Blar i Bergen Open Research Archive på forfatter "Gjertsen, Bjørn Tore"
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Increased plasma colloid osmotic pressure facilitates the uptake of therapeutic macromolecules in a xenograft tumour model
Hofmann, Matthias; McCormack, Emmet; Mujic, Maja; Roßberg, Maila; Bernd, August; Bereiter-Hahn, Jürgen; Gjertsen, Bjørn Tore; Wiig, Helge; Kippenberger, Stefan (Peer reviewed; Journal article, 2009-08)Elevated tumor interstitial fluid pressure (TIFP) is a characteristic of most solid tumors. Clinically, TIFP may hamper the uptake of chemotherapeutic drugs into the tumor tissue reducing their therapeutic efficacy. In ... -
Influence of p53 isoform expression on survival in high-grade serous ovarian cancers
Bischof, Katharina; Knappskog, Stian; Hjelle, Sigrun Margrethe; Stefansson, Ingunn; Woie, Kathrine; Salvesen, Helga; Gjertsen, Bjørn Tore; Bjørge, Line (Peer reviewed; Journal article, 2019-03-27)High-grade serous ovarian carcinoma (HGSOC) is characterised by alterations in the p53 pathway. The expression levels of p53 isoforms have been shown to be associated with patient survival in several cancers. This study ... -
Inhibition of tunneling nanotube (TNT) formation and Human T-cell leukemia virus type 1 (HTLV-1) transmission by cytarabine
Omsland, Maria; Pise-Masison, Cynthia A.; Fujikawa, Dai; Galli, Veronica; Fenizia, Claudio; Parks, Robyn Washington; Gjertsen, Bjørn Tore; Franchini, Genoveffa; Andresen, Vibeke (Peer reviewed; Journal article, 2018-07-24)The human T-cell leukemia virus type 1 (HTLV-1) is highly dependent on cell-to-cell interaction for transmission and productive infection. Cell-to-cell interactions through the virological synapse, bioflm-like structures ... -
Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells
Ersvær, Elisabeth; Liseth, Knut; Skavland, Jørn; Gjertsen, Bjørn Tore; Bruserud, Øystein (Peer reviewed; Journal article, 2010-07-09)Background Several observations suggest that immunological events early after chemotherapy, possibly during the period of severe treatment-induced cytopenia, are important for antileukemic immune reactivity in acute myeloid ... -
Interstitial changes in spleen during sepsis
Svendsen, Øyvind Sverre; Stangeland, Lodve; Elvevoll, Bjørg; Gjertsen, Bjørn Tore; Skavland, Jørn; Wiig, Helge; Tenstad, Olav; Husby, Paul (Conference poster, 2014-09-26) -
Intracellular signaling in key pathways is induced by treatment with ultrasound and microbubbles in a leukemia cell line, but not in healthy peripheral blood mononuclear cells
Haugse, Ragnhild; Langer, Anika; Gullaksen, Stein-Erik; Sundøy, Silje Maria; Gjertsen, Bjørn Tore; Kotopoulis, Spiros; Mc Cormack, Emmet (Peer reviewed; Journal article, 2019-07-06)Treatment with ultrasound and microbubbles (sonoporation) to enhance therapeutic efficacy in cancer therapy is rapidly expanding, but there is still very little consensus as to why it works. Despite the original assumption ... -
Liquid Biopsies in Solid Cancers: Implementation in a Nordic Healthcare System
Nordgård, Oddmund; Forthun, Rakel Brendsdal; Lapin, Morten; Grønberg, Bjørn Henning; Kalland, Karl Henning; Kopperud, Reidun Kristin; Thomsen, Liv Cecilie Vestrheim; Tjensvoll, Kjersti; Gilje, Bjørnar; Gjertsen, Bjørn Tore; Hovland, Randi (Journal article; Peer reviewed, 2021)Liquid biopsies have emerged as a potential new diagnostic tool, providing detailed information relevant for characterization and treatment of solid cancers. We here present an overview of current evidence supporting the ... -
Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells
Haugse, Ragnhild; Langer, Anika; Murvold, Elsa Thodesen; Costea, Daniela Elena; Gjertsen, Bjørn Tore; Gilja, Odd Helge; Kotopoulis, Spiros; Ruiz de Garibay, Gorka; McCormack, Emmet (Journal article; Peer reviewed, 2020)The use of ultrasound (US) and microbubbles (MB), usually referred to as sonoporation, has great potential to increase the efficacy of chemotherapy. However, the molecular mechanisms that mediate sonoporation response are ... -
