenine pathway, including neopterin, kynurenine:tryptophan ratio, C-reactive protein, tryptophan, and 6 kynurenines, as potential predictors of all-cause ...
    • Prognostic impact of vitamin B6 metabolism in lung cancer 

      Galluzzi, Lorenzo; Vitale, Ilio; Senovilla, Laura; Olaussen, Ken André; Pinna, Guillaume; Eisenberg, Tobias; Goubar, Aïcha; Martins, Isabelle; Michels, Judith; Kratassiouk, Guerorgui; Carmona-Gutierrez, Didac; Scoazec, Marie; Vacchelli, Erika; Schlemmer, Frederic; Kepp, Oliver; Shen, Sheshi; Tailler, Maximilien; Niso-Santano, Mireia; Morselli, Eugenia; Criollo, Alfredo; Adjemian, Sandy; Jemaa, Mohamed; Chaba, Kariman; Pailleret, Claire; Michaud, Mickaël; Pietrocola, Federico; Tajeddine, Nicolas; Rouge, Thibault de La Motte; Araujo, Natalia; Morozova, Nadya; Robert, Thomas; Ripoche, Hugues; Commo, Frederic; Besse, Benjamin; Validire, Pierre; Fouret, Pierre; Robin, Angélique; Dorvault, Nicolas; Girard, Philippe; Gouy, Sébastien; Pautier, Patricia; Jägemann, Nora; Nickel, Ann-Christin; Marsili, Sabrina; Paccard, Caroline; Servant, Nicolas; Hupé, Philippe; Behrens, Carmen; Behnam-Motlagh, Paviz; Kohno, Kimitoshi; Cremer, Isabelle; Damotte, Diane; Alifano, Marco; Midttun, Øivind; Ueland, Per Magne; Lazar, Vladimir; Dessen, Philippe; Zischka, Hans; Chatelut, Etienne; Castedo, Maria; Madeo, Frank; Barillot, Emmanuel; Thomale, Jürgen; Wistuba, Ignacio Ivan; Sautes-Fridman, Catherine; Zitvogel, Laurence; Soria, Jean-Charles; Harel-Bellan, Annick; Kroemer, Guido (Peer reviewed; Journal article, 2012-08-30)
      Patients with non-small cell lung cancer (NSCLC) are routinely treated with cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we identified vitamin B6 metabolism as a central regulator of cisplatin ...
    • The risk association of plasma total homocysteine with acute myocardial infarction is modified by serum vitamin A 

      Olsen, Thomas; Vinknes, Kathrine; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Dhar, Indu; Tell, Grethe S.; Blomhoff, Rune; Ueland, Per Magne; Midttun, Øivind; Refsum, Helga; Nygård, Ottar (Peer reviewed; Journal article, 2018)
      Background. Plasma total homocysteine (tHcy) has been implicated in the development of cardiovascular disease, but the mechanisms remain unclear. Vitamin A (Vit-A) is involved in homocysteine metabolism and we therefore ...
    • Short-term treatment with a peroxisome proliferator-activated receptor α agonist influences plasma one-carbon metabolites and B-vitamin status in rats 

      Lysne, Vegard; Bjørndal, Bodil; Grinna, Mari Lausund; Midttun, Øivind; Ueland, Per Magne; Berge, Rolf Kristian; Dierkes, Jutta; Nygård, Ottar; Strand, Elin (Peer reviewed; Journal article, 2019-12-05)
      Introduction: Peroxisome proliferator-activated receptors (PPARs) have been suggested to be involved in the regulation of one-carbon metabolism. Previously we have reported effects on plasma concentrations of metabolites ...
    • Smoking and body fat mass in relation to bone mineral density and hip fracture: The Hordaland Health Study 

      Øyen, Jannike; Gjesdal, Clara Gram; Nygård, Ottar; Lie, Stein Atle; Meyer, Haakon; Apalset, Ellen M.; Ueland, Per Magne; Pedersen, Eva Kristine Ringdal; Midttun, Øivind; Vollset, Stein Emil; Tell, Grethe Seppola (Peer reviewed; Journal article, 2014-03-25)
      Lower bone mineral density (BMD) in smokers may be attributable to lower body weight or fat mass, rather than to a direct effect of smoking. We analyzed the effects of smoking exposure, assessed by plasma cotinine, and ...
    • Smoking, plasma cotinine and risk of atrial fibrillation: the Hordaland Health Study 

      Zuo, Hui; Nygård, Ottar; Vollset, Stein Emil; Ueland, Per Magne; Ulvik, Arve; Midttun, Øivind; Meyer, Klaus; Igland, Jannicke; Sulo, Gerhard; Tell, Grethe S. (Peer reviewed; Journal article, 2018-01)
      Background: Cigarette smoking has been identified as a major modifiable risk factor for coronary heart disease and mortality. However, findings on the relationship between smoking and atrial fibrillation (AF) have been ...
    • Tryptophan catabolites as metabolic markers of vitamin B-6 status evaluated in cohorts of healthy adults and cardiovascular patients 

      Ulvik, Arve; Midttun, Øivind; McCann, Adrian; Meyer, Klaus; Tell, Grethe S.; Nygård, Ottar; Ueland, Per Magne (Journal article; Peer reviewed, 2020)
      Background Vitamin B-6 status is routinely measured as pyridoxal 5′-phosphate (PLP) in plasma. Low concentrations of PLP are associated with rheumatic, cardiovascular, and neoplastic diseases. We have previously shown ...
    • Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial 

      Borowczyk, Kamila; Piechocka, Justyna; Głowacki, Rafał; Dhar, Indu; Midttun, Øivind; Tell, Grethe S.; Ueland, Per Magne; Nygård, Ottar; Jakubowski, Hieronim (Peer reviewed; Journal article, 2018)
      Objectives: No individual homocysteine (Hcy) metabolite has been studied as a risk marker for coronary artery disease (CAD). Our objective was to examine Hcy‐thiolactone, a chemically reactive metabolite generated by ...