Blar i Bergen Open Research Archive på tidsskrift "Nature Communications"
Viser treff 21-40 av 115
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The DNA methylome of cervical cells can predict the presence of ovarian cancer
(Journal article; Peer reviewed, 2022)The vast majority of epithelial ovarian cancer arises from tissues that are embryologically derived from the Müllerian Duct. Here, we demonstrate that a DNA methylation signature in easy-to-access Müllerian Duct-derived ... -
Early response evaluation by single cell signaling profiling in acute myeloid leukemia
(Journal article; Peer reviewed, 2023)Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy is poorly understood. In this study, we investigate the initial signaling response to standard induction chemotherapy in a ... -
Electron Bernstein waves driven by electron crescents near the electron diffusion region
(Journal article; Peer reviewed, 2020)The Magnetospheric Multiscale (MMS) spacecraft encounter an electron diffusion region (EDR) of asymmetric magnetic reconnection at Earth’s magnetopause. The EDR is characterized by agyrotropic electron velocity distributions ... -
Estimating the burden of severe malarial anaemia and access to hospital care in East Africa
(Journal article; Peer reviewed, 2023)Severe malarial anaemia can be fatal if not promptly treated. Hospital studies may under-represent the true burden because cases often occur in settings with poor access to healthcare. We estimate the relationship of ... -
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation
(Journal article; Peer reviewed, 2023)Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery ... -
Evolution of tropical land temperature across the last glacial termination
(Journal article; Peer reviewed, 2022)The tropical West Pacific hosts the warmest part of the surface ocean and has a considerable impact on the global climate system. Reconstructions of past temperature in this region can elucidate climate connections between ... -
Experimental warming differentially affects vegetative and reproductive phenology of tundra plants
(Journal article; Peer reviewed, 2021)Rapid climate warming is altering Arctic and alpine tundra ecosystem structure and function, including shifts in plant phenology. While the advancement of green up and flowering are well-documented, it remains unclear ... -
Future strengthening of the Nordic Seas overturning circulation
(Journal article; Peer reviewed, 2023)The overturning circulation in the Nordic Seas involves the transformation of warm Atlantic waters into cold, dense overflows. These overflow waters return to the North Atlantic and form the headwaters to the deep limb of ... -
The genetic architecture of human brainstem structures and their involvement in common brain disorders
(Journal article, 2020)Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, ... -
The genetic architecture of sporadic and multiple consecutive miscarriage
(Journal article; Peer reviewed, 2020)Miscarriage is a common, complex trait affecting ~15% of clinically confirmed pregnancies. Here we present the results of large-scale genetic association analyses with 69,054 cases from five different ancestries for sporadic ... -
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
(Journal article; Peer reviewed, 2020)Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these ... -
Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
(Journal article; Peer reviewed, 2020)Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate ... -
Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells
(Journal article; Peer reviewed, 2022)Sjögren’s disease is a complex autoimmune disease with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel genome-wide significant (GWS) regions in Sjögren’s cases of ... -
Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth
(Peer reviewed; Journal article, 2019-10-01)Infant and childhood growth are dynamic processes with large changes in BMI during development. By performing genome-wide association studies of BMI at 12 time points from birth to eight years (9286 children, 74,105 ... -
Giant sponge grounds of Central Arctic seamounts are associated with extinct seep life
(Journal article; Peer reviewed, 2022)The Central Arctic Ocean is one of the most oligotrophic oceans on Earth because of its sea-ice cover and short productive season. Nonetheless, across the peaks of extinct volcanic seamounts of the Langseth Ridge (87°N, ... -
Global scale analysis on the extent of river channel belts
(Journal article; Peer reviewed, 2023)Rivers form channel belts that encompass the area of the river channel and its associated levees, bars, splays and overbank landforms. The channel belt is critical for understanding the physical river evolution through ... -
GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis
(Peer reviewed; Journal article, 2018-12-06)Autoantibodies have been associated with autoimmune diseases. However, studies have identified autoantibodies in healthy donors (HD) who do not develop autoimmune disorders. Here we provide evidence of a network of ... -
GWAS for autoimmune Addison's disease identifies multiple risk loci and highlights AIRE in disease susceptibility
(Journal article; Peer reviewed, 2021)Autoimmune Addison’s disease (AAD) is characterized by the autoimmune destruction of the adrenal cortex. Low prevalence and complex inheritance have long hindered successful genetic studies. We here report the first ... -
Histone demethylase Lsd1 is required for the differentiation of neural cells in Nematostella vectensis
(Journal article; Peer reviewed, 2022)Chromatin regulation is a key process in development but its contribution to the evolution of animals is largely unexplored. Chromatin is regulated by a diverse set of proteins, which themselves are tightly regulated in a ... -
Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediaterisk human prostate cancer
(Journal article; Peer reviewed, 2022)Hyperpolarised magnetic resonance imaging (HP 13C-MRI) is an emerging clinical technique to detect [1-13C]lactate production in prostate cancer (PCa) following intravenous injection of hyperpolarised [1-13C]pyruvate. Here ...