• Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns 

      Joubert, Bonnie R; Den Dekker, Herman T; Felix, Janine F; Bohlin, Jon; Ligthart, Symen; Beckett, Emma; Tiemeier, Henning; van Meurs, Joyce B; Uitterlinden, Andre G; Hofman, Albert; Håberg, Siri Eldevik; Reese, Sarah E; Peters, Marjolein J; Kulle Andreassen, Bettina; Steegers, Eric A P; Nilsen, Roy Miodini; Vollset, Stein Emil; Midttun, Øivind; Ueland, Per Magne; Franco, Oscar H; Dehghan, Abbas; De Jongste, Johan C; Wu, Michael C; Wang, Tianyuan; Peddada, Shyamal D; Jaddoe, Vincent W V; Nystad, Wenche; Duijts, Liesbeth; London, Stephanie J (Peer reviewed; Journal article, 2016-02-10)
      Folate is vital for fetal development. Periconceptional folic acid supplementation and food fortification are recommended to prevent neural tube defects. Mechanisms whereby periconceptional folate influences normal development ...
    • Maternal use of folic acid and multivitamin supplements and infant risk of birth defects in Norway, 1999–2013 

      Gildestad, Trude; Bjørge, Tone; Haaland, Øystein Ariansen; Klungsøyr, Kari; Vollset, Stein Emil; Øyen, Nina (Journal article; Peer reviewed, 2020)
      The association between folic acid supplementation and birth defects other than neural tube defects (NTD) remains unclear. We used a log-binomial regression model to investigate if periconceptional folic acid and/or ...
    • Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016 

      Fullman, Nancy; Yearwood, Jamal; Abay, Solomon M.; Abbafati, Cristiana; Abd-Allah, Foad; Abdela, Jemal; Abdelalim, Ahmed; Abebe, Zegeye; Abebo, Teshome Abuka; Aboyans, Victor; Abraha, Haftom Niguse; Abreu, Daisy M. X.; Abu-Raddad, Laith J.; Adane, Akilew Awoke; Adedoyin, Rufus Adesoji; Adetokunboh, Olatunji; Adhikari, Tara Ballav; Afarideh, Mohsen; Afshin, Ashkan; Agarwal, Gina; Agius, Dominic; Agrawal, Anurag; Agrawal, Sutapa; Kiadaliri, Aliasghar Ahmad; Aichour, Miloud Taki Eddine; Akibu, Mohammed; Akinyemi, Rufus Olusola; Akinyemiju, Tomi F.; Akseer, Nadia; Al Lami, Faris Hasan; Alahdab, Fares; Al-Aly, Ziyad; Alam, Khurshid; Alam, Tahiya; Alasfoor, Deena; Albittar, Mohammed I.; Alene, Kefyalew Addis; Al-Eyadhy, Ayman; Ali, Syed Danish; Alijanzadeh, Mehran; Aljunid, Syed M.; Alkerwi, Ala'a; Alla, Francois; Allebeck, Peter; Allen, Christine; Alomari, Mahmoud A.; Al-Raddadi, Rajaa; Alsharif, Ubai; Altirkawi, Khalid A.; Alvis-Guzman, Nelson; Amare, Azmeraw T.; Amenu, Kebede; Ammar, Walid; Amoako, Yaw Ampem; Anber, Nahla; Andrei, Catalina Liliana; Androudi, Sofia; Antonio, Carl Abelardo T.; Araujo, Valdelaine E. M.; Aremu, Olatunde; Arnlöv, Johan; Artaman, Al; Aryal, Krishna Kumar; Asayesh, Hamid; Asfaw, Ephrem Tsegay; Asgedom, Solomon Weldegebreal; Asghar, Rana Jawad; Ashebir, Mengistu Mitiku; Asseffa, Netsanet Abera; Atey, Tesfay Mehari; Atre, Sachin R.; Atteraya, Madhu S.; Avila-Burgos, Leticia; Avokpaho, Euripide Frinel G. Arthur; Awasthi, Ashish; Quintanilla, Beatriz Paulina Ayala; Ayalew, Animut Alebel; Ayele, Henok Tadesse; Ayer, Rakesh; Ayuk, Tambe Betrand; Azzopardi, Peter; Azzopardi-Muscat, Natasha; Babalola, Tesleem Kayode; Badali, Hamid; Badawi, Alaa; Banach, Maciej; Banerjee, Amitava; Banstola, Amrit; Barber, Ryan M.; Barboza, Miguel A.; Barker-Collo, Suzanne L.; Bärnighausen, Till; Barquera, Simon; Barrero, Lope H.; Bassat, Quique; Basu, Sanjay; Baune, Bernhard T.; Bazargan-Hejazi, Shahrzad; Bedi, Neeraj; Beghi, Ettore; Behzadifar, Masoud; Behzadifar, Meysam; Htet, Aung Soe; Kisa, Adnan; Norheim, Ole Frithjof; Savic, Miloje; Skirbekk, Vegard Fykse; Vollset, Stein Emil; Weiderpass, Elisabete; Winkler, Andrea Sylvia (Journal article; Peer reviewed, 2018)
      Background A key component of achieving universal health coverage is ensuring that all populations have access to quality health care. Examining where gains have occurred or progress has faltered across and within countries ...
    • Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016 

