Blar i Bergen Open Research Archive på forfatter "Hausken, Trygve"
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Gastroparesis Symptoms Associated with Intestinal Hypomotility: An Explorative Study Using Wireless Motility Capsule
Bekkelund, Mattis; Sangnes, Dag André; Søfteland, Eirik Wigtil; Aabakken, Lars; Biermann, Martin; Steinsvik, Elisabeth K.; Hausken, Trygve; Dimcevski, Georg; Hatlebakk, Jan Gunnar (Journal article; Peer reviewed, 2021)Objective: Gastric emptying measurements are mandatory in gastroparesis diagnostics, but the association between delayed emptying and symptoms is questionable. It is imperative to find biomarkers better correlated to symptom ... -
Immunophenotyping in post-giardiasis functional gastrointestinal disease and chronic fatigue syndrome
Hanevik, Kurt; Kristoffersen, Einar K.; Sørnes, Steinar; Mørch, Kristine; Næss, Halvor; Rivenes, Ann Christin; Bødtker, Jørn; Hausken, Trygve; Langeland, Nina (Peer reviewed; Journal article, 2012-10-14)Background: A Giardia outbreak was associated with development of post-infectious functional gastrointestinal disorders (PI-FGID) and chronic fatigue syndrome (PI-CFS). Markers of immune dysfunction have given conflicting ... -
Increased chromogranin A cell density in the large intestine of patients with irritable bowel syndrome after receiving dietary guidance
Mazzawi, Tarek; Gundersen, Doris Irene; Hausken, Trygve; El-Salhy, Magdy (Peer reviewed; Journal article, 2015)The large intestine contains five types of endocrine cells that regulate its functions by sensing its luminal contents and releasing specific hormones. Chromogranin A (CgA) is a common marker for the gastrointestinal ... -
Increased gastric chromogranin A cell density following changes to diets of patients with irritable bowel syndrome
Mazzawi, Tarek; Gundersen, Doris; Hausken, Trygve; El-Salhy, Magdy (Peer reviewed; Journal article, 2014-11)The gut endocrine cells control and regulate several functions of the gastrointestinal tract. They have been reported to be abnormal in irritable bowel syndrome (IBS), with alterations occurring in several functions regulated ... -
Increasing the Dose and/or Repeating Faecal Microbiota Transplantation (FMT) Increases the Response in Patients with Irritable Bowel Syndrome (IBS)
El-Salhy, Magdy; Hausken, Trygve; Hatlebakk, Jan Gunnar (Peer reviewed; Journal article, 2019-06-24)Background: Faecal microbiome transplantation (FMT) appears to be an effective method for treating irritable bowel syndrome (IBS) patients. However, it is not clear if a high transplant dose and/or repeating FMT are/is ... -
Interaction between ingested nutrients and gut endocrine cells in patients with irritable bowel syndrome (Review)
El-Salhy, Magdy; Gilja, Odd Helge; Gundersen, Doris Irene; Hatlebakk, Jan G; Hausken, Trygve (Peer reviewed; Journal article, 2014-08)Several endocrine cell abnormalities have been reported in different segments of the gastrointestinal tract of patients with irritable bowel syndrome (IBS). These cells have specialized microvilli that project into the ... -
Irritable bowel syndrome patients who are not likely to respond to fecal microbiota transplantation
El-Salhy, Magdy; Mazzawi, Tarek; Hausken, Trygve; Hatlebakk, Jan Gunnar (Journal article; Peer reviewed, 2022)Background Fecal microbiota transplantation (FMT) interventions have recently been advocated to not succeed in every irritable bowel syndrome (IBS) patient, since the outcome of FMT varies with the IBS subset. This study ... -
Is irritable bowel syndrome an organic disorder?
El-Salhy, Magdy; Gundersen, Doris Irene; Gilja, Odd Helge; Hatlebakk, Jan G; Hausken, Trygve (Peer reviewed; Journal article, 2014-01-14)Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that is generally considered to be functional because there appears to be no associated anatomical defect. Stress and psychological factors are thought ... -
The kinetics of gut microbial community composition in patients with irritable bowel syndrome following fecal microbiota transplantation
Mazzawi, Tarek; Lied, Gülen Arslan; Sangnes, Dag André; El-Salhy, Magdy; Hov, Johannes Espolin Roksund; Gilja, Odd Helge; Hatlebakk, Jan Gunnar; Hausken, Trygve (Peer reviewed; Journal article, 2018-11-14)Background: Gut microbiota alterations are important in irritable bowel syndrome (IBS). The aim was to investigate the effect of fecal microbiota transplantation (FMT) on gut microbiota and the symptoms in patients with ... -
A large community outbreak of waterborne giardiasis- delayed detection in a non-endemic urban area
Nygård, Karin; Schimmer, Barbara; Søbstad, Øystein; Walde, Anna; Tveit, Ingvar; Langeland, Nina; Hausken, Trygve; Aavitsland, Preben (BMC Public Health 6(141), Peer reviewed; Journal article, 2006-05-25)Background: Giardia is not endemic in Norway, and more than 90% of reported cases acquire the infection abroad. In late October 2004, an increase in laboratory confirmed cases of giardiasis was reported in the city of ... -
Long-term effects of fecal microbiota transplantation (FMT) in patients with irritable bowel syndrome
