• Experimental infection of healthy volunteers with enterotoxigenic Escherichia coli wild-type strain TW10598 in a hospital ward 

      Skrede, Steinar; Steinsland, Hans; Sommerfelt, Halvor; Aase, Audun; Brandtzaeg, Per; Langeland, Nina; Cox, Rebecca Jane; Sævik, Marianne; Wallevik, Marita; Skutlaberg, Dag Harald; Tellevik, Marit Gjerde; Sack, David A.; Nataro, James P.; Guttormsen, Anne Berit (Peer reviewed; Journal article, 2014-09-04)
      Background: Enterotoxigenic Escherichia coli (ETEC) is an important cause of childhood diarrhea in resource-limited regions. It is also an important cause of diarrhea in travellers to these areas. To evaluate the protective ...
    • Experimental Infection of Human Volunteers with the Heat-Stable Enterotoxin-Producing Enterotoxigenic Escherichia coli Strain TW11681 

      Sakkestad, Sunniva Todnem; Steinsland, Hans; Skrede, Steinar; Kleppa, Elisabeth; Lillebø, Kristine; Sævik, Marianne; Søyland, Hanne; Heien, Astrid Rykkje; Tellevik, Marit Gjerde; Barry, Eileen M.; Sommerfelt, Halvor; Hanevik, Kurt (Peer reviewed; Journal article, 2019-06-22)
      Infection with enterotoxigenic Escherichia coli (ETEC) producing the heat-stable enterotoxin (ST) is one of the most important causes of childhood diarrhoea in low- and middle-income countries. Here, we undertook a controlled ...
    • Global research priorities on COVID-19 for maternal, newborn, child and adolescent health 

      Ahmed, Nawshad Uddin; Maamri, Abdellatif; Falade, Adegoke G; Ayede, Adejumoke Idowu; Bhutta, Adnan; Gambhir, Ajay; Tagarro, Alfredo; Abdelmegeid, Ali; Ahmadi, Ali Reza; Barros, Aluísio J D; Mekasha, Amha; Srinivasaiyer, Anantha Kumar; da Silva, André Ricardo Araujo; Schultz, Andreas; Fatima, Batool; Dhar, Bishnupada; Magowan, Brian; Wills, Bridget; Raynes-Greenow, Camille; Homer, Caroline S.E.; Maclennan, Carolyn; Ward, Catherine L; Garcia, Daniel Martinez; Ross, David; Murdoch, David; Wilson, Deborah Joy; Adejuyigbe, Ebunoluwa A.; Stasii, Ecaterina; Scudde, Elaine; Sacks, Emma; McCollum, Eric D.; Althabe, Fernando; Russell, Fiona; Kumar, GS; Sommerfelt, Halvor; Graham, Hamish; Blencowe, Hannah; Tappis, Hannah; Saloojee, Haroon; Masaud, Hesham Abdussalam Ben; Tiwary, Hiresh; Asiodu, Ifeyinwa; Newton, James B; Bourdaire, Jessica; Adze, Joel Amwe; Martines, Jose Carlos; Lozano, Juan M; Walson, Judd; Bahl, Rajiv; Shamszai, Zainularab Zohra; Navabi, Zohreh Sadat (Journal article; Peer reviewed, 2021)
      Background This research prioritization aimed to identify major research gaps in maternal, newborn, child and adolescent health (MNCAH) to help mitigate the direct and indirect effects of the COVID-19 pandemic. Methods We ...
    • Growth effects of exclusive breastfeeding promotion by peer counsellors in sub-Saharan Africa: the cluster-randomised PROMISE EBF trial 

      Engebretsen, Ingunn Marie S.; Jackson, Debra; Fadnes, Lars Thore; Nankabirwa, Victoria; Diallo, Abdoulaye Hama; Doherty, Tanya Mark; Lombard, Carl; Swanevelder, Sonja; Nankunda, Jolly; Ramokolo, Vundli; Sanders, David; Wamani, Henry; Meda, Nicolas; Tumwine, James K.; Ekström, Eva-Charlotte; Van de Perre, Philippe; Kankasa, Chipepo; Sommerfelt, Halvor; Tylleskär, Thorkild; on behalf of the PROMISE EBF-study group (Peer reviewed; Journal article, 2014-06-21)
      Background: In this multi-country cluster-randomized behavioural intervention trial promoting exclusive breastfeeding (EBF) in Africa, we compared growth of infants up to 6 months of age living in communities where peer ...
    • Health equity impact of community-initiated kangaroo mother care: a randomized controlled trial 