      Fullman, Nancy; Barber, Ryan M.; Abajobir, Amanuel Alemu; Abate, Kalkidan Hassen; Abbafati, Cristiana; Abbas, Kaja M.; Abd-Allah, Foad; Abdulle, Abdishakur M.; Abera, Semaw Ferede; Aboyans, Victor; Abu-Raddad, Laith J.; Abu-Rmeileh, Niveen M. E.; Aryal, Krishna Kumar; Htet, Aung Soe; Kisa, Adnan; Norheim, Ole Frithjof; Vollset, Stein Emil; Weiderpass, Elisabete (Peer reviewed; Journal article, 2017-09)
      Background: The UN's Sustainable Development Goals (SDGs) are grounded in the global ambition of “leaving no one behind”. Understanding today's gains and gaps for the health-related SDGs is essential for decision makers ...
    • Mortality following first-time hospitalization with acute myocardial infarction in Norway, 2001-2014: Time trends, underlying causes and place of death 

      Sulo, Gerhard; Igland, Jannicke; Sulo, Enxhela; Øverland, Simon Nygaard; Egeland, Grace M.; Vollset, Stein Emil; Tell, Grethe S. (Journal article; Peer reviewed, 2019-11)
      Background Trends on cause-specific mortality following acute myocardial infarction (AMI) are poorly described and no studies have analyzed where do AMI patients die. We analyzed trends in 28-day and one-year mortality ...
    • Musculoskeletal disorders in Norway: Prevalence of chronicity and use of primary and specialist health care services 

      Kinge, Jonas Minet; Knudsen, Ann Kristin; Skirbekk, Vegard; Vollset, Stein Emil (Peer reviewed; Journal article, 2015-04-02)
      Background: Uncertainty exists with regards to the extent of prevalence and health care use for musculoskeletal disorders in Norway. The aim of this study was to estimate the prevalence of chronic musculoskeletal disorders ...
    • The PAr index, an indicator reflecting altered vitamin B-6 homeostasis, is associated with long-term risk of stroke in the general population: the Hordaland Health Study (HUSK) 

      Zuo, Hui; Tell, Grethe S.; Ueland, Per Magne; Nygård, Ottar; Vollset, Stein Emil; Midttun, Øivind; Meyer, Klaus; Ulvik, Arve (Peer reviewed; Journal article, 2018-01)
      Background: Vitamin B-6 homeostasis is altered during inflammation and immune activation. It is unknown whether altered vitamin B-6 homeostasis is associated with the risk of stroke. Objective: We investigated the relation ...
    • Parental income and mental disorders in children and adolescents: prospective register-based study 

      Kinge, Jonas Minet; Øverland, Simon Nygaard; Flatø, Martin; Dieleman, Joseph; Røgeberg, Ole Jørgen; Magnus, Maria Christine; Evensen, Miriam; Tesli, Martin Steen; Skrondal, Anders; Stoltenberg, Camilla; Vollset, Stein Emil; Håberg, Siri Eldevik; Torvik, Fartein Ask (Journal article; Peer reviewed, 2021)
      Background Children with low-income parents have a higher risk of mental disorders, although it is unclear whether other parental characteristics or genetic confounding explain these associations and whether it is true ...
    • Periconceptional Folic Acid Supplementation and Infant Risk of Congenital Heart Defects in Norway 1999-2009 

