Browsing Bergen Open Research Archive by Author "Staines, Harry"
Now showing items 1-15 of 15
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Activated factor XI-antithrombin complex presenting as an independent predictor of 30-days mortality in out-of-hospital cardiac arrest patients
Aarsetøy, Reidun; ten Cate, Hugo; Spronk, Henri; Van Oerle, Rene; Aarsetøy, Hildegunn; Staines, Harry; Nilsen, Dennis W.T. (Journal article; Peer reviewed, 2021)Background Cardiac arrest and cardiopulmonary resuscitation (CPR) are associated with activated coagulation and microvascular fibrin deposition with subsequent multiorgan failure and adverse outcome. Objectives Activated ... -
Angiopoietin-2 and angiopoietin-like 4 protein provide prognostic information in patients with suspected acute coronary syndrome
Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika E.; de la Fuente, Ricardo Leon; Pønitz, Volker; Andersen, Trygve Brugger; Grundt, Heidi; Staines, Harry; Nilsen, Dennis W.T. (Journal article; Peer reviewed, 2021)Background Plasma levels of angiopoietin-2 (ANGPT2) and angiopoietin-like 4 protein (ANGPTL4) reflect different pathophysiological aspects of cardiovascular disease. We evaluated their association with outcome in a ... -
B-type natriuretic peptide and high sensitive C-reactive protein predict 2-year all cause mortality in chest pain patients: a prospective observational study from Salta, Argentina
Fuente, Ricardo León de la; Næsgaard, Patrycja A.; Nilsen, Stein Tore; Woie, Leik; Aarsland, Torbjørn; Gallo, Patricio; Grundt, Heidi; Staines, Harry; Nilsen, Dennis W. T. (Peer reviewed; Journal article, 2011-09-29)Background: Several mechanisms are involved in the pathophysiology of the Acute Coronary Syndrome (ACS). We have addressed whether B-type natriuretic peptide (BNP) and high-sensitive C-reactive protein (hsCRP) in admission ... -
Borderline values of troponin-T and high sensitivityC-reactive protein did not predict 2-year mortality inTnTpositive chest-pain patients, whereas brain natriureticpeptide did
Nilsen, Dennis W.T.; Mjelva, Øistein; Leon de la Fuente, Ricardo; Næsgaard, Patrycja; Pønitz, Volker; Andersen, Trygve Brugger; Grundt, Heidi; Staines, Harry; Nilsen, Stein Tore (Peer reviewed; Journal article, 2015-04-08)Background: Troponin-T (TnT), high-sensitive C-reactive protein (hsCRP), and Brain Natriuretic Peptide (BNP) have been shown to be independent prognostic indicators of total and cardiac death during short- and long-term ... -
Complement component 7 is associated with total- and cardiac death in chest-pain patients with suspected acute coronary syndrome
Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika Elisabet; Leon de la Fuente, Ricardo; Grundt, Magnea Heidi Jonsdottir; Staines, Harry; Nygård, Ottar Kjell; Nilsen, Dennis W.T. (Journal article; Peer reviewed, 2021)Background Complement activation has been associated with atherosclerosis, atherosclerotic plaque destabilization and increased risk of cardiovascular events. Complement component 7 (CC7) binds to the C5bC6 complex which ... -
The Effect of Protease-Activated Receptor-1 (PAR-1) Inhibition on Endothelial-Related Biomarkers in Patients with Coronary Artery Disease
Nilsen, Dennis W.T.; Røysland, Michelle; Ueland, Thor; Aukrust, Pål; Michelsen, Annika Elisabet; Staines, Harry; Barvik, Ståle; Kontny, Frederic; Nordrehaug, Jan Erik; Bonarjee, Vernon V S (Journal article; Peer reviewed, 2022)Background: Vorapaxar has been shown to reduce cardiovascular mortality in postmyocardial infarction (MI) patients. Pharmacodynamic biomarker research related to protease-activated receptor-1 (PAR-1) inhibition with vorapaxar ... -
Low Levels of the Omega-3 Index are Associated with Sudden Cardiac Arrest and Remain Stable in Survivors in the Subacute Phase
Aarsetøy, Hildegunn; Aarsetøy, Reidun; Lindner, Thomas Werner; Staines, Harry; Harris, William S.; Nilsen, Dennis W. T. (Peer reviewed; Journal article, 2011-01-14)In previous studies, low blood levels of n-3 fatty acids (FA) have been associated with increased risk of cardiac death, and the omega-3 index (red blood cell (RBC) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) ... -
