Blar i Bergen Open Research Archive på forfatter "Haavik, Jan"

Viser treff 81-93 av 93

    • Risk factors of suicidal spectrum behaviors in adults and adolescents with attention-deficit / hyperactivity disorder – a systematic review 

      Austgulen, Amalie; Skram, Nanna Karen Gilberg; Haavik, Jan; Lundervold, Astri J. (Journal article; Peer reviewed, 2023-08-21)
      Introduction: Adolescents and adults with attention-deficit/hyperactivity disorder (ADHD) are at increased risk of suicidal spectrum behaviors (SSBs). However, there is limited knowledge about risk factors triggering SSBs ...

    • Serine 19 phosphorylation and 14‐3‐3 binding regulate phosphorylation and dephosphorylation of tyrosine hydroxylase on serine 31 and serine 40 

      Ghorbani, Sadaf; Szigetvari, Peter Daniel; Haavik, Jan; Kleppe, Rune (Peer reviewed; Journal article, 2019-09-17)
      Multisite phosphorylation and structural flexibility allow for complex regulation of proteins through cellular signaling. Tyrosine hydroxylase (TH), a key enzyme of catecholamine synthesis, is regulated by multiple neuronal ...

    • Serum concentrations of kynurenines in adult patients with attention-deficit hyperactivity disorder (ADHD): a case–control study 

      Hegvik, Tor-Arne; Ulvik, Arve; Halmøy, Anne; Haavik, Jan; Aarsland, Tore Ivar Malmei; Landaas, Elisabeth Toverud; Ueland, Per Magne (Peer reviewed; Journal article, 2015-11-05)
      Background: The essential amino acid tryptophan is catabolised mainly through the kynurenine pathway. Altered circulating levels of kynurenines have been reported in chronic inflammatory conditions and in several ...

    • Sex differences in parent–offspring recurrence of attention-deficit/hyperactivity disorder 

      Solberg, Berit Skretting; Hegvik, Tor-Arne; Halmøy, Anne; Skjaerven, Rolv; Engeland, Anders; Haavik, Jan; Klungsøyr, Kari (Journal article; Peer reviewed, 2020)
      Background Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder sharing genetic risk factors with other common psychiatric disorders. However, intergenerational recurrence ...

    • Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p 

      Weiner, Daniel J.; Ling, Emi; Erdin, Serkan; Tai, Derek J. C.; Yadav, Rachita; Grove, Jakob; Fu, Jack M.; Nadig, Ajay; Carey, Caitlin E.; Baya, Nikolas; Bybjerg-Grauholm, Jonas; Mortensen, Preben B.; Werge, Thomas; Demontis, Ditte; Mors, Ole; Nordentoft, Merete; Als, Thomas D.; Baekvad-Hansen, Marie; Rosengren, Anders; Havdahl, Alexandra Karoline Saasen; Hedemand, Anne; Palotie, Aarno; Chakravarti, Aravinda; Arking, Dan; Sulovari, Arvis; Starnawska, Anna; Thiruvahindrapuram, Bhooma; de Leeuw, Christiaan; Carey, Caitlin; Ladd-Acosta, Christine; van der Merwe, Celia; Devlin, Bernie; Cook, Edwin H.; Eichler, Evan; Corfield, Elizabeth Claire; Dieleman, Gwen; Schellenberg, Gerard; Hakonarson, Hakon; Coon, Hilary; Dziobek, Isabel; Vorstman, Jacob; Girault, Jessica; Sutcliffe, James S.; Duan, Jinjie; Nurnberger, John; Hallmayer, Joachim; Buxbaum, Joseph; Piven, Joseph; Weiss, Lauren; Davis, Lea; Janecka, Magdalena; Mattheisen, Manuel; State, Matthew W.; Gill, Michael; Daly, Mark; Uddin, Mohammed; Andreassen, Ole; Szatmari, Peter; Lee, Phil Hyoun; Anney, Richard; Ripke, Stephan; Satterstrom, Kyle; Santangelo, Susan; Kuo, Susan; van Elst, Ludger Tebartz; Rolland, Thomas; Bougeron, Thomas; Polderman, Tinca; Turner, Tychele; Underwood, Jack; Manikandan, Veera; Pillalamarri, Vamsee; Warrier, Varun; Philipsen, Alexandra; Reif, Andreas; Hinney, Anke; Cormand, Bru; Bau, Claiton H. D.; Rovaris, Diego Luiz; Sonuga-Barke, Edmund; Grevet, Eugenio Horacio; Salum, Giovanni; Larsson, Henrik Bo W.; Buitelaar, Jan; Haavik, Jan; McGough, James; Kuntsi, Jonna; Elia, Josephine; Lesch, Klaus-Peter; Klein, Marieke; Bellgrove, Mark; Tesli, Martin Steen; Leung, Patrick W. L.; Pan, Pedro M.; Dalsgaard, Søren; Loo, Sandra; Medland, Sarah; Faraone, Stephen; Reichborn-Kjennerud, Ted; Banaschewski, Tobias; Hawi, Ziarih; Berretta, Sabina; Macosko, Evan Z.; Sebat, Jonathan; O’Connor, Luke J.; Hougaard, David M.; Børglum, Anders D.; Talkowski, Michael E.; McCarroll, Steven A.; Robinson, Elise B. (Journal article; Peer reviewed, 2022)
      The canonical paradigm for converting genetic association to mechanism involves iteratively mapping individual associations to the proximal genes through which they act. In contrast, in the present study we demonstrate the ...

