Blar i Bergen Open Research Archive på forfatter "Berge, Rolf Kristian"
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Plasma Cholesterol- and Body Fat-Lowering Effects of Chicken Protein Hydrolysate and Oil in High-Fat Fed Male Wistar Rats
Aloysius, Thomas Aquinas; Tillander, Veronika; Pedrelli, Matteo; Dankel, Simon Erling Nitter; Berge, Rolf Kristian; Bjørndal, Bodil (Journal article; Peer reviewed, 2022)Rest raw materials provide a new source of bioactive dietary ingredients, and this study aimed to determine the health effects of diets with chicken protein hydrolysate (CPH) and chicken oil (CO) generated from deboned ... -
Plasma methylmalonic acid predicts risk of acute myocardial infarction and mortality in patients with coronary heart disease: A prospective 2-cohort study
Dhar, Indu; Lysne, Vegard; Ulvik, Arve; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Kristine Ringdal; Bjørnestad, Espen Øglænd; Olsen, Thomas; Borsholm, Robert Andre; Laupsa-Borge, Johnny; Ueland, Per Magne; Tell, Grethe Seppola; Berge, Rolf Kristian; Mellgren, Gunnar; Bønaa, Kaare Harald; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2023)Background Elevated plasma methylmalonic acid (MMA) is reported in patients with established coronary heart disease (CHD) and is considered a marker of vitamin B12 deficiency. Moreover, MMA-dependent reactions have been ... -
The PPAR pan-agonist tetradecylthioacetic acid promotes redistribution of plasma cholesterol towards large HDL
Lundåsen, Thomas; Pedrelli, Matteo; Bjørndal, Bodil; Rozell, Björn; Kuiper, Raoul; Burri, Lena; Pavanello, Chiara; Turri, Marta; Skorve, Jon; Berge, Rolf Kristian; Alexson, Stefan E.H.; Tillander, Veronika (Journal article; Peer reviewed, 2020)Tetradecylthioacetic acid (TTA) is a synthetic fatty acid with a sulfur substitution in the β-position. This modification renders TTA unable to undergo complete β-oxidation and increases its biological activity, including ... -
Prevention of Hypertension and Organ Damage in 2-Kidney, 1-Clip Rats by Tetradecylthioacetic Acid
Gudbrandsen, Oddrun Anita; Hultström, Michael; Leh, Sabine Maria; Bivol, Liliana Monica; Vågnes, Øyvind; Berge, Rolf Kristian; Iversen, Bjarne M. (Peer reviewed; Journal article, 2006-07-17)Dietary lipids are reported to affect the blood pressure in both humans and experimental animal models with hypertension. In the present study, 2-kidney, 1-clip (2K1C) hypertensive rats were treated with the modified fatty ... -
A protein extract from chicken reduces plasma homocysteine in rats
Lysne, Vegard; Bjørndal, Bodil; Vik, Rita; Nordrehaug, Jan Erik; Skorve, Jon; Nygård, Ottar; Berge, Rolf Kristian (Peer reviewed; Journal article, 2015-06-04)The present study aimed to evaluate effects of a water-soluble protein fraction of chicken (CP), with a low methionine/glycine ratio, on plasma homocysteine and metabolites related to homocysteine metabolism. Male Wistar ... -
A randomized, double-blind, placebo-controlled clinical study to investigate the efficacy of herring roe oil for treatment of psoriasis
Tveit, Kåre Steinar; Brokstad, Karl Albert; Berge, Rolf Kristian; Sæbø, Per Christian; Hallaråker, Hogne; Brekke, Stian; Meland, Nils; Bjørndal, Bodil (Journal article; Peer reviewed, 2020-05-07)The effect of omega-3 polyunsaturated fatty acid supplements in patients with psoriasis vulgaris has previously been investigated, but interventions varied in source, composition, dose, administration route and duration ... -
Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency
Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin; Rashidi, Azita; Michelsen, Annika; Lekva, Tove; Halvorsen, Bente; Trøseid, Marius; Mollnes, Tom Eirik; Berge, Rolf Kristian; Yndestad, Arne; Ueland, Thor; Karlsen, Tom Hemming; Aukrust, Pål; Hov, Johannes Espolin Roksund; Fevang, Børre (Peer reviewed; Journal article, 2019-01-17)Common variable immunodefciency (CVID) patients have reduced gut microbial diversity compared to healthy controls. The reduced diversity is associated with gut leakage, increased systemic infammation and ten “key” bacteria ... -
Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial
Awoyemi, Ayodeji Olawale; Mayerhofer, Cristiane; Felix, Alex S.; Hov, Johannes Espolin Roksund; Moscavitch, Samuel D.; Lappegård, Knut Tore; Hovland, Anders; Halvorsen, Sigrun; Halvorsen, Bente; Gregersen, Ida; Svardal, Asbjørn M.; Berge, Rolf Kristian; Hansen, Simen Hyll; Götz, Alexandra; Holm, Kristian; Aukrust, Pål; Åkra, Sissel; Seljeflot, Ingebjørg; Solheim, Svein; Lorenzo, Andrea; Gullestad, Lars; Trøseid, Marius; Broch, Kaspar (Journal article; Peer reviewed, 2021)Background The gut microbiota represents a potential treatment target in heart failure (HF) through microbial metabolites such as trimethylamine N-oxide (TMAO) and systemic inflammation. Treatment with the probiotic yeast ... -
Rosuvastatin alters the genetic composition of the human gut microbiome
Kummen, Martin; Solberg, Ole Geir; Larsen, Christopher Storm; Holm, Kristian; Ragnarsson, Asgrimur; Trøseid, Marius; Vestad, Beate; Skårdal, Rita; Yndestad, Arne; Ueland, Thor; Svardal, Asbjørn M.; Berge, Rolf Kristian; Seljeflot, Ingebjørg; Gullestad, Lars; Karlsen, Tom Hemming; Aaberge, Lars; Aukrust, Pål; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2020)The gut microbiome contributes to the variation of blood lipid levels, and secondary bile acids are associated with the effect of statins. Yet, our knowledge of how statins, one of our most common drug groups, affect the ... -
A salmon peptide diet alleviates experimental colitis as compared with fish oil
Grimstad, Tore; Bjørndal, Bodil; Cacabelos, Daniel; Aasprong, Ole Gunnar; Omdal, Roald; Svardal, Asbjørn M.; Bohov, Pavol; Pamplona, Reinald; Portero-Otin, Manuel; Berge, Rolf Kristian; Hausken, Trygve (Peer reviewed; Journal article, 2013-01-10)Fish oil (FO) has been shown to have anti-inflammatory properties in animal models of inflammatory bowel disease, but how fish peptides (FP) influence intestinal inflammation has been less studied. Male Wistar rats, divided ... -
A salmon protein hydrolysate exerts lipid-independent anti-atherosclerotic activity in apoE-deficient mice
Parolini, Cinzia; Vik, Rita; Busnelli, Marco; Bjørndal, Bodil; Holm, Sverre; Brattelid, Trond; Manzini, Stefano; Ganzetti, Giulia S.; Dellera, Federica; Halvorsen, Bente; Aukrust, Pål; Sirtori, Cesare R.; Nordrehaug, Jan Erik; Skorve, Jon; Berge, Rolf Kristian; Chiesa, Giulia (Peer reviewed; Journal article, 2014-05-19)Fish consumption is considered health beneficial as it decreases cardiovascular disease (CVD)-risk through effects on plasma lipids and inflammation. We investigated a salmon protein hydrolysate (SPH) that is hypothesized ... -
Serum Acylcarnitines and Risk of Cardiovascular Death and Acute Myocardial Infarction in Patients With Stable Angina Pectoris
Strand, Elin; Pedersen, Eva Ringdal; Svingen, Gard Frodahl Tveitevåg; Olsen, Thomas; Bjørndal, Bodil; Karlsson, Therese; Dierkes, Jutta; Njølstad, Pål Rasmus; Mellgren, Gunnar; Tell, Grethe S.; Berge, Rolf Kristian; Svardal, Asbjørn M.; Nygård, Ottar (Peer reviewed; Journal article, 2017-02)Background: Excess levels of serum acylcarnitines, which are intermediate products in metabolism, have been observed in metabolic diseases such as type 2 diabetes mellitus. However, it is not known whether acylcarnitines ... -
Sex-specific responses in glucose-insulin homeostasis and lipoprotein-lipid components after high-dose supplementation with marine n-3 PUFAs in abdominal obesity: a randomized double-blind crossover study
Laupsa-Borge, Johnny; Grytten, Elise; Bohov, Pavol; Bjørndal, Bodil; Strand, Elin; SKORVE, JON; Nordrehaug, Jan Erik; Berge, Rolf Kristian; Rostrup, Espen; Mellgren, Gunnar; Dankel, Simon N; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2023)Background: Clinical studies on effects of marine-derived omega-3 (n-3) polyunsaturated fatty acids (PUFAs), mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and the plant-derived omega-6 (n-6) PUFA ... -
