Blar i Bergen Open Research Archive på forfatter "Myhr, Kjell-Morten"

Viser treff 41-60 av 68

    • Mortality and cause of death in multiple sclerosis in western Norway 1950-2021: A registry-based linkage study 

      Willumsen, Johannes Sverre; Grytten, Nina; Aarseth, Jan Harald; Myklebust, Tor Åge; Myhr, Kjell-Morten; Midgard, Rune (Journal article; Peer reviewed, 2022)
      Background Persons with multiple sclerosis (pwMS) have higher risk of mortality compared with the general population. Longitudinal studies are important for understanding the evolution of survival in pwMS. Objective ...

    • mtDNA nt13708A Variant Increases the Risk of Multiple Sclerosis 

      Yu, Xinhua; Koczan, Dirk; Sulonen, Anna-Maija; Akkad, Denis A.; Kroner, Antje; Comabella, Manuel; Costa, Gianna; Corongiu, Daniela; Goertsches, Robert; Camina-Tato, Montserrat; Thiese, Hans-Juergen; Nyland, Harald Inge; Mørk, Sverre; Montalban, Xavier; Rieckmann, Peter; Marrosu, Maria G.; Myhr, Kjell-Morten; Epplen, Joerg T.; Saarela, Sanna; Ibrahim, Saleh M. (Peer reviewed; Journal article, 2008-02-13)
      Background: Mitochondrial DNA (mtDNA) polymorphism is a possible factor contributing to the maternal parent-of-origin effect in multiple sclerosis (MS) susceptibility. Methods and Findings: In order to investigate the role ...

    • Natural Variation of Vitamin D and Neurofilament Light Chain in Relapsing-Remitting Multiple Sclerosis 

      Røsjø, Egil Rørvik; Lindstrøm, Jonas Christoffer; Holmøy, Trygve; Myhr, Kjell-Morten; Varhaug, Kristin Nielsen; Torkildsen, Øivind Fredvik (Journal article; Peer reviewed, 2020-04-30)
      Background: High serum levels of 25-hydroxyvitamin D (25(OH)D) have been found among patients with a favorable disease course in relapsing-remitting MS (RRMS), indicating that this may limit clinical deterioration. Clinical ...

    • Neurofilament and Brain Atrophy and Their Association with Cognition in Multiple Sclerosis: A 10-Year Follow-Up Study 

      Bhan, Alok; Jacobsen, Cecilie; Dalen, Ingvild; Alves, Guido Werner; Bergsland, Niels; Myhr, Kjell-Morten; Zetterberg, Henrik; Zivadinov, Robert; Farbu, Elisabeth (Journal article; Peer reviewed, 2023)
      Introduction. Cognitive impairment is an important contributor to disability in multiple sclerosis (MS). Disconnection of neuronal circuits due to axonal injury is probably an important underlying mechanism for this ...

    • Neurofilament light chain as a biomarker in multiple sclerosis 

      Varhaug, Kristin Nielsen; Torkildsen, Øivind; Myhr, Kjell-Morten; Vedeler, Christian A. (Peer reviewed; Journal article, 2019-04-05)
      Due to the unpredictable course and heterogenous treatment response in multiple sclerosis (MS), there is a clear need for biomarkers that reflect disease activity in the clinical follow-up of these patients. Neurofilaments ...

    • Neurofilament light chain predicts disease activity in relapsing-remitting MS 

      Varhaug, Kristin Nielsen; Barro, Christian; Bjørnevik, Kjetil Lauvland; Myhr, Kjell-Morten; Torkildsen, Øivind; Wergeland, Stig; Bindoff, Laurence; Kuhle, Jens; Vedeler, Christian A. (Peer reviewed; Journal article, 2018)
      Objective: To investigate whether serum neurofilament light chain (NF-L) and chitinase 3-like 1 (CHI3L1) predict disease activity in relapsing-remitting MS (RRMS). Methods: A cohort of 85 patients with RRMS were followed ...