N-terminal pro-B-type natriuretic peptide as a prognostic indicator for 30-day mortality following out-of-hospital cardiac arrest: A prospective observational study
Aarsetøy, Reidun; Omland, Torbjørn; Røsjø, Helge; Strand, Heidi; Lindner, Thomas Werner; Aarsetøy, Hildegunn; Staines, Harry; Nilsen, Dennis W.T. (Journal article; Peer reviewed, 2020-08-24)Background Early risk stratification applying cardiac biomarkers may prove useful in sudden cardiac arrest patients. We investigated the prognostic utility of early-on levels of high sensitivity cardiac troponin-T (hs-cTnT), ... -
Podocan and Adverse Clinical Outcome in Patients Admitted With Suspected Acute Coronary Syndromes
Andersen, Thomas; Ueland, Thor; Aukrust, Pål; Nilsen, Dennis W.T.; Grundt, Magnea Heidi Jonsdottir; Staines, Harry; Kontny, Frederic (Journal article; Peer reviewed, 2022)Background: Markers of bone and extracellular matrix (ECM) remodeling may be associated with adverse outcomes in atherosclerotic cardiovascular disease. Podocan is a newly discovered ECM glycoprotein, previously not studied ... -
Procollagen type 1 N-terminal propeptide is associated with adverse outcome in acute chest pain of suspected coronary origin
Andersen, Thomas; Ueland, Thor; Aukrust, Pål; Nilsen, Dennis WT; Grundt, Magnea Heidi Jonsdottir; Staines, Harry; Pønitz, Volker; Kontny, Frederic (Journal article; Peer reviewed, 2023)Background: Extracellular matrix (ECM) is an integral player in the pathophysiology of a variety of cardiac diseases. Cardiac ECM is composed mainly of collagen, of which type 1 is the most abundant with procollagen type ... -
Prognostic utility of vitamin D in acute coronary syndrome patients in coastal Norway
Næsgaard, Patrycja A.; Pønitz, Volker; Aarsetøy, Hildegunn; Andersen, Trygve Brugger; Grundt, Heidi; Harris, William S; Staines, Harry; Nilsen, Dennis W.T. (Peer reviewed; Journal article, 2015)BACKGROUND: An inverse relationship between cardiovascular risk and levels of vitamin D and omega-3 index may exist. OBJECTIVES: To evaluate the prognostic utility of serum 25-hydroxyvitamin D [25(OH)D] in 871 patients ... -
Serum 25(OH)D Is a 2-Year Predictor of All-Cause Mortality, Cardiac Death and Sudden Cardiac Death in Chest Pain Patients from Northern Argentina
Næsgaard, Patrycja A.; Fuente, Ricardo León de la; Nilsen, Stein Tore; Woie, Leik; Aarsland, Torbjørn; Brede, Cato; Staines, Harry; Nilsen, Dennis W. T. (Peer reviewed; Journal article, 2012-09-06)Background: Several studies have shown an association between vitamin D deficiency and cardiovascular risk. Vitamin D status is assessed by determination of 25-hydroxyvitamin D [25(OH)D] in serum. Methods: We assessed the ... -
Socioeconomic Assessment and Impact of Social Security on Outcome in Patients Admitted with Suspected Coronary Chest Pain in the City of Salta, Argentina
Fuente, Ricardo León de la; Næsgaard, Patrycja A.; Nilsen, Stein Tore; Woie, Leik; Aarsland, Torbjørn; Staines, Harry; Nilsen, Dennis W. T. (Peer reviewed; Journal article, 2013) -
Vitamin D predicts all-cause and cardiac mortality in females with suspected acute coronary syndrome: a comparison with brain natriuretic peptide and high-sensitivity C-reactive protein
Næsgaard, Patrycja; Fuente, Ricardo León de la; Nilsen, Stein Tore; Woie, Leik; Årsland, Torbjørn; Staines, Harry; Nilsen, Dennis W.T. (Peer reviewed; Journal article, 2013)Vitamin D may not only reflect disease but may also serve as a prognostic indicator. Our aim was to assess the gender-specific utility of vitamin D measured as 25-hydroxy-vitamin D [25(OH)D] to predict all-cause and cardiac ... -
Vitamin D Uptake in Patients Treated with a High-Dosed Purified Omega-3 Compound in a Randomized Clinical Trial Following an Acute Myocardial Infarction
Næsgaard, Patrycja; Grundt, Heidi; Nordøy, Arne; Staines, Harry; Nilsen, Dennis W.T. (Peer reviewed; Journal article, 2017-07-24)Background: Fish is the natural dietary source of vitamin D. Reports on the influence of purified omega-3 fatty acids on its uptake are scarce. Objectives: We investigated the impact of a purified high-dose omega-3 compound ...