    • Structure and substrate specificity determinants of the taurine biosynthetic enzyme cysteine sulphinic acid decarboxylase 

      Mahootchi, Elaheh; Raasakk, Arne; Luan, Weisha; Muruganandam, Gopinath; Loris, Remy; Haavik, Jan; Kursula, Petri (Journal article; Peer reviewed, 2021)
      Pyridoxal 5́-phosphate (PLP) is an important cofactor for amino acid decarboxylases with many biological functions, including the synthesis of signalling molecules, such as serotonin, dopamine, histamine, γ-aminobutyric ...

    • Structure of the mouse acidic amino acid decarboxylase GADL1 

      Raasakka, Arne; Mahootchi, Elaheh; Winge, Ingeborg; Luan, Weisha; Kursula, Petri; Haavik, Jan (Journal article; Peer reviewed, 2018)
      Pyridoxal 5′-phosphate (PLP) is a ubiquitous cofactor in various enzyme classes, including PLP-dependent decarboxylases. A recently discovered member of this class is glutamic acid decarboxylase-like protein 1 (GADL1), ...

    • Synthetic corticosteroids as tryptophan hydroxylase stabilizers 

      Betari, Nibal; Teigen, Knut; Sahlholm, Kristoffer; Haavik, Jan (Journal article; Peer reviewed, 2021)
      Background: Clinically, corticosteroids are used mainly for their immune-modulatory properties but are also known to influence mood. Despite evidence of a role in regulating tryptophan hydroxylases (TPH), key enzymes in ...

    • Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease 

      Waløen, Kai; Kleppe, Rune; Martinez, Aurora; Haavik, Jan (Peer reviewed; Journal article, 2017)
      Introduction: The ancient and ubiquitous monoamine signalling molecules serotonin, dopamine, norepinephrine, and epinephrine are involved in multiple physiological functions. The aromatic amino acid hydroxylases tyrosine ...

    • Tyrosinemia Type 1 and symptoms of ADHD: Biochemical mechanisms and implications for treatment and prognosis 

      Barone, Helene; Bliksrud, Yngve Thomas; Elgen, Irene Bircow; Szigetvari, Peter Daniel; Kleppe, Rune; Ghorbani, Sadaf; Hansen, Eirik Vangsøy; Haavik, Jan (Peer reviewed; Journal article, 2020)
      Hereditary tyrosinemia Type 1 (HT‐1) is a rare metabolic disease where the enzyme catalyzing the final step of tyrosine breakdown is defect, leading to accumulation of toxic metabolites. Nitisinone inhibits the degradation ...