      Choudhary, Tarun Shankar; Mazumder, Sarmila; Haaland, Øystein Ariansen; Taneja, Sunita; Bahl, Rajiv; Martines, Jose Carlos; Bhan, Maharaj Kishan; Johansson, Kjell Arne; Sommerfelt, Halvor; Bhandari, Nita; Norheim, Ole Frithjof (Journal article; Peer reviewed, 2021)
      Background: Kangaroo mother care (KMC) can substantially enhance overall survival of low birthweight babies. In a large randomized controlled trial, we recently showed that supporting mothers to provide community initiated ...
    • The high burden of infant deaths in rural Burkina Faso: a prospective community-based cohort study 

      Diallo, Abdoulaye Hama; Meda, Nicolas; Sommerfelt, Halvor; Traore, Germain S.; Cousens, Simon; Tylleskär, Thorkild (Peer reviewed; Journal article, 2012-09-05)
      Background: Infant mortality rates (IMR) remain high in many sub-Saharan African countries, especially in rural settings where access to health services may be limited. Studies in such communities can provide relevant data ...
    • Impact of community-initiated Kangaroo Mother Care on survival of low birth weight infants: Study protocol for a randomized controlled trial 

      Mazumder, Sarmila; Taneja, Sunita; Dalpath, Suresh Kumar; Gupta, Rakesh; Dube, Brinda; Sinha, Bireshwar; Bhatia, Kiran; Yoshida, Sachiyo; Norheim, Ole Frithjof; Bahl, Rajiv; Sommerfelt, Halvor; Bhandari, Nita; Martines, Jose Carlos (Peer reviewed; Journal article, 2017-06-07)
      Background: Around 70% neonatal deaths occur in low birth weight (LBW) babies. Globally, 15% of babies are born with LBW. Kangaroo Mother Care (KMC) appears to be an effective way to reduce mortality and morbidity among ...
    • The incidence, aetiology, and adverse clinical consequences of less severe diarrhoeal episodes among infants and children residing in low-income and middle-income countries: a 12-month case-control study as a follow-on to the Global Enteric Multicenter Study (GEMS) 

      Kotloff, Karen L.; Nasrin, Dilruba; Blackwelder, William C.; Wu, Yukun; Farag, Tamer H.; Panchalingham, Sandra; Sow, Samba O.; Sur, Dipika; Zaidi, Anita K.M.; Faruque, Abu Syed Golam; Saha, Debasish; Alonso, Pedro L.; Tamboura, Boubou; Sanogo, Doh; Onwuchekwa, Uma; Manna, Byomkesh; Ramamurthy, Thandavarayan; Kanungo, Suman; Ahmed, Shahnawaz; Qureshi, Shahida; Quadri, Farheen; Hossain, Anowar; Das, Sumon K.; Antonio, Martin; Hossain, Mohammad Jahangir; Mandomando, Inacio; Acácio, Sozinho; Biswas, Kousick; Tennant, Sharon M.; Verweij, Jaco J.; Sommerfelt, Halvor; Nataro, James Paul; Robins-Browne, Roy M.; Levine, Myron M. (Peer reviewed; Journal article, 2019-05)
      Background Diarrheal diseases remain a leading cause of illness and death among children younger than 5 years in low-income and middle-income countries. The Global Enteric Multicenter Study (GEMS) has described the incidence, ...
    • Is vaccination coverage a good indicator of age-appropriate vaccination? A prospective study from Uganda 

