Now showing items 21-30 of 30

    • Longitudinal effects of adjuvant chemotherapy and lymph node staging on patient-reported outcomes in endometrial cancer survivors: a prospective cohort study 

      Forsse, David Erik; Barbero, Mark L.; Werner, Henrica Maria Johanna; Woie, Kathrine; Nordskar, Nina Jebens; Berge Nilsen, Elisabeth; Ellstrøm Engh, Marie; Vistad, Ingvild; Rege, Astri; Sævik-Lode, Margaret; Andreasen, Stine; Haldorsen, Ingfrid S.; Trovik, Jone; Krakstad, Camilla (Journal article; Peer reviewed, 2021)
      Background: Most patients with endometrial cancer with localized disease are effectively treated and survive for a long time. The primary treatment is hysterectomy, to which surgical staging procedures may be added to ...
    • Maintained survival outcome after reducing lymphadenectomy rates and optimizing adjuvant treatment in endometrial cancer 

      Forsse, David Erik; Berg, Hege Fredriksen; Bozickovic, Olivera; Engerud, Hilde Renate; Halle, Mari Kyllesø; Høivik, Erling Andre; Woie, Kathrine; Werner, Henrica Maria Johanna; Haldorsen, Ingfrid S.; Trovik, Jone; Krakstad, Camilla (Journal article; Peer reviewed, 2020)
      Objective: Main controversies in endometrial cancer treatment include the role of lymphadenectomy and optimal adjuvant treatment. We assessed clinical outcome in a population-based endometrial cancer cohort in relation to ...
    • Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1 

      Cheng, Timothy H.T.; Thompson, Deborah; Painter, Jodie; Omara, Tracy; Gorman, Maggie; Martin, Lynn; Palles, Claire; Jones, Angela; Buchanan, Daniel D.; Ko Win, Aung; Hopper, John; Jenkins, Mark; Lindor, Noralane M.; Newcomb, Polly A.; Gallinger, Steve; Conti, David; Schumacher, Fred; Casey, Graham; Giles, Graham G.; Pharoah, Paul; Peto, Julian; Cox, Angela; Swerdlow, Anthony; Couch, Fergus; Cunningham, Julie M.; Goode, Ellen L.; Winham, Stacey J.; Lambrechts, Diether; Fasching, Peter; Burwinkel, Barbara; Brenner, Hermann; Brauch, Hiltrud; Chang-Claude, Jenny; Salvesen, Helga Birgitte; Kristensen, Vessela N.; Darabi, Hatef; Li, Jingmei; Liu, Tao; Lindblom, Annika; Hall, Per; De Polanco, Magdalena Echeverry; Sans, Monica; Carracedo, Angel; Castellvi-Bel, Sergi; Rojas-Martinez, Augusto; Aguiar Jnr, Samuel; Teixeira, Manuel R.; Dunning, Alison M.; Dennis, Joe; Otton, Geoffrey; Proietto, Tony; Holliday, Elizabeth; Attia, John; Ashton, Katie; Scott, Rodney J.; McEvoy, Mark; Dowdy, Sean C.; Fridley, Brooke L.; Werner, Henrica Maria Johanna; Trovik, Jone; Njølstad, Tormund Salvesen; Tham, Emma; Mints, Miriam; Runnebaum, Ingo; Hillemanns, Peter; Dörk, Thilo; Amant, Frederic; Schrauwen, Stefanie; Hein, Alexander; Beckmann, Matthias W.; Ekici, Arif; Czene, Kamila; Meindl, Alfons; Bolla, Manjeet K.; Michailidou, Kyriaki; Tyrer, Jonathan P.; Wang, Qin; Ahmed, Shahana; Healey, Catherine S.; Shah, Mitul; Annibali, Daniela; Depreeuw, Jeroen; Al-Tassan, Nada A.; Harris, Rebecca; Meyer, Brian F; Whiffin, Nicola; Hosking, Fay J.; Kinnersley, Ben; Farrington, Susan M; Timofeeva, Maria; Tenesa, Albert; Campbell, Harry; Haile, Robert W.; Hodgson, Shirley; Carvajal-Carmona, Luis; Cheadle, Jeremy P.; Easton, Douglas; Dunlop, Malcolm; Houlston, Richard; Spurdle, Amanda; Tomlinson, Ian (Peer reviewed; Journal article, 2015-12-01)
      High-risk mutations in several genes predispose to both colorectal cancer (CRC) and endometrial cancer (EC). We therefore hypothesised that some lower-risk genetic variants might also predispose to both CRC and EC. Using ...
    • PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer 