    • No association of tobacco use and disease activity in multiple sclerosis 

      Kvistad, Silje; Myhr, Kjell-Morten; Holmøy, Trygve; Saltyte Benth, Jurate; Løken-Amsrud, Kristin Ingeleiv; Wergeland, Stig; Beiske, Antonie Giæver; Bjerve, Kristian S; Hovdal, Harald Olav; Lilleås, Finn; Midgard, Rune; Pedersen, Tom; Bakke, Søren Jacob; Torkildsen, Øivind (Peer reviewed; Journal article, 2016-08)
      Objective: To study whether tobacco use is associated with MRI and clinical disease activity in patients with multiple sclerosis (MS). Methods: Prospective cohort study of 87 patients with relapsing-remitting MS originally ...

    • Ocrelizumab and ofatumumab, but not rituximab, trigger complement induction in vitro 

      Førde, Jan-Lukas; Herfindal, Lars; Myhr, Kjell-Morten; Torkildsen, Øivind; Mollnes, Tom Eirik; Skrede, Silje (Journal article; Peer reviewed, 2023)
      The clinical and adverse effects of the therapeutic monoclonal antibodies (mAb) ocrelizumab, ofatumumab and rituximab in multiple sclerosis (MS) are presently subject to extensive study. While the two former are approved ...

    • Optimization of receptor occupancy assays in mass cytometry: Standardization across channels with QSC beads 

      Bringeland, Gerd Haga; Bader, Lucius; Blaser, Nello; Budzinski, Lisa; Schulz, Axel R.; Mei, Henrik E.; Myhr, Kjell-Morten; Vedeler, Christian A.; Gavasso, Sonia (Peer reviewed; Journal article, 2019)
      Receptor occupancy, the ratio between amount of drug bound and amount of total receptor on single cells, is a biomarker for treatment response to therapeutic monoclonal antibodies. Receptor occupancy is traditionally ...

    • Perinatal Depression and Anxiety in Women with Multiple Sclerosis: A Population-Based Cohort Study 

      Eid, Karine; Torkildsen, Øivind Fredvik Grytten; Aarseth, Jan Harald; Flemmen, Heidi Øyen; Holmøy, Trygve; Lorentzen, Åslaug Rudjord; Myhr, Kjell-Morten; Riise, Trond; Simonsen, Cecilia Smith; Torkildsen, Cecilie Fredvik; Wergeland, Stig; Willumsen, Johannes Sverre; Øksendal, Nina; Gilhus, Nils Erik; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2021)
      Objective: To assess the occurrence of perinatal depression and anxiety in women before and after diagnosis of multiple sclerosis (MS). Methods: 114,629 pregnant women were included in the Norwegian Mother, Father and Child ...

    • Poor Sleep in Patients with Multiple Sclerosis 

      Lunde, Hanne Marie Bøe; Aae, Tommy F.; Indrevåg, William; Aarseth, Jan Harald; Bjorvatn, Bjørn; Myhr, Kjell-Morten; Bø, Lars (Peer reviewed; Journal article, 2012-11-14)
      Background: Poor sleep is a frequent symptom in patients with multiple sclerosis (MS). Sleep may be influenced by MS-related symptoms and adverse effects from immunotherapy and symptomatic medications. We aimed to study ...

    • Predictors of hospitalization due to infection in rituximab-treated MS patients 

      Karlowicz, Jakob Rishovd; Klakegg, Mattias; Aarseth, Jan Harald; Bø, Lars; Myhr, Kjell-Morten; Torgauten, Hilde Marie; Torkildsen, Øivind; Wergeland, Stig (Journal article; Peer reviewed, 2023)
      Background: Rituximab is extensively used off-label to treat multiple sclerosis (MS), and long-term vigilance for adverse events is needed. This study was conducted to determine frequencies and predictors of hematological ...

    • Pregnancy outcomes after exposure to interferon beta: a register-based cohort study among women with MS in Finland and Sweden 

      Hakkarainen, Katja Marja; Juuti, Rosa; Burkill, Sarah; Geissbühler, Yvonne; Sabidó, Meritxell; Popescu, Catrinel; Suzart-Woischnik, Kiliana; Hillert, Jan; Artama, Miia; Verkkoniemi-Ahola, Auli; Myhr, Kjell-Morten; Mehtälä, Juha; Bahmanyar, Shahram; Montgomery, Scott; Korhonen, Pasi (Journal article; Peer reviewed, 2020)
      Background Our aim was to estimate and compare the prevalence of adverse pregnancy outcomes among pregnant women with multiple sclerosis (MS) exposed to interferon beta (IFNB) and among women with MS unexposed to any MS ...