      Fadnes, Lars Thore; Nankabirwa, Victoria; Sommerfelt, Halvor; Tylleskär, Thorkild; Tumwine, James K.; Engebretsen, Ingunn Marie S. (Peer reviewed; Journal article, 2011-04-27)
      Background: Timely vaccination is important to protect children from common infectious diseases. We assessed vaccination timeliness and vaccination coverage as well as coverage of vitamin A supplementation in a Ugandan ...
    • Malaria Parasitaemia among Infants and Its Association with Breastfeeding Peer Counselling and Vitamin A Supplementation: A Secondary Analysis of a Cluster Randomized Trial 

      Nankabirwa, Victoria; Tylleskär, Thorkild; Nankunda, Jolly; Engebretsen, Ingunn Marie S.; Sommerfelt, Halvor; Tumwine, James K. (Peer reviewed; Journal article, 2011-07-07)
      Background: Malaria is the second highest contributor to the disease burden in Africa and there is a need to identify low cost prevention strategies. The objectives of this study were to estimate the prevalence of malaria ...
    • Maternal education is associated with vaccination status of infants less than 6 months in Eastern Uganda: a cohort study 

      Nankabirwa, Victoria; Tylleskär, Thorkild; Tumwine, James K.; Sommerfelt, Halvor; PROMISE-EBF Study group (Peer reviewed; Journal article, 2010-12-15)
      Background: Despite provision of free childhood vaccinations, less than half of all Ugandan infants are fully vaccinated. This study compares women with some secondary schooling to those with only primary schooling with ...
    • Microbiota that affect risk for shigellosis in children in low-income countries 

      Lindsay, Brianna; Oundo, Joseph O.; Hossain, Mohammad Anowar; Antonio, Martin; Tamboura, Boubou; Walker, Alan W.; Paulson, Joseph N.; Parkhill, Julian; Omore, Richard; Faruque, Abu Syed Golam; Das, Suman Kumar; Ikumapayi, Usman Nurudeen; Adeyemi, Mitchell; Sanogo, Doh; Saha, Debasish; Sow, Samba O.; Farag, Tamer H.; Nasrin, Dilruba; Li, Shan; Panchalingam, Sandra; Levine, Myron M.; Kotloff, Karen; Magder, Laurence S.; Hungerford, Laura L.; Sommerfelt, Halvor; Pop, Mihai; Nataro, James Paul; Stine, Oscar Colin (Peer reviewed; Journal article, 2015)
      Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia ...
    • Neonatal sepsis at Mulago national referral hospital in Uganda: Etiology, antimicrobial resistance, associated factors and case fatality risk 

      Tumuhamye, Josephine; Sommerfelt, Halvor; Bwanga, Freddie; Ndeezi, Grace; Mukunya, David; Napyo, Agnes; Nankabirwa, Victoria; Tumwine, James K (Journal article; Peer reviewed, 2020)
      Background Sepsis is the third most common cause of death among neonates, with about 225,000 newborns dying every year globally. Data concerning the microbial etiology of neonatal sepsis and antimicrobial resistance ...
    • A New Human Challenge Model for Testing Heat-Stable Toxin-Based Vaccine Candidates for Enterotoxigenic Escherichia Coli Diarrhea - Dose Optimization, Clinical Outcomes, and CD4+ T Cell Responses 

      Sakkestad, Sunniva Todnem; Steinsland, Hans; Skrede, Steinar; Lillebø, Kristine; Skutlaberg, Dag Harald; Guttormsen, Anne Berit; Zavialov, Anton; Paavilainen, Sari; Søyland, Hanne; Sævik, Marianne; Rykkje Heien, Astrid; Gjerde Tellevik, Marit; Barry, Eileen; Langeland, Nina; Sommerfelt, Halvor; Hanevik, Kurt (Peer reviewed; Journal article, 2019-10-30)
      Enterotoxigenic Escherichia coli (ETEC) are a common cause of diarrheal illness in young children and travelers. There is yet no licensed broadly protective vaccine against ETEC. One promising vaccine development strategy ...
    • Pathogens Associated With Linear Growth Faltering in Children With Diarrhea and Impact of Antibiotic Treatment: The Global Enteric Multicenter Study 