      Leirgul, Elisabeth; Gildestad, Trude; Nilsen, Roy Miodini; Fomina, Tatiana; Brodwall, Kristoffer; Greve, Gottfried; Vollset, Stein Emil; Holmstrøm, Henrik; Tell, Grethe Seppola; Øyen, Nina (Peer reviewed; Journal article, 2015)
      Background The birth prevalence of congenital heart defects (CHDs) has decreased in Canada and Europe. Recommended intake of folic acid in pregnancy is a suggestive risk-reducing factor for CHDs. We investigated the ...
    • Plasma Biomarkers of Inflammation, the Kynurenine Pathway, and Risks of All-Cause, Cancer, and Cardiovascular Disease Mortality. The Hordaland Health Study 

      Zuo, Hui; Ueland, Per Magne; Ulvik, Arve; Eussen, Simone; Vollset, Stein Emil; Nygård, Ottar; Midttun, Øivind; Theofylaktopoulou, Despoina; Meyer, Klaus; Tell, Grethe Seppola (Peer reviewed; Journal article, 2016)
      We aimed to evaluate 10 biomarkers related to inflammation and the kynurenine pathway, including neopterin, kynurenine:tryptophan ratio, C-reactive protein, tryptophan, and 6 kynurenines, as potential predictors of all-cause ...
    • Plasma concentrations and dietary intakes of choline and betaine in association with atrial fibrillation risk: Results from 3 prospective cohorts with different health profiles 

      Zuo, Hui; Svingen, Gard Frodahl Tveitevåg; Tell, Grethe S.; Ueland, Per Magne; Vollset, Stein Emil; Pedersen, Eva Ringdal; Ulvik, Arve; Meyer, Klaus; Nordrehaug, Jan Erik; Nilsen, Dennis W.T.; Bønaa, Kaare; Nygård, Ottar (Peer reviewed; Journal article, 2018)
      Background: Although choline metabolism has been associated with atherosclerotic heart disease, less research attention has been paid to the associations of choline and its oxidative metabolite betaine with cardiac ...
    • Plasma free choline, betaine and cognitive performance: the Hordaland Health Study 

      Nurk, Eha; Refsum, Helga; Bjelland, Ingvar; Drevon, Christian A; Tell, Grethe S; Ueland, Per Magne; Vollset, Stein Emil; Engedal, Knut Arne; Nygaard, Harald A.; Smith, David A (Peer reviewed; Journal article, 2013-02)
      Choline and betaine are nutrients involved in one-carbon metabolism. Choline is essential for neurodevelopment and brain function. We studied the associations between cognitive function and plasma concentrations of free ...
    • Plasma methionine, choline, betaine, and dimethylglycine in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) 

      Nitter, Mathilde Hjelle; Norgård, Benedicte Wentzel; De Vogel, Stefan; Eussen, Simone; Meyer, Klaus; Ulvik, Arve; Ueland, Per Magne; Nygård, Ottar; Vollset, Stein Emil; Bjørge, Tone; Tjønneland, Anne; Hansen, Louise; Boutron-Ruault, Marie-Christine; Racine, Antoine; Cottet, Vanessa; Kaaks, Rudolf; Kühn, Tilman; Trichopoulou, Antonia; Bamia, Christina; Naska, Androniki; Grioni, Sara; Palli, Domenico; Panico, Salvatore; Tumino, Rosario; Vineis, Paolo; Bueno-de-Mesquita, H. Bas; Van Kranen, Henk J.; Peeters, Petra H. M.; Weiderpass, Elisabete; Dorronsoro, Miren; Jakszyn, Paula; Sánchez, María-José; Argüelles, Marcial Vicente; Huerta, José-Maria; Barricarte, Aurelio; Johansson, Matthias; Ljuslinder, Ingrid; Khaw, Kay Tee; Wareham, Nicholas J.; Freisling, Heinz; Duarte-Salles, Talita; Stepien, Magdalena; Gunter, Mark J.; Riboli, Élio B. (Peer reviewed; Journal article, 2014-08)
      Background Disturbances in one carbon metabolism may contribute to carcinogenesis by affecting methylation and synthesis of DNA. Choline and its oxidation product betaine are involved in this metabolism and can serve as ...
    • Prevalence and stability of mental disorders among young adults: Findings from a longitudinal study 