      Mjøs, Siv; Werner, Henrica Maria Johanna; Birkeland, Even; Holst, Frederik; Berg, Anna; Halle, Mari Kyllesø; Tangen, Ingvild Løberg; Kusonmano, Kanthida; Mauland, Karen Klepsland; Øyan, Anne Margrete; Kalland, Karl-Henning; Lewis, Aurelia Eva; Mills, Gordon B.; Krakstad, Camilla; Trovik, Jone; Salvesen, Helga; Høivik, Erling Andre (Peer reviewed; Journal article, 2017-08-31)
      Mutations of the phosphoinositide-3-kinase (PI3K) catalytic subunit alpha gene (PIK3CA) are frequent in endometrial cancer. We sequenced exon9 and exon20 of PIK3CA in 280 primary endometrial cancers to assess the relationship ...
    • Preoperative tumor size at MRI predicts deep myometrial invasion, lymph node metastases, and patient outcome in endometrial carcinomas 

      Ytre-Hauge, Sigmund; Husby, Jenny Hild Aase; Magnussen, Inger Johanne; Werner, Henrica Maria Johanna; Salvesen, Øyvind; Bjørge, Line; Trovik, Jone; Stefansson, Ingunn; Salvesen, Helga Birgitte; Haldorsen, Ingfrid S. (Peer reviewed; Journal article, 2015)
      OBJECTIVE: The aim of this study was to explore the relation between preoperative tumor size based on magnetic resonance imaging (MRI) and the surgical pathologic staging parameters (deep myometrial invasion, cervical ...
    • Salvage Radiation for Pelvic Relapse after Surgically Treated Endometrial Cancer 

      Lindemann, Kristina Yvonne Kathe; Smogeli, Aud Elisabeth Farstad; Småstuen, Milada Cvancarova; Bruheim, Kjersti; Trovik, Jone; Nordberg, Terje; Kristensen, Gunnar S Balle; Werner, Henrica Maria Johanna; Nakken, Ester (Journal article; Peer reviewed, 2021)
      (1) Background: This study evaluated the clinical outcome after salvage radiotherapy for first pelvic relapse after endometrial cancer (EC). (2) Methods: This multicenter retrospective study included EC patients with first ...
    • Stathmin Protein Level, a Potential Predictive Marker for Taxane Treatment Response in Endometrial Cancer 

      Werner, Henrica Maria Johanna; Trovik, Jone; Halle, Mari Kyllesø; Wik, Elisabeth; Akslen, Lars A.; Birkeland, Even; Bredholt, Therese; Tangen, Ingvild Løberg; Krakstad, Camilla; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2014-02-25)
      Stathmin is a prognostic marker in many cancers, including endometrial cancer. Preclinical studies, predominantly in breast cancer, have suggested that stathmin may additionally be a predictive marker for response to ...
    • Switch in FOXA1 status associates with endometrial cancer progression 

      Tangen, Ingvild Løberg; Krakstad, Camilla; Halle, Mari Kyllesø; Werner, Henrica Maria Johanna; Øyan, Anne Margrete; Kusonmano, Kanthida; Petersen, Kjell; Kalland, Karl-Henning; Akslen, Lars A.; Trovik, Jone; Rodriguez, Antoni Hurtado; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2014-05-21)
      Background: The transcription factor Forkhead box A1 (FOXA1) is suggested to be important in hormone dependent cancers, although with little data for endometrial cancer. We investigated expression levels of FOXA1 in primary ...
    • Tissue and imaging biomarkers for hypoxia predict poor outcome in endometrial cancer 

      Berg, Anna; Fasmer, Kristine Eldevik; Mauland, Karen Klepsland; Ytre-Hauge, Sigmund; Høivik, Erling Andre; Husby, Jenny Hild Aase; Tangen, Ingvild Løberg; Trovik, Jone; Halle, Mari Kyllesø; Woie, Kathrine; Bjørge, Line; Bjørnerud, Atle; Salvesen, Helga; Werner, Henrica Maria Johanna; Krakstad, Camilla; Haldorsen, Ingfrid S. (Peer reviewed; Journal article, 2016-09-13)
      Hypoxia is frequent in solid tumors and linked to aggressive phenotypes and therapy resistance. We explored expression patterns of the proposed hypoxia marker HIF-1α in endometrial cancer (EC) and investigate whether ...
    • What is the role of imaging at primary diagnostic work-up in uterine cervical cancer? 

      Haldorsen, Ingfrid S.; Lura, Njål; Blaakær, Jan; Fischerova, Daniela; Werner, Henrica Maria Johanna (Peer reviewed; Journal article, 2019-07-29)
      Purpose of Review For uterine cervical cancer, the recently revised International Federation of Gynecology and Obstetrics (FIGO) staging system (2018) incorporates imaging and pathology assessments in its staging. In this ...