      Nasrin, Dilruba; Blackwelder, William C.; Sommerfelt, Halvor; Wu, Yukun; Farag, Tamer H.; Panchalingam, Sandra; Biswas, Kousick; Saha, Debasish; Jahangir Hossain, Hossain; Sow, Samba O.; Reiman, Robert F B; Sur, Dipika; Faruque, Abu Syed Golam; Zaidi, Anita K M; Sanogo, Doh; Tamboura, Boubou; Onwuchekwa, Uma; Manna, Byomkesh; Ramamurthy, Thandavarayan; Kanungo, Suman; Omore, Richard; Ochieng, John B.; Oundo, Joseph O.; Das, Sumon K.; Ahmed, Shahnawaz; Qureshi, Shahida; Quadri, Farheen; Adegbola, Richard A.; Antonio, Martin; Mandomando, Inacio; Nhampossa, Tacilta; Bassat, Quique; Roose, Anna; O'Reilly, Ciara E.; Mintz, Eric D.; Ramakrishnan, Usha; Powell, Helen; Liang, Yuanyuan; Nataro, James Paul; Levine, Myron M.; Kotloff, Karen L. (Journal article; Peer reviewed, 2021)
      Background The association between childhood diarrheal disease and linear growth faltering in developing countries is well described. However, the impact attributed to specific pathogens has not been elucidated, nor has ...
    • Perinatal Mortality in Eastern Uganda: A Community Based Prospective Cohort Study 

      Nankabirwa, Victoria; Tumwine, James K.; Tylleskär, Thorkild; Nankunda, Jolly; Sommerfelt, Halvor (Peer reviewed; Journal article, 2011-05-09)
      Background: To achieve a child mortality reduction according to millennium development goal 4, it is necessary to considerably reduce neonatal mortality. We report stillbirth and early neonatal mortality risks as well as ...
    • Perinatal mortality in rural Burkina Faso: a prospective community-based cohort study 

      Diallo, Abdoulaye Hama; Meda, Nicolas; Zabsonré, Emmanuel; Sommerfelt, Halvor; Cousens, Simon; Tylleskär, Thorkild (Peer reviewed; Journal article, 2010-08-17)
      Background: There is a scarcity of reliable data on perinatal mortality (PNM) in Sub-Saharan Africa. The PROMISEEBF trial, during which we promoted exclusive breastfeeding, gave us the opportunity to describe the epidemiology ...
    • Predictors of Duration and Treatment Failure of Severe Pneumonia in Hospitalized Young Nepalese Children 

      Basnet, Sudha; Sharma, Arun; Mathisen, Maria; Shrestha, Prakash Sunder; Ghimire, Ram Kumar; Shrestha, Dhiraj Man; Valentiner-Branth, Palle; Sommerfelt, Halvor; Strand, Tor A. (Peer reviewed; Journal article, 2015-03-23)
      Background. Pneumonia in young children is still the most frequent cause of death in developing countries. We aimed to identify predictors for recovery and treatment failure in children hospitalized with severe pneumonia. ...
    • Predictors of time to recovery in infants with probable serious bacterial infection 

      Singh, Prashant; Wadhwa, Nitya; Lodha, Rakesh; Sommerfelt, Halvor; Aneja, Satinder; Natchu, Uma Chandra Mouli; Chandra, Jagdish; Rath, Bimbadhar; Sharma, Vinod Kumar; Kumari, Mohini; Saini, Saviti; Kabra, Sushil K.; Bhatnagar, Shinjini; Strand, Tor A. (Peer reviewed; Journal article, 2015-04-24)
      Introduction: Serious bacterial infections continue to be an important cause of death and illness among infants in developing countries. Time to recovery could be considered a surrogate marker of severity of the infection. ...
    • Prevalence of iron deficiency and anemia among young children with acute diarrhea in Bhaktapur, Nepal 

      Chandyo, Ram Krishna; Ulak, Manjeswori; Adhikari, Ramesh K.; Sommerfelt, Halvor; Strand, Tor A. (Peer reviewed; Journal article, 2015-07-21)
      Iron deficiency anemia is still common in children under five years of age and may impair their growth and cognitive development. Diarrhea is the second most common reason for seeking medical care for young children in ...