Blar i Bergen Open Research Archive på forfatter "Ulvik, Arve"
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Investigating novel biomarkers of immune activation and modulation in the context of sedentary behaviour: a multicentre prospective ischemic stroke cohort study
Alme, Katinka Nordheim; Askim, Torunn; Assmus, Jörg; Mollnes, Tom Eirik; Naik, Mala; Næss, Halvor; Saltvedt, Ingvild; Ueland, Per-Magne; Ulvik, Arve; Knapskog, Anne-Brita (Journal article; Peer reviewed, 2021)Background Sedentary behaviour is associated with disease, but the molecular mechanisms are not understood. Valid biomarkers with predictive and explanatory properties are required. Therefore, we have investigated traditional ... -
Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging
Solvang, Stein-Erik Hafstad; Hodge, Allison; Watne, Leiv; Cabral-Marques, Otavio; Nordrehaug, Jan Erik; Giles, Graham G.; Dugué, Pierre-Antoine; Nygård, Ottar Kjell; Ueland, Per Magne; McCann, Adrian; Idland, Ane-Victoria; Midttun, Øivind; Ulvik, Arve; Halaas, Nathalie Bodd; Tell, Grethe S.; Melvær, Giil Lasse (Journal article; Peer reviewed, 2022)The kynurenine pathway is implicated in aging, longevity, and immune regulation, but longitudinal studies and assessment of the cerebrospinal fluid (CSF) are lacking. We investigated tryptophan (Trp) and downstream kynurenine ... -
Markers of vitamin B6 status and metabolism as predictors of incident cancer: The Hordaland Health Study.
Zuo, Hui; Ueland, Per Magne; Eussen, Simone; Tell, Grethe Seppola; Vollset, Stein Emil; Nygård, Ottar; Midttun, Øivind; Meyer, Klaus; Ulvik, Arve (Peer reviewed; Journal article, 2014-11-26)Dietary intake and/or circulating concentrations of vitamin B6 have been associated with risk of cancer, but results are inconsistent and mechanisms uncertain. Pyridoxal 5'-phosphate (PLP) is the most commonly used marker ... -
Microheterogeneity and preanalytical stability of protein biomarkers of inflammation and renal function
Gao, Jie; Ulvik, Arve; McCann, Adrian; Ueland, Per Magne; Meyer, Klaus (Journal article; Peer reviewed, 2021)Protein biomarker microheterogeneity has attracted increasing attention in epidemiological and clinical research studies. Knowledge concerning the preanalytical stability of proteins is paramount to assess the biological ... -
Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of infammation measured three months after ischemic stroke
Alme, Katinka Nordheim; Ulvik, Arve; Askim, Torunn; Assmus, Jörg; Mollnes, Tom Eirik; Naik, Mala; Næss, Halvor; Saltvedt, Ingvild; Ueland, Per-Magne; Knapskog, Anne Brita (Journal article; Peer reviewed, 2021)Background Chronic low-grade inflammation is associated with both ischemic stroke and sedentary behaviour. The aim of this study was to investigate the predictive abilities of biomarkers of inflammation and immune modulation ... -
The Pah-R261Q mouse reveals oxidative stress associated with amyloid-like hepatic aggregation of mutant phenylalanine hydroxylase
Aubi Catevilla, Oscar; Prestegård, Karina Skjervheim; K C, Kunwar Jung; Shi, Tie-Jun; Ying, Ming; Grindheim, Ann Kari; Scherer, Tanja; Ulvik, Arve; McCann, Adrian; Spriet, Endy; Thöny, Beat; Martinez, Aurora (Journal article; Peer reviewed, 2021)Phenylketonuria (PKU) is caused by autosomal recessive variants in phenylalanine hydroxylase (PAH), leading to systemic accumulation of L-phenylalanine (L-Phe) that may reach neurotoxic levels. A homozygous Pah-R261Q mouse, ... -
The PAr index, an indicator reflecting altered vitamin B-6 homeostasis, is associated with long-term risk of stroke in the general population: the Hordaland Health Study (HUSK)
Zuo, Hui; Tell, Grethe S.; Ueland, Per Magne; Nygård, Ottar; Vollset, Stein Emil; Midttun, Øivind; Meyer, Klaus; Ulvik, Arve (Peer reviewed; Journal article, 2018-01)Background: Vitamin B-6 homeostasis is altered during inflammation and immune activation. It is unknown whether altered vitamin B-6 homeostasis is associated with the risk of stroke. Objective: We investigated the relation ... -