Modulation of phospho-proteins by interferon-alpha and valproic acid in acute myeloid leukemia
Forthun, Rakel Brendsdal; Hellesøy, Monica; Sulen, Andre; Kopperud, Reidun Kristin; Sjøholt, Gry; Bruserud, Øystein; McCormack, Emmet; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2019)Purpose. Valproic acid (VPA) is suggested to be therapeutically beneficial in combination with interferon-alpha (IFNα) in various cancers. Therefore, we examined IFNα and VPA alone and in combinations in selected AML models, ... -
Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia
Haaland, Ingvild; Opsahl, Jill Anette; Berven, Frode S.; Reikvam, Håkon; Fredly, Hanne Kristin; Haugse, Ragnhild; Thiede, Bernd; McCormack, Emmet; Lain, Sonia; Bruserud, Øystein; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2014-05-21)Background: The small-molecule MDM2 antagonist nutlin-3 has proved to be an effective p53 activating therapeutic compound in several preclinical cancer models, including acute myeloid leukemia (AML). We and others have ... -
Moxetumomab pasudotox in heavily pre-treated patients with relapsed/refractory hairy cell leukemia (HCL): long-term follow-up from the pivotal trial
Kreitman, Robert J.; Dearden, Claire; Zinzani, Pier Luigi; Delgado, Julio; Robak, Tadeusz; le Coutre, Philipp; Gjertsen, Bjørn Tore; Troussard, Xavier; Roboz, Gail J.; Karlin, Lionel; Gladstone, Douglas E.; Kuptsova-Clarkson, Nataliya; Liu, Shiyao; Patel, Priti; Rotolo, Federico; Mitry, Emmanuel; Pastan, Ira; Giles, Frank (Journal article; Peer reviewed, 2021)Background Moxetumomab pasudotox is a recombinant CD22-targeting immunotoxin. Here, we present the long-term follow-up analysis of the pivotal, multicenter, open-label trial (NCT01829711) of moxetumomab pasudotox in ... -
p53 Protein Isoform Profiles in AML: Correlation with Distinct Differentiation Stages and Response to Epigenetic Differentiation Therapy
Haaland, Ingvild; Hjelle, Sigrun Margrethe; Reikvam, Håkon; Sulen, André; Ryningen, Anita; McCormack, Emmet; Bruserud, Øystein; Gjertsen, Bjørn Tore (Journal article; Peer reviewed, 2021)p53 protein isoform expression has been found to correlate with prognosis and chemotherapy response in acute myeloid leukemia (AML). We aimed to investigate how p53 protein isoforms are modulated during epigenetic ... -
A phase I prospective, non-randomized trial of autologous dendritic cell-based cryoimmunotherapy in patients with metastatic castration-resistant prostate cancer
Thomsen, Liv Cecilie Vestrheim; Honore, Alfred; Reisæter, Lars Anders Rokne; Almås, Bjarte; Børretzen, Astrid; Helle, Svein Inge; Førde, Kristina; Kristoffersen, Einar Klæboe; Kaada, Silje Katrine Helland; Melve, Guro Kristin; Haslerud, Torjan Magne; Biermann, Martin; Bigalke, Iris; Kvalheim, Gunnar; Azeem, Waqas; Olsen, Jan Roger; Gabriel, Benjamin; Knappskog, Stian; Halvorsen, Ole Johan; Akslen, Lars Andreas; Bahn, Duke; Pantel, Klaus; Riethdorf, Sabine; Ragde, Haakon; Gjertsen, Bjørn Tore; Øyan, Anne Margrete; Kalland, Karl Henning; Beisland, Christian (Journal article; Peer reviewed, 2023)Metastatic castration-resistant prostate cancer (mCRPC) is an immunologically cold disease with dismal outcomes. Cryoablation destroys cancer tissue, releases tumor-associated antigens and creates a pro-inflammatory ... -
Phenotypic Characterization by Mass Cytometry of the Microenvironment in Ovarian Cancer and Impact of Tumor Dissociation Methods
