Browsing Bergen Open Research Archive by Author "Sorbye, Halfdan"
Now showing items 21-32 of 32
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Peptide receptor radionuclide therapy in gastroenteropancreatic NEN G3: A multicenter cohort study
Carlsen, Esben Andreas; Fazio, Nicola; Granberg, Dan; Grozinsky-Glasberg, Simona; Ahmadzadehfar, Hojjat; Grana, Chiara Maria; Zandee, Wouter T.; Cwikla, Jaroslaw; Walter, Martin A.; Oturai, Peter Sandor; Rinke, Anja; Weaver, Andrew; Frilling, Andrea; Gritti, Sara; Arveschoug, Anne Kirstine; Meirovitz, Amichay; Knigge, Ulrich; Sorbye, Halfdan (Peer reviewed; Journal article, 2019)Peptide receptor radionuclide therapy (PRRT) is an established treatment of metastatic neuroendocrine tumors grade 1–2 (G1–G2). However, its possible benefit in high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms ... -
Phase II study of everolimus and temozolomide as first-line treatment in metastatic high-grade gastroenteropancreatic neuroendocrine neoplasms
Morken, Siren; Langer, Seppo W.; Sundlöv, Anna; Vestermark, Lene Weber; Ladekarl, Morten; Hjortland, Geir Olav; Svensson, Johanna B.; Tabaksblat, Elizaveta Mitkina; Haslerud, Torjan Magne; Assmus, Jörg; Detlefsen, Sönke; Couvelard, Anne; Perren, Aurel; Sorbye, Halfdan (Journal article; Peer reviewed, 2023)Background The optimal treatment for metastatic high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms when Ki-67 ≤55% is unknown. A prospective multi-centre phase 2 study was performed to evaluate the efficacy ... -
Plasma protein biomarkers for the detection of pancreatic neuroendocrine tumors and differentiation from small intestinal neuroendocrine tumors
Thiis-Evensen, Espen; Kjellman, Magnus; Knigge, Ulrich; Gronbaek, Henning; Schalin-Jäntti, Camilla; Welin, Staffan; Sorbye, Halfdan; del Pilar Schneider, Maria; Belusa, Roger (Journal article; Peer reviewed, 2022)There is an unmet need for novel biomarkers to diagnose and monitor patients with neuroendocrine neoplasms. The EXPLAIN study explores a multi-plasma protein and supervised machine learning strategy to improve the diagnosis ... -
Predictive factors for time to recurrence, treatment and post-recurrence survival in patients with initially resected colorectal liver metastases
Angelsen, Jon-Helge; Viste, Asgaut; Løes, Inger Marie; Eide, Geir Egil; Hoem, Dag; Sorbye, Halfdan; Horn, Arild (Peer reviewed; Journal article, 2015-12-03)Background: Despite progress in resection for colorectal liver metastases (CLM), the majority of patients experience recurrence. We aimed to evaluate factors influencing time to recurrence (TTR), treatment and post-recurrence ... -
Prognostic value of baseline functional status measures and geriatric screening in vulnerable older patients with metastatic colorectal cancer receiving palliative chemotherapy – The randomized NORDIC9-study
Liposits, Gabor Isivan; Ryg, Jesper; Skuladottir, Halla; Winther, Stine B.; Möller, Sören; Hofsli, Eva; Shah, Carl-Henrik; Poulsen, Laurids Østergaard; Berglund, Åke; Qvortrup, Camilla; Osterlund, Pia; Glimelius, Bengt; Sorbye, Halfdan; Pfeiffer, Per (Journal article; Peer reviewed, 2023)Introduction Appropriate patient selection based on functional status is crucial when considering older adults for palliative chemotherapy. This pre-planned analysis of the randomized NORDIC9-study explored the prognostic ... -
The prognostic value of pre-treatment circulating biomarkers of systemic inflammation (CRP, dNLR, YKL-40, and IL-6) in vulnerable older patients with metastatic colorectal cancer receiving palliative chemotherapy—The Randomized NORDIC9-Study
