Blar i Bergen Open Research Archive på forfatter "Shi, Tie-Jun"
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Effect of nerve injury on the number of dorsal root ganglion neurons and autotomy behavior in adult Bax-deficient mice
Lyu, Chuang; Lyu, Gong-Wei; Martinez, Aurora; Shi, Tie-Jun (Peer reviewed; Journal article, 2017-08-30)Background: The proapoptotic molecule BAX, plays an important role in mitochondrial apoptotic pathway. Dorsal root ganglion (DRG) neurons depend on neurotrophic factors for survival at early developmental stages. Withdrawal ... -
Expression and regulation of FRMD6 in mouse DRG neurons and spinal cord after nerve injury
Lyu, Chuang; Lyu, Gong-Wei; Mulder, Jan; Uhlén, Mathias; Cai, Xue-Hui; Hökfelt, Tomas; Shi, Tie-Jun (Journal article; Peer reviewed, 2020)FRMD6, a member of the group of FERM-domain proteins, is involved both in communication between cells, interactions with extracellular matrix, cellular apoptotic and regenerative mechanisms. FRMD6 was first discovered in ... -
G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 Is Upregulated in Rat DRGs and Spinal Cord After Peripheral Nerve Injury
Lyu, Chuang; Lyu, Gong-Wei; Mulder, Jan; Martinez, Aurora; Shi, Tie-Jun (Journal article; Peer reviewed, 2020)Background: G protein-gated inwardly rectifying potassium (GIRK) channels are involved in the regulation of neuronal excitability. Four GIRK subunits (GIRK1-4) are expressed in rat dorsal root ganglia (DRGs). Recently, we ... -
How Far Have We Come in the Field of Nerve Regeneration After Trigeminal Nerve Injury?
Rosén, Annika; Tardast, Arezo; Shi, Tie-Jun (Peer reviewed; Journal article, 2016)Patients suffering from nerve injury with sensory disturbances or orofacial pain have greatly reduced quality of life, and it is a big cost for the society. Abnormal sensations caused by trigeminal nerve injury often become ... -
Neuronal plasticity of trigeminal ganglia in mice following nerve injury
Lynds, Randi; Lyu, Chuang; Lyu, Gong-Wei; Shi, Xie-Qi; Rosén, Annika; Mustafa, Kamal Babikeir Eln; Shi, Tie-Jun (Peer reviewed; Journal article, 2017-02-09)Background: Nerve injury may induce neuropathic pain. In studying the mechanisms of orofacial neuropathic pain, attention has been paid to the plastic changes that occur in the trigeminal ganglia (TGs) and nucleus in ... -
The Pah-R261Q mouse reveals oxidative stress associated with amyloid-like hepatic aggregation of mutant phenylalanine hydroxylase
Aubi Catevilla, Oscar; Prestegård, Karina Skjervheim; K C, Kunwar Jung; Shi, Tie-Jun; Ying, Ming; Grindheim, Ann Kari; Scherer, Tanja; Ulvik, Arve; McCann, Adrian; Spriet, Endy; Thöny, Beat; Martinez, Aurora (Journal article; Peer reviewed, 2021)Phenylketonuria (PKU) is caused by autosomal recessive variants in phenylalanine hydroxylase (PAH), leading to systemic accumulation of L-phenylalanine (L-Phe) that may reach neurotoxic levels. A homozygous Pah-R261Q mouse, ...