Physical activity and risk of all-cause mortality in patients with stable angina pectoris: Effect modification by β-blocker treatment
Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Ulvik, Arve; Bjørnestad, Espen Øglænd; Dankel, Simon N; Mellgren, Gunnar; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2022)Background Physical activity (PA) influences sympathetic stimulation, platelet activation as well as vascular function, and has been associated with improved health outcomes in patients with coronary heart disease. β-blocker ... -
Plasma Biomarkers of Inflammation, the Kynurenine Pathway, and Risks of All-Cause, Cancer, and Cardiovascular Disease Mortality. The Hordaland Health Study
Zuo, Hui; Ueland, Per Magne; Ulvik, Arve; Eussen, Simone; Vollset, Stein Emil; Nygård, Ottar; Midttun, Øivind; Theofylaktopoulou, Despoina; Meyer, Klaus; Tell, Grethe Seppola (Peer reviewed; Journal article, 2016)We aimed to evaluate 10 biomarkers related to inflammation and the kynurenine pathway, including neopterin, kynurenine:tryptophan ratio, C-reactive protein, tryptophan, and 6 kynurenines, as potential predictors of all-cause ... -
Plasma concentrations and dietary intakes of choline and betaine in association with atrial fibrillation risk: Results from 3 prospective cohorts with different health profiles
Zuo, Hui; Svingen, Gard Frodahl Tveitevåg; Tell, Grethe S.; Ueland, Per Magne; Vollset, Stein Emil; Pedersen, Eva Ringdal; Ulvik, Arve; Meyer, Klaus; Nordrehaug, Jan Erik; Nilsen, Dennis W.T.; Bønaa, Kaare; Nygård, Ottar (Peer reviewed; Journal article, 2018)Background: Although choline metabolism has been associated with atherosclerotic heart disease, less research attention has been paid to the associations of choline and its oxidative metabolite betaine with cardiac ... -
Plasma methionine, choline, betaine, and dimethylglycine in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Nitter, Mathilde Hjelle; Norgård, Benedicte Wentzel; De Vogel, Stefan; Eussen, Simone; Meyer, Klaus; Ulvik, Arve; Ueland, Per Magne; Nygård, Ottar; Vollset, Stein Emil; Bjørge, Tone; Tjønneland, Anne; Hansen, Louise; Boutron-Ruault, Marie-Christine; Racine, Antoine; Cottet, Vanessa; Kaaks, Rudolf; Kühn, Tilman; Trichopoulou, Antonia; Bamia, Christina; Naska, Androniki; Grioni, Sara; Palli, Domenico; Panico, Salvatore; Tumino, Rosario; Vineis, Paolo; Bueno-de-Mesquita, H. Bas; Van Kranen, Henk J.; Peeters, Petra H. M.; Weiderpass, Elisabete; Dorronsoro, Miren; Jakszyn, Paula; Sánchez, María-José; Argüelles, Marcial Vicente; Huerta, José-Maria; Barricarte, Aurelio; Johansson, Matthias; Ljuslinder, Ingrid; Khaw, Kay Tee; Wareham, Nicholas J.; Freisling, Heinz; Duarte-Salles, Talita; Stepien, Magdalena; Gunter, Mark J.; Riboli, Élio B. (Peer reviewed; Journal article, 2014-08)Background Disturbances in one carbon metabolism may contribute to carcinogenesis by affecting methylation and synthesis of DNA. Choline and its oxidation product betaine are involved in this metabolism and can serve as ... -
Plasma methylmalonic acid predicts risk of acute myocardial infarction and mortality in patients with coronary heart disease: A prospective 2-cohort study
Dhar, Indu; Lysne, Vegard; Ulvik, Arve; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Kristine Ringdal; Bjørnestad, Espen Øglænd; Olsen, Thomas; Borsholm, Robert Andre; Laupsa-Borge, Johnny; Ueland, Per Magne; Tell, Grethe Seppola; Berge, Rolf Kristian; Mellgren, Gunnar; Bønaa, Kaare Harald; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2023)Background Elevated plasma methylmalonic acid (MMA) is reported in patients with established coronary heart disease (CHD) and is considered a marker of vitamin B12 deficiency. Moreover, MMA-dependent reactions have been ... -