Short-term activation of peroxisome proliferator-activated receptors α and γ induces tissue-specific effects on lipid metabolism and fatty acid composition in male Wistar rats
Strand, Elin; Lysne, Vegard; Grinna, Mari Lausund; Bohov, Pavol; Svardal, Asbjørn M.; Nygård, Ottar; Berge, Rolf Kristian; Bjørndal, Bodil (Peer reviewed; Journal article, 2019-06-12)Dietary fatty acids (FAs) affect certain metabolic routes, including pathways controlled by the peroxisome proliferator-activated receptors (PPARs), but tissue-specific effects are not well-defined. Thus, the aim was to ... -
Short-term treatment with a peroxisome proliferator-activated receptor α agonist influences plasma one-carbon metabolites and B-vitamin status in rats
Lysne, Vegard; Bjørndal, Bodil; Grinna, Mari Lausund; Midttun, Øivind; Ueland, Per Magne; Berge, Rolf Kristian; Dierkes, Jutta; Nygård, Ottar; Strand, Elin (Peer reviewed; Journal article, 2019-12-05)Introduction: Peroxisome proliferator-activated receptors (PPARs) have been suggested to be involved in the regulation of one-carbon metabolism. Previously we have reported effects on plasma concentrations of metabolites ... -
Skeletal effects of the saturated 3-thia fatty acid tetradecylthioacetic acid in rats
Stunes, Astrid Kamilla; Westbroek, Irene; Fossmark, Reidar; Berge, Rolf Kristian; Reseland, Janne Elin; Syversen, Unni (Peer reviewed; Journal article, 2011-09-06)This study explores the skeletal effects of the peroxisome proliferator activated receptor (PPAR)pan agonist tetradecylthioacetic acid (TTA). Rats, without (Study I) and with ovariectomy (OVX) or sham operation (Study II), ... -
Tetradecylthioacetic Acid Increases Hepatic Mitochondrial b-Oxidation and Alters Fatty Acid Composition in a Mouse Model of Chronic Inflammation
Burri, Lena; Bjørndal, Bodil; Wergedahl, Hege; Berge, Kjetil; Bohov, Pavol; Svardal, Asbjørn; Berge, Rolf Kristian (Peer reviewed; Journal article, 2011-04-09)The administration of tetradecylthioacetic acid (TTA), a hypolipidemic and anti-inflammatory modified bioactive fatty acid, has in several experiments based on high fat diets been shown to improve lipid transport and ... -
Tetradecylthioacetic acid inhibits proliferation of human SW620 colon cancer cells - gene expression profiling implies endoplasmic reticulum stress
Lundemo, Anne G.; Pettersen, Caroline H.H.; Berge, Kjetil; Berge, Rolf Kristian; Schønberg, Svanhild A. (Peer reviewed; Journal article, 2011-10-25)Background: Previous reports have shown an antiproliferative effect of the synthetic, 3-thia fatty acid tetradecylthioacetic acid (TTA) on different cancer cells in vitro and in vivo. The mechanisms behind the observed ... -
Tetradecylthiopropionic acid induces hepatic mitochondrial dysfunction and steatosis, accompanied by increased plasma homocysteine in mice
Berge, Rolf Kristian; Bjørndal, Bodil; Strand, Elin; Bohov, Pavol; Lindquist, Carine; Nordrehaug, Jan Erik; Svardal, Asbjørn; Skorve, Jon; Nygård, Ottar (Peer reviewed; Journal article, 2016-02-05)Background: Hepatic mitochondrial dysfunction plays an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Methyl donor supplementation has been shown to alleviate NAFLD, connecting the condition ... -
Three differently generated salmon protein hydrolysates reveal opposite effects on hepatic lipid metabolism in mice fed a high-fat diet
Vik, Rita; Tilander, Veronika; Skorve, Jon; Vihervaara, Terhi; Ekroos, Kim; Alexson, Stefan E.H.; Berge, Rolf Kristian; Bjørndal, Bodil (Peer reviewed; Journal article, 2015-03-17)This study investigates the effects of salmon peptide fractions, generated using different enzymatic hydrolyzation methods, on hepatic lipid metabolism. Four groups of mice were fed a high-fat diet with 20% casein (control ...