Liposits, Gabor; Skuladottir, Halla; Ryg, Jesper; Winther, Stine Brændegaard; Möller, Sören; Hofsli, Eva; Shah, Carl-Henrik; Poulsen, Laurids Østergaard; Berglund, Åke; Qvortrup, Camilla; Osterlund, Pia; Johansen, Julia S.; Glimelius, Bengt; Sorbye, Halfdan; Pfeiffer, Per (Journal article; Peer reviewed, 2022)Appropriate patient selection for palliative chemotherapy is crucial in patients with metastatic colorectal cancer (mCRC). We investigated the prognostic value of C-reactive protein (CRP), derived neutrophil-to-lymphocyte ... -
Quality of Life in Vulnerable Older Patients with Metastatic Colorectal Cancer Receiving Palliative Chemotherapy—The Randomized NORDIC9-Study
Liposits, Gabor; Eshoj, Henrik; Möller, Sören; Winther, Stine Brændegaard; Skuladottir, Halla; Ryg, Jesper; Hofsli, Eva; Shah, Carl-Henrik; Poulsen, Laurids Østergaard; Berglund, Åke; Qvortrup, Camilla; Österlund, Pia; Glimelius, Bengt; Sorbye, Halfdan; Pfeiffer, Per (Journal article; Peer reviewed, 2021)Bowel cancer is one of the leading cancer-types in both sexes worldwide. Despite that most new cases and deaths occur in people aged 70 years or older, few clinical trials have investigated the best way to administer ... -
Survival According to Primary Tumor Location, Stage, and Treatment Patterns in Locoregional Gastroenteropancreatic High-grade Neuroendocrine Carcinomas
Dasari, Arvind; Shen, Chan; Devabhaktuni, Anjali; Nighot, Ruda; Sorbye, Halfdan (Journal article; Peer reviewed, 2022)Background: Although the gastrointestinal tract (including the pancreas, gastroenteropancreatic (GEP) is the most common site for extrapulmonary neuroendocrine carcinoma (NEC), the current treatment patterns of locoregional ... -
Survival and costs of colorectal cancer treatment and effects of changing treatment strategies: a model approach
Joranger, Pål; Nesbakken, Arild; Sorbye, Halfdan; Hoff, Geir; Oshaug, Arne; Aas, Eline (Peer reviewed; Journal article, 2020)New and emerging advances in colorectal cancer (CRC) treatment combined with limited healthcare resources highlight the need for detailed decision-analytic models to evaluate costs, survival and quality-adjusted life years. ... -
Total circulating cell-free DNA as a prognostic biomarker in metastatic colorectal cancer before first-line oxaliplatin-based chemotherapy
Hamfjord, Julian; Guren, Tormod Kyrre; Dajani, Olav; Johansen, Julia Sidenius; Glimelius, Bengt; Sorbye, Halfdan; Pfeiffer, Per; Lingjærde, Ole Christian; Tveit, Magne Kjell; Kure, Elin Wenche Hegland; Pallisgaard, Niels; Spindler, Karen-Lise Garm (Peer reviewed; Journal article, 2019-05-02)Background: Metastatic colorectal cancer (mCRC) is a heterogeneous disease where prognosis is dependent both on tumor biology and host factors. Total circulating cell-free DNA (cfDNA) has shown to harbor prognostic information ... -
Treatment efficacy in a metastatic small intestinal neuroendocrine tumour grade 2 cohort
Papantoniou, Dimitrios; Grönberg, Malin; Thiis-Evensen, Espen; Sorbye, Halfdan; Landerholm, Kalle; Welin, Staffan; Janson, Eva Tiensuu (Journal article; Peer reviewed, 2023)Small intestinal neuroendocrine tumours (Si-NET) are often studied as a uniform group. Proliferation index Ki-67 influences prognosis and determines tumour grade. We hypothesized that Si-NET grade 2 (G2) tumours, which ... -
Volumetric parameters from [18F]FDG PET/CT predicts survival in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms
Langen Stokmo, Henning; Aly, Mahmoud; Lothe, Inger Marie Bowitz; Borja, Austin J.; Seraj, Siavash Mehdizadeh; Ghorpade, Rina; Miao, Xuan; Hjortland, Geir Olav; Malinen, Eirik; Sorbye, Halfdan; Werner, Thomas J.; Alavi, Abass; Rootwelt-Revheim, Mona Elisabeth (Journal article; Peer reviewed, 2022)A positive fluorine-18 labelled 2-deoxy-2-fluoroglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) has been associated with more aggressive disease and less differentiated neuroendocrine neoplasms ...