Blar i Bergen Open Research Archive på tidsskrift "Nature Communications"
Viser treff 41-60 av 114
-
The Iceland-Faroe Slope Jet: a conduit for dense water toward the Faroe Bank Channel overflow
(Journal article; Peer reviewed, 2020)Dense water from the Nordic Seas passes through the Faroe Bank Channel and supplies the lower limb of the Atlantic Meridional Overturning Circulation, a critical component of the climate system. Yet, the upstream pathways ... -
Identification of biomarkers for glycaemic deterioration in type 2 diabetes
(Journal article; Peer reviewed, 2023)We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic ... -
Identification of nine new susceptibility loci for endometrial cancer
(Peer reviewed; Journal article, 2018-08-09)Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial ... -
Identification of susceptibility pathways for the roleof chromosome 15q25.1 in modifying lung cancerrisk
(Peer reviewed; Journal article, 2018-08-13)Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 ... -
An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver
(Journal article; Peer reviewed, 2023)A perimetastatic capsule is a strong positive prognostic factor in liver metastases, but its origin remains unclear. Here, we systematically quantify the capsule’s extent and cellular composition in 263 patients with ... -
An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment
(Peer reviewed; Journal article, 2019)How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis is still unclear. In 15 breast cancer gene expression datasets, we invariably identify three clusters of patients with gradual levels ... -
Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance
(Journal article; Peer reviewed, 2022)Human papillomavirus (HPV)-associated cervical cancer is a leading cause of cancer deaths in women. Here we present an integrated multi-omic analysis of 643 cervical squamous cell carcinomas (CSCC, the most common histological ... -
Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability
(Journal article; Peer reviewed, 2023)Variability in disease severity caused by a microbial pathogen is impacted by each infection representing a unique combination of host and pathogen genomes. Here, we show that the outcome of invasive Streptococcus pyogenes ... -
Irminger Sea deep convection injects oxygen and anthropogenic carbon to the ocean interior
(Peer reviewed; Journal article, 2016-10-27)Deep convection in the subpolar North Atlantic ventilates the ocean for atmospheric gases through the formation of deep water masses. Variability in the intensity of deep convection is believed to have caused large variations ... -
Irrigated areas drive irrigation water withdrawals
(Journal article; Peer reviewed, 2021)A sustainable management of global freshwater resources requires reliable estimates of the water demanded by irrigated agriculture. This has been attempted by the Food and Agriculture Organization (FAO) through country ... -
Large mesopelagic fishes biomass and trophic efficiency in the open ocean
(Peer reviewed; Journal article, 2014-02-07)With a current estimate of ~1,000 million tons, mesopelagic fishes likely dominate the world total fishes biomass. However, recent acoustic observations show that mesopelagic fishes biomass could be significantly larger ... -
Life histories determine divergent population trends for fishes under climate warming
(Journal article; Peer reviewed, 2020-08-14)Most marine fish species express life-history changes across temperature gradients, such as faster growth, earlier maturation, and higher mortality at higher temperature. However, such climate-driven effects on life histories ... -
Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae
(Journal article; Peer reviewed, 2023)Protein N-terminal (Nt) acetylation is one of the most abundant modifications in eukaryotes, covering ~50-80 % of the proteome, depending on species. Cells with defective Nt-acetylation display a wide array of phenotypes ... -
Macromolecular sheets direct the morphology and orientation of plate-like biogenic guanine crystals
(Journal article; Peer reviewed, 2023)Animals precisely control the morphology and assembly of guanine crystals to produce diverse optical phenomena in coloration and vision. However, little is known about how organisms regulate crystallization to produce ... -
Mantle exhumation at magma-poor rifted margins controlled by frictional shear zones
(Journal article; Peer reviewed, 2022)The transition zone from continental crust to the mature mid-ocean ridge spreading center of the Iberia-Newfoundland magma-poor rifted margins is mostly composed of exhumed mantle characterized by highs and domes with ... -
Melt volume at Atlantic volcanic rifted margins controlled by depth-dependent extension and mantle temperature
(Journal article; Peer reviewed, 2021)Breakup volcanism along rifted passive margins is highly variable in time and space. The factors controlling magmatic activity during continental rifting and breakup are not resolved and controversial. Here we use numerical ... -
Meltwater sediment transport as the dominating process in mid-latitude trough mouth fan formation
(Journal article; Peer reviewed, 2020)Trough mouth fans comprise the largest sediment deposits along glaciated margins, and record Pleistocene climate changes on a multi-decadal time scale. Here we present a model for the formation of the North Sea Fan derived ... -
Mesmerize is a dynamically adaptable user-friendly analysis platform for 2D and 3D calcium imaging data
(Journal article; Peer reviewed, 2021)Calcium imaging is an increasingly valuable technique for understanding neural circuits, neuroethology, and cellular mechanisms. The analysis of calcium imaging data presents challenges in image processing, data organization, ... -
Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
(Peer reviewed; Journal article, 2019-04-23)Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in ... -
Modeling assortative mating and genetic similarities between partners, siblings, and in-laws
(Journal article; Peer reviewed, 2022)Assortative mating on heritable traits can have implications for the genetic resemblance between siblings and in-laws in succeeding generations. We studied polygenic scores and phenotypic data from pairs of partners ...