• Quantification of the concentration gradient of biomarkers between ovarian carcinoma interstitial fluid and blood 

      Haslene-Hox, Hanne; Madani, Amina; Berg, Kaja Christine Graue; Woie, Kathrine; Salvesen, Helga Birgitte; Wiig, Helge; Tenstad, Olav (Peer reviewed; Journal article, 2014-12)
      Background: Tumor interstitial fluid (TIF) rather than plasma should be used in cancer biomarker discovery because of the anticipated higher concentration of locally produced proteins in the tumor microenvironment. ...
    • Transcapillary fluid flux and inflammatory response during neonatal therapeutic hypothermia: an open, longitudinal, observational study 

      Guthe, Hans Jørgen Timm; Nedrebø, Torbjørn; Damås, Jan Kristian; Wiig, Helge; Berg, Ansgar (Peer reviewed; Journal article, 2018-02-23)
      Background: Therapeutic hypothermia is neuroprotective in asphyxiated neonates by counteracting mechanisms contributing to brain injury. Although an initial increased permeability is part of an inflammatory reaction and ...
    • Tumor interstitial fluid formation, characterization, and clinical implications 

      Wagner, Marek; Wiig, Helge (Peer reviewed; Journal article, 2015-05-26)
      The interstitium, situated between the blood and lymph vessels and the cells, consists of a solid or matrix phase and a fluid phase representing the tissue microenvironment. In the present review, we focus on the interstitial ...
    • VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats 

      Samuelsson, Anne-Maj; Bartolomaeus, Theda Ulrike Patricia; Anandakumar, Harithaa; Thowsen, Irene Matre; Nikpey, Elham; Han, Jianhua; Marko, Lajos; Finne, Kenneth; Tenstad, Olav; Eckstein, Johannes; Berndt, Nikolaus; Kühne, Titus; Kedziora, Sarah; Sultan, Ibrahim; Skogstrand, Trude; Karlsen, Tine Veronica; Nurmi, Harri; Forslund, Sofia K.; Bollano, Entela; Alitalo, Kari; Muller, Dominik N.; Wiig, Helge (Journal article; Peer reviewed, 2023)
      Aims: Cardiac energy metabolism is centrally involved in heart failure (HF), although the direction of the metabolic alterations is complex and likely dependent on the particular stage of HF progression. Vascular endothelial ...