Serum concentrations of amino acids and tryptophan metabolites are affected by consumption of a light breakfast: a clinical intervention study in adults with overweight or obesity
Hagen, Ingrid Valheim; Helland, Anita; Bratlie, Marianne; Midttun, Bjørn Øivind; McCann, Adrian; Ulvik, Arve; Mellgren, Gunnar; Ueland, Per Magne; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2023)Background Epidemiological studies often investigate amino acids and their metabolites as biomarkers, but do not always consistently use fasting or non-fasting blood samples, or may lack information on the prandial ... -
Serum concentrations of kynurenines in adult patients with attention-deficit hyperactivity disorder (ADHD): a case–control study
Hegvik, Tor-Arne; Ulvik, Arve; Halmøy, Anne; Haavik, Jan; Aarsland, Tore Ivar Malmei; Landaas, Elisabeth Toverud; Ueland, Per Magne (Peer reviewed; Journal article, 2015-11-05)Background: The essential amino acid tryptophan is catabolised mainly through the kynurenine pathway. Altered circulating levels of kynurenines have been reported in chronic inflammatory conditions and in several ... -
Smoking, plasma cotinine and risk of atrial fibrillation: the Hordaland Health Study
Zuo, Hui; Nygård, Ottar; Vollset, Stein Emil; Ueland, Per Magne; Ulvik, Arve; Midttun, Øivind; Meyer, Klaus; Igland, Jannicke; Sulo, Gerhard; Tell, Grethe S. (Peer reviewed; Journal article, 2018-01)Background: Cigarette smoking has been identified as a major modifiable risk factor for coronary heart disease and mortality. However, findings on the relationship between smoking and atrial fibrillation (AF) have been ... -
Systemic Activation of the Kynurenine Pathway in Graves Disease With and Without Ophthalmopathy
Ueland, Hans Olav; Ulvik, Arve; Løvås, Kristian; Wolff, Anette Susanne Bøe; Breivik, Lars Ertesvåg; Stokland, Ann-Elin Meling; Rødahl, Eyvind; Nilsen, Roy Miodini; Husebye, Eystein Sverre; Ueland, Grethe Åstrøm (Journal article; Peer reviewed, 2023)Context Graves disease (GD) is one of the most common autoimmune disorders. Recent literature has shown an immune response involving several different inflammatory related proteins in these patients. Objective This ... -
Tryptophan catabolites as metabolic markers of vitamin B-6 status evaluated in cohorts of healthy adults and cardiovascular patients
Ulvik, Arve; Midttun, Øivind; McCann, Adrian; Meyer, Klaus; Tell, Grethe S.; Nygård, Ottar; Ueland, Per Magne (Journal article; Peer reviewed, 2020)Background Vitamin B-6 status is routinely measured as pyridoxal 5′-phosphate (PLP) in plasma. Low concentrations of PLP are associated with rheumatic, cardiovascular, and neoplastic diseases. We have previously shown ... -
Vitamin B6 catabolism and lung cancer risk: Results from the Lung Cancer Cohort Consortium (LC3)
Zuo, Hui; Ueland, Per Magne; Midttun, Øivind; Tell, Grethe S.; Fanidi, Anouar; Zheng, Wei; Shu, Xiao-Ou; Xiang, Yong-Bing; Wu, Jie; Prentice, Ross L.; Pettinger, Mary; Thomson, Cynthia A.; Giles, Graham G.; Hodge, Allison M.; Cai, Qiuyin; Blot, William J.; Johansson, Mikael B.; Hultdin, Johan; Grankvist, Kjell; Stevens, Victoria L.; McCullough, Marjorie L.; Weinstein, Stephanie J.; Albanes, Demetrius; Ziegler, Regina G.; Freedman, Neal David; Caporaso, Neil E.; Langhammer, Arnulf; Hveem, Kristian; Næss, Marit; Buring, Julie E.; Lee, I-Min; Gaziano, John Michael; Severi, Gianluca; Zhang, Xuehong; Stampfer, Meir Jonathan; Han, Jiali; Zeleniuch-Jacquotte, Anne; Marchand, Loïc Le; Yuan, Jian-Min; Wang, Renwei; Koh, Woon-Puay; Gao, Yutang; Ericson, Ulrika C.; Visvanathan, Kala; Jones, Michael R.; Relton, Caroline Laura; Brennan, Paul J.; Johansson, Mattias; Ulvik, Arve (Journal article; Peer reviewed, 2019-03)Background Increased vitamin B6 catabolism related to inflammation, as measured by the PAr index (the ratio of 4-pyridoxic acid over the sum of pyridoxal and pyridoxal-5'-phosphate), has been positively associated with ...