Browsing Bergen Open Research Archive by Author "Aabakken, Lars"
Now showing items 1-9 of 9
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Determination of lower cut-off levels of adalimumab associated with biochemical remission in Crohn's disease
Carlsen, Arne; Omdal, Roald; Karlsen, Lars Normann; Kvaløy, Jan Terje; Aabakken, Lars; Steinsbø, Øyvind; Bolstad, Nils; Warren, David; Lundin, Knut Erik Aslaksen; Grimstad, Tore (Peer reviewed; Journal article, 2020)Background and Aim: Adalimumab is administered and dosed using a standardized treatment regimen. Although therapeutic drug monitoring (TDM) may help optimize treatment efficacy, the lower cut‐off concentration of adalimumab ... -
Fatigue: a frequent and biologically based phenomenon in newly diagnosed celiac disease
Skjellerudsveen, Berit Mære; Omdal, Roald; Hetta, Anne Kristine; Kvaløy, Jan Terje; Aabakken, Lars; Skoie, Inger Marie; Grimstad, Tore Bjørn (Journal article; Peer reviewed, 2022)Fatigue is increasingly recognized as a major complaint in patients with chronic inflammatory and autoimmune diseases. Although fatigue is assumed to represent a significant problem in celiac disease, existing knowledge ... -
Gastroparesis Symptoms Associated with Intestinal Hypomotility: An Explorative Study Using Wireless Motility Capsule
Bekkelund, Mattis; Sangnes, Dag André; Søfteland, Eirik Wigtil; Aabakken, Lars; Biermann, Martin; Steinsvik, Elisabeth K.; Hausken, Trygve; Dimcevski, Georg; Hatlebakk, Jan Gunnar (Journal article; Peer reviewed, 2021)Objective: Gastric emptying measurements are mandatory in gastroparesis diagnostics, but the association between delayed emptying and symptoms is questionable. It is imperative to find biomarkers better correlated to symptom ... -
Heat-shock protein 90α in plasma reflects severity of fatigue in patients with Crohn’s disease
Grimstad, Tore; Kvivik, Ingeborg; Kvaløy, Jan Terje; Aabakken, Lars; Omdal, Roald (Peer reviewed; Journal article, 2020)Heat-shock proteins (HSPs) are evolutionarily conserved proteins with important cellular homeostasis functions during harmful conditions, including inflammation. Some HSPs are secreted extracellularly and act on distant ... -
Histologic healing and factors associated with complete remission following conventional treatment in ulcerative colitis
Steinsbø, Øyvind; Carlsen, Arne; Aasprong, Ole Gunnar; Aabakken, Lars; Tvedt-Gundersen, Espen; Bjørkhaug, Steinar Traae; Gjerde, Rune; Karlsen, Lars Normann; Grimstad, Tore Bjørn (Journal article; Peer reviewed, 2022)Background: Endoscopic and histological activity scores in ulcerative colitis (UC) are associated with clinical outcomes and have become important targets of clinical trials. However, these endpoints have been scarcely ... -
Less, but not gone—gluten-free diet effects on fatigue in celiac disease: a prospective controlled study
Skjellerudsveen, Berit Mære; Omdal, Roald; Hetta, Anne Kristine; Kvaløy, Jan Terje; Aabakken, Lars; Skoie, Inger Marie; Grimstad, Tore Bjørn (Journal article; Peer reviewed, 2023)Introduction: Fatigue is a frequent complaint in patients with celiac disease. A gluten-free diet is the only established treatment for celiac disease, but how this diet influences fatigue is uncertain. We aimed to investigate ... -
Pathophysiology of idiopathic gastroparesis and implications for therapy
Bekkelund, Mattis; Sangnes, Dag André; Hatlebakk, Jan Gunnar; Aabakken, Lars (Peer reviewed; Journal article, 2019)Objectives: Idiopathic gastroparesis is a gastric motility disorder characterized by chronic upper gastrointestinal symptoms and delayed gastric emptying without an identifiable underlying condition. This review summarizes ... -
Patient-Reported Outcome Measures after Endoscopic Retrograde Cholangiopancreatography: A Prospective, Multicenter Study
Glomsaker, Tom Birger; Hoff, Geir; Kvaløy, Jan Terje; Søreide, Kjetil; Aabakken, Lars; Søreide, Jon Arne; The Norwegian Gastronet ERCP group (Journal article, 2013)Objective: While patient-reported outcome measures (PROMs) in ERCP are scarce, these reports are important for making improvements in quality of care. This study sought to document patient satisfaction and specifically ... -
Randomised clinical trial and meta-analysis: mesalazine treatment in irritable bowel syndrome—effects on gastrointestinal symptoms and rectal biomarkers of immune activity
Castro Tejera, Valeria; Öhman, Lena; Aabakken, Lars; Fellström, Bengt; Hausken, Trygve; Hovde, Øistein; Hreinsson, Johann P.; Lindberg, Greger; Venge, Per; Simrén, Magnus; Törnblom, Hans (Journal article; Peer reviewed, 2022)Background Low-grade immune activation in the gut is a potential treatment target in irritable bowel syndrome (IBS). Aims To determine improvement in IBS symptoms after mesalazine treatment, and the utility of measures ...