Blar i Bergen Open Research Archive på forfatter "Hjelle, Sigrun Margrethe"
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A Comparison of p53 Isoform Profiles and Apoptosis Induced by Camptothecin or a Herbal Khat Extract (Catha Edulis (Vahl) Forssk. ex Endl.) in Leukemic Cell Lines: Exploring Cellular Responses in Therapy Development
Onyango, Therese Bredholt; Hjelle, Sigrun Margrethe; Haaland, Ingvild; Vintermyr, Olav Karsten; Johannessen, Anne Christine; Gjertsen, Bjørn Tore (Journal article; Peer reviewed, 2020)Khat (Catha edulis (Vahl) Forssk. ex Endl.) is habitually used as a natural stimulant by millions of people, but is associated with adverse effects on gastrointestinal, cardiovascular and central neural systems. At the ... -
Exercise-induced Laryngeal Obstruction: Protocol for a Randomized Controlled Treatment Trial
Clemm, Hege Synnøve Havstad; Røksund, Ola Drange; Andersen, Tiina Maarit; Heimdal, John-Helge; Karlsen, Tom; Hilland, Magnus; Fretheim-Kelly, Zoe; Hufthammer, Karl Ove; Sandnes, Astrid; Hjelle, Sigrun Margrethe; Vollsæter, Maria; Halvorsen, Thomas (Journal article; Peer reviewed, 2022)Background: Exercise-induced laryngeal obstruction (EILO) is a common cause of exertional breathing problems in young individuals, caused by paradoxical inspiratory adduction of laryngeal structures, and diagnosed by ... -
Gel2DE - A software tool for correlation analysis of 2D gel electrophoresis data
Øye, Ola Kristoffer; Jørgensen, Katarina Mariann; Hjelle, Sigrun Margrethe; Sulen, André; Ulvang, Dag Magne; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2013-07-06)Background: Two-dimensional gel electrophoresis (2DE) is a powerful technique for studying protein isoforms and their modifications. Existing commercial 2D image analysis tools rely on spot detection that limits analysis ... -
Influence of p53 isoform expression on survival in high-grade serous ovarian cancers
Bischof, Katharina; Knappskog, Stian; Hjelle, Sigrun Margrethe; Stefansson, Ingunn; Woie, Kathrine; Salvesen, Helga; Gjertsen, Bjørn Tore; Bjørge, Line (Peer reviewed; Journal article, 2019-03-27)High-grade serous ovarian carcinoma (HGSOC) is characterised by alterations in the p53 pathway. The expression levels of p53 isoforms have been shown to be associated with patient survival in several cancers. This study ... -
p53 Protein Isoform Profiles in AML: Correlation with Distinct Differentiation Stages and Response to Epigenetic Differentiation Therapy
Haaland, Ingvild; Hjelle, Sigrun Margrethe; Reikvam, Håkon; Sulen, André; Ryningen, Anita; McCormack, Emmet; Bruserud, Øystein; Gjertsen, Bjørn Tore (Journal article; Peer reviewed, 2021)p53 protein isoform expression has been found to correlate with prognosis and chemotherapy response in acute myeloid leukemia (AML). We aimed to investigate how p53 protein isoforms are modulated during epigenetic ...