    • Real-world discontinuation rate of teriflunomide and dimethyl fumarate in multiple sclerosis 

      Norborg, Hilde; Riise, Trond; Myhr, Kjell-Morten; Torkildsen, Nina Agnethe Grytten; Wergeland, Stig (Journal article; Peer reviewed, 2021)
      Background For patients with MS, medication switches increase the risk of disease reactivation. Objective Compare discontinuation rates due to treatment failure or side effects between teriflunomide and dimethyl ...

    • Recent progress in maintenance treatment of neuromyelitis optica spectrum disorder 

      Holmøy, Trygve; Høglund, Rune Alexander; Illes, Zsolt; Myhr, Kjell-Morten; Torkildsen, Øivind (Journal article; Peer reviewed, 2020)
      Background Treatment of neuromyelitis optica spectrum disorder (NMOSD) has so far been based on retrospective case series. The results of six randomized clinical trials including five different monoclonal antibodies ...

    • Relationship between White Matter Lesions and Gray Matter Atrophy in Multiple Sclerosis 

      Lie, Ingrid Anne; Weeda, Merlin M.; Mattiesing, Rozemarijn M.; Mol, Marijke A.E.; Pouwels, Petra J.W.; Barkhof, Frederik; Torkildsen, Øivind; Bø, Lars; Myhr, Kjell-Morten; Vrenken, Hugo (Journal article; Peer reviewed, 2022)
      Background and Objectives: There is currently no consensus about the extent of gray matter (GM) atrophy that can be attributed to secondary changes after white matter (WM) lesions or the temporal and spatial relationships ...

    • Safety and efficacy of rituximab as first- and second line treatment in multiple sclerosis – A cohort study 

      Torgauten, Hilde Marie; Myhr, Kjell-Morten; Wergeland, Stig; Bø, Lars; Aarseth, Jan Harald; Torkildsen, Øivind (Journal article; Peer reviewed, 2021-01-31)
      Background Rituximab is increasingly used as off-label therapy in multiple sclerosis (MS). More data are needed on safety and efficacy of rituximab, particularly in cohorts of de novo patients and patients in early therapy ...

    • Safety of breast feeding during rituximab treatment in multiple sclerosis 

      Rød, Brit Ellen; Torkildsen, Øivind; Myhr, Kjell-Morten; Bø, Lars; Wergeland, Stig (Journal article; Peer reviewed, 2022)
      Background There are limited data on the safety of breast feeding during rituximab therapy. Our objective is to determine exposure from breast feeding and biological effects of rituximab in breastfed infants. Methods ...

    • Serum neurofilament as a predictor of 10-year grey matter atrophy and clinical disability in multiple sclerosis: a longitudinal study 

      Lie, Ingrid Anne; Kacar, Sezgi; Wesnes, Kristin; Brouwer, Iman; Kvistad, Silje S.; Wergeland, Stig; Holmøy, Trygve; Midgard, Rune; Bru, Alla Nikolajevna S; Edland, Astrid; Eikeland, Randi; Gosal, Sonia; Harbo, Hanne-Cathrin Flinstad; Kleveland, Grethe; Sørenes, Yvonne; Øksendal, Nina; Varhaug, Kristin Nielsen; Vedeler, Christian Alexander; Barkhof, Frederik; Teunissen, Charlotte E.; Bø, Lars; Torkildsen, Øivind Fredvik Grytten; Myhr, Kjell-Morten; Vrenken, Hugo (Journal article; Peer reviewed, 2022)
      Background The predictive value of serum neurofilament light chain (sNfL) on long-term prognosis in multiple sclerosis (MS) is still unclear. Objective Investigate the relation between sNfL levels over a 2-year ...

    • Strong tuberculin response after BCG vaccination is associated with low multiple sclerosis risk: a population-based cohort study 

      Nakken, Ola; Holmøy, Trygve; Stigum, Hein; Myhr, Kjell-Morten; Dahl, Jesper; Heldal, Einar; Meyer, Haakon Eduard (Journal article; Peer reviewed, 2022)
      Background: Multiple sclerosis (MS) is characterized by inflammatory lesions in the central nervous system involving pro-inflammatory T-cells. Immune dysregulation is well described in prevalent disease, but it is not known ...