Browsing Bergen Open Research Archive by Author "Piirainen, Henni"

Now showing items 1-3 of 3

    • Apicomplexan actin polymerization depends on nucleation 

      Kumpula, Esa-Pekka; Pires, Isa; Lasiwa, Davki; Piirainen, Henni; Bergmann, Ulrich; Vahokoski, Juha; Kursula, Inari (Peer reviewed; Journal article, 2017-09-22)
      Filamentous actin is critical for apicomplexan motility and host cell invasion. Yet, parasite actin filaments are short and unstable. Their kinetic characterization has been hampered by the lack of robust quantitative ...

    • A function of profilin in force generation during malaria parasite motility that is independent of actin binding 

      Moreau, Catherine A.; Quadt, Katharina A.; Piirainen, Henni; Kumar, Hirdesh; Bhargav, Saligram P.; Strauss, Léanne; Tolia, Niraj H; Wade, Rebecca C.; Spatz, Joachim P; Kursula, Inari; Frischknecht, Friedrich (Journal article; Peer reviewed, 2020)
      During transmission of malaria-causing parasites from mosquito to mammal, Plasmodium sporozoites migrate at high speed within the skin to access the bloodstream and infect the liver. This unusual gliding motility is based ...

    • Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics 

      Dans, Madeline G.; Piirainen, Henni; Nguyen, William; Khurana, Sachin; Mehra, Somya; Razook, Zahra; Geoghegan, Niall D.; Dawson, Aurelie T.; Das, Sujaan; Schneider, Molly Parkyn; Jonsdottir, Thorey K.; Gabriela, Mikha; Gancheva, Maria R.; Tonkin, Christopher J.; Mollard, Vanessa; Goodman, Christopher Dean; McFadden, Geoffrey I.; Wilson, Danny W.; Rogers, Kelly L.; Barry, Alyssa E.; Crabb, Brendan S.; de Koning-Ward, Tania F.; Sleebs, Brad E.; Kursula, Inari Talvikki; Gilson, Paul R. (Journal article; Peer reviewed, 2023)
      With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently described a compound, MMV020291, as a specific inhibitor of red ...