      Gustavson, Kristin; Knudsen, Ann Kristin; Nesvåg, Ragnar; Knudsen, Gun Peggy S.; Vollset, Stein Emil; Reichborn-Kjennerud, Ted (Peer reviewed; Journal article, 2018-03-12)
      Background: Mental disorders often have onset early in life, contribute substantially to the global disease burden, and may interfere with young people’s ability to complete age-relevant tasks in important developmental ...
    • Prognostic Impact of In-Hospital and Postdischarge Heart Failure in Patients With Acute Myocardial Infarction: A Nationwide Analysis Using Data From the Cardiovascular Disease in Norway (CVDNOR) Project 

      Sulo, Gerhard; Igland, Jannicke; Nygård, Ottar; Vollset, Stein Emil; Ebbing, Marta; Poulter, Neil; Egeland, G.M.; Cerqueira, Charlotte; Jørgensen, Torben; Tell, Grethe S. (Peer reviewed; Journal article, 2017-03)
      Background: Heart failure (HF) is a serious complication of acute myocardial infarction (AMI). We explored the excess mortality associated with HF as an early or late complication of AMI and describe changes over time in ...
    • Risk of diabetes after gestational diabetes and preeclampsia. A registry-based study of 230,000 women in Norway 

      Engeland, Anders; Bjørge, Tone; Daltveit, Anne Kjersti; Skurtveit, Svetlana; Vangen, Siri; Vollset, Stein Emil; Furu, Kari (Peer reviewed; Journal article, 2011-02-06)
      This study aimed to use a population-based Prescription Database to explore later development of diabetes in women registered with gestational diabetes mellitus (GDM) and/or preeclampsia in the Medical Birth Registry of ...
    • Smoking and body fat mass in relation to bone mineral density and hip fracture: The Hordaland Health Study 

      Øyen, Jannike; Gjesdal, Clara Gram; Nygård, Ottar; Lie, Stein Atle; Meyer, Haakon; Apalset, Ellen M.; Ueland, Per Magne; Pedersen, Eva Kristine Ringdal; Midttun, Øivind; Vollset, Stein Emil; Tell, Grethe Seppola (Peer reviewed; Journal article, 2014-03-25)
      Lower bone mineral density (BMD) in smokers may be attributable to lower body weight or fat mass, rather than to a direct effect of smoking. We analyzed the effects of smoking exposure, assessed by plasma cotinine, and ...
    • Smoking prevalence and attributable disease burden in 195 countries and territories, 1990–2015: a systematic analysis from the Global Burden of Disease Study 2015 

      Reitsma, Marissa B; Fullman, Nancy; Ng, Marie; Neupane, Sudan Prasad; Vollset, Stein Emil; GBD 2015 Tobacco Collaborators (Peer reviewed; Journal article, 2017-05)
      Background: The scale-up of tobacco control, especially after the adoption of the Framework Convention for Tobacco Control, is a major public health success story. Nonetheless, smoking remains a leading risk for early death ...
    • Smoking, plasma cotinine and risk of atrial fibrillation: the Hordaland Health Study 

      Zuo, Hui; Nygård, Ottar; Vollset, Stein Emil; Ueland, Per Magne; Ulvik, Arve; Midttun, Øivind; Meyer, Klaus; Igland, Jannicke; Sulo, Gerhard; Tell, Grethe S. (Peer reviewed; Journal article, 2018-01)
      Background: Cigarette smoking has been identified as a major modifiable risk factor for coronary heart disease and mortality. However, findings on the relationship between smoking and atrial fibrillation (AF) have been ...
    • Supplemental folic acid in pregnancy and childhood cancer risk 

      Mortensen, Jan Helge Seglem; Øyen, Nina; Fomina, Tatiana; Melbye, Mads; Tretli, Steinar; Vollset, Stein Emil; Bjørge, Tone (Peer reviewed; Journal article, 2016)
      Background: We investigated the association between supplemental folic acid in pregnancy and childhood cancer in a nationwide study of 687 406 live births in Norway, 1999–2010, and 799 children diagnosed later with cancer. ...