    • Vagally mediated heart rate variability, stress, and perceived social support: a focus on sex differences 

      Kvadsheim, Elisabet; Sørensen, Lin; Fasmer, Ole Bernt; Osnes, Berge; Haavik, Jan; Williams, DeWayne P.; Thayer, Julian Francis; Koenig, Julian (Journal article; Peer reviewed, 2022)
      Higher vagally mediated heart rate variability (vmHRV), reflecting vagal activity as indexed by heart function and lower stress vulnerability, is associated with higher perceived social support. Seeking social support is ...

    • Validity and accuracy of the Adult Attention-Deficit/Hyperactivity Disorder (ADHD) Self-Report Scale (ASRS) and the Wender Utah Rating Scale (WURS) symptom checklists in discriminating between adults with and without ADHD 

      Brevik, Erlend Joramo; Lundervold, Astri J.; Haavik, Jan; Posserud, Maj-Britt Rocio (Journal article; Peer reviewed, 2020)
      Objective To validate the Adult ADHD Self‐Report Scale (ASRS) and the Wender Utah Rating Scale (WURS) in a well‐characterized sample of adult attention‐deficit/hyperactivity disorder (ADHD) patients and population ...

    • The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder 

      Faraone, Stephen; Banaschewski, Tobias; Coghill, David; Zheng, Yi; Biederman, Joseph; Bellgrove, Mark A.; Newcorn, Jeffrey H.; Gignac, Martin; Al Saud, Nouf M.; Manor, Iris; Rohde, Luis Augusto; Yang, Li; Cortese, Samuele; Almagor, Doron; Stein, Mark A.; Albatti, Turki H.; Aljoudi, Haya F.; Alqahtani, Mohammed M.J.; Asherson, Philip; Atwoli, Lukoye; Bölte, Sven; Buitelaar, Jan K.; Crunelle, Cleo L.; Daley, David; Dalsgaard, Søren; Döpfner, Manfred; Espinet, Stacey; Fitzgerald, Michael; Franke, Barbara; Gerlach, Manfred; Haavik, Jan; Hartman, Catharina A.; Hartung, Cynthia M.; Hinshaw, Stephen P.; Hoekstra, Pieter J.; Hollis, Chris; Kollins, Scott H.; Sandra Kooij, Kooij; Kuntsi, Jonna; Larsson, Henrik; Li, Tingyu; Liu, Jing; Merzon, Eugene; Mattingly, Gregory; Mattos, Paulo; McCarthy, Suzanne; Mikami, Amori Yee; Molina, Brooke S.G.; Nigg, Joel T.; Purper-Ouakil, Diane; Omigbodun, Olayinka O.; Polanczyk, Guilherme V.; Pollak, Yehuda; Poulton, Alison S.; Rajkumar, Ravi Philip; Reding, Andrew; Reif, Andreas; Rubia, Katya; Rucklidge, Julia; Romanos, Marcel; Ramos-Quiroga, J. Antoni; Schellekens, Arnt; Scheres, Anouk; Schoeman, Renata; Schweitzer, Julie B.; Shah, Henal; Solanto, Mary V.; Sonuga-Barke, Edmund; Soutullo, César; Steinhausen, Hans-Christoph; Swanson, James M.; Thapar, Anita; Tripp, G; van de Glind, Geurt; Brink, Wim van den; Van der Oord, Saskia; Venter, Andre; Vitiello, Benedetto; Walitza, Susanne; Wang, Yufeng (Journal article; Peer reviewed, 2021)
      Background Misconceptions about ADHD stigmatize affected people, reduce credibility of providers, and prevent/delay treatment. To challenge misconceptions, we curated findings with strong evidence base. Methods We ...