Browsing Bergen Open Research Archive by Author "Kursula, Inari Talvikki"

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    • Structure and function of Plasmodium actin II in the parasite mosquito stages 

      Lopez Moreno, Andrea Johana; Andreadaki, Maria; Vahokoski, Juha; Deligianni, Elena; Calder, Lesley J.; Camerini, Serena; Freitag, Anika; Bergmann, Ulrich; Rosenthal, Peter B.; Sidén-Kiamos, Inga; Kursula, Inari Talvikki (Journal article; Peer reviewed, 2023)
      Actins are filament-forming, highly-conserved proteins in eukaryotes. They are involved in essential processes in the cytoplasm and also have nuclear functions. Malaria parasites (Plasmodium spp.) have two actin isoforms ...

    • Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics 

      Dans, Madeline G.; Piirainen, Henni; Nguyen, William; Khurana, Sachin; Mehra, Somya; Razook, Zahra; Geoghegan, Niall D.; Dawson, Aurelie T.; Das, Sujaan; Schneider, Molly Parkyn; Jonsdottir, Thorey K.; Gabriela, Mikha; Gancheva, Maria R.; Tonkin, Christopher J.; Mollard, Vanessa; Goodman, Christopher Dean; McFadden, Geoffrey I.; Wilson, Danny W.; Rogers, Kelly L.; Barry, Alyssa E.; Crabb, Brendan S.; de Koning-Ward, Tania F.; Sleebs, Brad E.; Kursula, Inari Talvikki; Gilson, Paul R. (Journal article; Peer reviewed, 2023)
      With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently described a compound, MMV020291, as a specific inhibitor of red ...