Browsing Bergen Open Research Archive by Title
Now showing items 20361-20380 of 34095
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Molecular markers to predict prognosis and guide therapy in endometrial cancer
(Doctoral thesis, 2020-02-07)Background: Endometrial cancer is the most common gynecological malignancy in the Western world. The disease occurs in the epithelial lining of the uterus, called the endometrium. Although prognosis is good and most of the ... -
Molecular mechanisms governing development of the hindbrain choroid plexus and auditory projection: A validation of the seminal observations of Wilhelm His
(Journal article; Peer reviewed, 2022)Studies by His from 1868 to 1904 delineated the critical role of the dorsal roof plate in the development of the hindbrain choroid plexus, and of the rhombic lips in the development of hindbrain auditory centers. Modern ... -
Molecular mechanisms of adaptation emerging from the physics and evolution of nucleic acids and proteins
(Peer reviewed; Journal article, 2014)DNA, RNA and proteins are major biological macromolecules that coevolve and adapt to environments as components of one highly interconnected system. We explore here sequence/structure determinants of mechanisms of adaptation ... -
Molecular mechanisms of Charcot-Marie-Tooth neuropathy linked to mutations in human myelin protein P2
(Peer reviewed; Journal article, 2017-07-26)Charcot-Marie-Tooth (CMT) disease is one of the most common inherited neuropathies. Recently, three CMT1-associated point mutations (I43N, T51P, and I52T) were discovered in the abundant peripheral myelin protein P2. These ... -
Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia
(Peer reviewed; Journal article, 2014-05-21)Background: The small-molecule MDM2 antagonist nutlin-3 has proved to be an effective p53 activating therapeutic compound in several preclinical cancer models, including acute myeloid leukemia (AML). We and others have ... -
Molecular mechanisms of sonoporation in cancer therapy : Optimization of sonoporation parameters and investigations of intracellular signalling
(Doctoral thesis, 2020-06-17)Background: Sonoporation, which is treatment with ultrasound (US) and microbubbles (MB), has shown great potential for enhancing the therapeutic efficacy of chemotherapy in cancer therapy. However, there is still very ... -
Molecular oxygen-assisted in defect-rich ZnO for catalytic depolymerization of polyethylene terephthalate
(Journal article; Peer reviewed, 2023)Polyethylene terephthalate (PET) is the most produced polyester plastic; its waste has a disruptive impact on the environment and ecosystem. Here, we report a catalytic depolymerization of PET into bis(2-hydroxyethyl) ... -
Molecular pathogenesis of polymerase gamma-related neurodegeneration
(Peer reviewed; Journal article, 2014-07)Objective: Polymerase gamma (POLG) mutations are a common cause of mitochondrial disease and have also been linked to neurodegeneration and aging. We studied the molecular mechanisms underlying POLG-related neurodegeneration ... -
Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing
(Journal article, 2021)Objectives Systemic lupus erythematosus (SLE) is an autoimmune disease with extensive heterogeneity in disease presentation between patients, which is likely due to an underlying molecular diversity. Here, we aimed at ... -
Molecular patterning during the development of Phoronopsis harmeri reveals similarities to rhynchonelliform brachiopods
(Journal article; Peer reviewed, 2019)Background: Phoronids, rhynchonelliform and linguliform brachiopods show striking similarities in their embryonic fate maps, in particular in their axis specification and regionalization. However, although brachiopod ... -
Molecular phylogenies challenge the classification of Polymastiidae (Porifera, Demospongiae) based on morphology
(Peer reviewed; Journal article, 2016)Polymastiidae Gray, 1867 is a worldwide distributed sponge family, which has a great significance for understanding of the demosponge deep phylogeny since the former order Hadromerida Topsent, 1894 has been recently split ... -
Molecular phylogeny of bark and ambrosia beetles reveals multiple origins of fungus farming during periods of global warming
(Peer reviewed; Journal article, 2012-08-01)Background: Fungus farming is an unusual life style in insects that has evolved many times in the wood boring weevils named ‘ambrosia beetles’. Multiple occurrences of this behaviour allow for a detailed comparison of the ... -
Molecular Phylogeny of the Astrophorida (Porifera, Demospongiaep) Reveals an Unexpected High Level of Spicule Homoplasy
(Peer reviewed; Journal article, 2011-04-08)Background: The Astrophorida (Porifera, Demospongiaep) is geographically and bathymetrically widely distributed. Systema Porifera currently includes five families in this order: Ancorinidae, Calthropellidae, Geodiidae, ... -
A molecular phylogeny of the European nesticid spiders (Nesticidae, Araneae): Implications for their systematics and biogeography
(Journal article; Peer reviewed, 2023)Nesticidae is a small family of spiders with a worldwide distribution that includes 15 genera and 272 described species. Seven genera and 56 species are known from Europe, distributed from the Iberian Peninsula to the ... -
A molecular phylogeny of the Indo-West Pacific species of Haloa sensu lato gastropods (Cephalaspidea: Haminoeidae): Tethyan vicariance, generic diversity, and ecological specialization
(Peer reviewed; Journal article, 2019-07-06)The cephalaspidean gastropod genus Haminoea has been considered a worldwide radiation with species living in intertidal and shallow areas with algae, seagrass sandy-mud, mangroves, and coral reefs. Recently this monophyletic ... -
Molecular phylogeny of the marine snail genus Haminoea (Gastropoda, Cephalaspidea): A framework to study marine diversity and speciation
(Journal article; Peer reviewed, 2023)Haminoea are herbivorous, coastal snails occurring in temperate and tropical waters of the Atlantic and Eastern Pacific oceans, with one species present in temperate South Africa (Indian Ocean). The genus is taxonomically ... -
Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer
(Peer reviewed; Journal article, 2014-09-27)Background: About 20% of patients diagnosed with endometrial cancer (EC) are considered high-risk with unfavorable prognosis. In the framework of the European Network for Individualized Treatment in EC (ENITEC), we ... -
Molecular regionalization in the compact brain of the meiofaunal annelid Dinophilus gyrociliatus (Dinophilidae)
(Journal article; Peer reviewed, 2016-08-30)Background: Annelida is a morphologically diverse animal group that exhibits a remarkable variety in nervous system architecture (e.g., number and location of longitudinal cords, architecture of the brain). Despite this ... -
The molecular regulation of molting in the salmon louse (Lepeophtheirus salmonis)
(Doctoral thesis, 2021-12-10)The salmon louse, Lepeophtheirus salmonis, is a copepod and an ectoparasite that infects salmonids in the Northern hemisphere. At present, salmon louse infestations are the biggest threat to the health and welfare of wild ... -
Molecular structure and function of myelin protein P0 in membrane stacking
(Peer reviewed; Journal article, 2019)Compact myelin forms the basis of nerve insulation essential for higher vertebrates. Dozens of myelin membrane bilayers undergo tight stacking, and in the peripheral nervous system, this is partially enabled by myelin ...