Blar i Bergen Open Research Archive på forfatter "Husebye, Elisabeth Synnøve Nilsen"
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Does maternal genetic liability to folate deficiency influence the risk of antiseizure medication-associated language impairment and autistic traits in children of women with epilepsy?
Husebye, Elisabeth Synnøve Nilsen; Romanowska, Julia; Monsen, Anne-Lise Bjørke; Gilhus, Nils Erik; Selmer, Kaja Kristine; Gervin, Kristina; Riedel, Bettina Maria Ingeborg; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2023)Background: Prenatal exposure to antiseizure medication (ASM) may lead to low plasma folate concentrations and is associated with impaired neurodevelopment. Objectives: To examine whether maternal genetic liability to ... -
Folic Acid and Risk of Preterm Birth, Preeclampsia, and Fetal Growth Restriction Among Women With Epilepsy A Prospective Cohort Study
Alvestad, Silje; Husebye, Elisabeth Synnøve Nilsen; Christensen, Jakob; Dreier, Julie Werenberg; Sun, Yuelian; Igland, Jannicke; Leinonen, Maarit; Gissler, Mika; Gilhus, Nils Erik; Tomson, Torbjörn; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2022)Background and Objectives Women with epilepsy treated with antiseizure medication (ASM) have increased risk of pregnancy complications including preterm birth, fetal growth restriction, and preeclampsia. We aimed to ... -
Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero – the Norwegian Mother and Child Cohort Study
Husebye, Elisabeth Synnøve Nilsen; Gilhus, Nils Erik; Spigset, Olav; Daltveit, Anne Kjersti; Bjørk, Marte-Helene (Peer reviewed; Journal article, 2020)Background and purpose: The purpose was to examine the consequences of antiepileptic drug (AED) exposure during pregnancy on language abilities in children aged 5 and 8 years of mothers with epilepsy. Methods: The study ... -
Maternal pregnancy folate status and association to language impairment in children of women with epilepsy after prenatal antiseizure medication exposure
Husebye, Elisabeth Synnøve Nilsen (Doctoral thesis, 2022-05-05)Background: 2-8 out of 1000 pregnancies occur in women with epilepsy. Most women use antiseizure medication (ASM) during pregnancy to avoid potentially harmful epileptic seizures. Fetal exposure to ASM is associated with ... -
Plasma unmetabolized folic acid in pregnancy and risk of autistic traits and language impairment in antiseizure medication-exposed children of women with epilepsy
Husebye, Elisabeth Synnøve Nilsen; Wendel, Annabel Willemijn Karine; Gilhus, Nils Erik; Riedel, Bettina Maria Ingeborg; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2022)Background: Fetal exposure to unmetabolized folic acid (UMFA) during pregnancy may be associated with adverse neurodevelopment. Antiseizure medication (ASM) may interact with folate metabolism. Women with epilepsy using ... -
Pregnancy, folic acid, and antiseizure medication
Bjørk, Marte-Helene; Vegrim, Håkon Magne; Alvestad, Silje; Monsen, Anne-Lise Bjørke; Riedel, Bettina Maria Ingeborg; Gilhus, Nils Erik; Husebye, Elisabeth Synnøve Nilsen (Journal article; Peer reviewed, 2023)Background Although some antiseizure medications (ASMs) are teratogenic, most people with epilepsy need treatment in pregnancy. The risk of ASM fetotoxicity may be mitigated with folic acid. High-dose folic acid ... -
Prevalence of self-reported emotional, physical, and sexual abuse and association with fear of childbirth in pregnant women with epilepsy: The Norwegian Mother, Father, and Child Cohort Study
Vederhus, Johannes; Husebye, Elisabeth Synnøve Nilsen; Eid, Karine; Gilhus, Nils Erik; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2022)Objective This study was undertaken to examine the prevalence of self-reported experiences with abuse in pregnant women with epilepsy and the association between having experienced abuse and childbirth expectations, ... -
Verbal abilities in children of mothers with epilepsy: Association to maternal folate status
Husebye, Elisabeth Synnøve Nilsen; Gilhus, Nils Erik; Riedel, Bettina; Spigset, Olav; Daltveit, Anne Kjersti; Bjørk, Marte-Helene (Peer reviewed; Journal article, 2018-08)Objective: To examine the effect of maternal folic acid supplementation and maternal plasma folate and antiepileptic drug (AED) concentrations on language delay in AED-exposed children of mothers with epilepsy. Methods: ... -
Vitamin B status and association with antiseizure medication in pregnant women with epilepsy
Husebye, Elisabeth Synnøve Nilsen; Riedel, Bettina Maria Ingeborg; Monsen, Anne-Lise Bjørke; Spigset, Olav; Daltveit, Anne Kjersti Nesje; Gilhus, Nils Erik; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2021)Objective Antiseizure medication (ASM) use interacts with vitamin B status in nonpregnant epilepsy populations. We aimed to examine the association between ASM and vitamin B status in pregnant women with epilepsy. Methods ...