El-Salhy, Magdy; Bråthen Kristoffersen, Anja; Valeur, Jørgen; Casén, Christina; Hatlebakk, Jan Gunnar; Gilja, Odd Helge; Hausken, Trygve (Journal article; Peer reviewed, 2021)Background We recently found fecal microbiota transplantation (FMT) in irritable bowel syndrome (IBS) patients to be an effective and safe treatment after 3 months. The present follow-up study investigated the efficacy ... -
Low Densities of Serotonin and Peptide YY Cells in the Colon of Patients with Irritable Bowel Syndrome
El-Salhy, Magdy; Gundersen, Doris; Østgaard, Hege; Lomholt-Beck, B.; Hatlebakk, Jan Gunnar; Hausken, Trygve (Peer reviewed; Journal article, 2011-11-05)Background The gut hormones are important in regulating gastrointestinal motility. Disturbances in gastrointestinal motility have been reported in patients with irritable bowel syndrome (IBS). Reduced endocrine cell density, ... -
Plasma levels of guanylins are reduced in patients with Crohn’s disease
Volkmann, Hilde Løland Von; Brønstad, Ingeborg; Tronstad, Rune Rose; Dizdar, Vernesa; Nylund, Kim; Hanevik, Kurt; Hausken, Trygve; Gilja, Odd Helge; Fiskerstrand, Torunn (Journal article; Peer reviewed, 2020)Background: Guanylin (GN) and uroguanylin (UGN) are endogenous ligands for the intestinal receptor guanylate cyclase C (GC-C), an important regulator of intestinal fluid homeostasis. Gene expression and protein levels of ... -
Possible role of peptide YY (PYY) in the pathophysiology of irritable bowel syndrome (IBS)
El-Salhy, Magdy; Hatlebakk, Jan Gunnar; Hausken, Trygve (Peer reviewed; Journal article, 2020)Irritable bowel syndrome (IBS) is a common gastrointestinal disorder of unknown aetiology for which there is no effective treatment. Although IBS does not increase mortality, it reduces the quality of life and is an economic ... -
Postinfectious and sporadic functional gastrointestinal disorders have different prevalences and rates of overlap: results from a controlled cohort study 3 years after acute giardiasis
Wensaas, Knut-Arne; Hanevik, Kurt; Hausken, Trygve; Eide, Geir Egil; Langeland, Nina; Mørch, Kristine; Rørtveit, Guri (Peer reviewed; Journal article, 2016)Background: Irritable bowel syndrome (IBS) is a common complication following gastroenteritis, and a high prevalence of postgiardiasis IBS has previously been reported. This study aims to investigate the prevalence, adjusted ... -
Postprandial Symptoms in Patients With Functional Dyspepsia and Irritable Bowel Syndrome: Relations to Ultrasound Measurements and Psychological Factors
Steinsvik, Elisabeth Kjelsvik; Valeur, Jørgen; Hausken, Trygve; Gilja, Odd Helge (Journal article; Peer reviewed, 2020)Background/Aims Dyspeptic symptoms are common in patients with functional gastrointestinal (GI) disorders, and may be related to visceral hypersensitivity. We aim to explore the relation between visceral hypersensitivity ... -
Prolonged intestinal transit and diarrhea in patients with an activating GUCY2C mutation
Volkmann, Hilde Løland Von; Brønstad, Ingeborg; Gilja, Odd Helge; Tronstad, Rune Rose; Sangnes, Dag André; Nortvedt, Ragnar; Hausken, Trygve; Dimcevski, Georg Gjorgji; Fiskerstrand, Torunn; Nylund, Kim (Peer reviewed; Journal article, 2017)Introduction: Increased intestinal hydration by activation of the epithelial enzyme linked receptor guanylate cyclase C (GC-C) is a pharmacological principle for treating constipation. Activating mutations in the GUCY2C ... -
A psychological symptom based machine learning model for clinical evaluation of irritable bowel syndrome
Haleem, Noman; Lundervold, Astri J.; Lied, Gülen Arslan; Randulff Hillestad, Eline Margrethe; Bjorkevoll, Maja; Bjørsvik, Ben René; Teige, Erica; Brønstad, Ingeborg; Steinsvik, Elisabeth Kjelsvik; Nagaraja, Bharath Halandur; Hausken, Trygve; Jacobsen, Birgitte Berentsen; Lundervold, Arvid (Journal article; Peer reviewed, 2023)Background: Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by recurrent abdominal pain associated with alterations in stool form and/or stool frequency. Co-morbidities such ... -
Randomised clinical trial and meta-analysis: mesalazine treatment in irritable bowel syndrome—effects on gastrointestinal symptoms and rectal biomarkers of immune activity
Castro Tejera, Valeria; Öhman, Lena; Aabakken, Lars; Fellström, Bengt; Hausken, Trygve; Hovde, Øistein; Hreinsson, Johann P.; Lindberg, Greger; Venge, Per; Simrén, Magnus; Törnblom, Hans (Journal article; Peer reviewed, 2022)Background Low-grade immune activation in the gut is a potential treatment target in irritable bowel syndrome (IBS). Aims To determine improvement in IBS symptoms after mesalazine treatment, and the utility of measures ... -
The relation between celiac disease, nonceliac gluten sensitivity and irritable bowel syndrome
El-Salhy, Magdy; Hatlebakk, Jan Gunnar; Gilja, Odd Helge; Hausken, Trygve (Peer reviewed; Journal article, 2015-09-07)Wheat products make a substantial contribution to the dietary intake of many people worldwide. Despite the many beneficial aspects of consuming wheat products, it is also responsible for several diseases such as celiac ...