Anandan, Shamundeeswari; Thomsen, Liv Cecilie Vestrheim; Gullaksen, Stein-Erik; Abdelaal, Tamim; Kleinmanns, Katrin; Skavland, Jørn; Bredholt, Geir; Gjertsen, Bjørn Tore; Cormack, Emmet Mc; Bjørge, Line (Journal article; Peer reviewed, 2021)Improved molecular dissection of the tumor microenvironment (TME) holds promise for treating high-grade serous ovarian cancer (HGSOC), a gynecological malignancy with high mortality. Reliable disease-related biomarkers are ... -
Pre-apoptotic response to therapeutic DNA damage involves protein modulation of Mcl-1, Hdm2 and Flt3 in acute myeloid leukemia cells
Wergeland, Line; Sjøholt, Gry; Haaland, Ingvild; Hovland, Randi; Bruserud, Øystein; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2007)Background: Acute myeloid leukemia (AML) cells are characterized by non-mutated TP53, high levels of Hdm2, and frequent mutation of the Flt3 receptor tyrosine kinase. The juxtamembrane mutation of FLT3 is the strongest ... -
Pretreatment of glioblastoma with bortezomib potentiates natural killer cell cytotoxicity through TRAIL/DR5 mediated apoptosis and prolongs animal survival
Gras Navarro, Andrea; Espedal, Heidi; Vareecal Joseph, Justin; Moncho, Laura Trachsel; Bahador, Marzieh; Gjertsen, Bjørn Tore; Kristoffersen, Einar Klæboe; Simonsen, Anne; Miletic, Hrvoje; Enger, Per Øyvind; Rahman, Mohummad Aminur; Enger, Martha Chekenya (Peer reviewed; Journal article, 2019-07-17)Background: Natural killer (NK) cells are potential effectors in anti-cancer immunotherapy; however only a subset potently kills cancer cells. Here, we examined whether pretreatment of glioblastoma (GBM) with the proteasome ... -
Repurposing chlorpromazine for anti-leukaemic therapy by nanoparticle encapsulation
Gundersen, Edvin Tang; Førde, Jan-Lukas; Tislevoll, Benedicte Sjo; Leitch, Calum; Barratt, Gillian; Gjertsen, Bjørn Tore; Herfindal, Lars (Journal article; Peer reviewed, 2022)Treatment of acute myeloid leukaemia (AML) relies on decades-old drugs, and while recent years have seen some breakthroughs, AML is still characterised by poor prognosis and survival rate. Drug repurposing can expedite the ... -
Signaling effects of sodium hydrosulfide in healthy donor peripheral blood mononuclear cells
Sulen, Andre; Gullaksen, Stein-Erik; Bader, Lucius; McClymont, David; Skavland, Jørn; Gavasso, Sonia; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2016-11)Hydrogen sulfide (H2S) is an endogenous gasotransmitter in human physiology and inflammatory disease, however, with limited knowledge of how signal transduction pathways are involved in immune cells. To examine the effects ... -
Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib
Gullaksen, Stein-Erik; Skavland, Jørn; Gavasso, Sonia; Tosevski, Vinko; Warzocha, Krzysztof; Dumrese, Claudia; Ferrant, Augustin; Gedde-Dahl, Thobias; Hellmann, Andrzej; Janssen, Jeroen; Labar, Boris; Lang, Alois; Majeed, Mohammed Waleed; Mihaylov, Georgi; Stentoft, Jesper; Stenke, Leif; Thaler, Josef; Thielen, Noortje; Verhoef, Gregor; Voglova, Jaroslava; Ossenkoppele, Gert; Hochhaus, Andreas; Hjorth-Hansen, Henrik; Mustjoki, Satu; Sopper, Sieghart; Giles, Francis; Porkka, Kimmo; Wolf, Dominik; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2017-08)Monitoring of single cell signal transduction in leukemic cellular subsets has been proposed to provide deeper understanding of disease biology and prognosis, but has so far not been tested in a clinical trial of targeted ... -
Systemic Metabolomic Profiling of Acute Myeloid Leukemia Patients before and During Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid, Valproic Acid, and Low-Dose Chemotherapy
Grønningsæter, Ida Sofie; Fredly, Hanne Kristin; Gjertsen, Bjørn Tore; Hatfield, Kimberley Joanne; Bruserud, Øystein (Peer reviewed; Journal article, 2019-10-10)Acute myeloid leukemia (AML) is an aggressive malignancy, and many elderly/unfit patients cannot receive intensive and potentially curative therapy. These patients receive low-toxicity disease-stabilizing treatment. The ...