Browsing Bergen Open Research Archive by Author "Johannessen, Fredrik Gullaksen"
Now showing items 1-2 of 2
-
The efficiency of maltodextrin and porous silicon nanoparticles for the in vitro and in vivo stabilization of tyrosine hydroxylase
Johannessen, Fredrik Gullaksen (Master thesis, 2016-06-01)Parkinson's disease is a severe neurodegenerative disease, which causes deterioration of the dopaminergic neurons of the substantia nigra. Lack of dopamine causes motor function problems and cognitive decline. Due to ... -
Relevance of Electrostatics for the Interaction of Tyrosine Hydroxylase with Porous Silicon Nanoparticles
Bezem, Maria Teresa; Johannessen, Fredrik Gullaksen; Kråkenes, Trond-André; Sailor, Michael J.; Martinez, Aurora (Journal article; Peer reviewed, 2021)Tyrosine hydroxylase (TH) is the enzyme catalyzing the rate-limiting step in the synthesis of dopamine in the brain. Developing enzyme replacement therapies using TH could therefore be beneficial to patient groups with ...